Effects of a topical treatment with spleen tyrosine kinase inhibitor in healthy subjects and patients with cold urticaria or chronic spontaneous urticaria: Results of a phase 1a/b randomised double‐blind placebo‐controlled study
Dickson, Marion C., Walker, Alexandra, Grattan, Clive, Perry, Hayley, Williams, Nicola, Ratia, Nirav, Dewit, Odile, Gisbert, Sophie, Metz, Martin, Maurer, Marcus
Published in British journal of clinical pharmacology (01.12.2021)
Published in British journal of clinical pharmacology (01.12.2021)
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GSK2646264, a spleen tyrosine kinase inhibitor, attenuates the release of histamine in ex vivo human skin
Ramirez Molina, Cesar, Falkencrone, Sidsel, Skov, Per S., Hooper‐Greenhill, Edward, Barker, Mike, Dickson, Marion C.
Published in British journal of pharmacology (01.04.2019)
Published in British journal of pharmacology (01.04.2019)
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Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease
Barker, Michael D., Liddle, John, Atkinson, Francis L., Wilson, David Matthew, Dickson, Marion C., Ramirez-Molina, Cesar, Lewis, Huw, Davis, Rob P., Somers, Donald O., Neu, Margarete, Jones, Emma, Watson, Robert
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
Published in Bioorganic & medicinal chemistry letters (15.11.2018)
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Independent associations of anti-cyclic citrullinated peptide antibodies and rheumatoid factor with radiographic severity of rheumatoid arthritis
Mewar, Devesh, Coote, Annabel, Moore, David J, Marinou, Ioanna, Keyworth, Jodie, Dickson, Marion C, Montgomery, Doug S, Binks, Michael H, Wilson, Anthony G
Published in Arthritis research & therapy (01.01.2006)
Published in Arthritis research & therapy (01.01.2006)
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A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development
Dickson, Marion C., Ludbrook, Valerie J., Perry, Hayley C., Wilson, Paul A., Garthside, Sam J., Binks, Michael H.
Published in Inflammation research (01.04.2015)
Published in Inflammation research (01.04.2015)
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Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor
Liddle, John, Atkinson, Francis L., Barker, Michael D., Carter, Paul S., Curtis, Neil R., Davis, Rob P., Douault, Clement, Dickson, Marion C., Elwes, Dorothy, Garton, Neil S., Gray, Matthew, Hayhow, Thomas G., Hobbs, Clare I., Jones, Emma, Leach, Stuart, Leavens, Karen, Lewis, Huw D., McCleary, Scott, Neu, Margarete, Patel, Vipulkumar K., Preston, Alex G.S., Ramirez-Molina, Cesar, Shipley, Tracy J., Skone, Philip A., Smithers, Nick, Somers, Donald O., Walker, Ann L., Watson, Robert J., Weingarten, Gordon G.
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
Published in Bioorganic & medicinal chemistry letters (15.10.2011)
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Journal Article
The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis
Marinou, Ioanna, Montgomery, Douglas S, Dickson, Marion C, Binks, Michael H, Moore, David J, Bax, Deborah E, Wilson, Anthony G
Published in Arthritis research & therapy (01.01.2007)
Published in Arthritis research & therapy (01.01.2007)
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5-(1 H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase
Bamborough, Paul, Christopher, John A., Cutler, Geoffrey J., Dickson, Marion C., Mellor, Geoffrey W., Morey, James V., Patel, Champa B., Shewchuk, Lisa M.
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
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Journal Article
Fluid Shear Stress Induction of the Tissue Factor Promoter In Vitro and In Vivo Is Mediated by Egr-1
Houston, Parul, Dickson, Marion C, Ludbrook, Valerie, White, Brian, Schwachtgen, Jean-Luc, McVey, John H, Mackman, Nigel, Reese, Jason M, Gorman, Daniel G, Campbell, Callum, Braddock, Martin
Published in Arteriosclerosis, thrombosis, and vascular biology (01.02.1999)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.02.1999)
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Fluid Shear Stress Modulation of Gene Expression in Endothelial Cells
Braddock, Martin, Schwachtgen, Jean-Luc, Houston, Parul, Dickson, Marion C, Lee, Michael J, Campbell, Callum J
Published in News in physiological sciences (01.10.1998)
Published in News in physiological sciences (01.10.1998)
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Safety, pharmacokinetics and pharmacodynamics of a topical SYK inhibitor in cutaneous lupus erythematosus: A double‐blind Phase Ib study
Walker, Alex, Erwig, Lars, Foster, Katie, Nevin, Katherine, Wenzel, Joerg, Worm, Margitta, Williams, Nicola, Ratia, Nirav, Hoang, Bao, Schneider‐Merck, Tanja, Gisbert, Sophie, Carnarius, Heike, Dickson, Marion
Published in Experimental dermatology (01.11.2021)
Published in Experimental dermatology (01.11.2021)
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Highly selective SYK inhibitor, GSK 143, abrogates survival signals in chronic lymphocytic leukaemia
Varghese, Abraham M., Rawstron, Andy, Newton, Darren, Tooze, Reuben M., Munir, Talha, Dickson, Marion, Doody, Gina M., Hillmen, Peter
Published in British journal of haematology (01.09.2018)
Published in British journal of haematology (01.09.2018)
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Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor α, tumor necrosis factor receptor superfamily member 9, and macrophage colony‐stimulating factor
Rioja, Inmaculada, Hughes, Fiona J., Sharp, Catriona H., Warnock, Linda C., Montgomery, Doug S., Akil, Mohammed, Wilson, Anthony G., Binks, Michael H., Dickson, Marion C.
Published in Arthritis and rheumatism (01.08.2008)
Published in Arthritis and rheumatism (01.08.2008)
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Journal Article
Spleen tyrosine kinase (SYK) is a potential target for the treatment of cutaneous lupus erythematosus patients
Braegelmann, Christine, Hölzel, Michael, Ludbrook, Valerie, Dickson, Marion, Turan, Nil, Ferring-Schmitt, Sandra, Sternberg, Sonja, Bieber, Thomas, Kuhn, Annegret, Wenzel, Joerg
Published in Experimental dermatology (01.05.2016)
Published in Experimental dermatology (01.05.2016)
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Journal Article
Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia
Varghese, Abraham M., Rawstron, Andy, Newton, Darren, Tooze, Reuben M., Munir, Talha, Dickson, Marion, Doody, Gina M., Hillmen, Peter
Published in British journal of haematology (01.09.2018)
Published in British journal of haematology (01.09.2018)
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Journal Article
Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non‐DRB1 loci
Vignal, Charlotte, Bansal, Aruna T., Balding, David J., Binks, Michael H., Dickson, Marion C., Montgomery, Doug S., Wilson, Anthony G.
Published in Arthritis and rheumatism (01.01.2009)
Published in Arthritis and rheumatism (01.01.2009)
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