The operational model of allosteric modulation of pharmacological agonism
Jakubík, Jan, Randáková, Alena, Chetverikov, Nikolai, El-Fakahany, Esam E., Doležal, Vladimír
Published in Scientific reports (02.09.2020)
Published in Scientific reports (02.09.2020)
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Agonist-Specific Conformations of the M2 Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics
Randáková, Alena, Nelic, Dominik, Doležal, Vladimír, El-Fakahany, Esam E, Boulos, John, Jakubík, Jan
Published in Journal of chemical information and modeling (27.04.2020)
Published in Journal of chemical information and modeling (27.04.2020)
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Journal Article
Agonist-Specific Conformations of the M 2 Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics
Randáková, Alena, Nelic, Dominik, Doležal, Vladimír, El-Fakahany, Esam E, Boulos, John, Jakubík, Jan
Published in Journal of chemical information and modeling (27.04.2020)
Published in Journal of chemical information and modeling (27.04.2020)
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Novel long‐acting antagonists of muscarinic ACh receptors
Randáková, Alena, Rudajev, Vladimír, Doležal, Vladimír, Boulos, John, Jakubík, Jan
Published in British journal of pharmacology (01.05.2018)
Published in British journal of pharmacology (01.05.2018)
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Journal Article
Towards predictive docking at aminergic G-protein coupled receptors
Jakubík, Jan, El-Fakahany, Esam E., Doležal, Vladimír
Published in Journal of molecular modeling (01.11.2015)
Published in Journal of molecular modeling (01.11.2015)
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Journal Article
Membrane cholesterol content influences binding properties of muscarinic M 2 receptors and differentially impacts activation of second messenger pathways
Michal, Pavel, Rudajev, Vladimír, El-Fakahany, Esam E., Doležal, Vladimír
Published in European journal of pharmacology (15.03.2009)
Published in European journal of pharmacology (15.03.2009)
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Journal Article
Detection of choline transporter‐like 1 protein CTL1 in neuroblastoma × glioma cells and in the CNS, and its role in choline uptake
Machová, Eva, O’Regan, Seana, Newcombe, Jia, Meunier, François‐Marie, Prentice, Joanna, Dove, Rosamund, Lisá, Věra, Doležal, Vladimír
Published in Journal of neurochemistry (01.08.2009)
Published in Journal of neurochemistry (01.08.2009)
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Journal Article
Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators
Dolezal, Vladimír, Jakubík, Jan, El-Fakahany, Esam E, Randáková, Alena
Published in PloS one (27.03.2019)
Published in PloS one (27.03.2019)
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Journal Article
Apolipoprotein E4 reduces evoked hippocampal acetylcholine release in adult mice
Dolejší, Eva, Liraz, Ori, Rudajev, Vladimír, Zimčík, Pavel, Doležal, Vladimír, Michaelson, Daniel M.
Published in Journal of neurochemistry (01.02.2016)
Published in Journal of neurochemistry (01.02.2016)
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Journal Article
Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors
Jakubík, Jan, Randáková, Alena, Zimčík, Pavel, El-Fakahany, Esam E., Doležal, Vladimír
Published in Scientific reports (16.01.2017)
Published in Scientific reports (16.01.2017)
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Journal Article
Subtype differences in pre-coupling of muscarinic acetylcholine receptors
Dolezal, Vladimír, Jakubík, Jan, El-Fakahany, Esam E, Janícková, Helena, Randáková, Alena
Published in PloS one (16.11.2011)
Published in PloS one (16.11.2011)
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Journal Article
Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathways
MICHAL, Pavel, RUDAJEV, Vladimir, EL-FAKAHANY, Esam E, DOLEZAL, Vladimir
Published in European journal of pharmacology (15.03.2009)
Published in European journal of pharmacology (15.03.2009)
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Journal Article
Detection of choline transporter-like 1 protein CTL1 in neuroblastoma x glioma cells and in the CNS, and its role in choline uptake
Machová, Eva, O'Regan, Seana, Newcombe, Jia, Meunier, François-Marie, Prentice, Joanna, Dove, Rosamund, Lisá, Věra, Doležal, Vladimír
Published in Journal of neurochemistry (01.08.2009)
Published in Journal of neurochemistry (01.08.2009)
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Journal Article