AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965
Dite, Toby A., Langendorf, Christopher G., Hoque, Ashfaqul, Galic, Sandra, Rebello, Richard J., Ovens, Ashley J., Lindqvist, Lisa M., Ngoei, Kevin R.W., Ling, Naomi X.Y., Furic, Luc, Kemp, Bruce E., Scott, John W., Oakhill, Jonathan S.
Published in The Journal of biological chemistry (08.06.2018)
Published in The Journal of biological chemistry (08.06.2018)
Get full text
Journal Article
CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins
Langendorf, Christopher G., O'Brien, Matthew T., Ngoei, Kevin R.W., McAloon, Luke M., Dhagat, Urmi, Hoque, Ashfaqul, Ling, Naomi X.Y., Dite, Toby A., Galic, Sandra, Loh, Kim, Parker, Michael W., Oakhill, Jonathan S., Kemp, Bruce E., Scott, John W.
Published in The Journal of biological chemistry (27.11.2020)
Published in The Journal of biological chemistry (27.11.2020)
Get full text
Journal Article
Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
Vrahnas, Christina, Blank, Martha, Dite, Toby A., Tatarczuch, Liliana, Ansari, Niloufar, Crimeen-Irwin, Blessing, Nguyen, Huynh, Forwood, Mark R., Hu, Yifang, Ikegame, Mika, Bambery, Keith R., Petibois, Cyril, Mackie, Eleanor J., Tobin, Mark J., Smyth, Gordon K., Oakhill, Jonathan S., Martin, T. John, Sims, Natalie A.
Published in Nature communications (31.07.2019)
Published in Nature communications (31.07.2019)
Get full text
Journal Article
Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion
Lindqvist, Lisa M., Frank, Daniel, McArthur, Kate, Dite, Toby A., Lazarou, Michael, Oakhill, Jonathan S., Kile, Benjamin T., Vaux, David L.
Published in Cell death and differentiation (01.03.2018)
Published in Cell death and differentiation (01.03.2018)
Get full text
Journal Article
The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
Dite, Toby A., Ling, Naomi X. Y., Scott, John W., Hoque, Ashfaqul, Galic, Sandra, Parker, Benjamin L., Ngoei, Kevin R. W., Langendorf, Christopher G., O’Brien, Matthew T., Kundu, Mondira, Viollet, Benoit, Steinberg, Gregory R., Sakamoto, Kei, Kemp, Bruce E., Oakhill, Jonathan S.
Published in Nature communications (18.09.2017)
Published in Nature communications (18.09.2017)
Get full text
Journal Article
Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling
Roy, Michael J., Surudoi, Minglyanna G., Kropp, Ashleigh, Hou, Jianmei, Dai, Weiwen, Hardy, Joshua M., Liang, Lung-Yu, Cotton, Thomas R., Lechtenberg, Bernhard C., Dite, Toby A., Ma, Xiuquan, Daly, Roger J., Patel, Onisha, Lucet, Isabelle S.
Published in Nature communications (19.06.2023)
Published in Nature communications (19.06.2023)
Get full text
Journal Article
Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin
Sarson-Lawrence, Kaiseal T. G., Hardy, Joshua M., Iaria, Josephine, Stockwell, Dina, Behrens, Kira, Saiyed, Tamanna, Tan, Cyrus, Jebeli, Leila, Scott, Nichollas E., Dite, Toby A., Nicola, Nicos A., Leis, Andrew P., Babon, Jeffrey J., Kershaw, Nadia J.
Published in Nature communications (07.02.2024)
Published in Nature communications (07.02.2024)
Get full text
Journal Article
mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress
Ling, Naomi X Y, Kaczmarek, Adrian, Hoque, Ashfaqul, Davie, Elizabeth, Ngoei, Kevin R W, Morrison, Kaitlin R, Smiles, William J, Forte, Gabriella M, Wang, Tingting, Lie, Shervi, Dite, Toby A, Langendorf, Christopher G, Scott, John W, Oakhill, Jonathan S, Petersen, Janni
Published in Nature metabolism (01.01.2020)
Published in Nature metabolism (01.01.2020)
Get more information
Journal Article
Caspase-2 protects against ferroptotic cell death
Dawar, Swati, Benitez, Mariana C., Lim, Yoon, Dite, Toby A., Yousef, Jumana M., Thio, Niko, Garciaz, Sylvain, Jackson, Thomas D., Milne, Julia V., Dagley, Laura F., Phillips, Wayne A., Kumar, Sharad, Clemons, Nicholas J.
Published in Cell death & disease (01.03.2024)
Published in Cell death & disease (01.03.2024)
Get full text
Journal Article
Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4
Ngoei, Kevin R.W., Langendorf, Christopher G., Ling, Naomi X.Y., Hoque, Ashfaqul, Varghese, Swapna, Camerino, Michelle A., Walker, Scott R., Bozikis, Ylva E., Dite, Toby A., Ovens, Ashley J., Smiles, William J., Jacobs, Roxane, Huang, He, Parker, Michael W., Scott, John W., Rider, Mark H., Foitzik, Richard C., Kemp, Bruce E., Baell, Jonathan B., Oakhill, Jonathan S.
Published in Cell chemical biology (21.06.2018)
Published in Cell chemical biology (21.06.2018)
Get full text
Journal Article
Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization
Meng, Yanxiang, Garnish, Sarah E., Davies, Katherine A., Black, Katrina A., Leis, Andrew P., Horne, Christopher R., Hildebrand, Joanne M., Hoblos, Hanadi, Fitzgibbon, Cheree, Young, Samuel N., Dite, Toby, Dagley, Laura F., Venkat, Aarya, Kannan, Natarajan, Koide, Akiko, Koide, Shohei, Glukhova, Alisa, Czabotar, Peter E., Murphy, James M.
Published in Nature communications (26.10.2023)
Published in Nature communications (26.10.2023)
Get full text
Journal Article
Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism
Hoffman, Nolan J., Whitfield, Jamie, Janzen, Natalie R., Belhaj, Mehdi R., Galic, Sandra, Murray-Segal, Lisa, Smiles, William J., Ling, Naomi X.Y., Dite, Toby A., Scott, John W., Oakhill, Jonathan S., Brink, Robert, Kemp, Bruce E., Hawley, John A.
Published in Molecular metabolism (Germany) (01.11.2020)
Published in Molecular metabolism (Germany) (01.11.2020)
Get full text
Journal Article
Transient Expression of AMPK Heterotrimer Complexes in Mammalian Cells
Oakhill, Jonathan S, Scott, John W, Dite, Toby A
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2018)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2018)
Get more information
Journal Article
Author Correction: Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone
Vrahnas, Christina, Blank, Martha, Dite, Toby A., Tatarczuch, Liliana, Ansari, Niloufar, Crimeen-Irwin, Blessing, Nguyen, Huynh, Forwood, Mark R., Hu, Yifang, Ikegame, Mika, Bambery, Keith R., Petibois, Cyril, Mackie, Eleanor J., Tobin, Mark J., Smyth, Gordon K., Oakhill, Jonathan S., Martin, T. John, Sims, Natalie A.
Published in Nature communications (04.11.2019)
Published in Nature communications (04.11.2019)
Get full text
Journal Article
Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation
O’Brien, Matthew T., Oakhill, Jonathan S., Ling, Naomi X. Y., Langendorf, Christopher G., Hoque, Ashfaqul, Dite, Toby A., Means, Anthony R., Kemp, Bruce E., Scott, John W.
Published in Scientific reports (23.02.2017)
Published in Scientific reports (23.02.2017)
Get full text
Journal Article
Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder
Scott, John W., Park, Elizabeth, Rodriguiz, Ramona M., Oakhill, Jonathan S., Issa, Samah M. A., O’Brien, Matthew T., Dite, Toby A., Langendorf, Christopher G., Wetsel, William C., Means, Anthony R., Kemp, Bruce E.
Published in Scientific reports (23.09.2015)
Published in Scientific reports (23.09.2015)
Get full text
Journal Article
Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling
Scott, John W., Ling, Naomi, Issa, Samah M.A., Dite, Toby A., O’Brien, Matthew T., Chen, Zhi-Ping, Galic, Sandra, Langendorf, Christopher G., Steinberg, Gregory R., Kemp, Bruce E., Oakhill, Jonathan S.
Published in Chemistry & biology (22.05.2014)
Published in Chemistry & biology (22.05.2014)
Get full text
Journal Article
Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release
Scott, John W., Galic, Sandra, Graham, Kate L., Foitzik, Richard, Ling, Naomi X.Y., Dite, Toby A., Issa, Samah M.A., Langendorf, Chris G., Weng, Qing Ping, Thomas, Helen E., Kay, Thomas W., Birnberg, Neal C., Steinberg, Gregory R., Kemp, Bruce E., Oakhill, Jonathan S.
Published in Chemistry & biology (18.06.2015)
Published in Chemistry & biology (18.06.2015)
Get full text
Journal Article
NRPB1 is a WNK-like pseudokinase that modulates the activity of the WNK4-SPAK/OSR1 pathway with implications in the physiology of the distal convoluted tubule
Magaña-Aviila, German Ricardo, Carbajal-Contreras, Hector, Amnekar, Ramchandra, Dite, Toby, Vazquez, Norma, Gamba, Gerardo, Alessi, Dario
Published in Physiology (Bethesda, Md.) (01.05.2024)
Published in Physiology (Bethesda, Md.) (01.05.2024)
Get full text
Journal Article
The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs
Liang, Lung-Yu, Roy, Michael, Horne, Christopher R, Sandow, Jarrod J, Surudoi, Minglyanna, Dagley, Laura F, Young, Samuel N, Dite, Toby, Babon, Jeffrey J, Janes, Peter W, Patel, Onisha, Murphy, James M, Lucet, Isabelle S
Published in Biochemical journal (17.09.2021)
Published in Biochemical journal (17.09.2021)
Get more information
Journal Article