Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis
Wang, Zeneng, Roberts, Adam B., Buffa, Jennifer A., Levison, Bruce S., Zhu, Weifei, Org, Elin, Gu, Xiaodong, Huang, Ying, Zamanian-Daryoush, Maryam, Culley, Miranda K., DiDonato, Anthony J., Fu, Xiaoming, Hazen, Jennie E., Krajcik, Daniel, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
Published in Cell (17.12.2015)
Published in Cell (17.12.2015)
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A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors
Nemet, Ina, Saha, Prasenjit Prasad, Gupta, Nilaksh, Zhu, Weifei, Romano, Kymberleigh A., Skye, Sarah M., Cajka, Tomas, Mohan, Maradumane L., Li, Lin, Wu, Yuping, Funabashi, Masanori, Ramer-Tait, Amanda E., Naga Prasad, Sathyamangla Venkata, Fiehn, Oliver, Rey, Federico E., Tang, W.H. Wilson, Fischbach, Michael A., DiDonato, Joseph A., Hazen, Stanley L.
Published in Cell (05.03.2020)
Published in Cell (05.03.2020)
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Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Zhu, Weifei, Gregory, Jill C., Org, Elin, Buffa, Jennifer A., Gupta, Nilaksh, Wang, Zeneng, Li, Lin, Fu, Xiaoming, Wu, Yuping, Mehrabian, Margarete, Sartor, R. Balfour, McIntyre, Thomas M., Silverstein, Roy L., Tang, W.H. Wilson, DiDonato, Joseph A., Brown, J. Mark, Lusis, Aldons J., Hazen, Stanley L.
Published in Cell (24.03.2016)
Published in Cell (24.03.2016)
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Journal Article
Long-Term Changes in Gut Microbial Metabolite Trimethylamine N-Oxide and Coronary Heart Disease Risk
Heianza, Yoriko, Ma, Wenjie, DiDonato, Joseph A., Sun, Qi, Rimm, Eric B., Hu, Frank B., Rexrode, Kathryn M., Manson, JoAnn E., Qi, Lu
Published in Journal of the American College of Cardiology (25.02.2020)
Published in Journal of the American College of Cardiology (25.02.2020)
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Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential
Roberts, Adam B., Gu, Xiaodong, Buffa, Jennifer A., Hurd, Alex G., Wang, Zeneng, Zhu, Weifei, Gupta, Nilaksh, Skye, Sarah M., Cody, David B., Levison, Bruce S., Barrington, William T., Russell, Matthew W., Reed, Jodie M., Duzan, Ashraf, Lang, Jennifer M., Fu, Xiaoming, Li, Lin, Myers, Alex J., Rachakonda, Suguna, DiDonato, Joseph A., Brown, J. Mark, Gogonea, Valentin, Lusis, Aldons J., Garcia-Garcia, Jose Carlos, Hazen, Stanley L.
Published in Nature medicine (01.09.2018)
Published in Nature medicine (01.09.2018)
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l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans
Koeth, Robert A, Lam-Galvez, Betzabe Rachel, Kirsop, Jennifer, Wang, Zeneng, Levison, Bruce S, Gu, Xiaodong, Copeland, Matthew F, Bartlett, David, Cody, David B, Dai, Hong J, Culley, Miranda K, Li, Xinmin S, Fu, Xiaoming, Wu, Yuping, Li, Lin, DiDonato, Joseph A, Tang, W H Wilson, Garcia-Garcia, Jose Carlos, Hazen, Stanley L
Published in The Journal of clinical investigation (01.01.2019)
Published in The Journal of clinical investigation (01.01.2019)
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Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease
Gupta, Nilaksh, Buffa, Jennifer A, Roberts, Adam B, Sangwan, Naseer, Skye, Sarah M, Li, Lin, Ho, Karen J, Varga, John, DiDonato, Joseph A, Tang, W.H Wilson, Hazen, Stanley L
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2020)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2020)
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Journal Article
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, Robert A, Wang, Zeneng, Levison, Bruce S, Buffa, Jennifer A, Org, Elin, Sheehy, Brendan T, Britt, Earl B, Fu, Xiaoming, Wu, Yuping, Li, Lin, Smith, Jonathan D, DiDonato, Joseph A, Chen, Jun, Li, Hongzhe, Wu, Gary D, Lewis, James D, Warrier, Manya, Brown, J Mark, Krauss, Ronald M, Tang, W H Wilson, Bushman, Frederic D, Lusis, Aldons J, Hazen, Stanley L
Published in Nature medicine (01.05.2013)
Published in Nature medicine (01.05.2013)
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Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Zeneng, Klipfell, Elizabeth, Bennett, Brian J., Koeth, Robert, Levison, Bruce S., DuGar, Brandon, Feldstein, Ariel E., Britt, Earl B., Fu, Xiaoming, Chung, Yoon-Mi, Wu, Yuping, Schauer, Phil, Smith, Jonathan D., Allayee, Hooman, Tang, W. H. Wilson, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
Published in Nature (London) (07.04.2011)
Published in Nature (London) (07.04.2011)
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γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L-Carnitine to TMAO
Koeth, Robert A., Levison, Bruce S., Culley, Miranda K., Buffa, Jennifer A., Wang, Zeneng, Gregory, Jill C., Org, Elin, Wu, Yuping, Li, Lin, Smith, Jonathan D., Tang, W.H. Wilson, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.
Published in Cell metabolism (04.11.2014)
Published in Cell metabolism (04.11.2014)
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Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis
Witkowski, Marco, Witkowski, Mario, Friebel, Julian, Buffa, Jennifer A, Li, Xinmin S, Wang, Zeneng, Sangwan, Naseer, Li, Lin, DiDonato, Joseph A, Tizian, Caroline, Haghikia, Arash, Kirchhofer, Daniel, Mach, François, Räber, Lorenz, Matter, Christian M, Tang, W H Wilson, Landmesser, Ulf, Lüscher, Thomas F, Rauch, Ursula, Hazen, Stanley L
Published in Cardiovascular research (27.07.2022)
Published in Cardiovascular research (27.07.2022)
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The Cardioprotective Protein Apolipoprotein A1 Promotes Potent Anti-tumorigenic Effects
Zamanian-Daryoush, Maryam, Lindner, Daniel, Tallant, Thomas C., Wang, Zeneng, Buffa, Jennifer, Klipfell, Elizabeth, Parker, Yvonne, Hatala, Denise, Parsons-Wingerter, Patricia, Rayman, Pat, Yusufishaq, Mohamed Sharif S., Fisher, Edward A., Smith, Jonathan D., Finke, Jim, DiDonato, Joseph A., Hazen, Stanley L.
Published in The Journal of biological chemistry (19.07.2013)
Published in The Journal of biological chemistry (19.07.2013)
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Cancer Stem Cell‐Specific Scavenger Receptor CD36 Drives Glioblastoma Progression
Hale, James S., Otvos, Balint, Sinyuk, Maksim, Alvarado, Alvaro G., Hitomi, Masahiro, Stoltz, Kevin, Wu, Qiulian, Flavahan, William, Levison, Bruce, Johansen, Mette L., Schmitt, David, Neltner, Janna M., Huang, Ping, Ren, Bin, Sloan, Andrew E., Silverstein, Roy L., Gladson, Candece L., DiDonato, Joseph A., Brown, J. Mark, McIntyre, Thomas, Hazen, Stanley L., Horbinski, Craig, Rich, Jeremy N., Lathia, Justin D.
Published in Stem cells (Dayton, Ohio) (01.07.2014)
Published in Stem cells (Dayton, Ohio) (01.07.2014)
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Protein carbamylation links inflammation, smoking, uremia and atherogenesis
Wang, Zeneng, Barnard, John, DiDonato, Joseph A, Topol, Eric J, Nicholls, Stephen J, Rodriguez, E Rene, Hazen, Stanley L, Kummu, Outi, Reynolds, Wanda F, Hörkkö, Sohvi
Published in Nature medicine (01.10.2007)
Published in Nature medicine (01.10.2007)
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Modification of High Density Lipoprotein by Myeloperoxidase Generates a Pro-inflammatory Particle
Undurti, Arundhati, Huang, Ying, Lupica, Joseph A., Smith, Jonathan D., DiDonato, Joseph A., Hazen, Stanley L.
Published in The Journal of biological chemistry (06.11.2009)
Published in The Journal of biological chemistry (06.11.2009)
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Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models
Burdelya, Lyudmila G, Krivokrysenko, Vadim I, Tallant, Thomas C, Strom, Evguenia, Gleiberman, Anatoly S, Gupta, Damodar, Kurnasov, Oleg V, Fort, Farrel L, Osterman, Andrei L, DiDonato, Joseph A, Feinstein, Elena, Gudkov, Andrei V
Published in Science (American Association for the Advancement of Science) (11.04.2008)
Published in Science (American Association for the Advancement of Science) (11.04.2008)
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Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure
Romano, Kymberleigh A, Nemet, Ina, Prasad Saha, Prasenjit, Haghikia, Arash, Li, Xinmin S, Mohan, Maradumane L, Lovano, Beth, Castel, Laurie, Witkowski, Marco, Buffa, Jennifer A, Sun, Yu, Li, Lin, Menge, Christopher M, Demuth, Ilja, König, Maximilian, Steinhagen-Thiessen, Elisabeth, DiDonato, Joseph A, Deb, Arjun, Bäckhed, Fredrik, Tang, W H Wilson, Naga Prasad, Sathyamangla Venkata, Landmesser, Ulf, Van Wagoner, David R, Hazen, Stanley L
Published in Circulation. Heart failure (01.01.2023)
Published in Circulation. Heart failure (01.01.2023)
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Longitudinal Plasma Measures of Trimethylamine N-Oxide and Risk of Atherosclerotic Cardiovascular Disease Events in Community-Based Older Adults
Lee, Yujin, Nemet, Ina, Wang, Zeneng, Lai, Heidi T M, de Oliveira Otto, Marcia C, Lemaitre, Rozenn N, Fretts, Amanda M, Sotoodehnia, Nona, Budoff, Matthew, DiDonato, Joseph A, McKnight, Barbara, Tang, W H Wilson, Psaty, Bruce M, Siscovick, David S, Hazen, Stanley L, Mozaffarian, Dariush
Published in Journal of the American Heart Association (07.09.2021)
Published in Journal of the American Heart Association (07.09.2021)
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Pulsed-electromagnetic-field induced osteoblast differentiation requires activation of genes downstream of adenosine receptors A2A and A3
Kar, Niladri S, Ferguson, Daniel, Zhang, Nianli, Waldorff, Erik I, Ryaby, James T, DiDonato, Joseph A
Published in PloS one (25.02.2021)
Published in PloS one (25.02.2021)
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Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of β2-adrenergic receptors
Saha, Prasenjit Prasad, Gogonea, Valentin, Sweet, Wendy, Mohan, Maradumane L., Singh, Khuraijam Dhanachandra, Anderson, James T., Mallela, Deepthi, Witherow, Conner, Kar, Niladri, Stenson, Kate, Harford, Terri, Fischbach, Michael A., Brown, J. Mark, Karnik, Sadashiva S., Moravec, Christine S., DiDonato, Joseph A., Naga Prasad, Sathyamangla Venkata, Hazen, Stanley L.
Published in Nature communications (06.08.2024)
Published in Nature communications (06.08.2024)
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