Pyrazolopyridine Inhibitors of B-RafV600E. Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors
Wenglowsky, Steve, Ren, Li, Ahrendt, Kateri A, Laird, Ellen R, Aliagas, Ignacio, Alicke, Bruno, Buckmelter, Alex J, Choo, Edna F, Dinkel, Victoria, Feng, Bainian, Gloor, Susan L, Gould, Stephen E, Gross, Stefan, Gunzner-Toste, Janet, Hansen, Joshua D, Hatzivassiliou, Georgia, Liu, Bonnie, Malesky, Kim, Mathieu, Simon, Newhouse, Brad, Raddatz, Nicholas J, Ran, Yingqing, Rana, Sumeet, Randolph, Nikole, Risom, Tyler, Rudolph, Joachim, Savage, Scott, Selby, LeAnn T, Shrag, Michael, Song, Kyung, Sturgis, Hillary L, Voegtli, Walter C, Wen, Zhaoyang, Willis, Brandon S, Woessner, Richard D, Wu, Wen-I, Young, Wendy B, Grina, Jonas
Published in ACS medicinal chemistry letters (08.03.2011)
Published in ACS medicinal chemistry letters (08.03.2011)
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Journal Article
Potent and Selective Aminopyrimidine-Based B-Raf Inhibitors with Favorable Physicochemical and Pharmacokinetic Properties
Mathieu, Simon, Gradl, Stefan N, Ren, Li, Wen, Zhaoyang, Aliagas, Ignacio, Gunzner-Toste, Janet, Lee, Wendy, Pulk, Rebecca, Zhao, Guiling, Alicke, Bruno, Boggs, Jason W, Buckmelter, Alex J, Choo, Edna F, Dinkel, Victoria, Gloor, Susan L, Gould, Stephen E, Hansen, Joshua D, Hastings, Gregg, Hatzivassiliou, Georgia, Laird, Ellen R, Moreno, David, Ran, Yingqing, Voegtli, Walter C, Wenglowsky, Steve, Grina, Jonas, Rudolph, Joachim
Published in Journal of medicinal chemistry (22.03.2012)
Published in Journal of medicinal chemistry (22.03.2012)
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Journal Article
Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase
Wenglowsky, Steve, Ren, Li, Grina, Jonas, Hansen, Joshua D, Laird, Ellen R, Moreno, David, Dinkel, Victoria, Gloor, Susan L, Hastings, Gregg, Rana, Sumeet, Rasor, Kevin, Sturgis, Hillary L, Voegtli, Walter C, Vigers, Guy, Willis, Brandon, Mathieu, Simon, Rudolph, Joachim
Published in Bioorganic & medicinal chemistry letters (15.04.2014)
Published in Bioorganic & medicinal chemistry letters (15.04.2014)
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Abstract 852: ARRY-380, a potent, small molecule inhibitor of ErbB2, increases survival in intracranial ErbB2+ xenograft models in mice
Dinkel, Victoria, Anderson, Deborah, Winski, Shannon, Winkler, James, Koch, Kevin, Lee, Patrice A.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf(V600E) kinase with favorable physicochemical and pharmacokinetic properties
Ren, Li, Laird, Ellen R, Buckmelter, Alex J, Dinkel, Victoria, Gloor, Susan L, Grina, Jonas, Newhouse, Brad, Rasor, Kevin, Hastings, Gregg, Gradl, Stefan N, Rudolph, Joachim
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Journal Article
Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf super(V600E) kinase
Wenglowsky, Steve, Ren, Li, Grina, Jonas, Hansen, Joshua D, Laird, Ellen R, Moreno, David, Dinkel, Victoria, Gloor, Susan L, Hastings, Gregg, Rana, Sumeet, Rasor, Kevin, Sturgis, Hillary L, Voegtli, Walter C, Vigers, Guy, Willis, Brandon, Mathieu, Simon, Rudolph, Joachim
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
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Journal Article
Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-RafV600E kinase
Wenglowsky, Steve, Ren, Li, Grina, Jonas, Hansen, Joshua D., Laird, Ellen R., Moreno, David, Dinkel, Victoria, Gloor, Susan L., Hastings, Gregg, Rana, Sumeet, Rasor, Kevin, Sturgis, Hillary L., Voegtli, Walter C., Vigers, Guy, Willis, Brandon, Mathieu, Simon, Rudolph, Joachim
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
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Journal Article
Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors
Wenglowsky, Steve, Ren, Li, Ahrendt, Kateri A, Laird, Ellen R, Aliagas, Ignacio, Alicke, Bruno, Buckmelter, Alex J, Choo, Edna F, Dinkel, Victoria, Feng, Bainian, Gloor, Susan L, Gould, Stephen E, Gross, Stefan, Gunzner-Toste, Janet, Hansen, Joshua D, Hatzivassiliou, Georgia, Liu, Bonnie, Malesky, Kim, Mathieu, Simon, Newhouse, Brad, Raddatz, Nicholas J, Ran, Yingqing, Rana, Sumeet, Randolph, Nikole, Risom, Tyler, Rudolph, Joachim, Savage, Scott, Selby, LeAnn T, Shrag, Michael, Song, Kyung, Sturgis, Hillary L, Voegtli, Walter C, Wen, Zhaoyang, Willis, Brandon S, Woessner, Richard D, Wu, Wen-I, Young, Wendy B, Grina, Jonas
Published in ACS medicinal chemistry letters (12.05.2011)
Published in ACS medicinal chemistry letters (12.05.2011)
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Journal Article
Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-RafV600E kinase with favorable physicochemical and pharmacokinetic properties
Ren, Li, Laird, Ellen R., Buckmelter, Alex J., Dinkel, Victoria, Gloor, Susan L., Grina, Jonas, Newhouse, Brad, Rasor, Kevin, Hastings, Gregg, Gradl, Stefan N., Rudolph, Joachim
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Journal Article
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase
Ren, Li, Ahrendt, Kateri A., Grina, Jonas, Laird, Ellen R., Buckmelter, Alex J., Hansen, Joshua D., Newhouse, Brad, Moreno, David, Wenglowsky, Steve, Dinkel, Victoria, Gloor, Susan L., Hastings, Gregg, Rana, Sumeet, Rasor, Kevin, Risom, Tyler, Sturgis, Hillary L., Voegtli, Walter C., Mathieu, Simon
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
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Journal Article
Pyrazolopyridine Inhibitors of B-Raf V600E . Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors
Wenglowsky, Steve, Ren, Li, Ahrendt, Kateri A., Laird, Ellen R., Aliagas, Ignacio, Alicke, Bruno, Buckmelter, Alex J., Choo, Edna F., Dinkel, Victoria, Feng, Bainian, Gloor, Susan L., Gould, Stephen E., Gross, Stefan, Gunzner-Toste, Janet, Hansen, Joshua D., Hatzivassiliou, Georgia, Liu, Bonnie, Malesky, Kim, Mathieu, Simon, Newhouse, Brad, Raddatz, Nicholas J., Ran, Yingqing, Rana, Sumeet, Randolph, Nikole, Risom, Tyler, Rudolph, Joachim, Savage, Scott, Selby, LeAnn T., Shrag, Michael, Song, Kyung, Sturgis, Hillary L., Voegtli, Walter C., Wen, Zhaoyang, Willis, Brandon S., Woessner, Richard D., Wu, Wen-I, Young, Wendy B., Grina, Jonas
Published in ACS medicinal chemistry letters (12.05.2011)
Published in ACS medicinal chemistry letters (12.05.2011)
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Journal Article