GDC-0449—A potent inhibitor of the hedgehog pathway
Robarge, Kirk D., Brunton, Shirley A., Castanedo, Georgette M., Cui, Yong, Dina, Michael S., Goldsmith, Richard, Gould, Stephen E., Guichert, Oivin, Gunzner, Janet L., Halladay, Jason, Jia, Wei, Khojasteh, Cyrus, Koehler, Michael F.T., Kotkow, Karen, La, Hank, LaLonde, Rebecca L., Lau, Kevin, Lee, Leslie, Marshall, Derek, Marsters, James C., Murray, Lesley J., Qian, Changgeng, Rubin, Lee L., Salphati, Laurent, Stanley, Mark S., Stibbard, John H.A., Sutherlin, Daniel P., Ubhayaker, Savita, Wang, Shumei, Wong, Susan, Xie, Minli
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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A Novel Series of Non-Carboxylic Acid, Non-Hydantoin Inhibitors of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models: 6-(5-Chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and Congeners
Mylari, Banavara L, Armento, Sandra J, Beebe, David A, Conn, Edward L, Coutcher, James B, Dina, Michael S, O'Gorman, Melissa T, Linhares, Michael C, Martin, William H, Oates, Peter J, Tess, David A, Withbroe, Gregory J, Zembrowski, William J
Published in Journal of medicinal chemistry (06.10.2005)
Published in Journal of medicinal chemistry (06.10.2005)
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A Highly Selective, Non-Hydantoin, Non-Carboxylic Acid Inhibitor of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models: 6-(5-Chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one
Mylari, Banavara L, Armento, Sandra J, Beebe, David A, Conn, Edward L, Coutcher, James B, Dina, Michael S, O'Gorman, Melissa T, Linhares, Michael C, Martin, William H, Oates, Peter J, Tess, David A, Withbroe, Gregory J, Zembrowski, William J
Published in Journal of medicinal chemistry (05.06.2003)
Published in Journal of medicinal chemistry (05.06.2003)
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Sorbitol Dehydrogenase Inhibitors (SDIs): A New Potent, Enantiomeric SDI, 4-[2-1R-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1-sulfonic Acid Dimethylamide
Mylari, Banavara L, Oates, Peter J, Beebe, David A, Brackett, Nathaniel S, Coutcher, James B, Dina, Michael S, Zembrowski, William J
Published in Journal of medicinal chemistry (16.08.2001)
Published in Journal of medicinal chemistry (16.08.2001)
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PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
WANG SHUMEI, MALESKY KIMBERLY, GUNZNER JANET L, REYNOLDS MARK E, SUTHERLIN DANIEL P, STANLEY MARK S, LALONDE REBECCA L, BAO LIANG, SAVAGE SCOTT J, DINA MICHAEL S, CASTANEDO GEORGETTE
Year of Publication 17.12.2010
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Year of Publication 17.12.2010
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Corrigendum to “GDC-0449—A potent inhibitor of the hedgehog pathway” [Bioorg. Med. Chem. Lett. 19 (2009) 5576]
Robarge, Kirk D., Brunton, Shirley A., Castanedo, Georgette M., Cui, Yong, Dina, Michael S., Goldsmith, Richard, Gould, Stephen E., Guichert, Oivin, Gunzner, Janet L., Halladay, Jason, Jia, Wei, Khojasteh, Cyrus, Koehler, Michael F.T., Kotkow, Karen, La, Hank, LaLonde, Rebecca L., Lau, Kevin, Lee, Leslie, Marshall, Derek, Marsters, James C., Murray, Lesley J., Qian, Changgeng, Rubin, Lee L., Salphati, Laurent, Stanley, Mark S., Stibbard, John H.A., Sutherlin, Daniel P., Ubhayaker, Savita, Wang, Shumei, Wong, Susan, Xie, Minli
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
A Novel Series of Non-Carboxylic Acid, Non-Hydantoin Inhibitors of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models: 6-(5-Chloro-3-methylbenzofuran-2-sulfonyl)-2 H -pyridazin-3-one and Congeners
Mylari, Banavara L., Armento, Sandra J., Beebe, David A., Conn, Edward L., Coutcher, James B., Dina, Michael S., O'Gorman, Melissa T., Linhares, Michael C., Martin, William H., Oates, Peter J., Tess, David A., Withbroe, Gregory J., Zembrowski, William J.
Published in Journal of medicinal chemistry (01.10.2005)
Published in Journal of medicinal chemistry (01.10.2005)
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Journal Article
PYRIDYL INHIBITORS FOR HEDGEHOG SIGNALLING
SUTHERLIN, Daniel, STANLEY, Mark S, SAVAGE, Scott J, CASTANEDO, Georgette M, MALESKY, Kimberly, WANG, Shumei, GUNZNER-TOSTE, Janet L, DINA, Michael S, KOEHLER, Michael F.T, BAO, Liang, LALONDE, Rebecca L, REYNOLDS, Mark E
Year of Publication 11.04.2024
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Year of Publication 11.04.2024
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PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
STANLEY, Mark S, SAVAGE, Scott J, CASTANEDO, Georgette M, SUTHERLIN, Daniel P, MALESKY, Kimberly, WANG, Shumei, GUNZNER-TOSTE, Janet L, DINA, Michael S, KOEHLER, Michael F.T, BAO, Liang, LALONDE, Rebecca L, REYNOLDS, Mark E
Year of Publication 24.08.2023
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Year of Publication 24.08.2023
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PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
SUTHERLIN, Daniel, STANLEY, Mark S, SAVAGE, Scott J, CASTANEDO, Georgette M, MALESKY, Kimberly, WANG, Shumei, GUNZNER-TOSTE, Janet L, DINA, Michael S, KOEHLER, Michael F.T, BAO, Liang, LALONDE, Rebecca L, REYNOLDS, Mark E
Year of Publication 11.03.2021
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Year of Publication 11.03.2021
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PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
STANLEY, Mark S, SAVAGE, Scott J, CASTANEDO, Georgette M, SUTHERLIN, Daniel P, MALESKY, Kimberly, WANG, Shumei, GUNZNER-TOSTE, Janet L, DINA, Michael S, KOEHLER, Michael F.T, BAO, Liang, LALONDE, Rebecca L, REYNOLDS, Mark E
Year of Publication 18.06.2020
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Year of Publication 18.06.2020
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PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
SUTHERLIN, Daniel, STANLEY, Mark S, SAVAGE, Scott J, CASTANEDO, Georgette M, MALESKY, Kimberly, WANG, Shumei, GUNZNER-TOSTE, Janet L, DINA, Michael S, KOEHLER, Michael F.T, BAO, Liang, LALONDE, Rebecca L, REYNOLDS, Mark E
Year of Publication 09.01.2020
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Year of Publication 09.01.2020
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Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists
Robarge, Kirk D., Dina, Michael S., Somers, Todd C., Lee, Arthur, Rawson, Thomas E., Olivero, Alan G., Tischler, Maureen H., Webb, Robert R., Weese, Kenneth J., Aliagas, Ignacio, Blackburn, Brent K.
Published in Bioorganic & medicinal chemistry (01.12.1998)
Published in Bioorganic & medicinal chemistry (01.12.1998)
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PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
STANLEY, Mark S, SAVAGE, Scott J, CASTANEDO, Georgette M, SUTHERLIN, Daniel P, MALESKY, Kimberly, WANG, Shumei, GUNZNER-TOSTE, Janet L, DINA, Michael S, KOEHLER, Michael F.T, BAO, Liang, LALONDE, Rebecca L, REYNOLDS, Mark E
Year of Publication 13.09.2018
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Year of Publication 13.09.2018
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PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
SAVAGE Scott J, CASTANEDO Georgette M, DINA Michael S, GUNZNER-TOSTE Janet L, KOEHLER Michael F.T, BAO Liang, MALESKY Kimberly, LALONDE Rebecca L, WANG Shumei, REYNOLDS Mark E, SUTHERLIN Daniel, STANLEY Mark S
Year of Publication 01.02.2018
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Year of Publication 01.02.2018
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Pyridyl inhibitors of hedgehog signalling
Dina Michael S, Bao Liang, Malesky Kimberly, Sutherlin Daniel, Reynolds Mark E, Castanedo Georgette M, Lalonde Rebecca L, Savage Scott J, Koehler Michael F. T, Stanley Mark S, Wang Shumei, Gunzner-Toste Janet L
Year of Publication 17.10.2017
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Year of Publication 17.10.2017
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PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
SAVAGE Scott J, CASTANEDO Georgette M, DINA Michael S, GUNZNER-TOSTE Janet L, KOEHLER Michael F.T, BAO Liang, MALESKY Kimberly, SUTHERLIN Daniel P, LALONDE Rebecca L, WANG Shumei, REYNOLDS Mark E, STANLEY Mark S
Year of Publication 19.01.2017
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Year of Publication 19.01.2017
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PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
WANG SHUMEI, GUNZNER-TOSTE JANET L, CASTANEDO GEORGETTE M, MALESKY KIMBERLY, SUTHERLIN DANIEL, REYNOLDS MARK E, STANLEY MARK S, LALONDE REBECCA L, KOEHLER MICHAEL F.T, BAO LIANG, SAVAGE SCOTT J, DINA MICHAEL S
Year of Publication 02.06.2016
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Year of Publication 02.06.2016
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Pyridyl inhibitors of hedgehog signalling
WANG SHUMEI, KOEHLER MICHAEL F. T, GUNZNER-TOSTE JANET L, CASTANEDO GEORGETTE M, MALESKY KIMBERLY, SUTHERLIN DANIEL, REYNOLDS MARK E, STANLEY MARK S, LALONDE REBECCA L, BAO LIANG, SAVAGE SCOTT J, DINA MICHAEL S
Year of Publication 26.04.2016
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Year of Publication 26.04.2016
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Pyridyl inhibitors of hedgehog signalling
WANG SHUMEI, KOEHLER MICHAEL F. T, CASTANEDO GEORGETTE M, MALESKY KIMBERLY, GUNZNER JANET L, SUTHERLIN DANIEL, REYNOLDS MARK E, STANLEY MARK S, LALONDE REBECCA L, BAO LIANG, SAVAGE SCOTT J, DINA MICHAEL S
Year of Publication 08.03.2016
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Year of Publication 08.03.2016
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