Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
Yoo, Euna, Salunke, Deepak B, Sil, Diptesh, Guo, Xiaoqiang, Salyer, Alex C. D, Hermanson, Alec R, Kumar, Manoj, Malladi, Subbalakshmi S, Balakrishna, Rajalakshmi, Thompson, Ward H, Tanji, Hiromi, Ohto, Umeharu, Shimizu, Toshiyuki, David, Sunil A
Published in Journal of medicinal chemistry (09.10.2014)
Published in Journal of medicinal chemistry (09.10.2014)
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Journal Article
Self-Assembled Alkylated Polyamine Analogs as Supramolecular Anticancer Agents
Sil, Diptesh, Panja, Sudipta, Jogdeo, Chinmay M, Kumar, Raj, Yu, Ao, Holbert, Cassandra E, Ding, Ling, Foley, Jackson R, Stewart, Tracy Murray, Casero, Jr, Robert A, Oupický, David
Published in Molecules (Basel, Switzerland) (10.04.2022)
Published in Molecules (Basel, Switzerland) (10.04.2022)
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Journal Article
Exquisite Selectivity for Human Toll-Like Receptor 8 in Substituted Furo[2,3‑c]quinolines
Kokatla, Hari Prasad, Sil, Diptesh, Malladi, Subbalakshmi S, Balakrishna, Rajalakshmi, Hermanson, Alec R, Fox, Lauren M, Wang, Xinkun, Dixit, Anshuman, David, Sunil A
Published in Journal of medicinal chemistry (12.09.2013)
Published in Journal of medicinal chemistry (12.09.2013)
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Journal Article
Toll-like receptor-8 agonistic activities in C2, C4, and C8 modified thiazolo[4,5-c]quinolines
Kokatla, Hari Prasad, Yoo, Euna, Salunke, Deepak B., Sil, Diptesh, Ng, Cameron F., Balakrishna, Rajalakshmi, Malladi, Subbalakshmi S., Fox, Lauren M., David, Sunil A.
Published in Organic & biomolecular chemistry (21.02.2013)
Published in Organic & biomolecular chemistry (21.02.2013)
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Journal Article
Dually Active Polycation/miRNA Nanoparticles for the Treatment of Fibrosis in Alcohol-Associated Liver Disease
Zhang, Chuhan, Hang, Yu, Tang, Weimin, Sil, Diptesh, Jensen-Smith, Heather C, Bennett, Robert G, McVicker, Benita L, Oupický, David
Published in Pharmaceutics (18.03.2022)
Published in Pharmaceutics (18.03.2022)
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Journal Article
Structure-Based Design of Novel Human Toll-like Receptor 8 Agonists
Kokatla, Hari Prasad, Sil, Diptesh, Tanji, Hiromi, Ohto, Umeharu, Malladi, Subbalakshmi S., Fox, Lauren M., Shimizu, Toshiyoki, David, Sunil A.
Published in ChemMedChem (01.04.2014)
Published in ChemMedChem (01.04.2014)
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Journal Article
Potential adjuvantic properties of innate immune stimuli
Warshakoon, Hemamali J., Hood, Jennifer D., Kimbrell, Matthew R., Malladi, Subbalakshmi, Wu, Wen Yan, Shukla, Nikunj, Agnihotri, Geetanjali, Sil, Diptesh, David, Sunil A.
Published in Human vaccines (01.06.2009)
Published in Human vaccines (01.06.2009)
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Journal Article
Bound To Shock: Protection from Lethal Endotoxemic Shock by a Novel, Nontoxic, Alkylpolyamine Lipopolysaccharide Sequestrant
SIL, Diptesh, SHRESTHA, Anurupa, CROMER, Jens R, ARORA, Shravan, DATTA, Apurba, DAVID, Sunil A, KIMBRELL, Matthew R, NGUYEN, Thuan B, ADISECHAN, Ashok K, BALAKRISHNA, Rajalakshmi, ABBO, Benjamin G, MALLADI, Subbalakshmi, MILLER, Kelly A, SHORT, Shannon
Published in Antimicrobial Agents and Chemotherapy (01.08.2007)
Published in Antimicrobial Agents and Chemotherapy (01.08.2007)
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Journal Article
Intraperitoneal siRNA Nanoparticles for Augmentation of Gemcitabine Efficacy in the Treatment of Pancreatic Cancer
Tang, Siyuan, Hang, Yu, Ding, Ling, Tang, Weimin, Yu, Ao, Zhang, Chuhan, Sil, Diptesh, Xie, Ying, Oupický, David
Published in Molecular pharmaceutics (06.12.2021)
Published in Molecular pharmaceutics (06.12.2021)
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Journal Article
Oral Delivery of Nucleic Acid Therapies for Local and Systemic Action
Kumari, Neha, Siddhanta, Kasturi, Panja, Sudipta, Joshi, Vineet, Jogdeo, Chinmay, Kapoor, Ekta, Khan, Rubayat, Kollala, Sai Sundeep, Kumar, Balawant, Sil, Diptesh, Singh, Amar B., Murry, Daryl J., Oupický, David
Published in Pharmaceutical research (01.01.2023)
Published in Pharmaceutical research (01.01.2023)
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Journal Article
Polycation fluorination improves intraperitoneal siRNA delivery in metastatic pancreatic cancer
Hang, Yu, Tang, Siyuan, Tang, Weimin, Větvička, David, Zhang, Chuhan, Xie, Ying, Yu, Fei, Yu, Ao, Sil, Diptesh, Li, Jing, Singh, Rakesh K., Oupický, David
Published in Journal of controlled release (10.05.2021)
Published in Journal of controlled release (10.05.2021)
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Journal Article
Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity
Beesu, Mallesh, Caruso, Giuseppe, Salyer, Alex C. D., Khetani, Karishma K., Sil, Diptesh, Weerasinghe, Mihiri, Tanji, Hiromi, Ohto, Umeharu, Shimizu, Toshiyuki, David, Sunil A.
Published in Journal of medicinal chemistry (08.10.2015)
Published in Journal of medicinal chemistry (08.10.2015)
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Journal Article
Perfluorocarbon Nanoemulsions Enhance Therapeutic siRNA Delivery in the Treatment of Pulmonary Fibrosis
Ding, Ling, Tang, Siyuan, Tang, Weimin, Mosley, Deanna D., Yu, Ao, Sil, Diptesh, Romanova, Svetlana, Bailey, Kristina L., Knoell, Daren L., Wyatt, Todd A., Oupický, David
Published in Advanced science (01.03.2022)
Published in Advanced science (01.03.2022)
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Journal Article
Effect of tocopherol conjugation on polycation-mediated siRNA delivery to orthotopic pancreatic tumors
Tang, Siyuan, Kapoor, Ekta, Ding, Ling, Yu, Ao, Tang, Weimin, Hang, Yu, Smith, Lynette M, Sil, Diptesh, Oupický, David
Published in Biomaterials advances (01.02.2023)
Published in Biomaterials advances (01.02.2023)
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Journal Article
Antimalarial Dibenzannulated Medium-Ring Keto Lactams
Ren, Rongguo, Wang, Xiaofang, Leas, Derek A., Scheurer, Christian, Hoevel, Sarah, Cal, Monica, Chen, Gong, Zhong, Longjin, Katneni, Kasiram, Pham, Thao, Patil, Rahul, Sil, Diptesh, Walters, Matthias J., Schulze, Thomas T., Neville, Andrew J., Dong, Yuxiang, Wittlin, Sergio, Kaiser, Marcel, Davis, Paul H., Charman, Susan A., Vennerstrom, Jonathan L.
Published in ACS infectious diseases (13.10.2023)
Published in ACS infectious diseases (13.10.2023)
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Journal Article
Hyaluronate-coated perfluoroalkyl polyamine prodrugs as bioactive siRNA delivery systems for the treatment of peritoneal cancers
Yu, Ao, Tang, Siyuan, Ding, Ling, Foley, Jackson, Tang, Weimin, Jia, Huizhen, Panja, Sudipta, Holbert, Cassandra E, Hang, Yu, Stewart, Tracy Murray, Smith, Lynette M, Sil, Diptesh, Casero, Jr, Robert A, Oupický, David
Published in Biomaterials advances (01.05.2022)
Published in Biomaterials advances (01.05.2022)
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Journal Article
Hyaluronate-coated perfluoroalkyl polyamine prodrugs as bioactive siRNA delivery systems for the treatment of peritoneal cancers
Yu, Ao, Tang, Siyuan, Ding, Ling, Foley, Jackson, Tang, Weimin, Jia, Huizhen, Panja, Sudipta, Holbert, Cassandra E, Hang, Yu, Stewart, Tracy Murray, Smith, Lynette M, Sil, Diptesh, Casero, Jr, Robert A, Oupický, David
Published in Biomaterials advances (01.05.2022)
Published in Biomaterials advances (01.05.2022)
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Journal Article
Structure-Based Design of Novel Human Toll-like Receptor8 Agonists
Kokatla, Hari Prasad, Sil, Diptesh, Tanji, Hiromi, Ohto, Umeharu, Malladi, Subbalakshmi S, Fox, Lauren M, Shimizu, Toshiyoki, David, Sunil A
Published in ChemMedChem (01.04.2014)
Published in ChemMedChem (01.04.2014)
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Journal Article
Structure-based Ligand Design of Novel Human Toll-like Receptor 8 Agonists
Kokatla, Hari Prasad, Sil, Diptesh, Tanji, Hiromi, Ohto, Umeharu, Malladi, Subbalakshmi S., Fox, Lauren M., Shimizu, Toshiyoki, David, Sunil A.
Published in ChemMedChem (28.01.2014)
Published in ChemMedChem (28.01.2014)
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Journal Article