METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes
Moroz‐Omori, Elena V., Huang, Danzhi, Kumar Bedi, Rajiv, Cheriyamkunnel, Sherry J., Bochenkova, Elena, Dolbois, Aymeric, Rzeczkowski, Maciej D., Li, Yaozong, Wiedmer, Lars, Caflisch, Amedeo
Published in ChemMedChem (06.10.2021)
Published in ChemMedChem (06.10.2021)
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In Vivo Performance and Properties of Tamoxifen Metabolites for CreERT2 Control
Felker, Anastasia, Nieuwenhuize, Susan, Dolbois, Aymeric, Blazkova, Kristyna, Hess, Christopher, Low, Larry W L, Burger, Sibylle, Samson, Natasha, Carney, Tom J, Bartunek, Petr, Nevado, Cristina, Mosimann, Christian
Published in PloS one (14.04.2016)
Published in PloS one (14.04.2016)
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Structure-based design of ligands of the m6A-RNA reader YTHDC1
Li, Yaozong, Bedi, Rajiv Kumar, Nai, Francesco, von Roten, Valentin, Dolbois, Aymeric, Zálešák, František, Nachawati, Raed, Huang, Danzhi, Caflisch, Amedeo
Published in European journal of medicinal chemistry reports (01.08.2022)
Published in European journal of medicinal chemistry reports (01.08.2022)
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Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple)
Batiste, Laurent, Unzue, Andrea, Dolbois, Aymeric, Hassler, Fabrice, Wang, Xuan, Deerain, Nicholas, Zhu, Jian, Spiliotopoulos, Dimitrios, Nevado, Cristina, Caflisch, Amedeo
Published in ACS central science (28.02.2018)
Published in ACS central science (28.02.2018)
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The “Gatekeeper” Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains
Unzue, Andrea, Zhao, Hongtao, Lolli, Graziano, Dong, Jing, Zhu, Jian, Zechner, Melanie, Dolbois, Aymeric, Caflisch, Amedeo, Nevado, Cristina
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
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A Straightforward Entry to -Trifluoromethylated Allenamides and Their Synthetic Applications
Guissart, Celine, Dolbois, Aymeric, Tresse, Cedric, Saint-Auret, Sarah, Evano, Gwilherm, Blanchard, Nicolas
Published in Synlett (01.11.2016)
Published in Synlett (01.11.2016)
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Selectively Disrupting m 6 A-Dependent Protein-RNA Interactions with Fragments
Bedi, Rajiv Kumar, Huang, Danzhi, Wiedmer, Lars, Li, Yaozong, Dolbois, Aymeric, Wojdyla, Justyna Aleksandra, Sharpe, May Elizabeth, Caflisch, Amedeo, Sledz, Pawel
Published in ACS chemical biology (20.03.2020)
Published in ACS chemical biology (20.03.2020)
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Journal Article
Selectively Disrupting m6A‑Dependent Protein–RNA Interactions with Fragments
Bedi, Rajiv Kumar, Huang, Danzhi, Wiedmer, Lars, Li, Yaozong, Dolbois, Aymeric, Wojdyla, Justyna Aleksandra, Sharpe, May Elizabeth, Caflisch, Amedeo, Sledz, Pawel
Published in ACS chemical biology (20.03.2020)
Published in ACS chemical biology (20.03.2020)
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Journal Article
Structure-based design of ligands of the m 6 A-RNA reader YTHDC1
Li, Yaozong, Bedi, Rajiv Kumar, Nai, Francesco, von Roten, Valentin, Dolbois, Aymeric, Zálešák, František, Nachawati, Raed, Huang, Danzhi, Caflisch, Amedeo
Published in European journal of medicinal chemistry reports (2022)
Published in European journal of medicinal chemistry reports (2022)
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Journal Article
Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules
Zhu, Jian, Dong, Jing, Batiste, Laurent, Unzue, Andrea, Dolbois, Aymeric, Pascanu, Vlad, Śledź, Paweł, Nevado, Cristina, Caflisch, Amedeo
Published in ACS medicinal chemistry letters (13.09.2018)
Published in ACS medicinal chemistry letters (13.09.2018)
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Journal Article
Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers
Dolbois, Aymeric, Batiste, Laurent, Wiedmer, Lars, Dong, Jing, Brütsch, Manuela, Huang, Danzhi, Deerain, Nicholas M, Spiliotopoulos, Dimitrios, Cheng-Sánchez, Iván, Laul, Eleen, Nevado, Cristina, Śledź, Paweł, Caflisch, Amedeo
Published in ACS medicinal chemistry letters (13.08.2020)
Published in ACS medicinal chemistry letters (13.08.2020)
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Journal Article
N6-ADENOSINE-METHYLTRANSFERASE INHIBITORS IN CANCER TREATMENT
CAFLISCH, Amedeo, DOLBOIS, Aymeric, HUANG, Danzhi, ZALESAK, Frantisek
Year of Publication 02.05.2024
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Year of Publication 02.05.2024
Patent
N6-ADENOSINE-METHYLTRANSFERASE INHIBITORS IN CANCER TREATMENT
CAFLISCH, Amedeo, DOLBOIS, Aymeric, HUANG, Danzhi, ZALESAK, Frantisek
Year of Publication 27.03.2024
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Year of Publication 27.03.2024
Patent
N6-ADENOSINE-METHYLTRANSFERASE INHIBITORS IN CANCER TREATMENT
CAFLISCH, Amedeo, DOLBOIS, Aymeric, HUANG, Danzhi, ZALESAK, Frantisek
Year of Publication 24.11.2022
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Year of Publication 24.11.2022
Patent
N6-ADENOSINE-METHYLTRANSFERASE INHIBITORS IN CANCER TREATMENT
DOLBOIS, AYMERIC, HUANG, DANZHI, ZALESAK, FRANTISEK, CAFLISCH, AMEDEO
Year of Publication 24.11.2022
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Year of Publication 24.11.2022
Patent
N6-ADENOSINE-METHYLTRANSFERASE PROTACS AND METHODS OF USE THEREOF
INVERNIZZI, Annalisa, ERRANI, Francesco, CAFLISCH, Amedeo, HEROK, Marcin, DOLBOIS, Aymeric, HUANG, Danzhi, ZALESAK, Frantisek
Year of Publication 23.11.2023
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Year of Publication 23.11.2023
Patent
METTL3 inhibitors for epitranscriptomic modulation of cellular processes
Moroz-Omori, Elena V, Huang, Danzhi, Bedi, Rajiv Kumar, Cheriyamkunnel, Sherry J, Bochenkova, Elena, Dolbois, Aymeric, Rzeczkowski, Maciej D, Wiedmer, Lars, Caflisch, Amedeo
Published in bioRxiv (13.10.2020)
Published in bioRxiv (13.10.2020)
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Paper
COMPOUNDS, IN PARTICULAR FOR USE IN THE TREATMENT OF A DISEASE OR CONDITION FOR WHICH A BROMODOMAIN INHIBITOR IS INDICATED
DOLBOIS, AYMERIC, SPILIOTOPOULOS, DIMITRIOS, FRUGIER, EMILIE, DONG, JING, UNZUE LOPEZ, ANDREA, CAFLISCH, AMEDEO, XU, MIN, BLÁZQUEZ NEVADO, CRISTINA
Year of Publication 07.01.2016
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Year of Publication 07.01.2016
Patent