Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy
Oberli, Matthias A, Reichmuth, Andreas M, Dorkin, J. Robert, Mitchell, Michael J, Fenton, Owen S, Jaklenec, Ana, Anderson, Daniel G, Langer, Robert, Blankschtein, Daniel
Published in Nano letters (08.03.2017)
Published in Nano letters (08.03.2017)
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Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo
Dong, Yizhou, Dorkin, J. Robert, Wang, Weiheng, Chang, Philip H, Webber, Matthew J, Tang, Benjamin C, Yang, Junghoon, Abutbul-Ionita, Inbal, Danino, Dganit, DeRosa, Frank, Heartlein, Michael, Langer, Robert, Anderson, Daniel G
Published in Nano letters (10.02.2016)
Published in Nano letters (10.02.2016)
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Lipid-like materials for low-dose, in vivo gene silencing
Love, Kevin T, Mahon, Kerry P, Levins, Christopher G, Whitehead, Kathryn A, Querbes, William, Dorkin, J. Robert, Qin, June, Cantley, William, Qin, Liu Liang, Racie, Timothy, Frank-Kamenetsky, Maria, Yip, Ka Ning, Alvarez, Rene, Sah, Dinah W.Y, de Fougerolles, Antonin, Fitzgerald, Kevin, Koteliansky, Victor, Akinc, Akin, Langer, Robert, Anderson, Daniel G
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2010)
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Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse
Kauffman, Kevin J., Oberli, Matthias A., Dorkin, J. Robert, Hurtado, Juan E., Kaczmarek, James C., Bhadani, Shivani, Wyckoff, Jeff, Langer, Robert, Jaklenec, Ana, Anderson, Daniel G.
Published in Molecular therapy. Nucleic acids (02.03.2018)
Published in Molecular therapy. Nucleic acids (02.03.2018)
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Cytosine base editing inhibits hepatitis B virus replication and reduces HBsAg expression in vitro and in vivo
Smekalova, Elena M., Martinez, Maria G., Combe, Emmanuel, Kumar, Anuj, Dejene, Selam, Leboeuf, Dominique, Chen, Chao-Ying, Dorkin, J. Robert, Shuang, Lan Shuan, Kieft, Sarah, Young, Lauren, Barrera, Luis Alberto, Packer, Michael S., Ciaramella, Giuseppe, Testoni, Barbara, Gregoire, Francine, Zoulim, Fabien
Published in Molecular therapy. Nucleic acids (12.03.2024)
Published in Molecular therapy. Nucleic acids (12.03.2024)
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Non-viral vectors for gene-based therapy
Yin, Hao, Kanasty, Rosemary L., Eltoukhy, Ahmed A., Vegas, Arturo J., Dorkin, J. Robert, Anderson, Daniel G.
Published in Nature reviews. Genetics (01.08.2014)
Published in Nature reviews. Genetics (01.08.2014)
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Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
Kauffman, Kevin J, Dorkin, J. Robert, Yang, Jung H, Heartlein, Michael W, DeRosa, Frank, Mir, Faryal F, Fenton, Owen S, Anderson, Daniel G
Published in Nano letters (11.11.2015)
Published in Nano letters (11.11.2015)
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Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
Whitehead, Kathryn A., Dorkin, J. Robert, Vegas, Arturo J., Chang, Philip H., Veiseh, Omid, Matthews, Jonathan, Fenton, Owen S., Zhang, Yunlong, Olejnik, Karsten T., Yesilyurt, Volkan, Chen, Delai, Barros, Scott, Klebanov, Boris, Novobrantseva, Tatiana, Langer, Robert, Anderson, Daniel G.
Published in Nature communications (27.06.2014)
Published in Nature communications (27.06.2014)
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Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery
Fenton, Owen S., Kauffman, Kevin J., McClellan, Rebecca L., Appel, Eric A., Dorkin, J. Robert, Tibbitt, Mark W., Heartlein, Michael W., DeRosa, Frank, Langer, Robert, Anderson, Daniel G.
Published in Advanced materials (Weinheim) (20.04.2016)
Published in Advanced materials (Weinheim) (20.04.2016)
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Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
Akinc, Akin, Querbes, William, De, Soma, Qin, June, Frank-Kamenetsky, Maria, Jayaprakash, K. Narayanannair, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G, Cantley, William L, Dorkin, J Robert, Butler, James S, Qin, LiuLiang, Racie, Timothy, Sprague, Andrew, Fava, Eugenio, Zeigerer, Anja, Hope, Michael J, Zerial, Marino, Sah, Dinah WY, Fitzgerald, Kevin, Tracy, Mark A, Manoharan, Muthiah, Koteliansky, Victor, Fougerolles, Antonin de, Maier, Martin A
Published in Molecular therapy (01.07.2010)
Published in Molecular therapy (01.07.2010)
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Assessing siRNA Pharmacodynamics in a Luciferase-expressing Mouse
Svensson, Robert U, Shey, Michael R, Ballas, Zuhair K, Dorkin, J Robert, Goldberg, Michael, Akinc, Akin, Langer, Robert, Anderson, Daniel G, Bumcrot, David, Henry, Michael D
Published in Molecular therapy (01.12.2008)
Published in Molecular therapy (01.12.2008)
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Rational design of cationic lipids for siRNA delivery
Semple, Sean C, Akinc, Akin, Chen, Jianxin, Sandhu, Ammen P, Mui, Barbara L, Cho, Connie K, Sah, Dinah W Y, Stebbing, Derrick, Crosley, Erin J, Yaworski, Ed, Hafez, Ismail M, Dorkin, J Robert, Qin, June, Lam, Kieu, Rajeev, Kallanthottathil G, Wong, Kim F, Jeffs, Lloyd B, Nechev, Lubomir, Eisenhardt, Merete L, Jayaraman, Muthusamy, Kazem, Mikameh, Maier, Martin A, Srinivasulu, Masuna, Weinstein, Michael J, Chen, Qingmin, Alvarez, Rene, Barros, Scott A, De, Soma, Klimuk, Sandra K, Borland, Todd, Kosovrasti, Verbena, Cantley, William L, Tam, Ying K, Manoharan, Muthiah, Ciufolini, Marco A, Tracy, Mark A, de Fougerolles, Antonin, MacLachlan, Ian, Cullis, Pieter R, Madden, Thomas D, Hope, Michael J
Published in Nature biotechnology (01.02.2010)
Published in Nature biotechnology (01.02.2010)
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Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver
Akinc, Akin, Goldberg, Michael, Qin, June, Dorkin, J Robert, Gamba-Vitalo, Christina, Maier, Martin, Jayaprakash, K Narayanannair, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Koteliansky, Victor, Röhl, Ingo, Leshchiner, Elizaveta S, Langer, Robert, Anderson, Daniel G
Published in Molecular therapy (01.05.2009)
Published in Molecular therapy (01.05.2009)
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Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo
Dong, Yizhou, Eltoukhy, Ahmed A, Alabi, Christopher A, Khan, Omar F, Veiseh, Omid, Dorkin, J Robert, Sirirungruang, Sasilada, Yin, Hao, Tang, Benjamin C, Pelet, Jeisa M, Chen, Delai, Gu, Zhen, Xue, Yuan, Langer, Robert, Anderson, Daniel G
Published in Advanced healthcare materials (01.09.2014)
Published in Advanced healthcare materials (01.09.2014)
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Journal Article
Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates
Dong, Yizhou, Love, Kevin T., Dorkin, J. Robert, Sirirungruang, Sasilada, Zhang, Yunlong, Chen, Delai, Bogorad, Roman L., Yin, Hao, Chen, Yi, Vegas, Arturo J., Alabi, Christopher A., Sahay, Gaurav, Olejnik, Karsten T., Wang, Weiheng, Schroeder, Avi, Lytton-Jean, Abigail K. R., Siegwart, Daniel J., Akinc, Akin, Barnes, Carmen, Barros, Scott A., Carioto, Mary, Fitzgerald, Kevin, Hettinger, Julia, Kumar, Varun, Novobrantseva, Tatiana I., Qin, June, Querbes, William, Koteliansky, Victor, Langer, Robert, Anderson, Daniel G.
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2014)
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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
Anderson, Daniel G, Akinc, Akin, Zumbuehl, Andreas, Goldberg, Michael, Leshchiner, Elizaveta S, Busini, Valentina, Hossain, Naushad, Bacallado, Sergio A, Nguyen, David N, Fuller, Jason, Alvarez, Rene, Borodovsky, Anna, Borland, Todd, Constien, Rainer, de Fougerolles, Antonin, Dorkin, J Robert, Narayanannair Jayaprakash, K, Jayaraman, Muthusamy, John, Matthias, Koteliansky, Victor, Manoharan, Muthiah, Nechev, Lubomir, Qin, June, Racie, Timothy, Raitcheva, Denitza, Rajeev, Kallanthottathil G, Sah, Dinah W Y, Soutschek, Jürgen, Toudjarska, Ivanka, Vornlocher, Hans-Peter, Zimmermann, Tracy S, Langer, Robert
Published in Nature biotechnology (01.05.2008)
Published in Nature biotechnology (01.05.2008)
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