Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety
He, Rongjun, Finan, Brian, Mayer, John P, DiMarchi, Richard D
Published in Molecules (Basel, Switzerland) (14.05.2019)
Published in Molecules (Basel, Switzerland) (14.05.2019)
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Unimolecular Polypharmacy for Treatment of Diabetes and Obesity
Tschöp, Matthias H., Finan, Brian, Clemmensen, Christoffer, Gelfanov, Vasily, Perez-Tilve, Diego, Müller, Timo D., DiMarchi, Richard D.
Published in Cell metabolism (12.07.2016)
Published in Cell metabolism (12.07.2016)
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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Finan, Brian, Yang, Bin, Ottaway, Nickki, Smiley, David L, Ma, Tao, Clemmensen, Christoffer, Chabenne, Joe, Zhang, Lianshan, Habegger, Kirk M, Fischer, Katrin, Campbell, Jonathan E, Sandoval, Darleen, Seeley, Randy J, Bleicher, Konrad, Uhles, Sabine, Riboulet, William, Funk, Jürgen, Hertel, Cornelia, Belli, Sara, Sebokova, Elena, Conde-Knape, Karin, Konkar, Anish, Drucker, Daniel J, Gelfanov, Vasily, Pfluger, Paul T, Müller, Timo D, Perez-Tilve, Diego, DiMarchi, Richard D, Tschöp, Matthias H
Published in Nature medicine (01.01.2015)
Published in Nature medicine (01.01.2015)
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Journal Article
Reappraisal of GIP Pharmacology for Metabolic Diseases
Finan, Brian, Müller, Timo D, Clemmensen, Christoffer, Perez-Tilve, Diego, DiMarchi, Richard D, Tschöp, Matthias H
Published in Trends in molecular medicine (01.05.2016)
Published in Trends in molecular medicine (01.05.2016)
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Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
Mroz, Piotr A., Finan, Brian, Gelfanov, Vasily, Yang, Bin, Tschöp, Matthias H., DiMarchi, Richard D., Perez-Tilve, Diego
Published in Molecular metabolism (Germany) (01.02.2019)
Published in Molecular metabolism (Germany) (01.02.2019)
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Recent Advances in Incretin-Based Pharmacotherapies for the Treatment of Obesity and Diabetes
Tan, Qiming, Akindehin, Seun E, Orsso, Camila E, Waldner, Richelle C, DiMarchi, Richard D, Müller, Timo D, Haqq, Andrea M
Published in Frontiers in endocrinology (Lausanne) (01.03.2022)
Published in Frontiers in endocrinology (Lausanne) (01.03.2022)
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Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis
Weiss, Andy, Murdoch, Caitlin C., Edmonds, Katherine A., Jordan, Matthew R., Monteith, Andrew J., Perera, Yasiru R., Rodríguez Nassif, Aslin M., Petoletti, Amber M., Beavers, William N., Munneke, Matthew J., Drury, Sydney L., Krystofiak, Evan S., Thalluri, Kishore, Wu, Hongwei, Kruse, Angela R.S., DiMarchi, Richard D., Caprioli, Richard M., Spraggins, Jeffrey M., Chazin, Walter J., Giedroc, David P., Skaar, Eric P.
Published in Cell (09.06.2022)
Published in Cell (09.06.2022)
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Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice
Knerr, Patrick J., Mowery, Stephanie A., Douros, Jonathan D., Premdjee, Bhavesh, Hjøllund, Karina Rahr, He, Yantao, Kruse Hansen, Ann Maria, Olsen, Anette K., Perez-Tilve, Diego, DiMarchi, Richard D., Finan, Brian
Published in Molecular metabolism (Germany) (01.09.2022)
Published in Molecular metabolism (Germany) (01.09.2022)
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Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions
HABEGGER, Kirk M, STEMMER, Kerstin, KRISHNA, Radha, ARAFAT, Ayman M, KONKAR, Anish, BELLI, Sara, KAPPS, Martin, WOODS, Stephen C, HOFMANN, Susanna M, D'ALESSIO, David, PFLUGER, Paul T, PEREZ-TILVE, Diego, CHENG, Christine, SEELEY, Randy J, KONISHI, Morichika, ITOH, Nobuyujki, KHARITONENKOV, Alexei, SPRANGER, Joachim, DIMARCHI, Richard D, TSCHÖP, Matthias H, MÜLLER, Timo D, HEPPNER, Kristy M, OTTAWAY, Nickki, HOLLAND, Jenna, HEMBREE, Jazzminn L, SMILEY, David, GELFANOV, Vasily
Published in Diabetes (New York, N.Y.) (01.05.2013)
Published in Diabetes (New York, N.Y.) (01.05.2013)
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Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist
Moreau, Francois, Kirk, Nicholas S., Zhang, Fa, Gelfanov, Vasily, List, Edward O., Chrudinová, Martina, Venugopal, Hari, Lawrence, Michael C., Jimenez, Veronica, Bosch, Fatima, Kopchick, John J., DiMarchi, Richard D., Altindis, Emrah, Kahn, C. Ronald
Published in Nature communications (05.11.2022)
Published in Nature communications (05.11.2022)
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Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation
Wu, Fangzhou, Mayer, John P, Gelfanov, Vasily M, Liu, Fa, DiMarchi, Richard D
Published in Journal of organic chemistry (07.04.2017)
Published in Journal of organic chemistry (07.04.2017)
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Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice
Jall, Sigrid, Sachs, Stephan, Clemmensen, Christoffer, Finan, Brian, Neff, Frauke, DiMarchi, Richard D, Tschöp, Matthias H, Müller, Timo D, Hofmann, Susanna M
Published in Molecular metabolism (Germany) (01.05.2017)
Published in Molecular metabolism (Germany) (01.05.2017)
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Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy
Sánchez-Garrido, Miguel A., Serrano-López, Víctor, Ruiz-Pino, Francisco, Vázquez, María Jesús, Rodríguez-Martín, Andrea, Torres, Encarnación, Velasco, Inmaculada, Rodríguez, Ana Belén, Chicano-Gálvez, Eduardo, Mora-Ortiz, Marina, Ohlsson, Claes, Poutanen, Matti, Pinilla, Leonor, Gaytán, Francisco, Douros, Jonathan D., Yang, Bin, Müller, Timo D., DiMarchi, Richard D., Tschöp, Matthias H., Finan, Brian, Tena-Sempere, Manuel
Published in Nature communications (01.10.2024)
Published in Nature communications (01.10.2024)
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Correction: GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease
Sachs, Stephan, Götz, Anna, Finan, Brian, Feuchtinger, Annette, DiMarchi, Richard D, Döring, Yvonne, Weber, Christian, Tschöp, Matthias H, Müller, Timo D, Hofmann, Susanna M
Published in Cardiovascular diabetology (12.09.2024)
Published in Cardiovascular diabetology (12.09.2024)
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Optimized clinical performance of growth hormone with an expanded genetic code
Cho, Ho, Daniel, Tom, Buechler, Ying Ji, Litzinger, David C, Maio, Zhenwei, Putnam, Anna-Maria Hays, Kraynov, Vadim S, Sim, Bee-Cheng, Bussell, Stuart, Javahishvili, Tsotne, Kaphle, Sami, Viramontes, Guillermo, Ong, Mike, Chu, Stephanie, GC, Becky, Lieu, Ricky, Knudsen, Nick, Castiglioni, Paola, Norman, Thea C, Axelrod, Douglas W, Hoffman, Andrew R, Schultz, Peter G, DiMarchi, Richard D, Kimmel, Bruce E
Published in Proceedings of the National Academy of Sciences - PNAS (31.05.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (31.05.2011)
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FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
MU, James, PINKSTAFF, Jason, WU, Margaret, NORMAN, Thea C, RODRIGUEZ, Carlos G, KIMMEL, Bruce, METZGER, Joseph M, MANIBUSAN, Anthony, LEE, Darin, ZALLER, Dennis M, ZHANG, Bei B, DIMARCHI, Richard D, ZHIHUA LI, BERGER, Joel P, AXELROD, Douglas W, SKIDMORE, Lillian, NINA LI, MYLER, Heather, DALLAS-YANG, Qing, PUTNAM, Anna-Maria, JUN YAO, BUSSELL, Stuart
Published in Diabetes (New York, N.Y.) (01.02.2012)
Published in Diabetes (New York, N.Y.) (01.02.2012)
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Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless “C-Peptide” Chemical Excision
Thalluri, Kishore, Kou, Binbin, Gelfanov, Vasily, Mayer, John P, Liu, Fa, DiMarchi, Richard D
Published in Organic letters (03.02.2017)
Published in Organic letters (03.02.2017)
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