p38 mitogen‐activated protein kinase inhibitor LY2228820 enhances bortezomib‐induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications
Ishitsuka, Kenji, Hideshima, Teru, Neri, Paola, Vallet, Sonia, Shiraishi, Norihiko, Okawa, Yutaka, Shen, Zhenxin, Raje, Noopur, Kiziltepe, Tanyel, Ocio, Enrique M., Chauhan, Dharminder, Tassone, Pierfrancesco, Munshi, Nikhil, Campbell, Robert M., Dios, Alfonso De, Shih, Chuan, Starling, James J., Tamura, Kazuo, Anderson, Kenneth C.
Published in British journal of haematology (01.06.2008)
Published in British journal of haematology (01.06.2008)
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Journal Article
The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade
Schaer, David A., Beckmann, Richard P., Dempsey, Jack A., Huber, Lysiane, Forest, Amelie, Amaladas, Nelusha, Li, Yanxia, Wang, Ying Cindy, Rasmussen, Erik R., Chin, Darin, Capen, Andrew, Carpenito, Carmine, Staschke, Kirk A., Chung, Linda A., Litchfield, Lacey M., Merzoug, Farhana F., Gong, Xueqian, Iversen, Philip W., Buchanan, Sean, de Dios, Alfonso, Novosiadly, Ruslan D., Kalos, Michael
Published in Cell reports (Cambridge) (13.03.2018)
Published in Cell reports (Cambridge) (13.03.2018)
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Journal Article
Preclinical characterization of abemaciclib in hormone receptor positive breast cancer
Torres-Guzmán, Raquel, Calsina, Bruna, Hermoso, Ana, Baquero, Carmen, Alvarez, Beatriz, Amat, Joaquín, McNulty, Ann M, Gong, Xueqian, Boehnke, Karsten, Du, Jian, de Dios, Alfonso, Beckmann, Richard P, Buchanan, Sean, Lallena, María José
Published in Oncotarget (19.09.2017)
Published in Oncotarget (19.09.2017)
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Journal Article
Semi-Mechanistic Pharmacokinetic/Pharmacodynamic Modeling of the Antitumor Activity of LY2835219, a New Cyclin-Dependent Kinase 4/6 Inhibitor, in Mice Bearing Human Tumor Xenografts
TATE, Sonya C, SHUFEN CAI, AJAMIE, Rose T, BURKE, Teresa, BECKMANN, Richard P, CHAN, Edward M, DE DIOS, Alfonso, WISHART, Graham N, GELBERT, Lawrence M, CRONIER, Damien M
Published in Clinical cancer research (15.07.2014)
Published in Clinical cancer research (15.07.2014)
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Journal Article
A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models
Yin, Tinggui, Lallena, Maria J, Kreklau, Emiko L, Fales, Kevin R, Carballares, Santiago, Torrres, Raquel, Wishart, Graham N, Ajamie, Rose T, Cronier, Damien M, Iversen, Phillip W, Meier, Timothy I, Foreman, Robert T, Zeckner, Douglas, Sissons, Sean E, Halstead, Bart W, Lin, Aimee B, Donoho, Gregory P, Qian, Yuewei, Li, Shuyu, Wu, Song, Aggarwal, Amit, Ye, Xiang S, Starling, James J, Gaynor, Richard B, de Dios, Alfonso, Du, Jian
Published in Molecular cancer therapeutics (01.06.2014)
Published in Molecular cancer therapeutics (01.06.2014)
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Journal Article
Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy
Gharbi, Severine Isabelle, Pelletier, Laura A., Espada, Alfonso, Gutiérrez, Jesus, Sanfeliciano, Sonia Maria Gutiérrez, Rauch, Charles T., Ganado, Maria Patricia, Baquero, Carmen, Zapatero, Elisabet, Zhang, Aiping, Benach, Jordi, Russell, Anna-Maria, Cano, Leticia, Gomez, Sandra, Broughton, Howard, Pulliam, Nicholas, Perez, Carmen Maria, Torres, Raquel, Debets, Marjoke F., de Dios, Alfonso, Puig, Oscar, Hilgers, Mark T., Lallena, Maria Jose
Published in NPJ breast cancer (29.11.2022)
Published in NPJ breast cancer (29.11.2022)
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Journal Article
Author Correction: Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy
Gharbi, Severine Isabelle, Pelletier, Laura A., Espada, Alfonso, Gutiérrez, Jesus, Sanfeliciano, Sonia Maria Gutiérrez, Rauch, Charles T., Ganado, Maria Patricia, Baquero, Carmen, Zapatero, Elisabet, Zhang, Aiping, Benach, Jordi, Russell, Anna-Maria, Cano, Leticia, Gomez, Sandra, Broughton, Howard, Pulliam, Nicholas, Perez, Carmen Maria, Torres, Raquel, Debets, Marjoke F., de Dios, Alfonso, Puig, Oscar, Hilgers, Mark T., Lallena, Maria Jose
Published in NPJ breast cancer (28.12.2022)
Published in NPJ breast cancer (28.12.2022)
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Journal Article
Structural and conformational studies of 5-(1H-pyrrol-2-ylmethylene)-substituted imidazolidine-2,4-diones and thiazolidine-2,4-diones
Dios, Alfonso de, de la Puente, Maria Luz, Rivera-Sagredo, Alfonso, Espinosa, Juan Felix
Published in Canadian journal of chemistry (01.10.2002)
Published in Canadian journal of chemistry (01.10.2002)
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Journal Article
Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives
Mader, Mary M., Shih, Chuan, Considine, Eileen, Dios, Alfonso De, Grossman, Cora Sue, Hipskind, Philip A., Lin, Ho-Shen, Lobb, Karen L., Lopez, Beatriz, Lopez, José E., Cabrejas, Luisa M. Martin, Richett, Michael E., White, Wesley T., Cheung, Yiu-Yin, Huang, Zhongping, Reilly, John E., Dinn, Sean R.
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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Journal Article
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs
Sánchez-Martínez, Concepción, Gelbert, Lawrence M., Lallena, María José, de Dios, Alfonso
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
Published in Bioorganic & medicinal chemistry letters (01.09.2015)
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Journal Article
Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
Raub, Thomas J, Wishart, Graham N, Kulanthaivel, Palaniappan, Staton, Brian A, Ajamie, Rose T, Sawada, Geri A, Gelbert, Lawrence M, Shannon, Harlan E, Sanchez-Martinez, Concepcion, De Dios, Alfonso
Published in Drug metabolism and disposition (01.09.2015)
Published in Drug metabolism and disposition (01.09.2015)
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Journal Article
Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib
Gong, Xueqian, Litchfield, Lacey M., Webster, Yue, Chio, Li-Chun, Wong, Swee Seong, Stewart, Trent R., Dowless, Michele, Dempsey, Jack, Zeng, Yi, Torres, Raquel, Boehnke, Karsten, Mur, Cecilia, Marugán, Carlos, Baquero, Carmen, Yu, Chunping, Bray, Steven M., Wulur, Isabella H., Bi, Chen, Chu, Shaoyou, Qian, Hui-Rong, Iversen, Philip W., Merzoug, Farhana F., Ye, Xiang S., Reinhard, Christoph, De Dios, Alfonso, Du, Jian, Caldwell, Charles W., Lallena, María José, Beckmann, Richard P., Buchanan, Sean G.
Published in Cancer cell (11.12.2017)
Published in Cancer cell (11.12.2017)
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Journal Article
Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine
Gelbert, Lawrence M., Cai, Shufen, Lin, Xi, Sanchez-Martinez, Concepcion, del Prado, Miriam, Lallena, Maria Jose, Torres, Raquel, Ajamie, Rose T., Wishart, Graham N., Flack, Robert Steven, Neubauer, Blake Lee, Young, Jamie, Chan, Edward M., Iversen, Philip, Cronier, Damien, Kreklau, Emiko, de Dios, Alfonso
Published in Investigational new drugs (01.10.2014)
Published in Investigational new drugs (01.10.2014)
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Journal Article
Abemaciclib, a CDK4 and 6 inhibitor with unique pharmacological properties for breast cancer therapy
Torres-Guzmán, Raquel, Ganado, Maria Patricia, Mur Pérez, Cecila, Marugán, Carlos, Baquero, Carmen, Yang, Yanzhu, Du, Jian, de Dios, Alfonso, Puig, Oscar, Lallena, Maria Jose
Published in Journal of clinical oncology (20.05.2021)
Published in Journal of clinical oncology (20.05.2021)
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Journal Article
Continuous treatment with abemaciclib leads to sustained and efficient inhibition of breast cancer cell proliferation
Torres-Guzmán, Raquel, Ganado, Maria Patricia, Mur, Cecilia, Marugan, Carlos, Baquero, Carmen, Yang, Yanzhu, Zeng, Yi, Bian, Huimin, Du, Jian, de Dios, Alfonso, Puig, Oscar, Lallena, María José
Published in Oncotarget (02.07.2022)
Published in Oncotarget (02.07.2022)
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Journal Article
Abstract 1236: Preclinical characterization of LY3484356, a novel, potent and orally bioavailable selective estrogen receptor degrader (SERD)
Bhagwat, Shripad V., Zhao, Baohui, Shen, Weihua, Mur, Cecilia, Barr, Robert, Kindler, Lisa J., Rubio, Almudena, Bastian, Jolie A., Cohen, Jeffrey D., Mattioni, Brian E., Yuen, Eunice, Baker, Thomas K., Castanares, Mark A., Fei, Dongling, Manro, Jason R., Lallena, Maria Jose, Peng, Sheng-Bin, de Dios, Alfonso
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity
Campbell, Robert M, Anderson, Bryan D, Brooks, Nathan A, Brooks, Harold B, Chan, Edward M, De Dios, Alfonso, Gilmour, Raymond, Graff, Jeremy R, Jambrina, Enrique, Mader, Mary, McCann, Denis, Na, Songqing, Parsons, Stephen H, Pratt, Susan E, Shih, Chuan, Stancato, Louis F, Starling, James J, Tate, Courtney, Velasco, Juan A, Wang, Yong, Ye, Xiang S
Published in Molecular cancer therapeutics (01.02.2014)
Published in Molecular cancer therapeutics (01.02.2014)
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