Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists
Evans, B. E, Rittle, K. E, Bock, M. G, DiPardo, R. M, Freidinger, R. M, Whitter, W. L, Lundell, G. F, Veber, D. F, Anderson, P. S, Chang, R. S. L, Lotti, V. J, Cerino, D. J, Chen, T. B, Kling, P. J, Kunkel, K. A, Springer, J. P, Hirshfield, J
Published in Journal of medicinal chemistry (01.12.1988)
Published in Journal of medicinal chemistry (01.12.1988)
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Journal Article
Design of Potent, Orally Effective, Nonpeptidal Antagonists of the Peptide Hormone Cholecystokinin
Evans, Ben E., Bock, Mark G., Rittle, Kenneth E., DiPardo, Robert M., Whitter, Willie L., Veber, Daniel F., Anderson, Paul S., Freidinger, Roger M.
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.1986)
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.1986)
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Journal Article
Benzodiazepine gastrin and brain cholecystokinin receptor ligands; L-365,260
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Whitter, Willie L, Veber, Daniel F, Anderson, Paul S, Freidinger, Roger M
Published in Journal of medicinal chemistry (01.01.1989)
Published in Journal of medicinal chemistry (01.01.1989)
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Journal Article
Development of 1,4-benzodiazepine cholecystokinin type B antagonists
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Whitter, Willie L, Garsky, Victor M, Gilbert, Kevin F, Leighton, James L, Carson, Kenneth L
Published in Journal of medicinal chemistry (24.12.1993)
Published in Journal of medicinal chemistry (24.12.1993)
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Journal Article
Orally active, nonpeptide oxytocin antagonists
Evans, Ben E, Leighton, James L, Rittle, Kenneth E, Gilbert, Kevin F, Lundell, George F, Gould, Norman P, Hobbs, Doug W, DiPardo, Robert M, Veber, Daniel F, Pettibone, Douglas J, Clineschmidt, Bradley V, Anderson, Paul S, Freidinger, Roger M
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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Journal Article
Receptor ligands which bind the oxytocin receptor with selectivity and high affinity. Chemical modification of a Streptomyces silvensis derived cyclic hexapeptide
Bock, Mark G, DiPardo, R. M, Williams, P. D, Pettibone, D. J, Clineschmidt, B. V, Ball, R. G, Veber, D. F, Freidinger, R. M
Published in Journal of medicinal chemistry (01.09.1990)
Published in Journal of medicinal chemistry (01.09.1990)
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Journal Article
Design of nonpeptidal ligands for a peptide receptor: cholecystokinin antagonists
Evans, B. E, Rittle, K. E, Bock, M. G, DiPardo, R. M, Freidinger, R. M, Whitter, W. L, Gould, N. P, Lundell, G. F, Homnick, C. F
Published in Journal of medicinal chemistry (01.07.1987)
Published in Journal of medicinal chemistry (01.07.1987)
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Journal Article
Cyclic hexapeptide oxytocin antagonists. Potency-, selectivity-, and solubility-enhancing modifications
Freidinger, Roger M, Williams, P. D, Tung, R. D, Bock, M. G, Pettibone, D. J, Clineschmidt, B. V, DiPardo, R. M, Erb, J. M, Garsky, V. M
Published in Journal of medicinal chemistry (01.07.1990)
Published in Journal of medicinal chemistry (01.07.1990)
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Journal Article
Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potency
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Freidinger, Roger M, Rittle, Kenneth E, Payne, Linda S, Boger, Joshua, Whitter, Willie L, LaMont, Bruce I
Published in Journal of medicinal chemistry (01.10.1988)
Published in Journal of medicinal chemistry (01.10.1988)
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Journal Article
Cholecystokinin-A receptor ligands based on the .kappa.-opioid agonist tifluadom
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Whitter, Willie L, Veber, Daniel F, Freidinger, Roger M, Chang, Raymond S. L, Chen, T. B, Lotti, Victor J
Published in Journal of medicinal chemistry (01.01.1990)
Published in Journal of medicinal chemistry (01.01.1990)
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Journal Article
Cholecystokinin antagonists. Synthesis and biological evaluation of 3-substituted 1,4-benzodiazepin-2-amines
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Freidinger, Roger M, Chang, Raymond S. L, Lotti, Victor J
Published in Journal of medicinal chemistry (01.01.1988)
Published in Journal of medicinal chemistry (01.01.1988)
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Journal Article
Cholecystokinin antagonists. Synthesis and biological evaluation of 4-substituted 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepines
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Veber, Daniel F, Freidinger, Roger M, Chang, Raymond S. L, Lotti, Victor J
Published in Journal of medicinal chemistry (01.01.1988)
Published in Journal of medicinal chemistry (01.01.1988)
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Journal Article
Cholecystokinin antagonists. Synthesis of asperlicin analogs with improved potency and water solubility
Bock, Mark G, DiPardo, Robert M, Rittle, Kenneth E, Evans, Ben E, Freidinger, Roger M, Veber, Daniel F, Chang, Raymond S. L, Chen, Tsing Bau, Keegan, Maureen E, Lotti, Victor J
Published in Journal of medicinal chemistry (01.10.1986)
Published in Journal of medicinal chemistry (01.10.1986)
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Journal Article
Cyclic imides as potent and selective alpha-1A adrenergic receptor antagonists
DiPardo, R M, Patane, M A, Newton, R C, Price, R, Broten, T P, Chang, R S, Ransom, R W, Di Salvo, J, Freidinger, R M, Bock, M G
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
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Journal Article
Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini
Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Boger, Joshua, Poe, Martin, LaMont, Bruce I, Lynch, Robert J, Ulm, Edgar H
Published in Journal of medicinal chemistry (01.10.1987)
Published in Journal of medicinal chemistry (01.10.1987)
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Selective alpha-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity
Patane, M A, DiPardo, R M, Price, R P, Chang, R S, Ransom, R W, O'Malley, S S, Di Salvo, J, Bock, M G
Published in Bioorganic & medicinal chemistry letters (22.09.1998)
Published in Bioorganic & medicinal chemistry letters (22.09.1998)
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Journal Article
Phenylacetamides as selective alpha-1A adrenergic receptor antagonists
Patane, M A, DiPardo, R M, Newton, R C, Price, R P, Broten, T P, Chang, R S, Ransom, R W, Di Salvo, J, Nagarathnam, D, Forray, C, Gluchowski, C, Bock, M G
Published in Bioorganic & medicinal chemistry letters (07.08.2000)
Published in Bioorganic & medicinal chemistry letters (07.08.2000)
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Journal Article
A uniquely potent renin inhibitor and its unanticipated plasma binding component
Evans, Ben E, Rittle, Kenneth E, Bock, Mark G, Bennett, Carl D, DiPardo, Robert M, Boger, Joshua, Poe, Martin, Ulm, Edgar H, LaMont, Bruce I
Published in Journal of medicinal chemistry (01.12.1985)
Published in Journal of medicinal chemistry (01.12.1985)
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Journal Article
Renin inhibitors containing 2-substituted statine
Veber, D F, Bock, M G, Brady, S F, Ulm, E H, Cochran, D W, Smith, G M, LaMont, B I, Dipardo, R M, Poe, M, Freidinger, R M
Published in Biochemical Society transactions (01.12.1984)
Published in Biochemical Society transactions (01.12.1984)
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Journal Article
Second-Generation Benzodiazepine CCK-B Antagonists. Development of Subnanomolar Analogs with Selectivity and Water Solubility
Bock, Mark G, DiPardo, Robert M, Mellin, Eva C, Newton, Randall C, Veber, Daniel F, Freedman, Stephen B, Smith, Alison J, Patel, Smita, Kemp, John A, Marshall, George R, Fletcher, Alan E, Chapman, Kerry L, Anderson, Paul S, Freidinger, Roger M
Published in Journal of medicinal chemistry (01.03.1994)
Published in Journal of medicinal chemistry (01.03.1994)
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