Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics
McLaughlin, Jay P, Rayala, Ramanjaneyulu, Bunnell, Ashley J, Tantak, Mukund P, Eans, Shainnel O, Nefzi, Khadija, Ganno, Michelle L, Dooley, Colette T, Nefzi, Adel
Published in International journal of molecular sciences (25.08.2022)
Published in International journal of molecular sciences (25.08.2022)
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Mixture-Based Synthetic Combinatorial Libraries
Houghten, Richard A, Pinilla, Clemencia, Appel, Jon R, Blondelle, Sylvie E, Dooley, Colette T, Eichler, Jutta, Nefzi, Adel, Ostresh, John M
Published in Journal of medicinal chemistry (23.09.1999)
Published in Journal of medicinal chemistry (23.09.1999)
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Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs
Harris, Hannah M, Eans, Shainnel O, Ganno, Michelle L, Davis, Jennifer C, Dooley, Colette T, McLaughlin, Jay P, Nefzi, Adel
Published in Organic & biomolecular chemistry (07.06.2019)
Published in Organic & biomolecular chemistry (07.06.2019)
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Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at mu (MOR), delta (DOR), and kappa (KOR) Opioid Receptors
Eans, Shainnel O., Ganno, Michelle L., Mizrachi, Elisa, Houghten, Richard A., Dooley, Colette T., McLaughlin, Jay P., Nefzi, Adel
Published in Journal of medicinal chemistry (25.06.2015)
Published in Journal of medicinal chemistry (25.06.2015)
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Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library
Reilley, Kate J., Giulianotti, Marc, Dooley, Colette T., Nefzi, Adel, McLaughlin, Jay P., Houghten, Richard A.
Published in The AAPS journal (01.09.2010)
Published in The AAPS journal (01.09.2010)
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A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation
Shao, Jiaan, Houghten, Richard A., Dooley, Colette T., Cazares, Margret, McLaughlin, Jay P., Eans, Shainnel O., Ganno, Michelle L., Hoot, Michelle R., Giulianotti, Marc A., Yu, Yongping
Published in Organic & biomolecular chemistry (26.09.2017)
Published in Organic & biomolecular chemistry (26.09.2017)
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Ligand/kappa-opioid receptor interactions: Insights from the X-ray crystal structure
Martinez-Mayorga, Karina, Byler, Kendall G., Yongye, Austin B., Giulianotti, Marc A., Dooley, Colette T., Houghten, Richard A.
Published in European journal of medicinal chemistry (01.08.2013)
Published in European journal of medicinal chemistry (01.08.2013)
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Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines
Houghten, Richard A, Ganno, Michelle L, McLaughlin, Jay P, Dooley, Colette T, Eans, Shainnel O, Santos, Radleigh G, LaVoi, Travis, Nefzi, Adel, Welmaker, Greg, Giulianotti, Marc A, Toll, Lawrence
Published in ACS combinatorial science (11.01.2016)
Published in ACS combinatorial science (11.01.2016)
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Toxicity of 6-hydroxydopamine: live cell imaging of cytoplasmic redox flux
Dooley, Colette T., Li, Ling, Misler, Jaime A., Thompson, Jane H.
Published in Cell biology and toxicology (01.04.2012)
Published in Cell biology and toxicology (01.04.2012)
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Journal Article
Fluorescent Mu Selective Opioid Ligands from a Mixture Based Cyclic Peptide Library
Li, Yangmei, Dooley, Colette T, Misler, Jaime A, Debevec, Ginamarie, Giulianotti, Marc A, Cazares, Margaret E, Maida, Laura, Houghten, Richard A
Published in ACS combinatorial science (10.12.2012)
Published in ACS combinatorial science (10.12.2012)
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A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries
Giulianotti, Marc A, Debevec, Ginamarie, Santos, Radleigh G, Maida, Laura E, Chen, Wenteng, Ou, Lili, Yu, Yongping, Dooley, Colette T, Houghten, Richard A
Published in ACS combinatorial science (10.09.2012)
Published in ACS combinatorial science (10.09.2012)
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Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis
Martínez-Mayorga, Karina, Medina-Franco, Jose L., Giulianotti, Marc A., Pinilla, Clemencia, Dooley, Colette T., Appel, Jon R., Houghten, Richard A.
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries
NAGASAKI, Hiroshi, CHUNG, Shinjae, DOOLEY, Colette T, ZHIWEI WANG, CHUNYING LI, SAITO, Yumiko, CLARK, Stewart D, HOUGHTEN, Richard A, CIVELLI, Olivier
Published in European journal of pharmacology (14.01.2009)
Published in European journal of pharmacology (14.01.2009)
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Identification, structure–activity relationships and molecular modeling of potent triamine and piperazine opioid ligands
Yongye, Austin B., Appel, Jon R., Giulianotti, Marc A., Dooley, Colette T., Medina-Franco, Jose L., Nefzi, Adel, Houghten, Richard A., Martínez-Mayorga, Karina
Published in Bioorganic & medicinal chemistry (01.08.2009)
Published in Bioorganic & medicinal chemistry (01.08.2009)
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Identification of potent and highly selective chiral tri-amine and tetra-amine μ opioid receptors ligands: An example of lead optimization using mixture-based libraries
Nefzi, Adel, Ostresh, John M., Appel, Jon R., Bidlack, Jean, Dooley, Colette T., Houghten, Richard A.
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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