MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants
SUMMA, Vincenzo, LUDMERER, Steven W, GATES, Adam T, GRAHAM, Donald J, HARPER, Steven, HAZUDA, Daria J, MCHALE, Carolyn, MONTEAGUDO, Edith, PUCCI, Vincenzo, ROWLEY, Michael, RUDD, Michael T, SORIANO, Aileen, MCCAULEY, John A, STAHLHUT, Mark W, VACCA, Joseph P, OLSEN, David B, LIVERTON, Nigel J, CARROLL, Steven S, FANDOZZI, Christine, BURLEIN, Christine, CLAUDIO, Giuliano, COLEMAN, Paul J, DIMUZIO, Jillian M, FERRARA, Marco, DI FILIPPO, Marcello
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
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Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
McCauley, John A, McIntyre, Charles J, Rudd, Michael T, Nguyen, Kevin T, Romano, Joseph J, Butcher, John W, Gilbert, Kevin F, Bush, Kimberly J, Holloway, M. Katharine, Swestock, John, Wan, Bang-Lin, Carroll, Steven S, DiMuzio, Jillian M, Graham, Donald J, Ludmerer, Steven W, Mao, Shi-Shan, Stahlhut, Mark W, Fandozzi, Christine M, Trainor, Nicole, Olsen, David B, Vacca, Joseph P, Liverton, Nigel J
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike protein
DiMuzio, Jillian M., Heimbach, Baron C., Howanski, Raymond J., Dowling, John P., Patel, Nirja B., Henriquez, Noeleya, Nicolescu, Chris, Nath, Mitchell, Polley, Antonio, Bingaman, Jamie L., Smith, Todd, Harman, Benjamin C., Robinson, Matthew K., Morin, Michael J., Nikitin, Pavel A.
Published in Vaccine: X (01.08.2021)
Published in Vaccine: X (01.08.2021)
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Biochemical and cell-based assays for characterization of BACE-1 inhibitors
Pietrak, Beth L., Crouthamel, Ming-Chih, Tugusheva, Katherine, Lineberger, Janet E., Xu, Min, DiMuzio, Jillian M., Steele, Thomas, Espeseth, Amy S., Stachel, Shawn J., Coburn, Craig A., Graham, Samuel L., Vacca, Joseph P., Shi, Xiao-Ping, Simon, Adam J., Hazuda, Daria J., Lai, Ming-Tain
Published in Analytical biochemistry (01.07.2005)
Published in Analytical biochemistry (01.07.2005)
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Journal Article
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
Harper, Steven, McCauley, John A, Rudd, Michael T, Ferrara, Marco, DiFilippo, Marcello, Crescenzi, Benedetta, Koch, Uwe, Petrocchi, Alessia, Holloway, M. Katharine, Butcher, John W, Romano, Joseph J, Bush, Kimberly J, Gilbert, Kevin F, McIntyre, Charles J, Nguyen, Kevin T, Nizi, Emanuela, Carroll, Steven S, Ludmerer, Steven W, Burlein, Christine, DiMuzio, Jillian M, Graham, Donald J, McHale, Carolyn M, Stahlhut, Mark W, Olsen, David B, Monteagudo, Edith, Cianetti, Simona, Giuliano, Claudio, Pucci, Vincenzo, Trainor, Nicole, Fandozzi, Christine M, Rowley, Michael, Coleman, Paul J, Vacca, Joseph P, Summa, Vincenzo, Liverton, Nigel J
Published in ACS medicinal chemistry letters (12.04.2012)
Published in ACS medicinal chemistry letters (12.04.2012)
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Journal Article
P2-Quinazolinones and Bis-Macrocycles as New Templates for Next-Generation Hepatitis C Virus NS3/4a Protease Inhibitors: Discovery of MK-2748 and MK-6325
Rudd, Michael T., Butcher, John W., Nguyen, Kevin T., McIntyre, Charles J., Romano, Joseph J., Gilbert, Kevin F., Bush, Kimberly J., Liverton, Nigel J., Holloway, M. Katharine, Harper, Steven, Ferrara, Marco, DiFilippo, Marcello, Summa, Vincenzo, Swestock, John, Fritzen, Jeff, Carroll, Steven S., Burlein, Christine, DiMuzio, Jillian M., Gates, Adam, Graham, Donald J., Huang, Qian, McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark W., Black, Stuart, Chase, Robert, Soriano, Aileen, Fandozzi, Christine M., Taylor, Anne, Trainor, Nicole, Olsen, David B., Coleman, Paul J., Ludmerer, Steven W., McCauley, John A.
Published in ChemMedChem (01.04.2015)
Published in ChemMedChem (01.04.2015)
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Journal Article
MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants
Summa, Vincenzo, Ludmerer, Steven W, McCauley, John A, Fandozzi, Christine, Burlein, Christine, Claudio, Giuliano, Coleman, Paul J, DiMuzio, Jillian M, Ferrara, Marco, Filippo, Marcello Di, Gates, Adam T, Graham, Donald J, Harper, Steven, Hazuda, Daria J, Huang, Qian, McHale, Carolyn, Monteagudo, Edith, Pucci, Vincenzo, Rowley, Michael, Rudd, Michael T, Soriano, Aileen, Stahlhut, Mark W, Vacca, Joseph P, Olsen, David B, Liverton, Nigel J, Carroll, Steven S
Published in Antimicrobial agents and chemotherapy (01.08.2014)
Published in Antimicrobial agents and chemotherapy (01.08.2014)
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Journal Article
Inhibitors of the Hepatitis C Virus NS3 Protease with Basic Amine Functionality at the P3-Amino Acid N-Terminus: Discovery and Optimization of a New Series of P2−P4 Macrocycles
Harper, Steven, Ferrara, Marco, Crescenzi, Benedetta, Pompei, Marco, Palumbi, Maria Cecilia, DiMuzio, Jillian M, Donghi, Monica, Fiore, Fabrizio, Koch, Uwe, Liverton, Nigel J, Pesci, Silvia, Petrocchi, Alessia, Rowley, Michael, Summa, Vincenzo, Gardelli, Cristina
Published in Journal of medicinal chemistry (13.08.2009)
Published in Journal of medicinal chemistry (13.08.2009)
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Journal Article
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers
Rudd, Michael T., McIntyre, Charles J., Romano, Joseph J., Butcher, John W., Holloway, M. Katharine, Bush, Kimberly, Nguyen, Kevin T., Gilbert, Kevin F., Lyle, Terry A., Liverton, Nigel J., Wan, Bang-Lin, Summa, Vincenzo, Harper, Steven, Rowley, Michael, Vacca, Joseph P., Carroll, Steven S., Burlein, Christine, DiMuzio, Jillian M., Gates, Adam, Graham, Donald J., Huang, Qian, Ludmerer, Steven W., McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark, Fandozzi, Christine, Taylor, Anne, Trainor, Nicole, Olsen, David B., McCauley, John A.
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
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Journal Article
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease
Rudd, Michael T., McCauley, John A., Romano, Joseph J., Butcher, John W., Bush, Kimberly, McIntyre, Charles J., Nguyen, Kevin T., Gilbert, Kevin F., Lyle, Terry A., Holloway, M. Katharine, Wan, Bang-Lin, Vacca, Joseph P., Summa, Vincenzo, Harper, Steven, Rowley, Michael, Carroll, Steven S., Burlein, Christine, DiMuzio, Jillian M., Gates, Adam, Graham, Donald J., Huang, Qian, Ludmerer, Steven W., McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark, Fandozzi, Christine, Taylor, Anne, Trainor, Nicole, Olsen, David B., Liverton, Nigel J.
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
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Journal Article
Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure
Rudd, Michael T, McCauley, John A, Butcher, John W, Romano, Joseph J, McIntyre, Charles J, Nguyen, Kevin T, Gilbert, Kevin F, Bush, Kimberly J, Holloway, M. Katharine, Swestock, John, Wan, Bang-Lin, Carroll, Steven S, DiMuzio, Jillian M, Graham, Donald J, Ludmerer, Steven W, Stahlhut, Mark W, Fandozzi, Christine M, Trainor, Nicole, Olsen, David B, Vacca, Joseph P, Liverton, Nigel J
Published in ACS medicinal chemistry letters (10.03.2011)
Published in ACS medicinal chemistry letters (10.03.2011)
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Journal Article
P2-Quinazolinones and Bis-Macrocycles as New Templates for Next-Generation HepatitisC Virus NS3/4a Protease Inhibitors: Discovery of MK-2748 and MK-6325
Rudd, Michael T, Butcher, John W, Nguyen, Kevin T, McIntyre, Charles J, Romano, Joseph J, Gilbert, Kevin F, Bush, Kimberly J, Liverton, Nigel J, Holloway, M Katharine, Harper, Steven, Ferrara, Marco, DiFilippo, Marcello, Summa, Vincenzo, Swestock, John, Fritzen, Jeff, Carroll, Steven S, Burlein, Christine, DiMuzio, Jillian M, Gates, Adam, Graham, Donald J, Huang, Qian, McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark W, Black, Stuart, Chase, Robert, Soriano, Aileen, Fandozzi, Christine M, Taylor, Anne, Trainor, Nicole, Olsen, David B, Coleman, Paul J, Ludmerer, Steven W, McCauley, John A
Published in ChemMedChem (01.04.2015)
Published in ChemMedChem (01.04.2015)
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Journal Article
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2aP4 linkers
Rudd, Michael T, McIntyre, Charles J, Romano, Joseph J, Butcher, John W, Holloway, MKatharine, Bush, Kimberly, Nguyen, Kevin T, Gilbert, Kevin F, Lyle, Terry A, Liverton, Nigel J, Wan, Bang-Lin, Summa, Vincenzo, Harper, Steven, Rowley, Michael, Vacca, Joseph P, Carroll, Steven S, Burlein, Christine, DiMuzio, Jillian M, Gates, Adam, Graham, Donald J, Huang, Qian, Ludmerer, Steven W, McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark, Fandozzi, Christine, Taylor, Anne, Trainor, Nicole, Olsen, David B, McCauley, John A
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
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Journal Article
COMPOSITIONS FOR INHIBITING NLRP3 GENE EXPRESSION AND USES THEREOF
DIMUZIO, Jillian M, JIANG, Weiwen, ZHU, Fu-Gang, BHAGAT, Lakshmi, AGRAWAL, Sudhir, PUTTA, Mallikarjuna R
Year of Publication 12.09.2018
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Year of Publication 12.09.2018
Patent
Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike protein
Dimuzio, Jillian M, Heimbach, Baron C, Howanski, Raymond J, Dowling, John P, Patel, Nirja B, Henriquez, Noeleya, Nicolescu, Chris, Nath, Mitchell, Polley, Antonio, Bingaman, Jamie L, Smith, Todd, Harman, Benjamin C, Robinson, Matthew K, Morin, Michael J, Nikitin, Pavel A
Published in bioRxiv (28.01.2021)
Published in bioRxiv (28.01.2021)
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Paper
Preclinical Efficacy of IMM-BCP-01, a Highly Active Patient-Derived Anti-SARS-CoV-2 Antibody Cocktail
Nikitin, Pavel A, Dimuzio, Jillian M, Dowling, John P, Patel, Nirja B, Bingaman-Steele, Jamie L, Nicolescu, Chris, Heimbach, Baron C, Henriquez, Noeleya, Sikorsky, Eden L, Polley, Antonio, Howanski, Raymond J, Nath, Mitchell, Shukla, Halley, Scheaffer, Suzanne M, Finn, James P, Li-Fang, Liang, Smith, Todd, Storm, Nadia, Mckay, Lindsay Ga, Johnson, Rebecca I, Malsick, Lauren E, Honko, Anna N, Griffiths, Anthony, Diamond, Michael S, Sarma, Purnanand, Geising, Dennis H, Morin, Michael J, Robinson, Matthew K
Published in bioRxiv (18.05.2022)
Published in bioRxiv (18.05.2022)
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Paper
COMPOSITIONS FOR INHIBITING NLRP3 GENE EXPRESSION AND USES THEREOF
Jiang Weiwen, Agrawal Sudhir, Bhagat Lakshmi, Putta Mallikarjuna R, Zhu Fu-Gang, DiMuzio Jillian M
Year of Publication 25.05.2017
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Year of Publication 25.05.2017
Patent
COMPOSITIONS FOR INHIBITING NLRP3 GENE EXPRESSION AND USES THEREOF
DIMUZIO, Jillian M, JIANG, Weiwen, ZHU, Fu-Gang, BHAGAT, Lakshmi, AGRAWAL, Sudhir, PUTTA, Mallikarjuna R
Year of Publication 11.05.2017
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Year of Publication 11.05.2017
Patent
COMPOSITIONS FOR INHIBITING NLRP3 GENE EXPRESSION AND USES THEREOF
JIANG WEIWEN, DIMUZIO JILLIAN M, ZHU FU-GANG, PUTTA MALLIKARJUNA R, AGRAWAL SUDHIR, BHAGAT LAKSHMI
Year of Publication 11.01.2019
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Year of Publication 11.01.2019
Patent