Identification of a novel conformationally constrained glucagon receptor antagonist
Lee, Esther C.Y., Tu, Meihua, Stevens, Benjamin D., Bian, Jianwei, Aspnes, Gary, Perreault, Christian, Sammons, Matthew F., Wright, Stephen W., Litchfield, John, Kalgutkar, Amit S., Sharma, Raman, Didiuk, Mary T., Ebner, David C., Filipski, Kevin J., Brown, Janice, Atkinson, Karen, Pfefferkorn, Jeffrey A., Guzman-Perez, Angel
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
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The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus
Guzman-Perez, Angel, Pfefferkorn, Jeffrey A., Lee, Esther C.Y., Stevens, Benjamin D., Aspnes, Gary E., Bian, Jianwei, Didiuk, Mary T., Filipski, Kevin J., Moore, Dianna, Perreault, Christian, Sammons, Matthew F., Tu, Meihua, Brown, Janice, Atkinson, Karen, Litchfield, John, Tan, Beijing, Samas, Brian, Zavadoski, William J., Salatto, Christopher T., Treadway, Judith
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
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Pyrimidone-based series of glucokinase activators with alternative donor–acceptor motif
Filipski, Kevin J., Guzman-Perez, Angel, Bian, Jianwei, Perreault, Christian, Aspnes, Gary E., Didiuk, Mary T., Dow, Robert L., Hank, Richard F., Jones, Christopher S., Maguire, Robert J., Tu, Meihua, Zeng, Dongxiang, Liu, Shenping, Knafels, John D., Litchfield, John, Atkinson, Karen, Derksen, David R., Bourbonais, Francis, Gajiwala, Ketan S., Hickey, Michael, Johnson, Theodore O., Humphries, Paul S., Pfefferkorn, Jeffrey A.
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity
Filipski, Kevin J., Bian, Jianwei, Ebner, David C., Lee, Esther C.Y., Li, Jian-Cheng, Sammons, Matthew F., Wright, Stephen W., Stevens, Benjamin D., Didiuk, Mary T., Tu, Meihua, Perreault, Christian, Brown, Janice, Atkinson, Karen, Tan, Beijing, Salatto, Christopher T., Litchfield, John, Pfefferkorn, Jeffrey A., Guzman-Perez, Angel
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Discovery Tactics To Mitigate Toxicity Risks Due to Reactive Metabolite Formation with 2-(2-Hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives, Potent Calcium-Sensing Receptor Antagonists and Clinical Candidate(s) for the Treatment of Osteoporosis
Kalgutkar, Amit S, Griffith, David A, Ryder, Tim, Sun, Hao, Miao, Zhuang, Bauman, Jonathan N, Didiuk, Mary T, Frederick, Kosea S, Zhao, Sabrina X, Prakash, Chandra, Soglia, John R, Bagley, Scott W, Bechle, Bruce M, Kelley, Ryan M, Dirico, Kenneth, Zawistoski, Michael, Li, Jianke, Oliver, Robert, Guzman-Perez, Angel, Liu, Kevin K. C, Walker, Daniel P, Benbow, John W, Morris, Joel
Published in Chemical research in toxicology (21.06.2010)
Published in Chemical research in toxicology (21.06.2010)
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Toxicophores, reactive metabolites and drug safety: when is it a cause for concern?
Kalgutkar, Amit S, Fate, Gwendolyn, Didiuk, Mary T, Bauman, Jonathan
Published in Expert review of clinical pharmacology (01.07.2008)
Published in Expert review of clinical pharmacology (01.07.2008)
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Short-acting 5-(trifluoromethyl)pyrido[4,3- d]pyrimidin-4(3 H)-one derivatives as orally-active calcium-sensing receptor antagonists
Didiuk, Mary T., Griffith, David A., Benbow, John W., Liu, Kevin K.C., Walker, Daniel P., Christopher Bi, F., Morris, Joel, Guzman-Perez, Angel, Gao, Hua, Bechle, Bruce M., Kelley, Ryan M., Yang, Xiaojing, Dirico, Kenneth, Ahmed, Syed, Hungerford, William, DiBrinno, Joseph, Zawistoski, Michael P., Bagley, Scott W., Li, Jianke, Zeng, Yuan, Santucci, Stephanie, Oliver, Robert, Corbett, Matthew, Olson, Thanh, Chen, Chiliu, Li, Mei, Paralkar, Vishwas M., Riccardi, Keith A., Healy, David R., Kalgutkar, Amit S., Maurer, Tristan S., Nguyen, Hang T., Frederick, Kosea S.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Catalytic and Enantioselective Route to Medium-Ring Heterocycles. Asymmetric Zirconium-Catalyzed Ethylmagnesation of Seven- and Eight-Membered Rings
Visser, Michael S, Heron, Nicola M, Didiuk, Mary T, Sagal, John F, Hoveyda, Amir H
Published in Journal of the American Chemical Society (08.05.1996)
Published in Journal of the American Chemical Society (08.05.1996)
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Ni-Catalyzed Asymmetric Addition of Grignard Reagents to Unsaturated Cyclic Acetals. The Influence of Added Phosphine on Enantioselectivity
Gomez-Bengoa, Enrique, Heron, Nicola M, Didiuk, Mary T, Luchaco, Courtney A, Hoveyda, Amir H
Published in Journal of the American Chemical Society (05.08.1998)
Published in Journal of the American Chemical Society (05.08.1998)
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Enantio-, Diastereo-, and Regioselective Zirconium-Catalyzed Carbomagnesation of Cyclic Ethers with Higher Alkyls of Magnesium. Utility in Synthesis and Mechanistic Implications
Didiuk, Mary T, Johannes, Charles W, Morken, James P, Hoveyda, Amir H
Published in Journal of the American Chemical Society (01.07.1995)
Published in Journal of the American Chemical Society (01.07.1995)
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Zirconium-catalyzed asymmetric carbomagnesation
Morken, James P, Didiuk, Mary T, Hoveyda, Amir H
Published in Journal of the American Chemical Society (01.07.1993)
Published in Journal of the American Chemical Society (01.07.1993)
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Zirconium-Catalyzed Kinetic Resolution of Pyrans
Morken, James P, Didiuk, Mary T, Visser, Michael S, Hoveyda, Amir H
Published in Journal of the American Chemical Society (01.04.1994)
Published in Journal of the American Chemical Society (01.04.1994)
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Zirconium-catalyzed ethylmagnesiation of hydroxylated terminal alkenes; a catalytic and diastereoselective carbon-carbon bond-forming reaction
Houri, Ahmad F, Didiuk, Mary T, Xu, Zhongmin, Horan, Nina R, Hoveyda, Amir H
Published in Journal of the American Chemical Society (01.07.1993)
Published in Journal of the American Chemical Society (01.07.1993)
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Exploring Aromatic Chemical Space with NEAT: Novel and Electronically Equivalent Aromatic Template
Tu, Meihua, Rai, Brajesh K., Mathiowetz, Alan M., Didiuk, Mary, Pfefferkorn, Jeffrey A., Guzman-Perez, Angel, Benbow, John, Guimarães, Cristiano R. W., Mente, Scot, Hayward, Matthew M., Liras, Spiros
Published in Journal of chemical information and modeling (25.05.2012)
Published in Journal of chemical information and modeling (25.05.2012)
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Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus
Pfefferkorn, Jeffrey A., Guzman-Perez, Angel, Oates, Peter J., Litchfield, John, Aspnes, Gary, Basak, Arindrajit, Benbow, John, Berliner, Martin A., Bian, Jianwei, Choi, Chulho, Freeman-Cook, Kevin, Corbett, Jeffrey W., Didiuk, Mary, Dunetz, Joshua R., Filipski, Kevin J., Hungerford, William M., Jones, Christopher S., Karki, Kapil, Ling, Anthony, Li, Jian-Cheng, Patel, Leena, Perreault, Christian, Risley, Hud, Saenz, James, Song, Wei, Tu, Meihua, Aiello, Robert, Atkinson, Karen, Barucci, Nicole, Beebe, David, Bourassa, Patricia, Bourbounais, Francis, Brodeur, Anne M., Burbey, Rena, Chen, Jing, D'Aquila, Theresa, Derksen, David R., Haddish-Berhane, Nahor, Huang, Cong, Landro, James, Lee Lapworth, Amanda, MacDougall, Margit, Perregaux, David, Pettersen, John, Robertson, Alan, Tan, Beijing, Treadway, Judith L., Liu, Shenping, Qiu, Xiayang, Knafels, John, Ammirati, Mark, Song, Xi, DaSilva-Jardine, Paul, Liras, Spiros, Sweet, Laurel, Rolph, Timothy P.
Published in MedChemComm (01.09.2011)
Published in MedChemComm (01.09.2011)
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