Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis
Nygaard, Gyrid, Di Paolo, Julie A., Hammaker, Deepa, Boyle, David L., Budas, Grant, Notte, Gregory T., Mikaelian, Igor, Barry, Vivian, Firestein, Gary S.
Published in Biochemical pharmacology (01.05.2018)
Published in Biochemical pharmacology (01.05.2018)
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Journal Article
JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib
Traves, Paqui G, Murray, Bernard, Campigotto, Federico, Galien, René, Meng, Amy, Di Paolo, Julie A
Published in Annals of the rheumatic diseases (01.07.2021)
Published in Annals of the rheumatic diseases (01.07.2021)
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Journal Article
SYK inhibitor entospletinib prevents ocular and skin GVHD in mice
Poe, Jonathan C, Jia, Wei, Di Paolo, Julie A, Reyes, Nancy J, Kim, Ji Yun, Su, Hsuan, Sundy, John S, Cardones, Adela R, Perez, Victor L, Chen, Benny J, Chao, Nelson J, Cardona, Diana M, Saban, Daniel R, Sarantopoulos, Stefanie
Published in JCI insight (04.10.2018)
Published in JCI insight (04.10.2018)
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Journal Article
Characterization of the mechanism of action of lanraplenib, a novel spleen tyrosine kinase inhibitor, in models of lupus nephritis
Pohlmeyer, Christopher W, Shang, Ching, Han, Pei, Cui, Zhi-Hua, Jones, Randall M, Clarke, Astrid S, Murray, Bernard P, Lopez, David A, Newstrom, David W, Inzunza, M David, Matzkies, Franziska G, Currie, Kevin S, Di Paolo, Julie A
Published in BMC rheumatology (30.03.2021)
Published in BMC rheumatology (30.03.2021)
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Journal Article
Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase
Currie, Kevin S, Kropf, Jeffrey E, Lee, Tony, Blomgren, Peter, Xu, Jianjun, Zhao, Zhongdong, Gallion, Steve, Whitney, J. Andrew, Maclin, Deborah, Lansdon, Eric B, Maciejewski, Patricia, Rossi, Ann Marie, Rong, Hong, Macaluso, Jennifer, Barbosa, James, Di Paolo, Julie A, Mitchell, Scott A
Published in Journal of medicinal chemistry (08.05.2014)
Published in Journal of medicinal chemistry (08.05.2014)
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Journal Article
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis
Reif, Karin, Currie, Kevin S, Di Paolo, Julie A, Huang, Tao, Balazs, Mercedesz, Barbosa, James, Barck, Kai H, Bravo, Brandon J, Carano, Richard A D, Darrow, James, Davies, Douglas R, DeForge, Laura E, Diehl, Lauri, Ferrando, Ronald, Gallion, Steven L, Giannetti, Anthony M, Gribling, Peter, Hurez, Vincent, Hymowitz, Sarah G, Jones, Randall, Kropf, Jeffrey E, Lee, Wyne P, Maciejewski, Patricia M, Mitchell, Scott A, Rong, Hong, Staker, Bart L, Whitney, J Andrew, Yeh, Sherry, Young, Wendy B, Yu, Christine, Zhang, Juan
Published in Nature chemical biology (01.01.2011)
Published in Nature chemical biology (01.01.2011)
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Journal Article
Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases
Blomgren, Peter, Chandrasekhar, Jayaraman, Di Paolo, Julie A, Fung, Wanchi, Geng, Guoju, Ip, Carmen, Jones, Randall, Kropf, Jeffrey E, Lansdon, Eric B, Lee, Seung, Lo, Jennifer R, Mitchell, Scott A, Murray, Bernard, Pohlmeyer, Chris, Schmitt, Aaron, Suekawa-Pirrone, Kimberly, Wise, Sarah, Xiong, Jin-Ming, Xu, Jianjun, Yu, Helen, Zhao, Zhongdong, Currie, Kevin S
Published in ACS medicinal chemistry letters (09.04.2020)
Published in ACS medicinal chemistry letters (09.04.2020)
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Journal Article
Effects of GS-9876, a novel spleen tyrosine kinase inhibitor, on platelet function and systemic hemostasis
Clarke, Astrid S., Rousseau, Emma, Wang, Kelly, Kim, Ji-Yun, Murray, Bernard P., Bannister, Roy, Matzkies, Franziska, Currie, Kevin S., Di Paolo, Julie A.
Published in Thrombosis research (01.10.2018)
Published in Thrombosis research (01.10.2018)
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Journal Article
Pharmacokinetics, Pharmacodynamics, and Safety of Entospletinib, a Novel pSYK Inhibitor, Following Single and Multiple Oral Dosing in Healthy Volunteers
Ramanathan, Srini, Di Paolo, Julie A., Jin, Feng, Shao, Lixin, Sharma, Shringi, Robeson, Michelle, Kearney, Brian P.
Published in Clinical drug investigation (01.02.2017)
Published in Clinical drug investigation (01.02.2017)
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Journal Article
Abstract 4205: Mass-spectroscopy phosphorylation profiling identified differential activation of signaling molecules via spleen tyrosine kinase in B-cell receptor signaling and stromal cell stimulation in DLBCL and CLL cells that are inhibited by GS-9973
Paolo, Julie A. Di, Clarke, Astrid, Rong, Hong, Rousseau, Emma
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract 26: Evaluation of the safety, pharmacokinetics and pharmacodynamics of GS-9973, a novel SYK inhibitor, and GS-1101, a novel PI3Kδ inhibitor, when administered alone or in combination in humans
Jin, Feng, Di Paolo, Julie A., Shao, Lixin, Yellin, Ori, Hawkins, Michael J., Ramanathan, Srinivasan
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
Phase 2 Trial Of GS-9973, a Selective Syk Inhibitor, In Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin Lymphoma (NHL)
Sharman, Jeff P., Klein, Leonard, Boxer, Michael, Kolibaba, Kathryn S., Hawkins, Michael J., Di Paolo, Julie A, Hu, Jing, Reddy, Anita, Jin, Feng, Melchor-Khan, Flordeliza, Yasenchak, Christopher A.
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Journal Article
SYK inhibitors
Di Paolo, Julie A, Keegan, Kathleen S, Abella, Esteban M, Marcondes, Antonio Mario Querido, Pan, Yang, Rao, Arati V
Year of Publication 07.03.2019
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Year of Publication 07.03.2019
Patent
SYK inhibitors
Di Paolo, Julie A, Keegan, Kathleen S, Abella, Esteban M, Marcondes, Antonio Mario Querido, Pan, Yang, Rao, Arati V
Year of Publication 30.10.2018
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Year of Publication 30.10.2018
Patent