eIF2B activator prevents neurological defects caused by a chronic integrated stress response
Wong, Yao Liang, LeBon, Lauren, Basso, Ana M, Kohlhaas, Kathy L, Nikkel, Arthur L, Robb, Holly M, Donnelly-Roberts, Diana L, Prakash, Janani, Swensen, Andrew M, Rubinstein, Nimrod D, Krishnan, Swathi, McAllister, Fiona E, Haste, Nicole V, O'Brien, Jonathon J, Roy, Margaret, Ireland, Andrea, Frost, Jennifer M, Shi, Lei, Riedmaier, Stephan, Martin, Kathleen, Dart, Michael J, Sidrauski, Carmela
Published in eLife (09.01.2019)
Published in eLife (09.01.2019)
Get full text
Journal Article
Characterization of psoriasiform dermatitis induced by systemic injection of interleukin‐23 minicircles in mice
Leys, Laura, Wang, Yibing, Paulsboe, Stephanie, Edelmayer, Rebecca, Salte, Katie, Wetter, Joseph, Namovic, Marian, Phillips, Lucy, Dunstan, Robert, Gauvin, Donna, Donnelly‐Roberts, Diana, Su, Zhi, Honore, Prisca, McGaraughty, Steve
Published in Journal of dermatology (01.06.2019)
Published in Journal of dermatology (01.06.2019)
Get full text
Journal Article
[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors
Donnelly-Roberts, Diana L., Namovic, Marian T., Surber, Bruce, Vaidyanathan, Srirajan X., Perez-Medrano, Arturo, Wang, Ying, Carroll, William A., Jarvis, Michael F.
Published in Neuropharmacology (01.01.2009)
Published in Neuropharmacology (01.01.2009)
Get full text
Journal Article
Short-term oral gavage administration of adenine induces a model of fibrotic kidney disease in rats
Zhu, Chang Z., Doyle, Kelly J., Nikkel, Arthur L., Olsen, Lauren, Namovic, Marian T., Salte, Katherine, Widomski, Deborah, Su, Zhi, Donnelly-Roberts, Diana L., Gopalakrishnan, Murali M., McGaraughty, Steve
Published in Journal of pharmacological and toxicological methods (01.11.2018)
Published in Journal of pharmacological and toxicological methods (01.11.2018)
Get full text
Journal Article
Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors
Bertrand, Daniel, Lee, Chih-Hung L, Flood, Dorothy, Marger, Fabrice, Donnelly-Roberts, Diana
Published in Pharmacological reviews (01.10.2015)
Published in Pharmacological reviews (01.10.2015)
Get full text
Journal Article
Mitogen-Activated Protein Kinase and Caspase Signaling Pathways Are Required for P2X7 Receptor (P2X7R)-Induced Pore Formation in Human THP-1 Cells
Donnelly-Roberts, Diana L, Namovic, Marian T, Faltynek, Connie R, Jarvis, Michael F
Published in The Journal of pharmacology and experimental therapeutics (01.03.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2004)
Get full text
Journal Article
Activation of Dopamine D4 Receptors by ABT-724 Induces Penile Erection in Rats
Brioni, Jorge D., Moreland, Robert B., Cowart, Marlon, Hsieh, Gin C., Stewart, Andrew O., Hedlund, Petter, Donnelly-Roberts, Diana L., Nakane, Masaki, Lynch, James J., Kolasa, Teodozyi, Polakowski, James S., Osinski, Mark A., Marsh, Kennan, Andersson, Karl-Erik, Sullivan, James P., Beavo, Joseph A.
Published in Proceedings of the National Academy of Sciences - PNAS (27.04.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (27.04.2004)
Get full text
Journal Article
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design
Dietrich, Justin D, Longenecker, Kenton L, Wilson, Noel S, Goess, Christian, Panchal, Sanjay C, Swann, Steven L, Petros, Andrew M, Hobson, Adrian D, Ihle, David, Song, Danying, Richardson, Paul, Comess, Kenneth M, Cox, Philip B, Dombrowski, Amanda, Sarris, Kathy, Donnelly-Roberts, Diana L, Duignan, David B, Gomtsyan, Arthur, Jung, Paul, Krueger, A Chris, Mathieu, Suzanne, McClure, Andrea, Stoll, Vincent S, Wetter, Jill, Mankovich, John A, Hajduk, Philip J, Vasudevan, Anil, Stoffel, Robert H, Sun, Chaohong
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
Get full text
Journal Article
GDF15 is a dynamic biomarker of the integrated stress response in the central nervous system
Asundi, Jyoti, Zhang, Chunlian, Donnelly‐Roberts, Diana, Solorio, Josè Zavala, Challagundla, Malleswari, Connelly, Caitlin, Boch, Christina, Chen, Jun, Richter, Mario, Maneshi, Mohammad Mehdi, Swensen, Andrew M., Lebon, Lauren, Schiffmann, Raphael, Sanyal, Subhabrata, Sidrauski, Carmela, Kolumam, Ganesh, Baruch, Amos
Published in CNS neuroscience & therapeutics (01.02.2024)
Published in CNS neuroscience & therapeutics (01.02.2024)
Get full text
Journal Article
Central Mechanisms Regulating Penile Erection in Conscious Rats: The Dopaminergic Systems Related to the Proerectile Effect of Apomorphine
Hsieh, Gin C, Hollingsworth, Peter R, Martino, Brenda, Chang, Renjie, Terranova, Marc A, O'Neill, Alyssa B, Lynch, James J, Moreland, Robert B, Donnelly-Roberts, Diana L, Kolasa, Teodozyi, Mikusa, Joseph P, McVey, Jill M, Marsh, Kennan C, Sullivan, James P, Brioni, Jorge D
Published in The Journal of pharmacology and experimental therapeutics (01.01.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2004)
Get full text
Journal Article
Painful Purinergic Receptors
Donnelly-Roberts, Diana, McGaraughty, Steve, Shieh, Char-Chang, Honore, Prisca, Jarvis, Michael F
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
Get full text
Journal Article
A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat
Honore, Prisca, Donnelly-Roberts, Diana, Namovic, Marian T, Hsieh, Gin, Zhu, Chang Z, Mikusa, Joe P, Hernandez, Gricelda, Zhong, Chengmin, Gauvin, Donna M, Chandran, Prasant, Harris, Richard, Medrano, Arturo Perez, Carroll, William, Marsh, Kennan, Sullivan, James P, Faltynek, Connie R, Jarvis, Michael F
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
Get full text
Journal Article
Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7 Antagonists
Nelson, Derek W, Gregg, Robert J, Kort, Michael E, Perez-Medrano, Arturo, Voight, Eric A, Wang, Ying, Grayson, George, Namovic, Marian T, Donnelly-Roberts, Diana L, Niforatos, Wende, Honore, Prisca, Jarvis, Michael F, Faltynek, Connie R, Carroll, William A
Published in Journal of medicinal chemistry (15.06.2006)
Published in Journal of medicinal chemistry (15.06.2006)
Get full text
Journal Article
Selective P2X7 receptor antagonists for chronic inflammation and pain
Carroll, William A., Donnelly-Roberts, Diana, Jarvis, Michael F.
Published in Purinergic signalling (2009)
Published in Purinergic signalling (2009)
Get full text
Journal Article
Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists
Matulenko, Mark A, Hakeem, Ahmed A, Kolasa, Teodozyi, Nakane, Masaki, Terranova, Marc A, Uchic, Marie E, Miller, Loan N, Chang, Renjie, Donnelly-Roberts, Diana L, Namovic, Marian T, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O
Published in Bioorganic & medicinal chemistry (01.07.2004)
Published in Bioorganic & medicinal chemistry (01.07.2004)
Get full text
Journal Article
NRF2 activator A-1396076 ameliorates inflammation in autoimmune disease models by inhibiting antigen dependent T cell activation
Goess, Christian, Terrillon, Sonia, Mayo, Martha, Bousquet, Peter, Wallace, Craig, Hart, Michelle, Mathieu, Suzanne, Twomey, Rachel, Donnelly-Roberts, Diana, Namovic, Marian, Jung, Paul, Hu, Min, Richardson, Paul, Esbenshade, Tim, Cuff, Carolyn A.
Published in Journal of translational autoimmunity (Online) (01.01.2021)
Published in Journal of translational autoimmunity (Online) (01.01.2021)
Get full text
Journal Article
Discovery and Biological Evaluation of Novel Cyanoguanidine P2X(7) Antagonists with Analgesic Activity in a Rat Model of Neuropathic Pain
Perez-Medrano, Arturo, Donnelly-Roberts, Diana L., Honore, Prisca, Hsieh, Gin C., Namovic, Marian T., Peddi, Sridhar, Shuai, Qi, Wang, Ying, Faltynek, Connie R., Jarvis, Michael F., Carroll, William A.
Published in Journal of medicinal chemistry (28.05.2009)
Published in Journal of medicinal chemistry (28.05.2009)
Get full text
Journal Article
Discovery and Biological Evaluation of Novel Cyanoguanidine P2X7 Antagonists with Analgesic Activity in a Rat Model of Neuropathic Pain
Perez-Medrano, Arturo, Donnelly-Roberts, Diana L, Honore, Prisca, Hsieh, Gin C, Namovic, Marian T, Peddi, Sridhar, Shuai, Qi, Wang, Ying, Faltynek, Connie R, Jarvis, Michael F, Carroll, William A
Published in Journal of medicinal chemistry (28.05.2009)
Published in Journal of medicinal chemistry (28.05.2009)
Get full text
Journal Article
In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418
Donnelly-Roberts, Diana L., Xue, Iris C., Arneric, Stephen P., Sullivan, James P.
Published in Brain research (06.05.1996)
Published in Brain research (06.05.1996)
Get full text
Journal Article