Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity
Dietsch, Gregory N, Lu, Hailing, Yang, Yi, Morishima, Chihiro, Chow, Laura Q, Disis, Mary L, Hershberg, Robert M
Published in PloS one (29.02.2016)
Published in PloS one (29.02.2016)
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The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes
Dowling, David J, Tan, Zhen, Prokopowicz, Zofia M, Palmer, Christine D, Matthews, Maura-Ann H, Dietsch, Gregory N, Hershberg, Robert M, Levy, Ofer
Published in PloS one (04.03.2013)
Published in PloS one (04.03.2013)
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Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN
Chow, Laura Q M, Morishima, Chihiro, Eaton, Keith D, Baik, Christina S, Goulart, Bernardo H, Anderson, Leslie N, Manjarrez, Kristi L, Dietsch, Gregory N, Bryan, James Kyle, Hershberg, Robert M, Disis, Mary L, Martins, Renato G
Published in Clinical cancer research (15.05.2017)
Published in Clinical cancer research (15.05.2017)
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Prevention of cerebral vasospasm by a humanized anti-CD11/CD18 monoclonal antibody administered after experimental subarachnoid hemorrhage in nonhuman primates
Clatterbuck, Richard E, Gailloud, Philippe, Ogata, Lynn, Gebremariam, Abeyu, Dietsch, Gregory N, Murphy, Kieran J, Tamargo, Rafael J
Published in Journal of neurosurgery (01.08.2003)
Published in Journal of neurosurgery (01.08.2003)
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Prevention of vasospasm by anti-CD11/CD18 monoclonal antibody therapy following subarachnoid hemorrhage in rabbits
Pradilla, Gustavo, Wang, Paul P, Legnani, Federico G, Ogata, Lynn, Dietsch, Gregory N, Tamargo, Rafael J
Published in Journal of neurosurgery (01.07.2004)
Published in Journal of neurosurgery (01.07.2004)
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VTX-2337 Is a Novel TLR8 Agonist That Activates NK Cells and Augments ADCC
HAILING LU, DIETSCH, Gregory N, DISIS, Mary L, HERSHBERG, Robert M, MATTHEWS, Maura-Ann H, YI YANG, GHANEKAR, Smita, INOKUMA, Margaret, SUNI, Maria, MAINO, Vernon C, HENDERSON, Katherine E, HOWBERT, James Jeffry
Published in Clinical cancer research (15.01.2012)
Published in Clinical cancer research (15.01.2012)
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Effect of Adding Motolimod to Standard Combination Chemotherapy and Cetuximab Treatment of Patients With Squamous Cell Carcinoma of the Head and Neck: The Active8 Randomized Clinical Trial
Ferris, Robert L, Saba, Nabil F, Gitlitz, Barbara J, Haddad, Robert, Sukari, Ammar, Neupane, Prakash, Morris, John C, Misiukiewicz, Krzysztof, Bauman, Julie E, Fenton, Moon, Jimeno, Antonio, Adkins, Douglas R, Schneider, Charles J, Sacco, Assuntina G, Shirai, Keisuke, Bowles, Daniel W, Gibson, Michael, Nwizu, Tobenna, Gottardo, Raphael, Manjarrez, Kristi L, Dietsch, Gregory N, Bryan, James Kyle, Hershberg, Robert M, Cohen, Ezra E W
Published in JAMA oncology (01.11.2018)
Published in JAMA oncology (01.11.2018)
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Late-Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337)
Dietsch, Gregory N, Randall, Tressa D, Gottardo, Raphael, Northfelt, Donald W, Ramanathan, Ramesh K, Cohen, Peter A, Manjarrez, Kristi L, Newkirk, Mona, Bryan, James Kyle, Hershberg, Robert M
Published in Clinical cancer research (15.12.2015)
Published in Clinical cancer research (15.12.2015)
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A phase I dose-finding study of the novel Toll-like receptor 8 agonist VTX-2337 in adult subjects with advanced solid tumors or lymphoma
Northfelt, Donald W, Ramanathan, Ramesh K, Cohen, Peter A, Von Hoff, Daniel D, Weiss, Glen J, Dietsch, Gregory N, Manjarrez, Kristi L, Randall, Tressa D, Hershberg, Robert M
Published in Clinical cancer research (15.07.2014)
Published in Clinical cancer research (15.07.2014)
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The role of recombinant platelet-activating factor acetylhydrolase in a neonatal rat model of necrotizing enterocolitis
CAPLAN, M. S, LICKERMAN, M, ADLER, L, DIETSCH, G. N, YU, A
Published in Pediatric research (01.12.1997)
Published in Pediatric research (01.12.1997)
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Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity
Elavazhagan, Saranya, Fatehchand, Kavin, Santhanam, Vikram, Fang, Huiqing, Ren, Li, Gautam, Shalini, Reader, Brenda, Mo, Xiaokui, Cheney, Carolyn, Briercheck, Edward, Vasilakos, John P, Dietsch, Gregory N, Hershberg, Robert M, Caligiuri, Michael, Byrd, John C, Butchar, Jonathan P, Tridandapani, Susheela
Published in The Journal of immunology (1950) (15.03.2015)
Published in The Journal of immunology (1950) (15.03.2015)
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Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination
Fatehchand, Kavin, Ren, Li, Elavazhagan, Saranya, Fang, Huiqing, Mo, Xiaokui, Vasilakos, John P., Dietsch, Gregory N., Hershberg, Robert M., Tridandapani, Susheela, Butchar, Jonathan P.
Published in The Journal of biological chemistry (19.02.2016)
Published in The Journal of biological chemistry (19.02.2016)
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Recombinant Human Platelet-Activating Factor- Acetylhydrolase Inhibits Airway Inflammation and Hyperreactivity in Mouse Asthma Model
Henderson, William R., Jr, Lu, Jiangyang, Poole, Karen M, Dietsch, Gregory N, Chi, Emil Y
Published in The Journal of immunology (1950) (15.03.2000)
Published in The Journal of immunology (1950) (15.03.2000)
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VTX‐1463, a novel TLR‐8 agonist, attenuates nasal congestion after ragweed challenge in sensitized beagle dogs
Royer, Christopher M., Rudolph, Karin, Dietsch, Gregory N., Hershberg, Robert M., Barrett, Edward G.
Published in Immunity, Inflammation and Disease (01.03.2016)
Published in Immunity, Inflammation and Disease (01.03.2016)
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Characterization of the inflammatory response to a highly selective PDE4 inhibitor in the rat and the identification of biomarkers that correlate with toxicity
Dietsch, Gregory N, Dipalma, Chris R, Eyre, Russell J, Pham, Tuan Q, Poole, Karen M, Pefaur, Noah B, Welch, William D, Trueblood, Esther, Kerns, William D, Kanaly, Suzanne T
Published in Toxicologic pathology (2006)
Published in Toxicologic pathology (2006)
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엑토뉴클레오티드 피로포스파타아제-포스포디에스테라아제 1(ENPP-1) 저해제 및 그의 용도
GALLATIN WILLIAM MICHAEL, DIETSCH GREGORY N, DURAISWAMY ATHISAYAMANI JEYARAJ, ODINGO JOSHUA, FLORIO VINCENT, VENKATESHAPPA CHANDREGOWDA
Year of Publication 07.05.2020
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Year of Publication 07.05.2020
Patent
Inhibition of vasospasm with lymphocyte function-associated antigen-1 monoclonal antibody in a femoral artery model in rats
Clatterbuck, Richard E, Oshiro, Eric M, Hoffman, Patricia A, Dietsch, Gregory N, Pardoll, Drew M, Tamargo, Rafael J
Published in Journal of neurosurgery (01.09.2002)
Published in Journal of neurosurgery (01.09.2002)
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