In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides
Southwell, Amber L, Skotte, Niels H, Kordasiewicz, Holly B, Østergaard, Michael E, Watt, Andrew T, Carroll, Jeffrey B, Doty, Crystal N, Villanueva, Erika B, Petoukhov, Eugenia, Vaid, Kuljeet, Xie, Yuanyun, Freier, Susan M, Swayze, Eric E, Seth, Punit P, Bennett, Clarence Frank, Hayden, Michael R
Published in Molecular therapy (01.12.2014)
Published in Molecular therapy (01.12.2014)
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Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients
Skotte, Niels H, Southwell, Amber L, Østergaard, Michael E, Carroll, Jeffrey B, Warby, Simon C, Doty, Crystal N, Petoukhov, Eugenia, Vaid, Kuljeet, Kordasiewicz, Holly, Watt, Andrew T, Freier, Susan M, Hung, Gene, Seth, Punit P, Bennett, C Frank, Swayze, Eric E, Hayden, Michael R
Published in PloS one (10.09.2014)
Published in PloS one (10.09.2014)
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Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin
Graham, Rona K., Deng, Yu, Slow, Elizabeth J., Haigh, Brendan, Bissada, Nagat, Lu, Ge, Pearson, Jacqueline, Shehadeh, Jacqueline, Bertram, Lisa, Murphy, Zoe, Warby, Simon C., Doty, Crystal N., Roy, Sophie, Wellington, Cheryl L., Leavitt, Blair R., Raymond, Lynn A., Nicholson, Donald W., Hayden, Michael R.
Published in Cell (16.06.2006)
Published in Cell (16.06.2006)
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Bidirectional Control of Postsynaptic Density-95 (PSD-95) Clustering by Huntingtin
Parsons, Matthew P., Kang, Rujun, Buren, Caodu, Dau, Alejandro, Southwell, Amber L., Doty, Crystal N., Sanders, Shaun S., Hayden, Michael R., Raymond, Lynn A.
Published in The Journal of biological chemistry (07.02.2014)
Published in The Journal of biological chemistry (07.02.2014)
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Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
Østergaard, Michael E., Southwell, Amber L., Kordasiewicz, Holly, Watt, Andrew T., Skotte, Niels H., Doty, Crystal N., Vaid, Kuljeet, Villanueva, Erika B., Swayze, Eric E., Frank Bennett, C., Hayden, Michael R., Seth, Punit P.
Published in Nucleic acids research (01.11.2013)
Published in Nucleic acids research (01.11.2013)
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HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia
WARBY, Simon C, VISSCHER, Henk, COLLINS, Jennifer A, DOTY, Crystal N, CARTER, Catherine, BUTLAND, Stefanie L, HAYDEN, Anna R, KANAZAWA, Ichiro, ROSS, Colin J, HAYDEN, Michael R
Published in European journal of human genetics : EJHG (01.05.2011)
Published in European journal of human genetics : EJHG (01.05.2011)
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HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity
Mattis, Virginia B, Tom, Colton, Akimov, Sergey, Saeedian, Jasmine, Østergaard, Michael E, Southwell, Amber L, Doty, Crystal N, Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Arjomand, Jamshid, Hayden, Michael R, Ross, Christopher A, Svendsen, Clive N
Published in Human molecular genetics (01.06.2015)
Published in Human molecular genetics (01.06.2015)
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Journal Article
Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS
Østergaard, Michael E, Southwell, Amber L, Kordasiewicz, Holly, Watt, Andrew T, Skotte, Niels H, Doty, Crystal N, Vaid, Kuljeet, Villanueva, Erika B, Swayze, Eric E, Bennett, C Frank, Hayden, Michael R, Seth, Punit P
Published in Nucleic acids research (01.11.2013)
Published in Nucleic acids research (01.11.2013)
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Journal Article
Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease
Southwell, Amber L, Kordasiewicz, Holly B, Langbehn, Douglas, Skotte, Niels H, Parsons, Matthew P, Villanueva, Erika B, Caron, Nicholas S, Østergaard, Michael E, Anderson, Lisa M, Xie, Yuanyun, Cengio, Louisa Dal, Findlay-Black, Hailey, Doty, Crystal N, Fitsimmons, Bethany, Swayze, Eric E, Seth, Punit P, Raymond, Lynn A, Frank Bennett, C, Hayden, Michael R
Published in Science translational medicine (03.10.2018)
Published in Science translational medicine (03.10.2018)
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Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry
Kay, Chris, Collins, Jennifer A, Skotte, Niels H, Southwell, Amber L, Warby, Simon C, Caron, Nicholas S, Doty, Crystal N, Nguyen, Betty, Griguoli, Annamaria, Ross, Colin J, Squitieri, Ferdinando, Hayden, Michael R
Published in Molecular therapy (01.11.2015)
Published in Molecular therapy (01.11.2015)
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Journal Article
A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease
Bečanović, Kristina, Nørremølle, Anne, Neal, Scott J, Kay, Chris, Collins, Jennifer A, Arenillas, David, Lilja, Tobias, Gaudenzi, Giulia, Manoharan, Shiana, Doty, Crystal N, Beck, Jessalyn, Lahiri, Nayana, Portales-Casamar, Elodie, Warby, Simon C, Connolly, Colúm, De Souza, Rebecca A G, Tabrizi, Sarah J, Hermanson, Ola, Langbehn, Douglas R, Hayden, Michael R, Wasserman, Wyeth W, Leavitt, Blair R
Published in Nature neuroscience (01.06.2015)
Published in Nature neuroscience (01.06.2015)
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HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia
Warby, Simon C, Visscher, Henk, Collins, Jennifer A, Doty, Crystal N, Carter, Catherine, Butland, Stefanie L, Hayden, Anna R, Kanazawa, Ichiro, Ross, Colin J, Hayden, Michael R
Published in European journal of human genetics : EJHG (01.05.2011)
Published in European journal of human genetics : EJHG (01.05.2011)
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Journal Article
A fully humanized transgenic mouse model of Huntington disease
Southwell, Amber L, Warby, Simon C, Carroll, Jeffrey B, Doty, Crystal N, Skotte, Niels H, Zhang, Weining, Villanueva, Erika B, Kovalik, Vlad, Xie, Yuanyun, Pouladi, Mahmoud A, Collins, Jennifer A, Yang, X William, Franciosi, Sonia, Hayden, Michael R
Published in Human molecular genetics (01.01.2013)
Published in Human molecular genetics (01.01.2013)
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High frequency of intermediate alleles on huntington disease-associated haplotypes in British Columbia's general population
Semaka, Alicia, Kay, Chris, Doty, Crystal N., Collins, Jennifer A., Tam, Natalie, Hayden, Michael R.
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (01.12.2013)
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (01.12.2013)
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Journal Article
Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease
Sutton, Liza M, Sanders, Shaun S, Butland, Stefanie L, Singaraja, Roshni R, Franciosi, Sonia, Southwell, Amber L, Doty, Crystal N, Schmidt, Mandi E, Mui, Katherine K N, Kovalik, Vlad, Young, Fiona B, Zhang, Weining, Hayden, Michael R
Published in Human molecular genetics (01.02.2013)
Published in Human molecular genetics (01.02.2013)
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Huntington disease in the South African population occurs on diverse and ethnically distinct genetic haplotypes
Baine, Fiona K, Kay, Chris, Ketelaar, Maria E, Collins, Jennifer A, Semaka, Alicia, Doty, Crystal N, Krause, Amanda, Greenberg, L Jacquie, Hayden, Michael R
Published in European journal of human genetics : EJHG (01.10.2013)
Published in European journal of human genetics : EJHG (01.10.2013)
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Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus
Warby, Simon C., Doty, Crystal N., Graham, Rona K., Carroll, Jeffrey B., Yang, Yu-Zhou, Singaraja, Roshni R., Overall, Christopher M., Hayden, Michael R.
Published in Human molecular genetics (01.08.2008)
Published in Human molecular genetics (01.08.2008)
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Reliable Resolution of Full-Length Huntingtin Alleles by Quantitative Immunoblotting
Caron, Nicholas S., Anderson, Christine, Black, Hailey Findlay, Sanders, Shaun S., Lemarié, Fanny L., Doty, Crystal N., Hayden, Michael R.
Published in Journal of Huntington's disease (01.01.2021)
Published in Journal of Huntington's disease (01.01.2021)
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Journal Article
Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin
Carroll, Jeffrey B, Warby, Simon C, Southwell, Amber L, Doty, Crystal N, Greenlee, Sarah, Skotte, Niels, Hung, Gene, Bennett, C Frank, Freier, Susan M, Hayden, Michael R
Published in Molecular therapy (01.12.2011)
Published in Molecular therapy (01.12.2011)
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