A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer
Schmidt, Stefanie, Gay, David, Uthe, Friedrich Wilhelm, Denk, Sarah, Paauwe, Madelon, Matthes, Niels, Diefenbacher, Markus Elmar, Bryson, Sheila, Warrander, Fiona Clare, Erhard, Florian, Ade, Carsten Patrick, Baluapuri, Apoorva, Walz, Susanne, Jackstadt, Rene, Ford, Catriona, Vlachogiannis, Georgios, Valeri, Nicola, Otto, Christoph, Schülein-Völk, Christina, Maurus, Katja, Schmitz, Werner, Knight, John Raymond Philip, Wolf, Elmar, Strathdee, Douglas, Schulze, Almut, Germer, Christoph-Thomas, Rosenwald, Andreas, Sansom, Owen James, Eilers, Martin, Wiegering, Armin
Published in Nature cell biology (01.11.2019)
Published in Nature cell biology (01.11.2019)
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RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival
Novak, Rostislav, Ahmad, Yamen Abu, Timaner, Michael, Bitman-Lotan, Eliya, Oknin-Vaisman, Avital, Horwitz, Roi, Hartmann, Oliver, Reissland, Michaela, Buck, Viktoria, Rosenfeldt, Mathias, Nikomarov, David, Diefenbacher, Markus Elmar, Shaked, Yuval, Orian, Amir
Published in Cell death & disease (24.09.2022)
Published in Cell death & disease (24.09.2022)
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JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer
Ruiz, E Josue, Lan, Linxiang, Diefenbacher, Markus Elmar, Riising, Eva Madi, Da Costa, Clive, Chakraborty, Atanu, Hoeck, Joerg D, Spencer-Dene, Bradley, Kelly, Gavin, David, Jean-Pierre, Nye, Emma, Downward, Julian, Behrens, Axel
Published in JCI insight (08.07.2021)
Published in JCI insight (08.07.2021)
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A MYC-GCN2-eIF2[alpha] negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer
Schmidt, Stefanie, Gay, David, Uthe, Friedrich Wilhelm, Denk, Sarah, Paauwe, Madelon, Matthes, Niels, Diefenbacher, Markus Elmar
Published in Nature cell biology (01.11.2019)
Published in Nature cell biology (01.11.2019)
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c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK
Schreck, Ilona, Al-Rawi, Marco, Mingot, José-Manuel, Scholl, Christine, Diefenbacher, Markus Elmar, O’Donnell, Paul, Bohmann, Dirk, Weiss, Carsten
Published in Biochemical and biophysical research communications (22.04.2011)
Published in Biochemical and biophysical research communications (22.04.2011)
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PTEN mutant NSCLC require ATM to suppress pro-apoptotic signalling and evade radiotherapy
Fischer, Thomas, Hartmann, Oliver, Reissland, Michaela, Prieto-Garcia, Cristian, Klann, Kevin, Schuelein-Voelk, Christina, Polat, Buelent, Gebhard-Hartmann, Elena, Rosenfeldt, Mathias, Muench, Christian, Flentje, Michael, Markus Elmar Diefenbacher
Published in bioRxiv (25.07.2021)
Published in bioRxiv (25.07.2021)
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USP28 enables oncogenic transformation of respiratory cells and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K
Prieto-Garcia, Cristian, Hartmann, Oliver, Reissland, Michaela, Braun, Fabian, Bozkurt, Sueleyman, Fuss, Carmina Teresa, Schuelein-Voelk, Christina, Buchberger, Alexander, Calzado, Marco A, Rosenfeldt, Mathias T, Dikic, Ivan, Muench, Christian, Markus Elmar Diefenbacher
Published in bioRxiv (06.09.2021)
Published in bioRxiv (06.09.2021)
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