Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression
Lauring, Brett, Taggart, Andrew K P, Tata, James R, Dunbar, Richard, Caro, Luzelena, Cheng, Kang, Chin, Jayne, Colletti, Steven L, Cote, Josee, Khalilieh, Sauzanne, Liu, Jiajun, Luo, Wen-Lin, Maclean, Alexandra A, Peterson, Laurence B, Polis, Adam B, Sirah, Waheeda, Wu, Tsuei-Ju, Liu, Xuan, Jin, Lan, Wu, Kenneth, Boatman, P Douglas, Semple, Graeme, Behan, Dominic P, Connolly, Daniel T, Lai, Eseng, Wagner, John A, Wright, Samuel D, Cuffie, Cynthia, Mitchel, Yale B, Rader, Daniel J, Paolini, John F, Waters, M Gerard, Plump, Andrew
Published in Science translational medicine (22.08.2012)
Published in Science translational medicine (22.08.2012)
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Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat
Tran, Thuy-Anh, Shin, Young-Jun, Kramer, Bryan, Choi, Juyi, Zou, Ning, Vallar, Pureza, Martens, Peter, Douglas Boatman, P., Adams, John W., Ramirez, Juan, Shi, Yunqing, Morgan, Michael, Unett, David J., Chang, Steve, Shu, Hsin-Hui, Tung, Shiu-Feng, Semple, Graeme
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
Published in Bioorganic & medicinal chemistry letters (01.03.2015)
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Nicotinic Acid Receptor Agonists
Boatman, P. Douglas, Richman, Jeremy G, Semple, Graeme
Published in Journal of medicinal chemistry (25.12.2008)
Published in Journal of medicinal chemistry (25.12.2008)
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Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection
Zhang, Tong, Li, Zhuangjie, Dang, Huong, Chen, Ruoping, Liaw, Chen, Tran, Thuy-Anh, Boatman, P Douglas, Connolly, Daniel T, Adams, John W
Published in American journal of physiology. Heart and circulatory physiology (01.01.2012)
Published in American journal of physiology. Heart and circulatory physiology (01.01.2012)
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Discovery of 2‑(((1r,4r)‑4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension
Tran, Thuy-Anh, Kramer, Bryan, Shin, Young-Jun, Vallar, Pureza, Boatman, P. Douglas, Zou, Ning, Sage, Carleton R, Gharbaoui, Tawfik, Krishnan, Ashwin, Pal, Biman, Shakya, Sagar R, Garrido Montalban, Antonio, Adams, John W, Ramirez, Juan, Behan, Dominic P, Shifrina, Anna, Blackburn, Anthony, Leakakos, Tina, Shi, Yunqing, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Unett, David J, Gaidarov, Ibragim, Chen, Xiaohua, Chang, Steve, Shu, Hsin-Hui, Tung, Shiu-Feng, Semple, Graeme
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans
Boatman, P. Douglas, Lauring, Brett, Schrader, Thomas O, Kasem, Michelle, Johnson, Benjamin R, Skinner, Philip, Jung, Jae-Kyu, Xu, Jerry, Cherrier, Martin C, Webb, Peter J, Semple, Graeme, Sage, Carleton R, Knudsen, Jens, Chen, Ruoping, Luo, Wen-Lin, Caro, Luzelena, Cote, Josee, Lai, Eseng, Wagner, John, Taggart, Andrew K, Carballo-Jane, Ester, Hammond, Milton, Colletti, Steven L, Tata, James R, Connolly, Daniel T, Waters, M. Gerard, Richman, Jeremy G
Published in Journal of medicinal chemistry (26.04.2012)
Published in Journal of medicinal chemistry (26.04.2012)
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3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice
Semple, Graeme, Skinner, Philip J, Gharbaoui, Tawfik, Shin, Young-Jun, Jung, Jae-Kyu, Cherrier, Martin C, Webb, Peter J, Tamura, Susan Y, Boatman, P. Douglas, Sage, Carleton R, Schrader, Thomas O, Chen, Ruoping, Colletti, Steven L, Tata, James R, Waters, M. Gerard, Cheng, Kang, Taggart, Andrew K, Cai, Tian-Quan, Carballo-Jane, Ester, Behan, Dominic P, Connolly, Daniel T, Richman, Jeremy G
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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Analogues of Acifran: Agonists of the High and Low Affinity Niacin Receptors, GPR109a and GPR109b
Jung, Jae-Kyu, Johnson, Benjamin R, Duong, Tracy, Decaire, Marc, Uy, Jane, Gharbaoui, Tawfik, Boatman, P. Douglas, Sage, Carleton R, Chen, Ruoping, Richman, Jeremy G, Connolly, Daniel T, Semple, Graeme
Published in Journal of medicinal chemistry (05.04.2007)
Published in Journal of medicinal chemistry (05.04.2007)
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Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)
Boatman, P. Douglas, Schrader, Thomas O., Kasem, Michelle, Johnson, Benjamin R., Skinner, Philip J., Jung, Jae-Kyu, Xu, Jerry, Cherrier, Martin C., Webb, Peter J., Semple, Graeme, Sage, Carleton R., Knudsen, Jens, Chen, Ruoping, Taggart, Andrew K., Carballo-Jane, Ester, Richman, Jeremy G.
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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First total synthesis of taxol. 2. Completion of the C and D rings
Holton, Robert A, Kim, Hyeong Baik, Somoza, Carmen, Liang, Feng, Biediger, Ronald J, Boatman, P. Douglas, Shindo, Mitsuru, Smith, Chase C, Kim, Soekchan
Published in Journal of the American Chemical Society (01.02.1994)
Published in Journal of the American Chemical Society (01.02.1994)
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First total synthesis of taxol. 1. Functionalization of the B ring
Holton, Robert A, Somoza, Carmen, Kim, Hyeong Baik, Liang, Feng, Biediger, Ronald J, Boatman, P. Douglas, Shindo, Mitsuru, Smith, Chase C, Kim, Soekchan
Published in Journal of the American Chemical Society (01.02.1994)
Published in Journal of the American Chemical Society (01.02.1994)
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Agonist lead identification for the high affinity niacin receptor GPR109a
Gharbaoui, Tawfik, Skinner, Philip J., Shin, Young-Jun, Averbuj, Claudia, Jung, Jae-Kyu, Johnson, Benjamin R., Duong, Tracy, Decaire, Marc, Uy, Jane, Cherrier, Martin C., Webb, Peter J., Tamura, Susan Y., Zou, Ning, Rodriguez, Nathalie, Boatman, P. Douglas, Sage, Carleton R., Lindstrom, Andrew, Xu, Jerry, Schrader, Thomas O., Smith, Brian M., Chen, Ruoping, Richman, Jeremy G., Connolly, Daniel T., Colletti, Steven L., Tata, James R., Semple, Graeme
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
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(1a R ,5a R )1a,3,5,5a-Tetrahydro-1 H -2,3-diaza-cyclopropa[ a ]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans
Boatman, P. Douglas, Lauring, Brett, Schrader, Thomas O., Kasem, Michelle, Johnson, Benjamin R., Skinner, Philip, Jung, Jae-Kyu, Xu, Jerry, Cherrier, Martin C., Webb, Peter J., Semple, Graeme, Sage, Carleton R., Knudsen, Jens, Chen, Ruoping, Luo, Wen-Lin, Caro, Luzelena, Cote, Josee, Lai, Eseng, Wagner, John, Taggart, Andrew K., Carballo-Jane, Ester, Hammond, Milton, Colletti, Steven L., Tata, James R., Connolly, Daniel T., Waters, M. Gerard, Richman, Jeremy G.
Published in Journal of medicinal chemistry (26.04.2012)
Published in Journal of medicinal chemistry (26.04.2012)
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Recent progress in the discovery of niacin receptor agonists
Semple, Graeme, Boatman, P Douglas, Richman, Jeremy G
Published in Current opinion in drug discovery & development (01.07.2007)
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Published in Current opinion in drug discovery & development (01.07.2007)
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Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection
TONG ZHANG, ZHUANGJIE LI, HUONG DANG, RUOPING CHEN, LIAW, Chen, TRAN, Thuy-Anh, DOUGLAS BOATMAN, P, CONNOLLY, Daniel T, ADAMS, John W
Published in American journal of physiology. Heart and circulatory physiology (2012)
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Published in American journal of physiology. Heart and circulatory physiology (2012)
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Secondary Structure Peptide Mimetics: Design, Synthesis, and Evaluation of β-Strand Mimetic Thrombin Inhibitors
Boatman, P. Douglas, Ogbu, Cyprian O, Eguchi, Masakatsu, Kim, Hwa-Ok, Nakanishi, Hiroshi, Cao, Bolong, Shea, J. Paul, Kahn, Michael
Published in Journal of medicinal chemistry (22.04.1999)
Published in Journal of medicinal chemistry (22.04.1999)
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Highly efficient and versatile synthesis of libraries of constrained β-strand mimetics
Ogbu, Cyprian O., Qabar, Maher N., Boatman, P.Douglas, Urban, Jan, Meara, Joseph P., Ferguson, Mark D., Tulinsky, John, Lum, Chris, Babu, Suresh, Blaskovich, Mark A., Nakanishi, Hiroshi, Ruan, Fuqiang, Cao, Bolong, Minarik, Ryan, Little, Tom, Nelson, Sherry, Nguyen, Minh, Gall, Anna, Kann, Michael
Published in Bioorganic & medicinal chemistry letters (08.09.1998)
Published in Bioorganic & medicinal chemistry letters (08.09.1998)
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