Deconstructing Retinal Organoids: Single Cell RNA‐Seq Reveals the Cellular Components of Human Pluripotent Stem Cell‐Derived Retina
Collin, Joseph, Queen, Rachel, Zerti, Darin, Dorgau, Birthe, Hussain, Rafiqul, Coxhead, Jonathan, Cockell, Simon, Lako, Majlinda
Published in Stem cells (Dayton, Ohio) (01.05.2019)
Published in Stem cells (Dayton, Ohio) (01.05.2019)
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Cellular regeneration strategies for macular degeneration: past, present and future
Chichagova, Valeria, Hallam, Dean, Collin, Joseph, Zerti, Darin, Dorgau, Birthe, Felemban, Majed, Lako, Majlinda, Steel, David H.
Published in Eye (London) (01.05.2018)
Published in Eye (London) (01.05.2018)
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Journal Article
Room temperature shipment does not affect the biological activity of pluripotent stem cell-derived retinal organoids
Georgiou, Maria, Chichagova, Valeria, Hilgen, Gerrit, Dorgau, Birthe, Sernagor, Evelyne, Armstrong, Lyle, Lako, Majlinda
Published in PloS one (01.06.2020)
Published in PloS one (01.06.2020)
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An integrated transcriptional analysis of the developing human retina
Mellough, Carla B, Bauer, Roman, Collin, Joseph, Dorgau, Birthe, Zerti, Darin, Dolan, David W P, Jones, Carl M, Izuogu, Osagie G, Yu, Min, Hallam, Dean, Steyn, Jannetta S, White, Kathryn, Steel, David H, Santibanez-Koref, Mauro, Elliott, David J, Jackson, Michael S, Lindsay, Susan, Grellscheid, Sushma, Lako, Majlinda
Published in Development (Cambridge) (15.01.2019)
Published in Development (Cambridge) (15.01.2019)
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Journal Article
Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina
Dorgau, Birthe, Collin, Joseph, Rozanska, Agata, Zerti, Darin, Unsworth, Adrienne, Crosier, Moira, Hussain, Rafiqul, Coxhead, Jonathan, Dhanaseelan, Tamil, Patel, Aara, Sowden, Jane C., FitzPatrick, David R., Queen, Rachel, Lako, Majlinda
Published in Nature communications (26.04.2024)
Published in Nature communications (26.04.2024)
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Journal Article
Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences
Mellough, Carla B., Collin, Joseph, Queen, Rachel, Hilgen, Gerrit, Dorgau, Birthe, Zerti, Darin, Felemban, Majed, White, Kathryn, Sernagor, Evelyne, Lako, Majlinda
Published in Stem cells translational medicine (01.07.2019)
Published in Stem cells translational medicine (01.07.2019)
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Journal Article
Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface
Collin, Joseph, Queen, Rachel, Zerti, Darin, Dorgau, Birthe, Georgiou, Maria, Djidrovski, Ivo, Hussain, Rafiqul, Coxhead, Jonathan M., Joseph, Agatha, Rooney, Paul, Lisgo, Steven, Figueiredo, Francisco, Armstrong, Lyle, Lako, Majlinda
Published in The ocular surface (01.01.2021)
Published in The ocular surface (01.01.2021)
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Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix
Felemban, Majed, Dorgau, Birthe, Hunt, Nicola Claire, Hallam, Dean, Zerti, Darin, Bauer, Roman, Ding, Yuchun, Collin, Joseph, Steel, David, Krasnogor, Natalio, Al-Aama, Jumana, Lindsay, Susan, Mellough, Carla, Lako, Majlinda
Published in Acta biomaterialia (01.07.2018)
Published in Acta biomaterialia (01.07.2018)
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Deciphering the impact of PROM1 alternative splicing on human photoreceptor development and maturation
Moya-Molina, Marina, Dorgau, Birthe, Flood, Emily, Letteboer, Stef J. F., Lorentzen, Esben, Coxhead, Jonathan, Smith, Graham, Roepman, Ronald, Nagaraja Grellscheid, Sushma, Armstrong, Lyle, Lako, Majlinda
Published in Cell death & disease (01.10.2024)
Published in Cell death & disease (01.10.2024)
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Using Zinc Finger Nuclease Technology to Generate CRX‐Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation
Collin, Joseph, Mellough, Carla B, Dorgau, Birthe, Przyborski, Stefan, Moreno‐Gimeno, Inmaculada, Lako, Majlinda
Published in Stem cells (Dayton, Ohio) (01.02.2016)
Published in Stem cells (Dayton, Ohio) (01.02.2016)
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PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects
Atkinson, Robert, Georgiou, Maria, Yang, Chunbo, Szymanska, Katarzyna, Lahat, Albert, Vasconcelos, Elton J. R., Ji, Yanlong, Moya Molina, Marina, Collin, Joseph, Queen, Rachel, Dorgau, Birthe, Watson, Avril, Kurzawa-Akanbi, Marzena, Laws, Ross, Saxena, Abhijit, Shyan Beh, Chia, Siachisumo, Chileleko, Goertler, Franziska, Karwatka, Magdalena, Davey, Tracey, Inglehearn, Chris F., McKibbin, Martin, Lührmann, Reinhard, Steel, David H., Elliott, David J., Armstrong, Lyle, Urlaub, Henning, Ali, Robin R., Grellscheid, Sushma-Nagaraja, Johnson, Colin A., Mozaffari-Jovin, Sina, Lako, Majlinda
Published in Nature communications (11.04.2024)
Published in Nature communications (11.04.2024)
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Deciphering the spatiotemporal transcriptional and chromatin accessibility of human retinal organoid development at the single-cell level
Dorgau, Birthe, Collin, Joseph, Rozanska, Agata, Boczonadi, Veronika, Moya-Molina, Marina, Unsworth, Adrienne, Hussain, Rafiqul, Coxhead, Jonathan, Dhanaseelan, Tamil, Armstrong, Lyle, Queen, Rachel, Lako, Majlinda
Published in iScience (19.04.2024)
Published in iScience (19.04.2024)
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Journal Article
Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light
Celiker, Canan, Weissova, Kamila, Cerna, Katerina Amruz, Oppelt, Jan, Dorgau, Birthe, Gambin, Francisco Molina, Sebestikova, Jana, Lako, Majlinda, Sernagor, Evelyne, Liskova, Petra, Barta, Tomas
Published in iScience (21.07.2023)
Published in iScience (21.07.2023)
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Journal Article
Transplanted pluripotent stem cell‐derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration
Zerti, Darin, Hilgen, Gerrit, Dorgau, Birthe, Collin, Joseph, Ader, Marius, Armstrong, Lyle, Sernagor, Evelyne, Lako, Majlinda
Published in Stem cells (Dayton, Ohio) (01.07.2021)
Published in Stem cells (Dayton, Ohio) (01.07.2021)
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Journal Article
Human‐Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient‐Dependent Efficiency
Hallam, Dean, Hilgen, Gerrit, Dorgau, Birthe, Zhu, Lili, Yu, Min, Bojic, Sanja, Hewitt, Philip, Schmitt, Michael, Uteng, Marianne, Kustermann, Stefan, Steel, David, Nicholds, Mike, Thomas, Robert, Treumann, Achim, Porter, Andrew, Sernagor, Evelyne, Armstrong, Lyle, Lako, Majlinda
Published in Stem cells (Dayton, Ohio) (01.10.2018)
Published in Stem cells (Dayton, Ohio) (01.10.2018)
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Journal Article
Developing a simple method to enhance the generation of cone and rod photoreceptors in pluripotent stem cell‐derived retinal organoids
Zerti, Darin, Dorgau, Birthe, Felemban, Majed, Ghareeb, Ali E., Yu, Min, Ding, Yuchun, Krasnogor, Natalio, Lako, Majlinda
Published in Stem cells (Dayton, Ohio) (01.01.2020)
Published in Stem cells (Dayton, Ohio) (01.01.2020)
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Journal Article
Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids
Dorgau, Birthe, Felemban, Majed, Hilgen, Gerrit, Kiening, Martin, Zerti, Darin, Hunt, Nicola Claire, Doherty, Mary, Whitfield, Phil, Hallam, Dean, White, Kathryn, Ding, Yuchun, Krasnogor, Natalio, Al-Aama, Jumana, Asfour, Hani Z., Sernagor, Evelyne, Lako, Majlinda
Published in Biomaterials (01.04.2019)
Published in Biomaterials (01.04.2019)
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Journal Article
A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells
Collin, Joseph, Queen, Rachel, Zerti, Darin, Bojic, Sanja, Dorgau, Birthe, Moyse, Nicky, Molina, Marina Moya, Yang, Chunbo, Dey, Sunanda, Reynolds, Gary, Hussain, Rafiqul, Coxhead, Jonathan M., Lisgo, Steven, Henderson, Deborah, Joseph, Agatha, Rooney, Paul, Ghosh, Saurabh, Clarke, Lucy, Connon, Che, Haniffa, Muzlifah, Figueiredo, Francisco, Armstrong, Lyle, Lako, Majlinda
Published in The ocular surface (01.07.2021)
Published in The ocular surface (01.07.2021)
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Journal Article
Single-cell RNA sequencing reveals transcriptional changes of human choroidal and retinal pigment epithelium cells during fetal development, in healthy adult and intermediate age-related macular degeneration
Collin, Joseph, Hasoon, Megan S R, Zerti, Darin, Hammadi, Sarah, Dorgau, Birthe, Clarke, Lucy, Steel, David, Hussain, Rafiqul, Coxhead, Jonathan, Lisgo, Steven, Queen, Rachel, Lako, Majlinda
Published in Human molecular genetics (05.05.2023)
Published in Human molecular genetics (05.05.2023)
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