Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer
Cox, Christopher D, Coleman, Paul J, Breslin, Michael J, Whitman, David B, Garbaccio, Robert M, Fraley, Mark E, Buser, Carolyn A, Walsh, Eileen S, Hamilton, Kelly, Schaber, Michael D, Lobell, Robert B, Tao, Weikang, Davide, Joseph P, Diehl, Ronald E, Abrams, Marc T, South, Vicki J, Huber, Hans E, Torrent, Maricel, Prueksaritanont, Thomayant, Li, Chunze, Slaughter, Donald E, Mahan, Elizabeth, Fernandez-Metzler, Carmen, Yan, Youwei, Kuo, Lawrence C, Kohl, Nancy E, Hartman, George D
Published in Journal of medicinal chemistry (24.07.2008)
Published in Journal of medicinal chemistry (24.07.2008)
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Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop Phosphorylation
Sunami, Tomoko, Byrne, Noel, Diehl, Ronald E., Funabashi, Kaoru, Hall, Dawn L., Ikuta, Mari, Patel, Sangita B., Shipman, Jennifer M., Smith, Robert F., Takahashi, Ikuko, Zugay-Murphy, Joan, Iwasawa, Yoshikazu, Lumb, Kevin J., Munshi, Sanjeev K., Sharma, Sujata
Published in The Journal of biological chemistry (12.02.2010)
Published in The Journal of biological chemistry (12.02.2010)
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An Inhibitor of the Kinesin Spindle Protein Activates the Intrinsic Apoptotic Pathway Independently of p53 and De Novo Protein Synthesis
Tao, Weikang, South, Victoria J., Diehl, Ronald E., Davide, Joseph P., Sepp-Lorenzino, Laura, Fraley, Mark E., Arrington, Kenneth L., Lobell, Robert B.
Published in Molecular and Cellular Biology (01.01.2007)
Published in Molecular and Cellular Biology (01.01.2007)
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Structure of Human Prostasin, a Target for the Regulation of Hypertension
Rickert, Keith W., Kelley, Paul, Byrne, Noel J., Diehl, Ronald E., Hall, Dawn L., Montalvo, Allison M., Reid, John C., Shipman, Jennifer M., Thomas, Bradley W., Munshi, Sanjeev K., Darke, Paul L., Su, Hua-Poo
Published in The Journal of biological chemistry (12.12.2008)
Published in The Journal of biological chemistry (12.12.2008)
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Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase
Soisson, Stephen M, Patel, Sangita B, Abeywickrema, Pravien D, Byrne, Noel J, Diehl, Ronald E, Hall, Dawn L, Ford, Rachael E, Reid, John C, Rickert, Keith W, Shipman, Jennifer M, Sharma, Sujata, Lumb, Kevin J
Published in BMC structural biology (11.06.2010)
Published in BMC structural biology (11.06.2010)
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Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP
Roecker, Anthony J., Coleman, Paul J., Mercer, Swati P., Schreier, John D., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Lobell, Robert B., Tao, Weikang, Diehl, Ronald E., South, Vicki J., Davide, Joseph P., Kohl, Nancy E., Yan, Youwei, Kuo, Lawrence C., Li, Chunze, Fernandez-Metzler, Carmen, Mahan, Elizabeth A., Prueksaritanont, Thomayant, Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP
Garbaccio, Robert M., Tasber, Edward S., Neilson, Lou Anne, Coleman, Paul J., Fraley, Mark E., Olson, Christy, Bergman, Jeff, Torrent, Maricel, Buser, Carolyn A., Rickert, Keith, Walsh, Eileen S., Hamilton, Kelly, Lobell, Robert B., Tao, Weikang, South, Vicki J., Diehl, Ronald E., Davide, Joseph P., Yan, Youwei, Kuo, Lawrence C., Li, Chunze, Prueksaritanont, Thomayant, Fernandez-Metzler, Carmen, Mahan, Elizabeth A., Slaughter, Donald E., Salata, Joseph J., Kohl, Nancy E., Huber, Hans E., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
Published in Bioorganic & medicinal chemistry letters (15.10.2007)
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Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4
Allen, Samantha J., Parthasarathy, Gopal, Darke, Paul L., Diehl, Ronald E., Ford, Rachael E., Hall, Dawn L., Johnson, Scott A., Reid, John C., Rickert, Keith W., Shipman, Jennifer M., Soisson, Stephen M., Zuck, Paul, Munshi, Sanjeev K., Lumb, Kevin J.
Published in The Journal of biological chemistry (14.08.2015)
Published in The Journal of biological chemistry (14.08.2015)
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Expression, purification and crystallization of human prolylcarboxypeptidase
Abeywickrema, Pravien D., Patel, Sangita B., Byrne, Noel J., Diehl, Ronald E., Hall, Dawn L., Ford, Rachael E., Rickert, Keith W., Reid, John C., Shipman, Jennifer M., Geissler, Wayne M., Pryor, Kelly D., SinhaRoy, Ranabir, Soisson, Stephen M., Lumb, Kevin J., Sharma, Sujata
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.06.2010)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.06.2010)
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Cloning of bovine GAP and its interaction with oncogenic ras p21
Vogel, U S, Dixon, R A, Schaber, M D, Diehl, R E, Marshall, M S, Scolnick, E M, Sigal, I S, Gibbs, J B
Published in Nature (London) (01.09.1988)
Published in Nature (London) (01.09.1988)
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Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP
Coleman, Paul J., Schreier, John D., Cox, Christopher D., Fraley, Mark E., Garbaccio, Robert M., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Lobell, Robert B., Rickert, Keith, Tao, Weikang, Diehl, Ronald E., South, Vicki J., Davide, Joseph P., Kohl, Nancy E., Yan, Youwei, Kuo, Lawrence, Prueksaritanont, Thomayant, Li, Chunze, Mahan, Elizabeth A., Fernandez-Metzler, Carmen, Salata, Joseph J., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases
Omer, Charles A, Kral, Astrid M, Diehl, Ronald E, Prendergast, George C, Powers, Scott, Allen, Charles M, Gibbs, Jackson B, Kohl, Nancy E
Published in Biochemistry (Easton) (18.05.1993)
Published in Biochemistry (Easton) (18.05.1993)
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Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin
Dixon, R A, Kobilka, B K, Strader, D J, Benovic, J L, Dohlman, H G, Frielle, T, Bolanowski, M A, Bennett, C D, Rands, E, Diehl, R E, Mumford, R A, Slater, E E, Sigal, I S, Caron, M G, Lefkowitz, R J, Strader, C D
Published in Nature (London) (01.05.1986)
Published in Nature (London) (01.05.1986)
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Journal Article
Structure of Human Prostasin, a Target for the Regulation of HypertensionS
Rickert, Keith W., Kelley, Paul, Byrne, Noel J., Diehl, Ronald E., Hall, Dawn L., Montalvo, Allison M., Reid, John C., Shipman, Jennifer M., Thomas, Bradley W., Munshi, Sanjeev K., Darke, Paul L., Su, Hua-Poo
Published in The Journal of biological chemistry (12.12.2008)
Published in The Journal of biological chemistry (12.12.2008)
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Journal Article
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl :protein transferase inhibitor
OMER, C. A, ZUNXUAN CHEN, DAVIDE, J. P, ELLIS, M. S, GIBBS, J. B, GREENBERG, I, HAMILTON, K, KOBLAN, K. S, KRAL, A. M, DONGMING LIU, LOBELL, R. B, MILLER, P. J, DIEHL, R. E, MOSSER, S. D, O'NEILL, T. J, RANDS, E, SCHABER, M. D, SENDERAK, E. T, OLIFF, A, KOHL, N. E, CONNER, M. W, CHEN, H. Y, TRUMBAUER, M. E, GOPAL-TRUTER, S, SEEBURGER, G, BHIMNATHWALA, H, ABRAMS, M. T
Published in Cancer research (Chicago, Ill.) (15.05.2000)
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Published in Cancer research (Chicago, Ill.) (15.05.2000)
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Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2 S )-4-(2,5-Difluorophenyl)- N -[(3 R ,4 S )-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)- N -methyl-2-phenyl-2,5-dihydro-1 H -pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer
Cox, Christopher D., Coleman, Paul J., Breslin, Michael J., Whitman, David B., Garbaccio, Robert M., Fraley, Mark E., Buser, Carolyn A., Walsh, Eileen S., Hamilton, Kelly, Schaber, Michael D., Lobell, Robert B., Tao, Weikang, Davide, Joseph P., Diehl, Ronald E., Abrams, Marc T., South, Vicki J., Huber, Hans E., Torrent, Maricel, Prueksaritanont, Thomayant, Li, Chunze, Slaughter, Donald E., Mahan, Elizabeth, Fernandez-Metzler, Carmen, Yan, Youwei, Kuo, Lawrence C., Kohl, Nancy E., Hartman, George D.
Published in Journal of medicinal chemistry (01.07.2008)
Published in Journal of medicinal chemistry (01.07.2008)
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Journal Article
Kinesin spindle protein KSP inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP
ROECKER, Anthony J, COLEMAN, Paul J, SOUTH, Vicki J, DAVIDE, Joseph P, KOHL, Nancy E, YOUWEI YAN, KUO, Lawrence C, CHUNZE LI, FERNANDEZ-METZLER, Carmen, MAHAN, Elizabeth A, PRUEKSARITANONT, Thomayant, HARTMAN, George D, MERCER, Swati P, SCHREIER, John D, BUSER, Carolyn A, WALSH, Eileen S, HAMILTON, Kelly, LOBELL, Robert B, WEIKANG TAO, DIEHL, Ronald E
Published in Bioorganic & medicinal chemistry letters (2007)
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Published in Bioorganic & medicinal chemistry letters (2007)
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Mutational analysis of conserved residues of the beta-subunit of human farnesyl:protein transferase
Kral, A M, Diehl, R E, deSolms, S J, Williams, T M, Kohl, N E, Omer, C A
Published in The Journal of biological chemistry (24.10.1997)
Published in The Journal of biological chemistry (24.10.1997)
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cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I
ZHANG, F. L, DIEHL, R. E, KOHL, N. E, GIBBS, J. B, GIROS, B, CASEY, P. J, OMER, C. A
Published in The Journal of biological chemistry (04.02.1994)
Published in The Journal of biological chemistry (04.02.1994)
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