Anti-obesity drug discovery: advances and challenges
Müller, Timo D., Blüher, Matthias, Tschöp, Matthias H., DiMarchi, Richard D.
Published in Nature reviews. Drug discovery (01.03.2022)
Published in Nature reviews. Drug discovery (01.03.2022)
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Journal Article
Pursuit of a perfect insulin
Zaykov, Alexander N., Mayer, John P., DiMarchi, Richard D.
Published in Nature reviews. Drug discovery (01.06.2016)
Published in Nature reviews. Drug discovery (01.06.2016)
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Journal Article
Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety
He, Rongjun, Finan, Brian, Mayer, John P, DiMarchi, Richard D
Published in Molecules (Basel, Switzerland) (14.05.2019)
Published in Molecules (Basel, Switzerland) (14.05.2019)
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Journal Article
Unimolecular Polypharmacy for Treatment of Diabetes and Obesity
Tschöp, Matthias H., Finan, Brian, Clemmensen, Christoffer, Gelfanov, Vasily, Perez-Tilve, Diego, Müller, Timo D., DiMarchi, Richard D.
Published in Cell metabolism (12.07.2016)
Published in Cell metabolism (12.07.2016)
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Journal Article
The Sustained Effects of a Dual GIP/GLP-1 Receptor Agonist, NNC0090-2746, in Patients with Type 2 Diabetes
Frias, Juan Pablo, Bastyr, Edward J., Vignati, Louis, Tschöp, Matthias H., Schmitt, Christophe, Owen, Klara, Christensen, Rune Haubo, DiMarchi, Richard D.
Published in Cell metabolism (01.08.2017)
Published in Cell metabolism (01.08.2017)
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Journal Article
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Finan, Brian, Yang, Bin, Ottaway, Nickki, Smiley, David L, Ma, Tao, Clemmensen, Christoffer, Chabenne, Joe, Zhang, Lianshan, Habegger, Kirk M, Fischer, Katrin, Campbell, Jonathan E, Sandoval, Darleen, Seeley, Randy J, Bleicher, Konrad, Uhles, Sabine, Riboulet, William, Funk, Jürgen, Hertel, Cornelia, Belli, Sara, Sebokova, Elena, Conde-Knape, Karin, Konkar, Anish, Drucker, Daniel J, Gelfanov, Vasily, Pfluger, Paul T, Müller, Timo D, Perez-Tilve, Diego, DiMarchi, Richard D, Tschöp, Matthias H
Published in Nature medicine (01.01.2015)
Published in Nature medicine (01.01.2015)
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Journal Article
Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes
Capozzi, Megan E, DiMarchi, Richard D, Tschöp, Matthias H, Finan, Brian, Campbell, Jonathan E
Published in Endocrine reviews (01.10.2018)
Published in Endocrine reviews (01.10.2018)
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Journal Article
Reappraisal of GIP Pharmacology for Metabolic Diseases
Finan, Brian, Müller, Timo D, Clemmensen, Christoffer, Perez-Tilve, Diego, DiMarchi, Richard D, Tschöp, Matthias H
Published in Trends in molecular medicine (01.05.2016)
Published in Trends in molecular medicine (01.05.2016)
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Journal Article
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling
Zhang, Qian, Delessa, Challa Tenagne, Augustin, Robert, Bakhti, Mostafa, Colldén, Gustav, Drucker, Daniel J., Feuchtinger, Annette, Caceres, Cristina Garcia, Grandl, Gerald, Harger, Alexandra, Herzig, Stephan, Hofmann, Susanna, Holleman, Cassie Lynn, Jastroch, Martin, Keipert, Susanne, Kleinert, Maximilian, Knerr, Patrick J., Kulaj, Konxhe, Legutko, Beata, Lickert, Heiko, Liu, Xue, Luippold, Gerd, Lutter, Dominik, Malogajski, Emilija, Medina, Marta Tarquis, Mowery, Stephanie A., Blutke, Andreas, Perez-Tilve, Diego, Salinno, Ciro, Sehrer, Laura, DiMarchi, Richard D., Tschöp, Matthias H., Stemmer, Kerstin, Finan, Brian, Wolfrum, Christian, Müller, Timo D.
Published in Cell metabolism (06.04.2021)
Published in Cell metabolism (06.04.2021)
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Journal Article
Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
Mroz, Piotr A., Finan, Brian, Gelfanov, Vasily, Yang, Bin, Tschöp, Matthias H., DiMarchi, Richard D., Perez-Tilve, Diego
Published in Molecular metabolism (Germany) (01.02.2019)
Published in Molecular metabolism (Germany) (01.02.2019)
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Journal Article
Recent Advances in Incretin-Based Pharmacotherapies for the Treatment of Obesity and Diabetes
Tan, Qiming, Akindehin, Seun E, Orsso, Camila E, Waldner, Richelle C, DiMarchi, Richard D, Müller, Timo D, Haqq, Andrea M
Published in Frontiers in endocrinology (Lausanne) (01.03.2022)
Published in Frontiers in endocrinology (Lausanne) (01.03.2022)
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Journal Article
GLP-1/glucagon receptor co-agonism for treatment of obesity
Sánchez-Garrido, Miguel A., Brandt, Sara J., Clemmensen, Christoffer, Müller, Timo D., DiMarchi, Richard D., Tschöp, Matthias H.
Published in Diabetologia (01.10.2017)
Published in Diabetologia (01.10.2017)
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Journal Article
Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis
Weiss, Andy, Murdoch, Caitlin C., Edmonds, Katherine A., Jordan, Matthew R., Monteith, Andrew J., Perera, Yasiru R., Rodríguez Nassif, Aslin M., Petoletti, Amber M., Beavers, William N., Munneke, Matthew J., Drury, Sydney L., Krystofiak, Evan S., Thalluri, Kishore, Wu, Hongwei, Kruse, Angela R.S., DiMarchi, Richard D., Caprioli, Richard M., Spraggins, Jeffrey M., Chazin, Walter J., Giedroc, David P., Skaar, Eric P.
Published in Cell (09.06.2022)
Published in Cell (09.06.2022)
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Journal Article
Transforming obesity: The advancement of multi-receptor drugs
Kusminski, Christine M., Perez-Tilve, Diego, Müller, Timo D., DiMarchi, Richard D., Tschöp, Matthias H., Scherer, Philipp E.
Published in Cell (25.07.2024)
Published in Cell (25.07.2024)
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Journal Article
Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice
Knerr, Patrick J., Mowery, Stephanie A., Douros, Jonathan D., Premdjee, Bhavesh, Hjøllund, Karina Rahr, He, Yantao, Kruse Hansen, Ann Maria, Olsen, Anette K., Perez-Tilve, Diego, DiMarchi, Richard D., Finan, Brian
Published in Molecular metabolism (Germany) (01.09.2022)
Published in Molecular metabolism (Germany) (01.09.2022)
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