INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models
Liu, Phillip C C, Koblish, Holly, Wu, Liangxing, Bowman, Kevin, Diamond, Sharon, DiMatteo, Darlise, Zhang, Yue, Hansbury, Michael, Rupar, Mark, Wen, Xiaoming, Collier, Paul, Feldman, Patricia, Klabe, Ronald, Burke, Krista A, Soloviev, Maxim, Gardiner, Christine, He, Xin, Volgina, Alla, Covington, Maryanne, Ruggeri, Bruce, Wynn, Richard, Burn, Timothy C, Scherle, Peggy, Yeleswaram, Swamy, Yao, Wenqing, Huber, Reid, Hollis, Gregory
Published in PloS one (21.04.2020)
Published in PloS one (21.04.2020)
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The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy
Zhang, Qiang, Zhang, Yan, Diamond, Sharon, Boer, Jason, Harris, Jennifer J, Li, Yu, Rupar, Mark, Behshad, Elham, Gardiner, Christine, Collier, Paul, Liu, Phillip, Burn, Timothy, Wynn, Richard, Hollis, Gregory, Yeleswaram, Swamy
Published in Drug metabolism and disposition (01.10.2014)
Published in Drug metabolism and disposition (01.10.2014)
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Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies
Koblish, Holly, Li, Yun-Long, Shin, Niu, Hall, Leslie, Wang, Qian, Wang, Kathy, Covington, Maryanne, Marando, Cindy, Bowman, Kevin, Boer, Jason, Burke, Krista, Wynn, Richard, Margulis, Alex, Reuther, Gary W, Lambert, Que T, Dostalik Roman, Valerie, Zhang, Ke, Feng, Hao, Xue, Chu-Biao, Diamond, Sharon, Hollis, Greg, Yeleswaram, Swamy, Yao, Wenqing, Huber, Reid, Vaddi, Kris, Scherle, Peggy
Published in PloS one (21.06.2018)
Published in PloS one (21.06.2018)
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Metabolism, Excretion, and Pharmacokinetics of [14C]INCB018424, a Selective Janus Tyrosine Kinase 1/2 Inhibitor, in Humans
SHILLING, Adam D, NEDZA, Frank M, SHEPARD, Stacey, RODGERS, James, YUE, Tai-Yuen, YELESWARAM, Swamy, EMM, Thomas, DIAMOND, Sharon, MCKEEVER, Edward, PUNWANI, Naresh, WILLIAMS, William, ARVANITIS, Argyrios, GALYA, Laurine G, MEI LI
Published in Drug metabolism and disposition (01.11.2010)
Published in Drug metabolism and disposition (01.11.2010)
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Discovery and Pharmacological Characterization of a Novel Rodent-Active CCR2 Antagonist, INCB3344
Brodmerkel, Carrie M, Huber, Reid, Covington, Maryanne, Diamond, Sharon, Hall, Leslie, Collins, Robert, Leffet, Lynn, Gallagher, Karen, Feldman, Patricia, Collier, Paul, Stow, Mark, Gu, Xiaomei, Baribaud, Frederic, Shin, Niu, Thomas, Beth, Burn, Tim, Hollis, Greg, Yeleswaram, Swamy, Solomon, Kim, Friedman, Steve, Wang, Anlai, Xue, Chu Biao, Newton, Robert C, Scherle, Peggy, Vaddi, Kris
Published in The Journal of immunology (1950) (15.10.2005)
Published in The Journal of immunology (1950) (15.10.2005)
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Inhibition of Clinically Relevant Mutant Variants of HIV-1 by Quinazolinone Non-Nucleoside Reverse Transcriptase Inhibitors
Corbett, Jeffrey W, Ko, Soo S, Rodgers, James D, Gearhart, Lisa A, Magnus, Nicholas A, Bacheler, Lee T, Diamond, Sharon, Jeffrey, Susan, Klabe, Ronald M, Cordova, Beverly C, Garber, Sena, Logue, Kelly, Trainor, George L, Anderson, Paul S, Erickson-Viitanen, Susan K
Published in Journal of medicinal chemistry (18.05.2000)
Published in Journal of medicinal chemistry (18.05.2000)
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Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist
Zheng, Changsheng, Cao, Ganfeng, Xia, Michael, Feng, Hao, Glenn, Joseph, Anand, Rajan, Zhang, Ke, Huang, Taisheng, Wang, Anlai, Kong, Ling, Li, Mei, Galya, Laurine, Hughes, Robert O., Devraj, Rajesh, Morton, Phillip A., Rogier, D. Joseph, Covington, Maryanne, Baribaud, Fred, Shin, Niu, Scherle, Peggy, Diamond, Sharon, Yeleswaram, Swamy, Vaddi, Kris, Newton, Robert, Hollis, Greg, Friedman, Steven, Metcalf, Brian, Xue, Chu-Biao
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
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Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist
Xue, Chu-Biao, Feng, Hao, Cao, Ganfeng, Huang, Taisheng, Glenn, Joseph, Anand, Rajan, Meloni, David, Zhang, Ke, Kong, Lingquan, Wang, Anlai, Zhang, Yingxin, Zheng, Changsheng, Xia, Michael, Chen, Lihua, Tanaka, Hiroyuki, Han, Qi, Robinson, D. J, Modi, Dilip, Storace, Lou, Shao, Lixin, Sharief, Vaqar, Li, Mei, Galya, Laurine G, Covington, Maryanne, Scherle, Peggy, Diamond, Sharon, Emm, Tom, Yeleswaram, Swamy, Contel, Nancy, Vaddi, Kris, Newton, Robert, Hollis, Greg, Friedman, Steven, Metcalf, Brian
Published in ACS medicinal chemistry letters (09.06.2011)
Published in ACS medicinal chemistry letters (09.06.2011)
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Expanded-Spectrum Nonnucleoside Reverse Transcriptase Inhibitors Inhibit Clinically Relevant Mutant Variants of Human Immunodeficiency Virus Type 1
Corbett, J W, Ko, S S, Rodgers, J D, Jeffrey, S, Bacheler, L T, Klabe, R M, Diamond, S, Lai, C M, Rabel, S R, Saye, J A, Adams, S P, Trainor, G L, Anderson, P S, Erickson-Viitanen, S K
Published in Antimicrobial Agents and Chemotherapy (01.12.1999)
Published in Antimicrobial Agents and Chemotherapy (01.12.1999)
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DPC 817: a Cytidine Nucleoside Analog with Activity against Zidovudine- and Lamivudine-Resistant Viral Variants
SCHINAZI, Raymond F, MELLORS, John, WU, Jing-Tao, HANGCHUN ZHANG, HAMMOND, Jennifer, BACHELER, Lee, MANION, Douglas J, OTTO, Michael J, STUYVER, Lieven, TRAINOR, George, LIOTTA, Dennis C, ERICKSON-VIITANEN, Susan, BAZMI, Holly, DIAMOND, Sharon, GARBER, Sena, GALLAGHER, Karen, GELEZIUNAS, Romas, KLABE, Ron, PIERCE, Michael, RAYNER, Marlene
Published in Antimicrobial Agents and Chemotherapy (01.05.2002)
Published in Antimicrobial Agents and Chemotherapy (01.05.2002)
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Plasma pharmacokinetics and distribution of ruxolitinib into skin following oral and topical administration in minipigs
Persaud, Indushekhar, Diamond, Sharon, Pan, Rina, Burke, Krista, Harris, Jennifer, Conlin, Michelle, Yeleswaram, Swamy
Published in International journal of pharmaceutics (30.11.2020)
Published in International journal of pharmaceutics (30.11.2020)
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Effects of Epacadostat on Brain Extracellular Fluid Concentrations of Serotonin-an Intracerebral Microdialysis Study in Sprague-Dawley Rats
Zhang, Yan, Bowman, Kevin, Maleski, Janet, Diamond, Sharon, Yeleswaram, Swamy
Published in Drug metabolism and disposition (01.07.2019)
Published in Drug metabolism and disposition (01.07.2019)
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Journal Article
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor
Wu, Liangxing, Zhang, Colin, He, Chunhong, Qian, Dingquan, Lu, Liang, Sun, Yaping, Xu, Meizhong, Zhuo, Jincong, Liu, Phillip C. C, Klabe, Ronald, Wynn, Richard, Covington, Maryanne, Gallagher, Karen, Leffet, Lynn, Bowman, Kevin, Diamond, Sharon, Koblish, Holly, Zhang, Yue, Soloviev, Maxim, Hollis, Gregory, Burn, Timothy C, Scherle, Peggy, Yeleswaram, Swamy, Huber, Reid, Yao, Wenqing
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Journal Article
Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor
Koblish, Holly K, Wu, Liangxing, Wang, Liang-Chuan S, Liu, Phillip C C, Wynn, Richard, Rios-Doria, Jonathan, Spitz, Susan, Liu, Hao, Volgina, Alla, Zolotarjova, Nina, Kapilashrami, Kanishk, Behshad, Elham, Covington, Maryanne, Yang, Yan-Ou, Li, Jingwei, Diamond, Sharon, Soloviev, Maxim, O'Hayer, Kevin, Rubin, Stephen, Kanellopoulou, Chrysi, Yang, Gengjie, Rupar, Mark, DiMatteo, Darlise, Lin, Luping, Stevens, Christina, Zhang, Yue, Thekkat, Pramod, Geschwindt, Ryan, Marando, Cindy, Yeleswaram, Swamy, Jackson, Jeff, Scherle, Peggy, Huber, Reid, Yao, Wenqing, Hollis, Gregory
Published in Cancer discovery (02.06.2022)
Published in Cancer discovery (02.06.2022)
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Preclinical characterization of itacitinib (INCB039110), a novel selective inhibitor of JAK1, for the treatment of inflammatory diseases
Covington, Maryanne, He, Xin, Scuron, Monika, Li, Jun, Collins, Robert, Juvekar, Ashish, Shin, Niu, Favata, Margaret, Gallagher, Karen, Sarah, Sarala, Xue, Chu-biao, Peel, Michael, Burke, Krista, Oliver, Julian, Fay, Brittany, Yao, Wenqing, Huang, Taisheng, Scherle, Peggy, Diamond, Sharon, Newton, Robert, Zhang, Yan, Smith, Paul
Published in European journal of pharmacology (15.10.2020)
Published in European journal of pharmacology (15.10.2020)
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A Novel Kinase Inhibitor, INCB28060, Blocks c-MET-Dependent Signaling, Neoplastic Activities, and Cross-Talk with EGFR and HER-3
XIANGDONG LIU, QIAN WANG, BOER, Jason, DIAMOND, Sharon, CHUNHONG HE, MEIZHONG XU, JINCONG ZHUO, WENQING YAO, NEWTON, Robert C, SCHERLE, Peggy A, GENGJIE YANG, MARANDO, Cindy, KOBLISH, Holly K, HALL, Leslie M, FRIDMAN, Jordan S, BEHSHAD, Elham, WYNN, Richard, YU LI
Published in Clinical cancer research (15.11.2011)
Published in Clinical cancer research (15.11.2011)
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Interaction of Ritonavir on Tissue Distribution of a [14C]L-Valinamide, a Potent Human Immunodeficiency Virus-1 Protease Inhibitor, in Rats Using Quantitative Whole-Body Autoradiography
SOLON, Eric G, BALANI, Suresh K, LEE, Frank W, GANG LUO, YANG, Tian J, HAINES, Paula J, LIFEI WANG, DEMOND, Tonya, DIAMOND, Sharon, CHRIST, David D, GAN, Liang-Shang
Published in Drug metabolism and disposition (01.11.2002)
Published in Drug metabolism and disposition (01.11.2002)
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