Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer
Li, Qun, Woods, Keith W., Thomas, Sheela, Zhu, Gui-Dong, Packard, Garrick, Fisher, John, Li, Tongmei, Gong, Jianchun, Dinges, Jurgen, Song, Xiaohong, Abrams, Jason, Luo, Yan, Johnson, Eric F., Shi, Yan, Liu, Xuesong, Klinghofer, Vered, Des Jong, Ron, Oltersdorf, Tilman, Stoll, Vincent S., Jakob, Clarissa G., Rosenberg, Saul H., Giranda, Vincent L.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Hit-to-lead optimization of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of KDR kinase inhibitors
Dinges, Jürgen, Akritopoulou-Zanze, Irini, Arnold, Lee D., Barlozzari, Teresa, Bousquet, Peter F., Cunha, George A., Ericsson, Anna M., Iwasaki, Nobuhiko, Michaelides, Michael R., Ogawa, Nobuo, Phelan, Kathleen M., Rafferty, Paul, Sowin, Thomas J., Stewart, Kent D., Tokuyama, Ryukou, Xia, Zhiren, Zhang, Henry Q.
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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1,4-Dihydroindeno[1,2- c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors
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Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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A convergent approach toward the tigliane ring system
Dauben, William G, Dinges, Jurgen, Smith, Timothy C
Published in Journal of organic chemistry (01.12.1993)
Published in Journal of organic chemistry (01.12.1993)
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Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-xL from NMR and Parallel Synthesis
Petros, Andrew M, Dinges, Jurgen, Augeri, David J, Baumeister, Steven A, Betebenner, David A, Bures, Mark G, Elmore, Steven W, Hajduk, Philip J, Joseph, Mary K, Landis, Shelley K, Nettesheim, David G, Rosenberg, Saul H, Shen, Wang, Thomas, Sheela, Wang, Xilu, Zanze, Irini, Zhang, Haichao, Fesik, Stephen W
Published in Journal of medicinal chemistry (26.01.2006)
Published in Journal of medicinal chemistry (26.01.2006)
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An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Fesik, Stephen W, Rosenberg, Saul H, Oltersdorf, Tilman, Elmore, Steven W, Shoemaker, Alexander R, Armstrong, Robert C, Augeri, David J, Belli, Barbara A, Bruncko, Milan, Deckwerth, Thomas L, Dinges, Jurgen, Hajduk, Philip J, Joseph, Mary K, Kitada, Shinichi, Korsmeyer, Stanley J, Kunzer, Aaron R, Letai, Anthony, Li, Chi, Mitten, Michael J, Nettesheim, David G, Ng, ShiChung, Nimmer, Paul M, O'Connor, Jacqueline M, Oleksijew, Anatol, Petros, Andrew M, Reed, John C, Shen, Wang, Tahir, Stephen K, Thompson, Craig B, Tomaselli, Kevin J, Wang, Baole, Wendt, Michael D, Zhang, Haichao
Published in Nature (02.06.2005)
Published in Nature (02.06.2005)
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Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-x L from NMR and Parallel Synthesis
Petros, Andrew M., Dinges, Jurgen, Augeri, David J., Baumeister, Steven A., Betebenner, David A., Bures, Mark G., Elmore, Steven W., Hajduk, Philip J., Joseph, Mary K., Landis, Shelley K., Nettesheim, David G., Rosenberg, Saul H., Shen, Wang, Thomas, Sheela, Wang, Xilu, Zanze, Irini, Zhang, Haichao, Fesik, Stephen W.
Published in Journal of medicinal chemistry (26.01.2006)
Published in Journal of medicinal chemistry (26.01.2006)
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Creation of a S1P Lyase bacterial surrogate for structure-based drug design
Argiriadi, Maria A., Banach, David, Radziejewska, Elzbieta, Marchie, Susan, DiMauro, Jennifer, Dinges, Jurgen, Dominguez, Eric, Hutchins, Charles, Judge, Russell A., Queeney, Kara, Wallace, Grier, Harris, Christopher M.
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
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Published in Bioorganic & medicinal chemistry letters (01.05.2016)
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Creation of a S1P Lyase bacterial surrogate for structure-based drug design
Argiriadi, Maria A., Banach, David, Radziejewska, Elzbieta, Marchie, Susan, DiMauro, Jennifer, Dinges, Jurgen, Dominguez, Eric, Hutchins, Charles, Judge, Russell A., Queeney, Kara, Wallace, Grier, Harris, Christopher M.
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
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1,4-Dihydroindeno[1,2-c]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel
Dinges, Jürgen, Albert, Daniel H, Arnold, Lee D, Ashworth, Kimba L, Akritopoulou-Zanze, Irini, Bousquet, Peter F, Bouska, Jennifer J, Cunha, George A, Davidsen, Steven K, Diaz, Gilbert J, Djuric, Stevan W, Gasiecki, Alan F, Gintant, Gary A, Gracias, Vijaya J, Harris, Christopher M, Houseman, Kathryn A, Hutchins, Charles W, Johnson, Eric F, Li, Hu, Marcotte, Patrick A, Martin, Ruth L, Michaelides, Michael R, Nyein, Michelle, Sowin, Thomas J, Su, Zhi, Tapang, Paul H, Xia, Zhiren, Zhang, Henry Q
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors
Dinges, Jurgen, Harris, Christopher M., Wallace, Grier A., Argiriadi, Maria A., Queeney, Kara L., Perron, Denise C., Dominguez, Eric, Kebede, Tegest, Desino, Kelly E., Patel, Hetal, Vasudevan, Anil
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
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NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A
DRESCHER KARLA, FROGGETT JAYNE, GENESTE HERVE, OCHSE MICHAEL, JANTOS KATJA, JAKOB CLARISSA, DINGES JURGEN
Year of Publication 17.11.2015
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Year of Publication 17.11.2015
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Discovery of adamantane ethers as inhibitors of 11β-HSD-1: Synthesis and biological evaluation
Patel, Jyoti R., Shuai, Qi, Dinges, Jurgen, Winn, Marty, Pliushchev, Marina, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Pan, Liping, Wagaw, Seble, Engstrom, Kenneth, Kerdesky, Francis A., Longenecker, Kenton, Judge, Russell, Qin, Wenying, Imade, Hovis M., Stolarik, DeAnne, Beno, David W.A., Brune, Michael, Chovan, Linda E., Sham, Hing L., Jacobson, Peer, Link, J.T.
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2- c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors
Akritopoulou-Zanze, Irini, Albert, Daniel H., Bousquet, Peter F., Cunha, George A., Harris, Christopher M., Moskey, Maria, Dinges, Jurgen, Stewart, Kent D., Sowin, Thomas J.
Published in Bioorganic & medicinal chemistry letters (01.06.2007)
Published in Bioorganic & medicinal chemistry letters (01.06.2007)
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Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands
Faghih, Ramin, Dwight, Wesley, Vasudevan, Anil, Dinges, Jurgen, Conner, Scott E., Esbenshade, Timothy A., Bennani, Youssef L., Hancock, Arthur A.
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
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ADAMANTYL DERIVATIVES AS INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME
YEH VINCE S, YONG HONG, PATEL JYOTI R, LINK JAMES T, SHUAI QI, SORENSEN BRYAN K, WINN MARTIN, DINGES JURGEN, ROHDE JEFFREY J
Year of Publication 18.03.2013
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Year of Publication 18.03.2013
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A concise synthesis of ortho-substituted aryl-acrylamides—potent activators of soluble guanylyl cyclase
Zhang, Henry Q., Xia, Zhiren, Kolasa, Teodozyj, Dinges, Jurgen
Published in Tetrahedron letters (24.11.2003)
Published in Tetrahedron letters (24.11.2003)
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