Active γ-Secretase Complexes Contain Only One of Each Component
Sato, Toru, Diehl, Thekla S., Narayanan, Saravanakumar, Funamoto, Satoru, Ihara, Yasuo, De Strooper, Bart, Steiner, Harald, Haass, Christian, Wolfe, Michael S.
Published in The Journal of biological chemistry (23.11.2007)
Published in The Journal of biological chemistry (23.11.2007)
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Activity-Dependent Isolation of the Presenilin- γ-Secretase Complex Reveals Nicastrin and a γ Substrate
Esler, William P., Kimberly, W. Taylor, Ostaszewski, Beth L., Ye, Wenjuan, Diehl, Thekla S., Selkoe, Dennis J., Wolfe, Michael S.
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2002)
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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1
Esler, W P, Kimberly, W T, Ostaszewski, B L, Diehl, T S, Moore, C L, Tsai, J Y, Rahmati, T, Xia, W, Selkoe, D J, Wolfe, M S
Published in Nature cell biology (01.07.2000)
Published in Nature cell biology (01.07.2000)
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Evidence that the 42- and 40-Amino Acid Forms of Amyloid β Protein are Generated from the β -amyloid Precursor Protein by Different Protease Activities
Citron, Martin, Diehl, Thekla S., Gordon, Grace, Biere, Anja Leona, Seubert, Peter, Selkoe, Dennis J.
Published in Proceedings of the National Academy of Sciences - PNAS (12.11.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (12.11.1996)
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Journal Article
Designed Helical Peptides Inhibit an Intramembrane Protease
Das, Chittaranjan, Berezovska, Oksana, Diehl, Thekla S, Genet, Cedric, Buldyrev, Ilya, Tsai, Jui-Yi, Hyman, Bradley T, Wolfe, Michael S
Published in Journal of the American Chemical Society (01.10.2003)
Published in Journal of the American Chemical Society (01.10.2003)
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Amyloid-lowering isocoumarins are not direct inhibitors of γ-secretase
Esler, William P, Das, Chittaranjan, Campbell, William A, Kimberly, W. Taylor, Kornilova, Anna Y, Diehl, Thekla S, Ye, Wenjuan, Ostaszewski, Beth L, Xia, Weiming, Selkoe, Dennis J, Wolfe, Michael S
Published in Nature cell biology (01.05.2002)
Published in Nature cell biology (01.05.2002)
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Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein
Citron, Martin, Eckman, Christopher B., Diehl, Thekla S., Corcoran, Chris, Ostaszewski, Beth L., Xia, Weiming, Levesque, Georges, St. George Hyslop, Peter, Younkin, Steven G., Selkoe, Dennis J.
Published in Neurobiology of disease (01.08.1998)
Published in Neurobiology of disease (01.08.1998)
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Protofibrillar Intermediates of Amyloid beta -Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons
Hartley, Dean M, Walsh, Dominic M, Ye, Chianping P, Diehl, Thekla, Vasquez, Sara, Vassilev, Peter M, Teplow, David B, Selkoe, Dennis. J
Published in The Journal of neuroscience (15.10.1999)
Published in The Journal of neuroscience (15.10.1999)
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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
Citron, M, Westaway, D, Xia, W, Carlson, G, Diehl, T, Levesque, G, Johnson-Wood, K, Lee, M, Seubert, P, Davis, A, Kholodenko, D, Motter, R, Sherrington, R, Perry, B, Yao, H, Strome, R, Lieberburg, I, Rommens, J, Kim, S, Schenk, D, Fraser, P, St George Hyslop, P, Selkoe, D J
Published in Nature medicine (01.01.1997)
Published in Nature medicine (01.01.1997)
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Notch and the Amyloid Precursor Protein Are Cleaved by Similar γ-Secretase(s)
Kimberly, W. Taylor, Esler, William P, Ye, Wenjuan, Ostaszewski, Beth L, Gao, Jun, Diehl, Thekla, Selkoe, Dennis J, Wolfe, Michael S
Published in Biochemistry (Easton) (14.01.2003)
Published in Biochemistry (Easton) (14.01.2003)
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Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue
Podlisny, M B, Citron, M, Amarante, P, Sherrington, R, Xia, W, Zhang, J, Diehl, T, Levesque, G, Fraser, P, Haass, C, Koo, E H, Seubert, P, St George-Hyslop, P, Teplow, D B, Selkoe, D J
Published in Neurobiology of disease (1997)
Published in Neurobiology of disease (1997)
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Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue
Podlisny, Marcia B., Citron, Martin, Amarante, Patricia, Sherrington, Robin, Xia, Weiming, Zhang, Jimin, Diehl, Thekla, Levesque, George, Fraser, Paul, Haass, Christian, Koo, Edward H.M., Seubert, Peter, St. George-Hyslop, Peter, Teplow, David B., Selkoe, Dennis J.
Published in Neurobiology of disease (01.01.1997)
Published in Neurobiology of disease (01.01.1997)
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Journal Article
Amyloid-lowering isocoumarins are not direct inhibitors of [gamma]-secretase
Esler, William P, Das, Chittaranjan, Campbell, William A, W. Taylor Kimberly, Kornilova, Anna Y, Diehl, Thekla S, Ye, Wenjuan, Ostaszewski, Beth L, Xia, Weiming, Selkoe, Dennis J, Wolfe, Michael S
Published in Nature cell biology (01.05.2002)
Published in Nature cell biology (01.05.2002)
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Journal Article
Toward identification of gamma-secretase using transition-state analogue inhibitors
Esler, William P., Diehl, Thekla S., Ostaszewski, Beth L., Moore, Chad L., Xia, Weiming, Kimberly, William T., Selkoe, Dennis J., Wolfe, Michael S.
Published in Neurobiology of aging (01.05.2000)
Published in Neurobiology of aging (01.05.2000)
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Journal Article
Transition-state analogue inhibitors of -secretase bind directly to presenilin-1
Wolfe, Michael S, Esler, William P, Kimberly, W. Taylor, Ostaszewski, Beth L, Diehl, Thekla S, Moore, Chad L, Tsai, Jui-Yi, Rahmati, Talat, Xia, Weiming, Selkoe, Dennis J
Published in Nature cell biology (01.07.2000)
Published in Nature cell biology (01.07.2000)
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