A phase I, open-label dose-escalation study of continuous treatment with BIBF 1120 in combination with paclitaxel and carboplatin as first-line treatment in patients with advanced non-small-cell lung cancer
Doebele, R.C., Conkling, P., Traynor, A.M., Otterson, G.A., Zhao, Y., Wind, S., Stopfer, P., Kaiser, R., Camidge, D.R.
Published in Annals of oncology (01.08.2012)
Published in Annals of oncology (01.08.2012)
Get full text
Journal Article
Evolution of MET and NRAS gene amplification as acquired resistance mechanisms in EGFR mutant NSCLC
Peters, T. L., Patil, T., Le, A. T., Davies, K. D., Brzeskiewicz, P. M., Nijmeh, H., Bao, L., Camidge, D. R., Aisner, D. L., Doebele, R. C.
Published in NPJ precision oncology (12.10.2021)
Published in NPJ precision oncology (12.10.2021)
Get full text
Journal Article
HER2 exon 20 insertions in non-small-cell lung cancer are sensitive to the irreversible pan-HER receptor tyrosine kinase inhibitor pyrotinib
Wang, Y., Jiang, T., Qin, Z., Jiang, J., Wang, Q., Yang, S., Rivard, C., Gao, G., Ng, T.L., Tu, M.M., Yu, H., Ji, H., Zhou, C., Ren, S., Zhang, J., Bunn, P., Doebele, R.C., Camidge, D.R., Hirsch, F.R.
Published in Annals of oncology (01.03.2019)
Published in Annals of oncology (01.03.2019)
Get full text
Journal Article
Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation study
Hong, D.S., Bauer, T.M., Lee, J.J., Dowlati, A., Brose, M.S., Farago, A.F., Taylor, M., Shaw, A.T., Montez, S., Meric-Bernstam, F., Smith, S., Tuch, B.B., Ebata, K., Cruickshank, S., Cox, M.C., Burris, H.A., Doebele, R.C.
Published in Annals of oncology (01.02.2019)
Published in Annals of oncology (01.02.2019)
Get full text
Journal Article
Exploratory analysis of the association of depth of response and survival in patients with metastatic non-small-cell lung cancer treated with a targeted therapy or immunotherapy
McCoach, C.E., Blumenthal, G.M., Zhang, L., Myers, A., Tang, S., Sridhara, R., Keegan, P., Pazdur, R., Doebele, R.C., Kazandjian, D.
Published in Annals of oncology (01.11.2017)
Published in Annals of oncology (01.11.2017)
Get full text
Journal Article
Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in NSCLC
Bokhari, A.A., Lai, W-Y., Le, A.T., Gabre, J.L., Chuang, T-P., Fransson, S., Bergman, B., Djos, A., Chen, N., Martinsson, T., Van den Eynden, J., Doebele, R.C., Palmer, R.H., Hallberg, B., Umapathy, G.
Published in Lung cancer (Amsterdam, Netherlands) (01.09.2022)
Published in Lung cancer (Amsterdam, Netherlands) (01.09.2022)
Get full text
Journal Article
Exploratory analysis of the association of depth of response and survival in patients with metastatic non-small-cell lung cancer treated with a targeted therapy or immunotherapy
McCoach, C E, Blumenthal, G M, Zhang, L, Myers, A, Tang, S, Sridhara, R, Keegan, P, Pazdur, R, Doebele, R C, Kazandjian, D
Published in Annals of oncology (01.03.2019)
Published in Annals of oncology (01.03.2019)
Get full text
Journal Article
Efficacy and safety of entrectinib in patients with NTRK fusion-positive (NTRK-fp) Tumors: Pooled analysis of STARTRK-2, STARTRK-1 and ALKA-372-001
Demetri, G.D., Paz-Ares, L., Farago, A.F., Liu, S.V., Chawla, S.P., Tosi, D., Kim, E.S., Blakely, C., Krauss, J.C., Sigal, D., Bazhenova, L., John, T., Besse, B., Wolf, J., Seto, T., Chow-Maneval, E., Multani, P.S., Johnson, A.D., Simmons, B., Doebele, R.C.
Published in Annals of oncology (01.10.2018)
Published in Annals of oncology (01.10.2018)
Get full text
Journal Article
Entrectinib in NTRK fusion-positive non-small cell lung cancer (NSCLC): Integrated analysis of patients (pts) enrolled in STARTRK-2, STARTRK-1 and ALKA-372-001
Paz-Ares, L., Doebele, R.C., Farago, A.F., Liu, S.V., Chawla, S.P., Tosi, D., Blakely, C.M., Krauss, J.C., Sigal, D., Bazhenova, L., John, T., Besse, B., Wolf, J., Seto, T., Chow-Maneval, E., Ye, C., Simmons, B., Demetri, G.D.
Published in Annals of oncology (01.04.2019)
Published in Annals of oncology (01.04.2019)
Get full text
Journal Article
Entrectinib in locally advanced or metastatic ROS1 fusion-positive non-small cell lung cancer (NSCLC): Integrated analysis of ALKA-372-001, STARTRK-1 and STARTRK-2
Barlesi, F., Drilon, A., De Braud, F., Cho, B.C., Ahn, M.J., Siena, S., Krebs, M.G., Lin, C.C., John, T., Tan, D.S.W., Seto, T., Dziadziuszko, R., Arkenau, H.-T., Rolfo, C., Wolf, J., Ye, C., Riehl, T., Eng, S., Doebele, R.C.
Published in Annals of oncology (01.04.2019)
Published in Annals of oncology (01.04.2019)
Get full text
Journal Article
Randomized phase II trial of osimertinib with or without local consolidation therapy (LCT) for patients with EGFR-mutant metastatic NSCLC (NORTHSTAR)
Elamin, Y.Y., Antonoff, M., Blakely, C., Baggstorm, M., Bivona, T., Le, X., Louie, A.V., Doebele, R.C., Rusthoven, C., Lee, P., Govindan, R., Swisher, S.G., Papadimitrakopoulou, V.A., Heymach, J.V., Gomez, D.R.
Published in Annals of oncology (01.10.2018)
Published in Annals of oncology (01.10.2018)
Get full text
Journal Article
Efficacy and safety of entrectinib in patients with NTRK fusion-positive tumours: Pooled analysis of STARTRK-2, STARTRK-1, and ALKA-372-001
Demetri, G.D., Paz-Ares, L., Farago, A.F., Liu, S.V., Chawla, S.P., Tosi, D., Kim, E.S., Blakely, C.M., Krauss, J.C., Sigal, D., Bazhenova, L., John, T., Besse, B., Wolf, J., Seto, T., Chow-Maneval, E., Multani, P.S., Johnson, A., Simmons, B., Doebele, R.C.
Published in Annals of oncology (01.11.2018)
Published in Annals of oncology (01.11.2018)
Get full text
Journal Article
Interaction of HLA-DR with an Acidic Face of HLA-DM Disrupts Sequence-Dependent Interactions with Peptides
Pashine, Achal, Busch, Robert, Belmares, Michael P., Munning, Jason N., Doebele, Robert C., Buckingham, Megan, Nolan, Gary P., Mellins, Elizabeth D.
Published in Immunity (Cambridge, Mass.) (01.08.2003)
Published in Immunity (Cambridge, Mass.) (01.08.2003)
Get full text
Journal Article
Determination of the HLA-DM Interaction Site on HLA-DR Molecules
Doebele, Robert C., Busch, Robert, Scott, Hyman M., Pashine, Achal, Mellins, Elizabeth D.
Published in Immunity (Cambridge, Mass.) (01.10.2000)
Published in Immunity (Cambridge, Mass.) (01.10.2000)
Get full text
Journal Article
Accessory molecules for MHC class II peptide loading
Busch, R, Doebele, R C, Patil, N S, Pashine, A, Mellins, E D
Published in Current opinion in immunology (01.02.2000)
Published in Current opinion in immunology (01.02.2000)
Get full text
Journal Article
Point Mutations in or Near the Antigen-Binding Groove of HLA-DR3 Implicate Class II-Associated Invariant Chain Peptide Affinity as a Constraint on MHC Class II Polymorphism
Doebele, Robert C, Pashine, Achal, Liu, Wendy, Zaller, Dennis M, Belmares, Michael, Busch, Robert, Mellins, Elizabeth D
Published in The Journal of immunology (1950) (01.05.2003)
Published in The Journal of immunology (1950) (01.05.2003)
Get full text
Journal Article
476PUpdated efficacy and safety of entrectinib in patients with NTRK fusion-positive tumors: Integrated analysis of STARTRK-2, STARTRK-1 and ALKA-372-001
Rolfo, C, Dziadziuszko, R, Doebele, R C, Demetri, G, Simmons, B, Huang, X, Ye, C, Paz-Ares, L
Published in Annals of oncology (01.10.2019)
Published in Annals of oncology (01.10.2019)
Get full text
Journal Article
1488PDEntrectinib in locally advanced/metastatic ROS1 and NTRK fusion-positive non-small cell lung cancer (NSCLC): Updated integrated analysis of STARTRK-2, STARTRK-1 and ALKA-372-001
Braud, F G M De, Siena, S, Barlesi, F, Drilon, A, Simmons, B P, Huang, X, Ye, C, Doebele, R C
Published in Annals of oncology (01.10.2019)
Published in Annals of oncology (01.10.2019)
Get full text
Journal Article