Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss
Scekic-Zahirovic, Jelena, Sendscheid, Oliver, El Oussini, Hajer, Jambeau, Mélanie, Sun, Ying, Mersmann, Sina, Wagner, Marina, Dieterlé, Stéphane, Sinniger, Jérome, Dirrig-Grosch, Sylvie, Drenner, Kevin, Birling, Marie-Christine, Qiu, Jinsong, Zhou, Yu, Li, Hairi, Fu, Xiang-Dong, Rouaux, Caroline, Shelkovnikova, Tatyana, Witting, Anke, Ludolph, Albert C, Kiefer, Friedemann, Storkebaum, Erik, Lagier-Tourenne, Clotilde, Dupuis, Luc
Published in The EMBO journal (17.05.2016)
Published in The EMBO journal (17.05.2016)
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A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis
Palamiuc, Lavinia, Schlagowski, Anna, Ngo, Shyuan T, Vernay, Aurelia, Dirrig‐Grosch, Sylvie, Henriques, Alexandre, Boutillier, Anne‐Laurence, Zoll, Joffrey, Echaniz‐Laguna, Andoni, Loeffler, Jean‐Philippe, René, Frédérique
Published in EMBO molecular medicine (01.05.2015)
Published in EMBO molecular medicine (01.05.2015)
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Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis
Scekic-Zahirovic, Jelena, Oussini, Hajer El, Mersmann, Sina, Drenner, Kevin, Wagner, Marina, Sun, Ying, Allmeroth, Kira, Dieterlé, Stéphane, Sinniger, Jérôme, Dirrig-Grosch, Sylvie, René, Frédérique, Dormann, Dorothee, Haass, Christian, Ludolph, Albert C., Lagier-Tourenne, Clotilde, Storkebaum, Erik, Dupuis, Luc
Published in Acta neuropathologica (01.06.2017)
Published in Acta neuropathologica (01.06.2017)
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Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects
Scekic-Zahirovic, Jelena, Sanjuan-Ruiz, Inmaculada, Kan, Vanessa, Megat, Salim, De Rossi, Pierre, Dieterlé, Stéphane, Cassel, Raphaelle, Jamet, Marguerite, Kessler, Pascal, Wiesner, Diana, Tzeplaeff, Laura, Demais, Valérie, Sahadevan, Sonu, Hembach, Katharina M, Muller, Hans-Peter, Picchiarelli, Gina, Mishra, Nibha, Antonucci, Stefano, Dirrig-Grosch, Sylvie, Kassubek, Jan, Rasche, Volker, Ludolph, Albert, Boutillier, Anne-Laurence, Roselli, Francesco, Polymenidou, Magdalini, Lagier-Tourenne, Clotilde, Liebscher, Sabine, Dupuis, Luc
Published in Nature communications (21.05.2021)
Published in Nature communications (21.05.2021)
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Journal Article
Degeneration of serotonin neurons triggers spasticity in amyotrophic lateral sclerosis
El Oussini, Hajer, Scekic‐Zahirovic, Jelena, Vercruysse, Pauline, Marques, Christine, Dirrig‐Grosch, Sylvie, Dieterlé, Stéphane, Picchiarelli, Gina, Sinniger, Jérôme, Rouaux, Caroline, Dupuis, Luc
Published in Annals of neurology (01.09.2017)
Published in Annals of neurology (01.09.2017)
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Journal Article
Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase
Henriques, Alexandre, Croixmarie, Vincent, Priestman, David A, Rosenbohm, Angela, Dirrig-Grosch, Sylvie, D'Ambra, Eleonora, Huebecker, Mylene, Hussain, Ghulam, Boursier-Neyret, Claire, Echaniz-Laguna, Andoni, Ludolph, Albert C, Platt, Frances M, Walther, Bernard, Spedding, Michael, Loeffler, Jean-Philippe, Gonzalez De Aguilar, Jose-Luis
Published in Human molecular genetics (20.12.2015)
Published in Human molecular genetics (20.12.2015)
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Longitudinal transcriptomic analysis of altered pathways in a CHMP2Bintron5-based model of ALS-FTD
Waegaert, Robin, Dirrig-Grosch, Sylvie, Parisot, Florian, Keime, Céline, Henriques, Alexandre, Loeffler, Jean-Philippe, René, Frédérique
Published in Neurobiology of disease (01.03.2020)
Published in Neurobiology of disease (01.03.2020)
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Journal Article
Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis
Kabashi, Edor, El Oussini, Hajer, Bercier, Valérie, Gros-Louis, François, Valdmanis, Paul N, McDearmid, Jonathan, Mejier, Inge A, Dion, Patrick A, Dupre, Nicolas, Hollinger, David, Sinniger, Jérome, Dirrig-Grosch, Sylvie, Camu, William, Meininger, Vincent, Loeffler, Jean-Philippe, René, Frédérique, Drapeau, Pierre, Rouleau, Guy A, Dupuis, Luc
Published in Human molecular genetics (15.06.2013)
Published in Human molecular genetics (15.06.2013)
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Journal Article
Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation
Sanjuan-Ruiz, Inmaculada, Govea-Perez, Noé, McAlonis-Downes, Melissa, Dieterle, Stéphane, Megat, Salim, Dirrig-Grosch, Sylvie, Picchiarelli, Gina, Piol, Diana, Zhu, Qiang, Myers, Brian, Lee, Chao-Zong, Cleveland, Don W, Lagier-Tourenne, Clotilde, Da Cruz, Sandrine, Dupuis, Luc
Published in Molecular neurodegeneration (06.09.2021)
Published in Molecular neurodegeneration (06.09.2021)
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Journal Article
Alteration of the Neuromuscular Junction and Modifications of Muscle Metabolism in Response to Neuron-Restricted Expression of the CHMP2Bintron5 Mutant in a Mouse Model of ALS-FTD Syndrome
Waegaert, Robin, Dirrig-Grosch, Sylvie, Liu, Haoyi, Boutry, Marion, Luan, Ping, Loeffler, Jean-Philippe, René, Frédérique
Published in Biomolecules (Basel, Switzerland) (24.03.2022)
Published in Biomolecules (Basel, Switzerland) (24.03.2022)
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Cocaine induces the expression of MEF2C transcription factor in rat striatum through activation of SIK1 and phosphorylation of the histone deacetylase HDAC5
Dietrich, Jean-Bernard, Takemori, Hiroshi, Grosch-Dirrig, Sylvie, Bertorello, Alejandro, Zwiller, Jean
Published in Synapse (New York, N.Y.) (01.01.2012)
Published in Synapse (New York, N.Y.) (01.01.2012)
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Systemic down-regulation of delta-9 desaturase promotes muscle oxidative metabolism and accelerates muscle function recovery following nerve injury
Hussain, Ghulam, Schmitt, Florent, Henriques, Alexandre, Lequeu, Thiebault, Rene, Frederique, Bindler, Françoise, Dirrig-Grosch, Sylvie, Oudart, Hugues, Palamiuc, Lavinia, Metz-Boutigue, Marie-Helene, Dupuis, Luc, Marchioni, Eric, Gonzalez De Aguilar, Jose-Luis, Loeffler, Jean-Philippe
Published in PloS one (13.06.2013)
Published in PloS one (13.06.2013)
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Journal Article
Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils
Glattard, Elise, Welters, Ingeborg D, Lavaux, Thomas, Muller, Arnaud H, Laux, Alexis, Zhang, Dan, Schmidt, Alexander R, Delalande, François, Laventie, Benoît-Joseph, Dirrig-Grosch, Sylvie, Colin, Didier A, Van Dorsselaer, Alain, Aunis, Dominique, Metz-Boutigue, Marie-Hélène, Schneider, Francis, Goumon, Yannick
Published in PloS one (20.01.2010)
Published in PloS one (20.01.2010)
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Mapping of endogenous morphine-like compounds in the adult mouse brain: Evidence of their localization in astrocytes and GABAergic cells
Laux, Alexis, Muller, Arnaud H., Miehe, Monique, Dirrig-Grosch, Sylvie, Deloulme, Jean Christophe, Delalande, François, Stuber, Denise, Sage, Dominique, Van Dorsselaer, Alain, Poisbeau, Pierrick, Aunis, Dominique, Goumon, Yannick
Published in Journal of comparative neurology (1911) (15.08.2011)
Published in Journal of comparative neurology (1911) (15.08.2011)
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Journal Article
Transmembrane peptides as inhibitors of ErbB receptor signaling
Bennasroune, Amar, Fickova, Maria, Gardin, Anne, Dirrig-Grosch, Sylvie, Aunis, Dominique, Crémel, Gérard, Hubert, Pierre
Published in Molecular biology of the cell (01.07.2004)
Published in Molecular biology of the cell (01.07.2004)
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Evidence that corticofugal propagation of ALS pathology is not mediated by prion-like mechanism
Scekic-Zahirovic, Jelena, Fischer, Mathieu, Stuart-Lopez, Geoffrey, Burg, Thibaut, Gilet, Johan, Dirrig-Grosch, Sylvie, Marques, Christine, Birling, Marie-Christine, Kessler, Pascal, Rouaux, Caroline
Published in Progress in neurobiology (01.05.2021)
Published in Progress in neurobiology (01.05.2021)
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