A Framework Proposal to Follow‐Up on Preclinical Convulsive Signals of a New Molecular Entity in First‐in‐Human Studies Using Electroencephalographic Monitoring
Abt, Markus, Dinklo, Theo, Rothfuss, Andreas, Husar, Elisabeth, Dannecker, Robert, Kallivroussis, Katja, Peck, Richard, Doessegger, Lucette, Wandel, Christoph
Published in Clinical pharmacology and therapeutics (01.11.2019)
Published in Clinical pharmacology and therapeutics (01.11.2019)
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Journal Article
Unexpected neurotoxicity in chronic toxicity studies with a HBV viral expression inhibitor
Bopst, Martin, Dinklo, Theo, Funk, Juergen, Greiter-Wilke, Andrea, Lenz, Barbara, Kustermann, Stefan, Jiang, Tianyi, Xie, Jianxun
Published in Regulatory toxicology and pharmacology (01.06.2023)
Published in Regulatory toxicology and pharmacology (01.06.2023)
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Journal Article
Non-human primate neuropharmacology refinement: Polysomnography and regional qEEG with social housing in ETS 123 compliant cages
Dinklo, Theo, Garces, Pilar, Chatham, Christopher, Pouliot, Mylene, Authier, Simon
Published in Journal of pharmacological and toxicological methods (01.09.2019)
Published in Journal of pharmacological and toxicological methods (01.09.2019)
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Journal Article
Rodent respiratory findings with mGlu5 positive allosteric modulator RG7342, translation to non-rodent and man
Dinklo, Theo, Waiz, David, Roberts, Sonia, Sturm, Stefan, Jenni, Roland, Aegler, Monika, Greiter-Wilke, Andrea
Published in Journal of pharmacological and toxicological methods (01.09.2019)
Published in Journal of pharmacological and toxicological methods (01.09.2019)
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Journal Article
Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative
DaSilva, Jamie K., Breidenbach, Laura, Deats, Tracy, Li, Dingzhou, Treinen, Kimberley, Dinklo, Theo, Kervyn, Sophie, Teuns, Greet, Traebert, Martin, Hempel, Katja
Published in Journal of pharmacological and toxicological methods (01.05.2020)
Published in Journal of pharmacological and toxicological methods (01.05.2020)
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Journal Article
Reprint of: Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative
DaSilva, Jamie K., Breidenbach, Laura, Deats, Tracy, Li, Dingzhou, Treinen, Kimberly, Dinklo, Theo, Kervyn, Sophie, Teuns, Greet, Traebert, Martin, Hempel, Katja
Published in Journal of pharmacological and toxicological methods (01.09.2020)
Published in Journal of pharmacological and toxicological methods (01.09.2020)
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Journal Article
Evaluation of the Subjective Similarity of the GlyT1 Inhibitor Bitopertin to Five Drugs of Abuse Using Drug Discrimination Testing in the Rat
Dinklo, Theo, Gauvin, David, Järbe, Torbjörn, Gifford, Roger, Körner, Annette, Alberati, Daniela
Published in Journal of pharmacological and toxicological methods (01.11.2017)
Published in Journal of pharmacological and toxicological methods (01.11.2017)
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Journal Article
Inter-company reproducibility of Irwin/FOB CNS safety assessment following reference drugs chlorpromazine and amphetamine
Himmel, Herbert M., Heers, Cara, van Amsterdam, Christoph, Habermann, Christopher, Schauerte, Heike, Rosch, Anke, van der Linde, Henk, Teuns, Greet, Eriksson Faelker, Therese M., Hempel, Katja, Traebert, Martin, Deurinck, Mark, Dinklo, Theo, Delaunois, Annie
Published in Journal of pharmacological and toxicological methods (01.09.2018)
Published in Journal of pharmacological and toxicological methods (01.09.2018)
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Journal Article
Irwin/FOB tests for CNS safety assessment: What are we doing?
Heers, Cara, van Amsterdam, Christoph, Habermann, Christopher, Schauerte, Heike, van der Linde, Henk, Himmel, Herbert, Traebert, Martin, Dinklo, Theo
Published in Journal of pharmacological and toxicological methods (01.09.2016)
Published in Journal of pharmacological and toxicological methods (01.09.2016)
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Journal Article
Characterization of JNJ-1930942, a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor
Lesage, Anne, Dinklo, Theo, Thuring, Jan-Willem, Grantham, Christopher, Peeters, Luc, Lavreysen, Hilde, Shaban, Hamdy, Stevens, Karen E., Zheng, Lijun
Published in Biochemical pharmacology (01.10.2009)
Published in Biochemical pharmacology (01.10.2009)
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Journal Article
Characterization of 2-[[4-Fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a Novel Positive Allosteric Modulator of the α 7 Nicotinic Acetylcholine Receptor
Dinklo, Theo, Shaban, Hamdy, Thuring, Jan Willem, Lavreysen, Hilde, Stevens, Karen E., Zheng, Lijun, Mackie, Claire, Grantham, Christopher, Vandenberk, Ine, Meulders, Greet, Peeters, Luc, Verachtert, Hanne, De Prins, Erik, Lesage, Anne S. J.
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
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Journal Article
Characterization of JNJ-1930942, a novel positive allosteric modulator of the α 7 nicotinic acetylcholine receptor
Lesage, Anne, Dinklo, Theo, Thuring, Jan-Willem, Grantham, Christopher, Peeters, Luc, Lavreysen, Hilde, Shaban, Hamdy, Stevens, Karen E., Zheng, Lijun
Published in Biochemical pharmacology (2009)
Published in Biochemical pharmacology (2009)
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Journal Article
Desensitization Characteristics of the Human α7nAChR/5HT3A Chimera Receptor
Dinklo, Theo, Lesage, Anne S., Grantham, Christopher G.
Published in Journal of molecular neuroscience (01.09.2006)
Published in Journal of molecular neuroscience (01.09.2006)
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Journal Article
Desensitization characteristics of the human [alpha]7nAChR/5HT3A chimera receptor
Dinklo, Theo, Lesage, Anne S, Grantham, Christopher G
Published in Journal of molecular neuroscience (01.02.2006)
Published in Journal of molecular neuroscience (01.02.2006)
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Journal Article