Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation
Shen, Ying‐Qiang, Guerra‐Librero, Ana, Fernandez‐Gil, Beatriz I., Florido, Javier, García‐López, Sergio, Martinez‐Ruiz, Laura, Mendivil‐Perez, Miguel, Soto‐Mercado, Viviana, Acuña‐Castroviejo, Darío, Ortega‐Arellano, Hector, Carriel, Victor, Diaz‐Casado, María E., Reiter, Russel J., Rusanova, Iryna, Nieto, Ana, López, Luis C., Escames, Germaine
Published in Journal of pineal research (01.04.2018)
Published in Journal of pineal research (01.04.2018)
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Journal Article
Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin
Sayed, Ramy K A, Fernández-Ortiz, Marisol, Diaz-Casado, María E, Aranda-Martínez, Paula, Fernández-Martínez, José, Guerra-Librero, Ana, Escames, Germaine, López, Luis C, Alsaadawy, Reem M, Acuña-Castroviejo, Darío
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (04.10.2019)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (04.10.2019)
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Journal Article
The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes
Sayed, Ramy K A, Fernández-Ortiz, Marisol, Diaz-Casado, María E, Rusanova, Iryna, Rahim, Ibtissem, Escames, Germaine, López, Luis C, Mokhtar, Doaa M, Acuña-Castroviejo, Darío
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (11.09.2018)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (11.09.2018)
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Journal Article
Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans
Acuna-Castroviejo, Dario, Rodríguez-Mañas, Leocadio, García-García, Francisco J., Guerra-Librero, Ana, Aranda-Martínez, Paula, Fernández-Ortiz, Marisol, Diaz-Casado, María E., Rusanova, Iryna, Escames, Germaine
Published in Oxidative medicine and cellular longevity (01.01.2018)
Published in Oxidative medicine and cellular longevity (01.01.2018)
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Journal Article
Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin
Volt, Huayqui, García, José A., Doerrier, Carolina, Díaz-Casado, María E., Guerra-Librero, Ana, López, Luis C., Escames, Germaine, Tresguerres, Jesús A., Acuña-Castroviejo, Darío
Published in Journal of pineal research (01.03.2016)
Published in Journal of pineal research (01.03.2016)
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Journal Article
Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network
Díaz-Casado, María E., Lima, Elena, García, José A, Doerrier, Carolina, Aranda, Paula, Sayed, Ramy KA, Guerra-Librero, Ana, Escames, Germaine, López, Luis C, Acuña-Castroviejo, Darío
Published in Journal of pineal research (01.08.2016)
Published in Journal of pineal research (01.08.2016)
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Journal Article
A review of the melatonin functions in zebrafish physiology
Lima-Cabello, Elena, Díaz-Casado, María E., Guerrero, Jose A., Otalora, Beatriz B., Escames, Germaine, López, Luis C., Reiter, Russel J., Acuña-Castroviejo, Darío
Published in Journal of pineal research (01.08.2014)
Published in Journal of pineal research (01.08.2014)
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Journal Article
Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases
López, Ana, Ortiz, Francisco, Doerrier, Carolina, Venegas, Carmen, Fernández-Ortiz, Marisol, Aranda, Paula, Díaz-Casado, María E, Fernández-Gil, Beatriz, Barriocanal-Casado, Eliana, Escames, Germaine, López, Luis C, Acuña-Castroviejo, Darío
Published in PloS one (11.08.2017)
Published in PloS one (11.08.2017)
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Journal Article
Extrapineal melatonin: sources, regulation, and potential functions
Acuña-Castroviejo, Darío, Escames, Germaine, Venegas, Carmen, Díaz-Casado, María E, Lima-Cabello, Elena, López, Luis C, Rosales-Corral, Sergio, Tan, Dun-Xian, Reiter, Russel J
Published in Cellular and molecular life sciences : CMLS (01.08.2014)
Published in Cellular and molecular life sciences : CMLS (01.08.2014)
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Journal Article
Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network
Doerrier, Carolina, García, José A, Volt, Huayqui, Díaz-Casado, María E, Luna-Sánchez, Marta, Fernández-Gil, Beatriz, Escames, Germaine, López, Luis C, Acuña-Castroviejo, Darío
Published in Mitochondrion (01.03.2016)
Published in Mitochondrion (01.03.2016)
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Journal Article
Melatonin, clock genes and mitochondria in sepsis
Acuña-Castroviejo, Darío, Rahim, Ibtissem, Acuña-Fernández, Carlos, Fernández-Ortiz, Marisol, Solera-Marín, Jorge, Sayed, Ramy K. A., Díaz-Casado, María E., Rusanova, Iryna, López, Luis C., Escames, Germaine
Published in Cellular and molecular life sciences : CMLS (01.11.2017)
Published in Cellular and molecular life sciences : CMLS (01.11.2017)
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Journal Article
Daily Changes in the Expression of Clock Genes in Sepsis and Their Relation with Sepsis Outcome and Urinary Excretion of 6-Sulfatoximelatonin
Acuña-Fernández, Carlos, Marín, Jorge Solera, Díaz-Casado, María E, Rusanova, Iryna, Darias-Delbey, Beneharo, Pérez-Guillama, Luis, Florido-Ruiz, Javier, Acuña-Castroviejo, Darío
Published in Shock (Augusta, Ga.) (01.05.2020)
Published in Shock (Augusta, Ga.) (01.05.2020)
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Journal Article
Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry
Doerrier, Carolina, García, José A., Volt, Huayqui, Díaz-Casado, María E., Lima-Cabello, Elena, Ortiz, Francisco, Luna-Sánchez, Marta, Escames, Germaine, López, Luis C., Acuña-Castroviejo, Darío
Published in Life sciences (1973) (15.01.2015)
Published in Life sciences (1973) (15.01.2015)
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Journal Article
In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy
Díaz-Casado, María E, Rusanova, Iryna, Aranda, Paula, Fernández-Ortiz, Marisol, Sayed, Ramy K A, Fernández-Gil, Beatriz I, Hidalgo-Gutiérrez, Agustín, Escames, Germaine, López, Luis C, Acuña-Castroviejo, Darío
Published in Zebrafish (01.02.2018)
Published in Zebrafish (01.02.2018)
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Journal Article
Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy
Escames, Germaine, Díaz-Casado, María E., Doerrier, Carolina, Luna-Sánchez, Marta, López, Luis C., Acuña-Castroviejo, Darío
Published in Hormone molecular biology and clinical investigation (01.12.2013)
Published in Hormone molecular biology and clinical investigation (01.12.2013)
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Journal Article
Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/ PINK 1/ DJ ‐1/ MUL 1 network
Díaz‐Casado, María E., Lima, Elena, García, José A, Doerrier, Carolina, Aranda, Paula, Sayed, Ramy KA, Guerra‐Librero, Ana, Escames, Germaine, López, Luis C, Acuña‐Castroviejo, Darío
Published in Journal of pineal research (01.08.2016)
Published in Journal of pineal research (01.08.2016)
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Journal Article