The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment
Väyrynen, Juha P, Haruki, Koichiro, Lau, Mai Chan, Väyrynen, Sara A, Zhong, Rong, Dias Costa, Andressa, Borowsky, Jennifer, Zhao, Melissa, Fujiyoshi, Kenji, Arima, Kota, Twombly, Tyler S, Kishikawa, Junko, Gu, Simeng, Aminmozaffari, Saina, Shi, Shanshan, Baba, Yoshifumi, Akimoto, Naohiko, Ugai, Tomotaka, Da Silva, Annacarolina, Guerriero, Jennifer L, Song, Mingyang, Wu, Kana, Chan, Andrew T, Nishihara, Reiko, Fuchs, Charles S, Meyerhardt, Jeffrey A, Giannakis, Marios, Ogino, Shuji, Nowak, Jonathan A
Published in Cancer immunology research (01.01.2021)
Published in Cancer immunology research (01.01.2021)
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Journal Article
Prognostic Significance of Immune Cell Populations Identified by Machine Learning in Colorectal Cancer Using Routine Hematoxylin and Eosin-Stained Sections
Väyrynen, Juha P, Lau, Mai Chan, Haruki, Koichiro, Väyrynen, Sara A, Dias Costa, Andressa, Borowsky, Jennifer, Zhao, Melissa, Fujiyoshi, Kenji, Arima, Kota, Twombly, Tyler S, Kishikawa, Junko, Gu, Simeng, Aminmozaffari, Saina, Shi, Shanshan, Baba, Yoshifumi, Akimoto, Naohiko, Ugai, Tomotaka, Da Silva, Annacarolina, Song, Mingyang, Wu, Kana, Chan, Andrew T, Nishihara, Reiko, Fuchs, Charles S, Meyerhardt, Jeffrey A, Giannakis, Marios, Ogino, Shuji, Nowak, Jonathan A
Published in Clinical cancer research (15.08.2020)
Published in Clinical cancer research (15.08.2020)
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Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer
Ugai, Tomotaka, Väyrynen, Juha P., Lau, Mai Chan, Borowsky, Jennifer, Akimoto, Naohiko, Väyrynen, Sara A., Zhao, Melissa, Zhong, Rong, Haruki, Koichiro, Dias Costa, Andressa, Fujiyoshi, Kenji, Arima, Kota, Wu, Kana, Chan, Andrew T., Cao, Yin, Song, Mingyang, Fuchs, Charles S., Wang, Molin, Lennerz, Jochen K., Ng, Kimmie, Meyerhardt, Jeffrey A., Giannakis, Marios, Nowak, Jonathan A., Ogino, Shuji
Published in Cancer Immunology, Immunotherapy (01.04.2022)
Published in Cancer Immunology, Immunotherapy (01.04.2022)
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Journal Article
Smoking and Incidence of Colorectal Cancer Subclassified by Tumor-Associated Macrophage Infiltrates
Ugai, Tomotaka, Väyrynen, Juha P, Haruki, Koichiro, Akimoto, Naohiko, Lau, Mai Chan, Zhong, Rong, Kishikawa, Junko, Väyrynen, Sara A, Zhao, Melissa, Fujiyoshi, Kenji, Dias Costa, Andressa, Borowsky, Jennifer, Arima, Kota, Guerriero, Jennifer L, Fuchs, Charles S, Zhang, Xuehong, Song, Mingyang, Wang, Molin, Giannakis, Marios, Meyerhardt, Jeffrey A, Nowak, Jonathan A, Ogino, Shuji
Published in JNCI : Journal of the National Cancer Institute (11.01.2022)
Published in JNCI : Journal of the National Cancer Institute (11.01.2022)
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An integrated analysis of lymphocytic reaction, tumour molecular characteristics and patient survival in colorectal cancer
Haruki, Koichiro, Kosumi, Keisuke, Li, Peilong, Arima, Kota, Väyrynen, Juha P., Lau, Mai Chan, Twombly, Tyler S., Hamada, Tsuyoshi, Glickman, Jonathan N., Fujiyoshi, Kenji, Chen, Yang, Du, Chunxia, Guo, Chunguang, Väyrynen, Sara A., Dias Costa, Andressa, Song, Mingyang, Chan, Andrew T., Meyerhardt, Jeffrey A., Nishihara, Reiko, Fuchs, Charles S., Liu, Li, Zhang, Xuehong, Wu, Kana, Giannakis, Marios, Nowak, Jonathan A., Ogino, Shuji
Published in British journal of cancer (01.04.2020)
Published in British journal of cancer (01.04.2020)
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Journal Article
Spatial Organization and Prognostic Significance of NK and NKT-like Cells via Multimarker Analysis of the Colorectal Cancer Microenvironment
Väyrynen, Juha P, Haruki, Koichiro, Lau, Mai Chan, Väyrynen, Sara A, Ugai, Tomotaka, Akimoto, Naohiko, Zhong, Rong, Zhao, Melissa, Dias Costa, Andressa, Borowsky, Jennifer, Bell, Phoenix, Takashima, Yasutoshi, Fujiyoshi, Kenji, Arima, Kota, Kishikawa, Junko, Shi, Shan-Shan, Twombly, Tyler S, Song, Mingyang, Wu, Kana, Chan, Andrew T, Zhang, Xuehong, Fuchs, Charles S, Meyerhardt, Jeffrey A, Giannakis, Marios, Ogino, Shuji, Nowak, Jonathan A
Published in Cancer immunology research (01.02.2022)
Published in Cancer immunology research (01.02.2022)
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Multicenter randomized controlled trial of neoadjuvant chemoradiotherapy alone or in combination with pembrolizumab in patients with resectable or borderline resectable pancreatic adenocarcinoma
Katz, Matthew H G, Petroni, Gina R, Bauer, Todd, Reilley, Matthew J, Wolpin, Brian M, Stucky, Chee-Chee, Bekaii-Saab, Tanios S, Elias, Rawad, Merchant, Nipun, Dias Costa, Andressa, Lenehan, Patrick, Cardot-Ruffino, Victoire, Rodig, Scott, Pfaff, Kathleen, Dougan, Stephanie K, Nowak, Jonathan Andrew, Varadhachary, Gauri R, Slingluff, Craig L, Rahma, Osama
Published in Journal for immunotherapy of cancer (01.12.2023)
Published in Journal for immunotherapy of cancer (01.12.2023)
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Journal Article
Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer
Byrne, Katelyn T, Betts, Courtney B, Mick, Rosemarie, Sivagnanam, Shamilene, Bajor, David L, Laheru, Daniel A, Chiorean, E Gabriela, O'Hara, Mark H, Liudahl, Shannon M, Newcomb, Craig, Alanio, Cécile, Ferreira, Ana P, Park, Byung S, Ohtani, Takuya, Huffman, Austin P, Väyrynen, Sara A, Dias Costa, Andressa, Kaiser, Judith C, Lacroix, Andreanne M, Redlinger, Colleen, Stern, Martin, Nowak, Jonathan A, Wherry, E John, Cheever, Martin A, Wolpin, Brian M, Furth, Emma E, Jaffee, Elizabeth M, Coussens, Lisa M, Vonderheide, Robert H
Published in Clinical cancer research (15.08.2021)
Published in Clinical cancer research (15.08.2021)
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Journal Article
Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma
Chung, Katherine Minjee, Singh, Jaffarguriqbal, Lawres, Lauren, Dorans, Kimberly Judith, Garcia, Cathy, Burkhardt, Daniel B., Robbins, Rebecca, Bhutkar, Arjun, Cardone, Rebecca, Zhao, Xiaojian, Babic, Ana, Vayrynen, Sara A., Dias Costa, Andressa, Nowak, Jonathan A., Chang, Daniel T., Dunne, Richard F., Hezel, Aram F., Koong, Albert C., Wilhelm, Joshua J., Bellin, Melena D., Nylander, Vibe, Gloyn, Anna L., McCarthy, Mark I., Kibbey, Richard G., Krishnaswamy, Smita, Wolpin, Brian M., Jacks, Tyler, Fuchs, Charles S., Muzumdar, Mandar Deepak
Published in Cell (14.05.2020)
Published in Cell (14.05.2020)
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Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
Liudahl, Shannon M, Betts, Courtney B, Sivagnanam, Shamilene, Morales-Oyarvide, Vicente, da Silva, Annacarolina, Yuan, Chen, Hwang, Samuel, Grossblatt-Wait, Alison, Leis, Kenna R, Larson, William, Lavoie, Meghan B, Robinson, Padraic, Dias Costa, Andressa, Väyrynen, Sara A, Clancy, Thomas E, Rubinson, Douglas A, Link, Jason, Keith, Dove, Horton, Wesley, Tempero, Margaret A, Vonderheide, Robert H, Jaffee, Elizabeth M, Sheppard, Brett, Goecks, Jeremy, Sears, Rosalie C, Park, Byung S, Mori, Motomi, Nowak, Jonathan A, Wolpin, Brian M, Coussens, Lisa M
Published in Cancer discovery (01.08.2021)
Published in Cancer discovery (01.08.2021)
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Journal Article
Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer
Dias Costa, Andressa, Väyrynen, Sara A, Chawla, Akhil, Zhang, Jinming, Väyrynen, Juha P, Lau, Mai Chan, Williams, Hannah L, Yuan, Chen, Morales-Oyarvide, Vicente, Elganainy, Dalia, Singh, Harshabad, Cleary, James M, Perez, Kimberly, Ng, Kimmie, Freed-Pastor, William, Mancias, Joseph D, Dougan, Stephanie K, Wang, Jiping, Rubinson, Douglas A, Dunne, Richard F, Kozak, Margaret M, Brais, Lauren, Reilly, Emma, Clancy, Thomas, Linehan, David C, Chang, Daniel T, Hezel, Aram F, Koong, Albert C, Aguirre, Andrew J, Wolpin, Brian M, Nowak, Jonathan A
Published in Clinical cancer research (01.12.2022)
Published in Clinical cancer research (01.12.2022)
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Journal Article
Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment
Borowsky, Jennifer, Haruki, Koichiro, Lau, Mai Chan, Dias Costa, Andressa, Väyrynen, Juha P, Ugai, Tomotaka, Arima, Kota, da Silva, Annacarolina, Felt, Kristen D, Zhao, Melissa, Gurjao, Carino, Twombly, Tyler S, Fujiyoshi, Kenji, Väyrynen, Sara A, Hamada, Tsuyoshi, Mima, Kosuke, Bullman, Susan, Harrison, Tabitha A, Phipps, Amanda I, Peters, Ulrike, Ng, Kimmie, Meyerhardt, Jeffrey A, Song, Mingyang, Giovannucci, Edward L, Wu, Kana, Zhang, Xuehong, Freeman, Gordon J, Huttenhower, Curtis, Garrett, Wendy S, Chan, Andrew T, Leggett, Barbara A, Whitehall, Vicki L J, Walker, Neal, Brown, Ian, Bettington, Mark, Nishihara, Reiko, Fuchs, Charles S, Lennerz, Jochen K, Giannakis, Marios, Nowak, Jonathan A, Ogino, Shuji
Published in Clinical cancer research (15.05.2021)
Published in Clinical cancer research (15.05.2021)
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Journal Article
Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity
Williams, Hannah L, Dias Costa, Andressa, Zhang, Jinming, Raghavan, Srivatsan, Winter, Peter S, Kapner, Kevin S, Ginebaugh, Scott P, Väyrynen, Sara A, Väyrynen, Juha P, Yuan, Chen, Navia, Andrew W, Wang, Junning, Yang, Annan, Bosse, Timothy L, Kalekar, Radha L, Lowder, Kristen E, Lau, Mai Chan, Elganainy, Dalia, Morales-Oyarvide, Vicente, Rubinson, Douglas A, Singh, Harshabad, Perez, Kimberly, Cleary, James M, Clancy, Thomas E, Wang, Jiping, Mancias, Joseph D, Brais, Lauren K, Hill, Emma R, Kozak, Margaret M, Linehan, David C, Dunne, Richard F, Chang, Daniel T, Koong, Albert C, Hezel, Aram F, Hahn, William C, Shalek, Alex K, Aguirre, Andrew J, Nowak, Jonathan A, Wolpin, Brian M
Published in Cancer research (Chicago, Ill.) (03.02.2023)
Published in Cancer research (Chicago, Ill.) (03.02.2023)
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Journal Article
Insulin-Like Growth Factor-1 Receptor Expression and Disease Recurrence and Survival in Patients with Resected Pancreatic Ductal Adenocarcinoma
Du, Chunxia, da Silva, Annacarolina, Morales-Oyarvide, Vicente, Dias Costa, Andressa, Kozak, Margaret M, Dunne, Richard F, Rubinson, Douglas A, Perez, Kimberly, Masugi, Yohei, Hamada, Tsuyoshi, Brais, Lauren K, Yuan, Chen, Babic, Ana, Ducar, Matthew D, Thorner, Aaron R, Aguirre, Andrew, Kulke, Matthew H, Ng, Kimmie, Clancy, Thomas E, Findeis-Hosey, Jennifer J, Chang, Daniel T, Hornick, Jason L, Fuchs, Charles S, Ogino, Shuji, Koong, Albert C, Hezel, Aram F, Wolpin, Brian M, Nowak, Jonathan A
Published in Cancer epidemiology, biomarkers & prevention (01.08.2020)
Published in Cancer epidemiology, biomarkers & prevention (01.08.2020)
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Machine learning links T-cell function and spatial localization to neoadjuvant immunotherapy and clinical outcome in pancreatic cancer
Blise, Katie E, Sivagnanam, Shamilene, Betts, Courtney B, Betre, Konjit, Kirchberger, Nell, Tate, Benjamin J, Furth, Emma E, Dias Costa, Andressa, Nowak, Jonathan A, Wolpin, Brian M, Vonderheide, Robert H, Goecks, Jeremy, Coussens, Lisa M, Byrne, Katelyn T
Published in Cancer immunology research (02.05.2024)
Published in Cancer immunology research (02.05.2024)
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Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment
Väyrynen, Juha P, Haruki, Koichiro, Väyrynen, Sara A, Lau, Mai Chan, Dias Costa, Andressa, Borowsky, Jennifer, Zhao, Melissa, Ugai, Tomotaka, Kishikawa, Junko, Akimoto, Naohiko, Zhong, Rong, Shi, Shanshan, Chang, Tzuu-Wang, Fujiyoshi, Kenji, Arima, Kota, Twombly, Tyler S, Da Silva, Annacarolina, Song, Mingyang, Wu, Kana, Zhang, Xuehong, Chan, Andrew T, Nishihara, Reiko, Fuchs, Charles S, Meyerhardt, Jeffrey A, Giannakis, Marios, Ogino, Shuji, Nowak, Jonathan A
Published in Journal for immunotherapy of cancer (01.04.2021)
Published in Journal for immunotherapy of cancer (01.04.2021)
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Journal Article
Bayesian risk prediction model for colorectal cancer mortality through integration of clinicopathologic and genomic data
Zhao, Melissa, Lau, Mai Chan, Haruki, Koichiro, Väyrynen, Juha P., Gurjao, Carino, Väyrynen, Sara A., Dias Costa, Andressa, Borowsky, Jennifer, Fujiyoshi, Kenji, Arima, Kota, Hamada, Tsuyoshi, Lennerz, Jochen K., Fuchs, Charles S., Nishihara, Reiko, Chan, Andrew T., Ng, Kimmie, Zhang, Xuehong, Meyerhardt, Jeffrey A., Song, Mingyang, Wang, Molin, Giannakis, Marios, Nowak, Jonathan A., Yu, Kun-Hsing, Ugai, Tomotaka, Ogino, Shuji
Published in NPJ precision oncology (10.06.2023)
Published in NPJ precision oncology (10.06.2023)
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960 Randomized multicenter study of neoadjuvant chemoradiation therapy (CRT) alone or in combination with pembrolizumab in patients with resectable or borderline resectable pancreatic cancer
Rahma, Osama, Katz, Mathew, Bauer, Todd, Wolpin, Brian, Stucky, Chee-Chee, Bekaii-Saab, Tanios, Elias, Rawad, Dias-Costa, Andressa, Nowak, Jonathan, Patrick, Lenehan, Petroni, Gina, Dougan, Stephanie, Slingluff, Craig
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer
Väyrynen, Sara A, Zhang, Jinming, Yuan, Chen, Väyrynen, Juha P, Dias Costa, Andressa, Williams, Hannah, Morales-Oyarvide, Vicente, Lau, Mai Chan, Rubinson, Douglas A, Dunne, Richard F, Kozak, Margaret M, Wang, Wenjia, Agostini-Vulaj, Diana, Drage, Michael G, Brais, Lauren, Reilly, Emma, Rahma, Osama, Clancy, Thomas, Wang, Jiping, Linehan, David C, Aguirre, Andrew J, Fuchs, Charles S, Coussens, Lisa M, Chang, Daniel T, Koong, Albert C, Hezel, Aram F, Ogino, Shuji, Nowak, Jonathan A, Wolpin, Brian M
Published in Clinical cancer research (15.02.2021)
Published in Clinical cancer research (15.02.2021)
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Impact of vitamin d on the colon tumor immune microenvironment: Results of a randomized clinical trial of preoperative vitamin D supplementation in patients with stage I-III colon cancer
Dias Costa, Andressa, Kim, Suryun, Zhang, Jinming, Bleday, Ronald, Goldberg, Joel, Irani, Jennifer, Melnitchouk, Nelya, Lowder, Kristen, Yuan, Chen, Brais, Lauren K., Wolpin, Brian M., Nowak, Jonathan, Ng, Kimmie
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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