Search Results - "Doi, Satoki" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders

by Noji, Satoru, Hara, Yoshinori, Miura, Tomoya, Yamanaka, Hiroshi, Maeda, Katsuya, Hori, Akimi, Yamamoto, Hiroshi, Obika, Shingo, Inoue, Masafumi, Hase, Yasunori, Orita, Takuya, Doi, Satoki, Adachi, Tsuyoshi, Tanimoto, Atsuo, Oki, Chika, Kimoto, Yukari, Ogawa, Yoshihiro, Negoro, Tamotsu, Hashimoto, Hiromasa, Shiozaki, Makoto
Published in Journal of medicinal chemistry (09.07.2020)

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Broad Antiretroviral Activity and Resistance Profile of the Novel Human Immunodeficiency Virus Integrase Inhibitor Elvitegravir (JTK-303/GS-9137)

by SHIMURA, Kazuya, KODAMA, Eiichi, KANO, Mitsuki, IKEDA, Satoru, MATSUOKA, Masao, SAKAGAMI, Yasuko, MATSUZAKI, Yuji, WATANABE, Wataru, YAMATAKA, Kazunobu, WATANABE, Yasuo, OHATA, Yoshitsugu, DOI, Satoki, SATO, Motohide
Published in Journal of Virology (01.01.2008)

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Discovery of Conformationally Constrained Tetracyclic Compounds as Potent Hepatitis C Virus NS5B RNA Polymerase Inhibitors

Discovery of Conformationally Constrained Tetracyclic Compounds as Potent Hepatitis C Virus NS5B RNA Polymerase Inhibitors

by Ikegashira, Kazutaka, Oka, Takahiro, Hirashima, Shintaro, Noji, Satoru, Yamanaka, Hiroshi, Hara, Yoshinori, Adachi, Tsuyoshi, Tsuruha, Jun-Ichiro, Doi, Satoki, Hase, Yasunori, Noguchi, Toru, Ando, Izuru, Ogura, Naoki, Ikeda, Satoru, Hashimoto, Hiromasa
Published in Journal of medicinal chemistry (30.11.2006)

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Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques

Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques

by Asano, Wataru, Yamanaka, Kenji, Ohara, Yasunori, Uhara, Toru, Doi, Satoki, Orita, Takuya, Iwanaga, Tomoko, Adachi, Tsuyoshi, Fujioka, Shingo, Akaki, Tatsuo, Ikegashira, Kazutaka, Hantani, Yoshiji
Published in Biochemistry (Easton) (18.07.2023)

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The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxa-mides as AMPD2 inhibitors with a novel mechanism of action

The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxa-mides as AMPD2 inhibitors with a novel mechanism of action

by Kitao, Yuki, Saito, Tadataka, Watanabe, Satoshi, Ohe, Yasuhiro, Takahashi, Koichi, Akaki, Tatsuo, Adachi, Tsuyoshi, Doi, Satoki, Yamanaka, Kenji, Murai, Yasutaka, Oba, Makoto, Suzuki, Takayoshi
Published in Bioorganic & medicinal chemistry letters (15.01.2023)

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The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action

The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action

by Kitao, Yuki, Saito, Tadataka, Watanabe, Satoshi, Ohe, Yasuhiro, Takahashi, Koichi, Akaki, Tatsuo, Adachi, Tsuyoshi, Doi, Satoki, Yamanaka, Kenji, Murai, Yasutaka, Oba, Makoto, Suzuki, Takayoshi
Published in Bioorganic & medicinal chemistry letters (15.01.2023)

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Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases

Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases

by Akaki, Tatsuo, Bessho, Yuki, Ito, Takashi, Fujioka, Shingo, Ubukata, Minoru, Mori, Genki, Yamanaka, Kenji, Orita, Takuya, Doi, Satoki, Iwanaga, Tomoko, Ikegashira, Kazutaka, Hantani, Yoshiji, Nakanishi, Isao, Adachi, Tsuyoshi
Published in Bioorganic & medicinal chemistry (15.08.2021)

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Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models

Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models

by Ikegashira, Kazutaka, Ikenogami, Taku, Yamasaki, Takayuki, Hase, Yasunori, Yamaguchi, Takayuki, Inagaki, Koji, Doi, Satoki, Adachi, Tsuyoshi, Koga, Yoshihisa, Hashimoto, Hiromasa
Published in Bioorganic & medicinal chemistry letters (01.01.2019)

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Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors

Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors

by Bessho, Yuki, Akaki, Tatsuo, Hara, Yoshinori, Yamakawa, Maki, Obika, Shingo, Mori, Genki, Ubukata, Minoru, Yasue, Katsutaka, Nakane, Yoshitomi, Terasako, Yasuo, Orita, Takuya, Doi, Satoki, Iwanaga, Tomoko, Fujishima, Ayumi, Adachi, Tsuyoshi, Ueno, Hiroshi, Motomura, Takahisa
Published in Bioorganic & medicinal chemistry (15.12.2021)

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Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold

Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold

by Kotoku, Masayuki, Maeba, Takaki, Fujioka, Shingo, Yokota, Masahiro, Seki, Noriyoshi, Ito, Keisuke, Suwa, Yoshihiro, Ikenogami, Taku, Hirata, Kazuyuki, Hase, Yasunori, Katsuda, Yoshiaki, Miyagawa, Naoki, Arita, Kojo, Asahina, Kota, Noguchi, Masato, Nomura, Akihiro, Doi, Satoki, Adachi, Tsuyoshi, Crowe, Paul, Tao, Haiyan, Thacher, Scott, Hashimoto, Hiromasa, Suzuki, Takayoshi, Shiozaki, Makoto
Published in Journal of medicinal chemistry (14.03.2019)

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Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction

Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction

by Noguchi, Masato, Nomura, Akihiro, Doi, Satoki, Yamaguchi, Keishi, Hirata, Kazuyuki, Shiozaki, Makoto, Maeda, Katsuya, Hirashima, Shintaro, Kotoku, Masayuki, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Crowe, Paul, Tao, Haiyan, Thacher, Scott, Adachi, Tsuyoshi
Published in Scientific reports (26.11.2018)

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SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR gamma Inhibitor

SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR gamma Inhibitor

by Hirata, Kazuyuki, Kotoku, Masayuki, Seki, Noriyoshi, Maeba, Takaki, Maeda, Katsuya, Hirashima, Shintaro, Sakai, Takayuki, Obika, Shingo, Hori, Akimi, Hase, Yasunori, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Hata, Takahiro, Miyagawa, Naoki, Arita, Kojo, Nomura, Yukihiro, Asahina, Kota, Aratsu, Yusuke, Kamada, Masafumi, Adachi, Tsuyoshi, Noguchi, Masato, Doi, Satoki, Crowe, Paul, Bradley, Erin, Steensma, Ruo, Tao, Haiyan, Fenn, Morgan, Babine, Robert, Li, Xiaolin, Thacher, Scott, Hashimoto, Hiromasa, Shiozaki, Makoto
Published in ACS medicinal chemistry letters (14.01.2016)

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Ternary complex of human ROR[gamma] ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment

Ternary complex of human ROR[gamma] ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment

by Noguchi, Masato, Nomura, Akihiro, Murase, Ken, Doi, Satoki, Yamaguchi, Keishi, Hirata, Kazuyuki, Shiozaki, Makoto, Hirashima, Shintaro, Kotoku, Masayuki, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Steensma, Ruo, Li, Xioalin, Tao, Haiyan, Tse, Bruno, Fenn, Morgan, Babine, Robert, Bradley, Erin, Crowe, Paul, Thacher, Scott, Adachi, Tsuyoshi, Kamada, Masafumi
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.06.2017)

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Ternary complex of human RORγ ligand‐binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment

Ternary complex of human RORγ ligand‐binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment

by Noguchi, Masato, Nomura, Akihiro, Murase, Ken, Doi, Satoki, Yamaguchi, Keishi, Hirata, Kazuyuki, Shiozaki, Makoto, Hirashima, Shintaro, Kotoku, Masayuki, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Steensma, Ruo, Li, Xioalin, Tao, Haiyan, Tse, Bruno, Fenn, Morgan, Babine, Robert, Bradley, Erin, Crowe, Paul, Thacher, Scott, Adachi, Tsuyoshi, Kamada, Masafumi
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.06.2017)

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SAR Exploration Guided by LE and Fsp3: Discovery of a Selective and Orally Efficacious RORγ Inhibitor

SAR Exploration Guided by LE and Fsp3: Discovery of a Selective and Orally Efficacious RORγ Inhibitor

by Hirata, Kazuyuki, Kotoku, Masayuki, Seki, Noriyoshi, Maeba, Takaki, Maeda, Katsuya, Hirashima, Shintaro, Sakai, Takayuki, Obika, Shingo, Hori, Akimi, Hase, Yasunori, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Hata, Takahiro, Miyagawa, Naoki, Arita, Kojo, Nomura, Yukihiro, Asahina, Kota, Aratsu, Yusuke, Kamada, Masafumi, Adachi, Tsuyoshi, Noguchi, Masato, Doi, Satoki, Crowe, Paul, Bradley, Erin, Steensma, Ruo, Tao, Haiyan, Fenn, Morgan, Babine, Robert, Li, Xiaolin, Thacher, Scott, Hashimoto, Hiromasa, Shiozaki, Makoto
Published in ACS medicinal chemistry letters (14.01.2016)

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Journal Article

SAR Exploration Guided by LE and Fsp 3 : Discovery of a Selective and Orally Efficacious RORγ Inhibitor

SAR Exploration Guided by LE and Fsp 3 : Discovery of a Selective and Orally Efficacious RORγ Inhibitor

by Hirata, Kazuyuki, Kotoku, Masayuki, Seki, Noriyoshi, Maeba, Takaki, Maeda, Katsuya, Hirashima, Shintaro, Sakai, Takayuki, Obika, Shingo, Hori, Akimi, Hase, Yasunori, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Hata, Takahiro, Miyagawa, Naoki, Arita, Kojo, Nomura, Yukihiro, Asahina, Kota, Aratsu, Yusuke, Kamada, Masafumi, Adachi, Tsuyoshi, Noguchi, Masato, Doi, Satoki, Crowe, Paul, Bradley, Erin, Steensma, Ruo, Tao, Haiyan, Fenn, Morgan, Babine, Robert, Li, Xiaolin, Thacher, Scott, Hashimoto, Hiromasa, Shiozaki, Makoto
Published in ACS medicinal chemistry letters (14.01.2016)

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TRIAZOLE-ISOXAZOLE COMPOUND AND MEDICAL USE THEREOF

TRIAZOLE-ISOXAZOLE COMPOUND AND MEDICAL USE THEREOF

by ITO, KEISUKE, SHINAGAWA, YUKO, SUWA, YOSHIHIRO, YOKOTA, MASAHIRO, HARA, YOSHINORI, HIRASHIMA, SHINTARO, MAEBA, TAKAKI, OBIKA, SHINGO, OKA, TAKAHIRO, KOTOKU, MASAYUKI, FUJIOKA, SHINGO, MAEDA, KATSUYA, HIRATA, KAZUYUKI, IKENOGAMI, TAKU, DOI, SATOKI, SEKI, NORIYOSHI, SAKAI, TAKAYUKI, MATSUO, TAKUYA, NOJI, SATORU, SHIOZAKI, MAKOTO, YAMANAKA, HIROSHI
Year of Publication 01.05.2014

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Patent

NOVEL PIPERAZINE COMPOUND, AND USE THEREOF AS HCV POLYMERASE INHIBITOR

NOVEL PIPERAZINE COMPOUND, AND USE THEREOF AS HCV POLYMERASE INHIBITOR

by YOKOTA, MASAHIRO, ABE, HIROYUKI, UEYAMA, KAZUHITO, NOGUCHI, TORU, TSURUHA, JUNICHIRO, ADACHI, TSUYOSHI, TANAKA, MASAHIRO, IIO, KIYOSEI, SUMA, AKIRA, DOI, SATOKI, SUGIMOTO, KAZUYUKI, MOTODA, DAI, SHIOZAKI, MAKOTO
Year of Publication 25.10.2007

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Patent

TRIAZOLE-ISOXAZOLE COMPOUND AND MEDICAL USE THEREOF

TRIAZOLE-ISOXAZOLE COMPOUND AND MEDICAL USE THEREOF

by FUJIOKA SHINGO, SHIOZAKI MAKOTO, MATSUO TAKUYA, OBIKA SHINGO, SHINAGAWA YUKO, IKENOGAMI TAKU, YAMANAKA HIROSHI, MAEDA KATSUYA, KOTOKU MASAYUKI, MAEBA TAKAKI, NOJI SATORU, DOI SATOKI, ITO KEISUKE, SAKAI TAKAYUKI, SUWA YOSHIHIRO, HIRASHIMA SHINTARO, YOKOTA MASAHIRO, HARA YOSHINORI, HIRATA KAZUYUKI, OKA TAKAHIRO, SEKI NORIYOSHI
Year of Publication 19.05.2016

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NOVEL PIPERAZINE COMPOUND, AND USE THEREOF AS HCV POLYMERASE INHIBITOR

NOVEL PIPERAZINE COMPOUND, AND USE THEREOF AS HCV POLYMERASE INHIBITOR

by HIROYUKI ABE, KAZUYUKI SUGIMOTO, AKIRA SUMA, KIYOSEI IIO, JUNICHIRO TSURUHA, SATOKI DOI, MAKOTO SHIOZAKI, TORU NOGUCHI, KAZUHITO UEYAMA, MASAHIRO TANAKA, TSUYOSHI ADACHI, MASAHIRO YOKOTA, DAI MOTODA
Year of Publication 15.10.2012

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Patent