Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial
Longo, Nicola, MD, Harding, Cary O, MD, Burton, Barbara K, MD, Grange, Dorothy K, MD, Vockley, Jerry, MD, Wasserstein, Melissa, MD, Rice, Gregory M, MD, Dorenbaum, Alejandro, MD, Neuenburg, Jutta K, MD, Musson, Donald G, PhD, Gu, Zhonghua, PhD, Sile, Saba, MD
Published in The Lancet (British edition) (05.07.2014)
Published in The Lancet (British edition) (05.07.2014)
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Journal Article
Safety, tolerability and pharmacodynamics of apical sodium-dependent bile acid transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a randomised placebo-controlled trial
Tiessen, Renger G, Kennedy, Ciara A, Keller, Bradley T, Levin, Nancy, Acevedo, Lisette, Gedulin, Bronislava, van Vliet, Andre A, Dorenbaum, Alejandro, Palmer, Melissa
Published in BMC gastroenterology (05.01.2018)
Published in BMC gastroenterology (05.01.2018)
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Journal Article
Maralixibat for the treatment of PFIC: Long‐term, IBAT inhibition in an open‐label, Phase 2 study
Loomes, Kathleen M., Squires, Robert H., Kelly, Deirdre, Rajwal, Sanjay, Soufi, Nisreen, Lachaux, Alain, Jankowska, Irena, Mack, Cara, Setchell, Kenneth D. R., Karthikeyan, Palaniswamy, Kennedy, Ciara, Dorenbaum, Alejandro, Desai, Nirav K., Garner, Will, Jaecklin, Thomas, Vig, Pamela, Miethke, Alexander, Thompson, Richard J.
Published in Hepatology communications (01.09.2022)
Published in Hepatology communications (01.09.2022)
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Journal Article
Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma
Schatz, Michael, MD, MS, Hsu, Jin-Wen Y., PhD, Zeiger, Robert S., MD, PhD, Chen, Wansu, MS, Dorenbaum, Alejandro, MD, Chipps, Bradley E., MD, Haselkorn, Tmirah, PhD
Published in Journal of allergy and clinical immunology (01.06.2014)
Published in Journal of allergy and clinical immunology (01.06.2014)
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Journal Article
Impact of asthma exacerbations and asthma triggers on asthma-related quality of life in patients with severe or difficult-to-treat asthma
Luskin, Allan T, Chipps, Bradley E, Rasouliyan, Lawrence, Miller, Dave P, Haselkorn, Tmirah, Dorenbaum, Alejandro
Published in The journal of allergy and clinical immunology in practice (Cambridge, MA) (01.09.2014)
Published in The journal of allergy and clinical immunology in practice (Cambridge, MA) (01.09.2014)
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Journal Article
Treatment of VLCAD-Deficient Patient Fibroblasts with Peroxisome Proliferator-Activated Receptor δ Agonist Improves Cellular Bioenergetics
D'Annibale, Olivia M, Phua, Yu Leng, Van't Land, Clinton, Karunanidhi, Anuradha, Dorenbaum, Alejandro, Mohsen, Al-Walid, Vockley, Jerry
Published in Cells (Basel, Switzerland) (24.08.2022)
Published in Cells (Basel, Switzerland) (24.08.2022)
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Journal Article
Clinical burden and predictors of asthma exacerbations in patients on guideline-based steps 4-6 asthma therapy in the TENOR cohort
Calhoun, William J, Haselkorn, Tmirah, Mink, David R, Miller, Dave P, Dorenbaum, Alejandro, Zeiger, Robert S
Published in The journal of allergy and clinical immunology in practice (Cambridge, MA) (01.03.2014)
Published in The journal of allergy and clinical immunology in practice (Cambridge, MA) (01.03.2014)
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Journal Article
Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort
Chipps, Bradley E., Zeiger, Robert S., Dorenbaum, Alejandro, Borish, Larry, Wenzel, Sally E., Miller, Dave P., Hayden, Mary Lou, Bleecker, Eugene R., Simons, F. Estelle R., Szefler, Stanley J., Weiss, Scott T., Haselkorn, Tmirah
Published in Current respiratory care reports (01.12.2012)
Published in Current respiratory care reports (01.12.2012)
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Journal Article
Efficacy and safety of maralixibat treatment in patients with Alagille syndrome and cholestatic pruritus (ICONIC): a randomised phase 2 study
Gonzales, Emmanuel, Hardikar, Winita, Stormon, Michael, Baker, Alastair, Hierro, Loreto, Gliwicz, Dorota, Lacaille, Florence, Lachaux, Alain, Sturm, Ekkehard, Setchell, Kenneth D R, Kennedy, Ciara, Dorenbaum, Alejandro, Steinmetz, Jana, Desai, Nirav K, Wardle, Andrew J, Garner, Will, Vig, Pamela, Jaecklin, Thomas, Sokal, Etienne M, Jacquemin, Emmanuel
Published in The Lancet (British edition) (30.10.2021)
Published in The Lancet (British edition) (30.10.2021)
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Journal Article
Phase I Safety and Pharmacokinetics Study of Micronized Atovaquone in Human Immunodeficiency Virus-Infected Infants and Children
HUGHES, W, DORENBAUM, A, SADLER, B, YOGEV, R, BEAUCHAMP, B, JING XU, MCNAMARA, J, MOYE, J, PURDUE, L, VAN DYKE, R, ROGERS, M
Published in Antimicrobial Agents and Chemotherapy (01.06.1998)
Published in Antimicrobial Agents and Chemotherapy (01.06.1998)
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Journal Article
PS-193-Phase 2 open-label study with a placebo-controlled drug withdrawal period of the apical sodium-dependent bile acid transporter inhibitor maralixibat in children with Alagille Syndrome: 48-week interim efficacy analysis
Gonzales, Emmanuel, Sturm, Ekkehard, Stormon, Michael, Sokal, Etienne, Hardikar, Winita, Lacaille, Florence, Gliwicz, Dorota, Hierro, Loreto, Jaecklin, Thomas, Gu, Joan, Desai, Nirav K., Dorenbaum, Alejandro, Kennedy, Ciara, Baker, Alastair, Jacquemin, Emmanuel
Published in Journal of hepatology (01.04.2019)
Published in Journal of hepatology (01.04.2019)
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Journal Article
A Recombinant Antibody to Siglec-8 Shows Selective ADCC Activity Against Mast Cells from Systemic Mastocytosis Patients
Falahati, Rustom, Bright, Jessica, Dorenbaum, Alejandro, Bebbington, Christopher, Tomasevic, Nenad, Lidke, Diane, George, Tracy I., Gotlib, Jason
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis
Mayo, Marlyn J., Pockros, Paul J., Jones, David, Bowlus, Christopher L., Levy, Cynthia, Patanwala, Imran, Bacon, Bruce, Luketic, Velimir, Vuppalanchi, Raj, Medendorp, Sharon, Dorenbaum, Alejandro, Kennedy, Ciara, Novak, Patricia, Gu, Joan, Apostol, George, Hirschfield, Gideon M.
Published in Hepatology communications (01.03.2019)
Published in Hepatology communications (01.03.2019)
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Journal Article
Safety, tolerability, and efficacy of maralixibat in adults with primary sclerosing cholangitis: Open-label pilot study
Bowlus, Christopher L, Eksteen, Bertus, Cheung, Angela C, Thorburn, Douglas, Moylan, Cynthia A, Pockros, Paul J, Forman, Lisa M, Dorenbaum, Alejandro, Hirschfield, Gideon M, Kennedy, Ciara, Jaecklin, Thomas, McKibben, Andrew, Chien, Elaine, Baek, Marshall, Vig, Pamela, Levy, Cynthia
Published in Hepatology communications (01.06.2023)
Published in Hepatology communications (01.06.2023)
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Journal Article
Development of a Novel Tool to Assess the Impact of Itching in Pediatric Cholestasis
Kamath, Binita M., Abetz-Webb, Linda, Kennedy, Ciara, Hepburn, Bonnie, Gauthier, Martha, Johnson, Nathan, Medendorp, Sharon, Dorenbaum, Alejandro, Todorova, Lora, Shneider, Benjamin L.
Published in The patient : patient-centered outcomes research (01.02.2018)
Published in The patient : patient-centered outcomes research (01.02.2018)
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Journal Article
Two-Dose Intrapartum/Newborn Nevirapine and Standard Antiretroviral Therapy to Reduce Perinatal HIV Transmission: A Randomized Trial
Dorenbaum, Alejandro, Cunningham, Coleen K, Gelber, Richard D, Culnane, Mary, Mofenson, Lynne, Britto, Paula, Rekacewicz, Claire, Newell, Marie-Louise, Delfraissy, Jean Francois, Cunningham-Schrader, Bethann, Mirochnick, Mark, Sullivan, John L, for the International PACTG 316 Team
Published in JAMA : the journal of the American Medical Association (10.07.2002)
Published in JAMA : the journal of the American Medical Association (10.07.2002)
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Journal Article