Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma
Zhang, Liang, Yao, Yixin, Zhang, Shaojun, Liu, Yang, Guo, Hui, Ahmed, Makhdum, Bell, Taylor, Zhang, Hui, Han, Guangchun, Lorence, Elizabeth, Badillo, Maria, Zhou, Shouhao, Sun, Yuting, Di Francesco, M Emilia, Feng, Ningping, Haun, Randy, Lan, Renny, Mackintosh, Samuel G, Mao, Xizeng, Song, Xingzhi, Zhang, Jianhua, Pham, Lan V, Lorenzi, Philip L, Marszalek, Joseph, Heffernan, Tim, Draetta, Giulio, Jones, Philip, Futreal, Andrew, Nomie, Krystle, Wang, Linghua, Wang, Michael
Published in Science translational medicine (08.05.2019)
Published in Science translational medicine (08.05.2019)
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Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [ 18 F]FAZA PET In Vivo
Gammon, Seth T, Pisaneschi, Federica, Bandi, Madhavi L, Smith, Melinda G, Sun, Yuting, Rao, Yi, Muller, Florian, Wong, Franklin, De Groot, John, Ackroyd, Jeffrey, Mawlawi, Osama, Davies, Michael A, Gopal, Y N Vashisht, Di Francesco, M Emilia, Marszalek, Joseph R, Dewhirst, Mark, Piwnica-Worms, David
Published in Cells (Basel, Switzerland) (21.11.2019)
Published in Cells (Basel, Switzerland) (21.11.2019)
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Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase
Di Francesco, M. Emilia, Avolio, Salvatore, Pompei, Marco, Pesci, Silvia, Monteagudo, Edith, Pucci, Vincenzo, Giuliano, Claudio, Fiore, Fabrizio, Rowley, Michael, Summa, Vincenzo
Published in Bioorganic & medicinal chemistry (01.08.2012)
Published in Bioorganic & medicinal chemistry (01.08.2012)
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Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells
Naguib, Adam, Mathew, Grinu, Reczek, Colleen R., Watrud, Kaitlin, Ambrico, Alexandra, Herzka, Tali, Salas, Irene Casanova, Lee, Matthew F., El-Amine, Nour, Zheng, Wu, Di Francesco, M. Emilia, Marszalek, Joseph R., Pappin, Darryl J., Chandel, Navdeep S., Trotman, Lloyd C.
Published in Cell reports (Cambridge) (03.04.2018)
Published in Cell reports (Cambridge) (03.04.2018)
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Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy
Ager, Casey R., Zhang, Huaping, Wei, Zhanlei, Jones, Philip, Curran, Michael A., Di Francesco, M. Emilia
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
Published in Bioorganic & medicinal chemistry letters (15.10.2019)
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Synthesis and Antiviral Properties of Novel Tetracyclic Nucleoside Inhibitors of Hepatitis C NS5B Polymerase
Francesco, M. Emilia Di, Avolio, Salvatore, Dessole, Gabriella, Koch, Uwe, Pompei, Marco, Pucci, Vincenzo, Rowley, Michael, Summa, Vincenzo
Published in Nucleosides, nucleotides & nucleic acids (01.08.2012)
Published in Nucleosides, nucleotides & nucleic acids (01.08.2012)
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Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia
Baran, Natalia, Lodi, Alessia, Dhungana, Yogesh, Herbrich, Shelley, Collins, Meghan, Sweeney, Shannon, Pandey, Renu, Skwarska, Anna, Patel, Shraddha, Tremblay, Mathieu, Kuruvilla, Vinitha Mary, Cavazos, Antonio, Kaplan, Mecit, Warmoes, Marc O., Veiga, Diogo Troggian, Furudate, Ken, Rojas-Sutterin, Shanti, Haman, Andre, Gareau, Yves, Marinier, Anne, Ma, Helen, Harutyunyan, Karine, Daher, May, Garcia, Luciana Melo, Al-Atrash, Gheath, Piya, Sujan, Ruvolo, Vivian, Yang, Wentao, Shanmugavelandy, Sriram Saravanan, Feng, Ningping, Gay, Jason, Du, Di, Yang, Jun J., Hoff, Fieke W., Kaminski, Marcin, Tomczak, Katarzyna, Eric Davis, R., Herranz, Daniel, Ferrando, Adolfo, Jabbour, Elias J., Emilia Di Francesco, M., Teachey, David T., Horton, Terzah M., Kornblau, Steven, Rezvani, Katayoun, Sauvageau, Guy, Gagea, Mihai, Andreeff, Michael, Takahashi, Koichi, Marszalek, Joseph R., Lorenzi, Philip L., Yu, Jiyang, Tiziani, Stefano, Hoang, Trang, Konopleva, Marina
Published in Nature communications (19.05.2022)
Published in Nature communications (19.05.2022)
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Cork-in-bottle mechanism of inhibitor binding to mammalian complex I
Chung, Injae, Serreli, Riccardo, Cross, Jason B, Di Francesco, M Emilia, Marszalek, Joseph R, Hirst, Judy
Published in Science advances (01.05.2021)
Published in Science advances (01.05.2021)
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PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
Giuliani, Virginia, Miller, Meredith A., Liu, Chiu-Yi, Hartono, Stella R., Class, Caleb A., Bristow, Christopher A., Suzuki, Erika, Sanz, Lionel A., Gao, Guang, Gay, Jason P., Feng, Ningping, Rose, Johnathon L., Tomihara, Hideo, Daniele, Joseph R., Peoples, Michael D., Bardenhagen, Jennifer P., Geck Do, Mary K., Chang, Qing E., Vangamudi, Bhavatarini, Vellano, Christopher, Ying, Haoqiang, Deem, Angela K., Do, Kim-Anh, Genovese, Giannicola, Marszalek, Joseph R., Kovacs, Jeffrey J., Kim, Michael, Fleming, Jason B., Guccione, Ernesto, Viale, Andrea, Maitra, Anirban, Emilia Di Francesco, M., Yap, Timothy A., Jones, Philip, Draetta, Giulio, Carugo, Alessandro, Chedin, Frederic, Heffernan, Timothy P.
Published in Nature communications (30.07.2021)
Published in Nature communications (30.07.2021)
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The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus NS3 Protease
Ontoria, Jesus M, Di Marco, Stefania, Conte, Immacolata, Di Francesco, M. Emilia, Gardelli, Cristina, Koch, Uwe, Matassa, Victor G, Poma, Marco, Steinkühler, Christian, Volpari, Cinzia, Harper, Steven
Published in Journal of medicinal chemistry (16.12.2004)
Published in Journal of medicinal chemistry (16.12.2004)
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Dihydroxypyrimidine-4-carboxamides as Novel Potent and Selective HIV Integrase Inhibitors
Pace, Paola, Di Francesco, M. Emilia, Gardelli, Cristina, Harper, Steven, Muraglia, Ester, Nizi, Emanuela, Orvieto, Federica, Petrocchi, Alessia, Poma, Marco, Rowley, Michael, Scarpelli, Rita, Laufer, Ralph, Gonzalez Paz, Odalys, Monteagudo, Edith, Bonelli, Fabio, Hazuda, Daria, Stillmock, Kara A, Summa, Vincenzo
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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Novel Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease Featuring a 2-Amino-1,3-thiazole as a P4 Carbamate Replacement
Di Francesco, M. Emilia, Dessole, Gabriella, Nizi, Emanuela, Pace, Paola, Koch, Uwe, Fiore, Fabrizio, Pesci, Silvia, Di Muzio, Jillian, Monteagudo, Edith, Rowley, Michael, Summa, Vincenzo
Published in Journal of medicinal chemistry (26.11.2009)
Published in Journal of medicinal chemistry (26.11.2009)
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Development of 2- t butyl- N-methyl pyrimidones as potent inhibitors of HIV integrase
Di Francesco, M. Emilia, Pace, Paola, Fiore, Fabrizio, Naimo, Francesca, Bonelli, Fabio, Rowley, Michael, Summa, Vincenzo
Published in Bioorganic & medicinal chemistry letters (15.04.2008)
Published in Bioorganic & medicinal chemistry letters (15.04.2008)
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An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Molina, Jennifer R., Sun, Yuting, Protopopova, Marina, Gera, Sonal, Bandi, Madhavi, Bristow, Christopher, McAfoos, Timothy, Morlacchi, Pietro, Ackroyd, Jeffrey, Agip, Ahmed-Noor A., Al-Atrash, Gheath, Asara, John, Bardenhagen, Jennifer, Carrillo, Caroline C., Carroll, Christopher, Chang, Edward, Ciurea, Stefan, Cross, Jason B., Czako, Barbara, Deem, Angela, Daver, Naval, de Groot, John Frederick, Dong, Jian-Wen, Feng, Ningping, Gao, Guang, Gay, Jason, Do, Mary Geck, Greer, Jennifer, Giuliani, Virginia, Han, Jing, Han, Lina, Henry, Verlene K., Hirst, Judy, Huang, Sha, Jiang, Yongying, Kang, Zhijun, Khor, Tin, Konoplev, Sergej, Lin, Yu-Hsi, Liu, Gang, Lodi, Alessia, Lofton, Timothy, Ma, Helen, Mahendra, Mikhila, Matre, Polina, Mullinax, Robert, Peoples, Michael, Petrocchi, Alessia, Rodriguez-Canale, Jaime, Serreli, Riccardo, Shi, Thomas, Smith, Melinda, Tabe, Yoko, Theroff, Jay, Tiziani, Stefano, Xu, Quanyun, Zhang, Qi, Muller, Florian, DePinho, Ronald A., Toniatti, Carlo, Draetta, Giulio F., Heffernan, Timothy P., Konopleva, Marina, Jones, Philip, Di Francesco, M. Emilia, Marszalek, Joseph R.
Published in Nature medicine (01.07.2018)
Published in Nature medicine (01.07.2018)
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Journal Article
Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types
Pilié, Patrick G, Giuliani, Virginia, Wang, Wei-Lien, McGrail, Daniel J, Bristow, Christopher A, Ngoi, Natalie Y L, Kyewalabye, Keith, Wani, Khalida M, Le, Hung, Campbell, Erick, Sanchez, Nora S, Yang, Dong, Gheeya, Jinesh S, Goswamy, Rohit Vivek, Holla, Vijaykumar, Shaw, Kenna Rael, Meric-Bernstam, Funda, Liu, Chiu-Yi, Ma, XiaoYan, Feng, Ningping, Machado, Annette A, Bardenhagen, Jennifer P, Vellano, Christopher P, Marszalek, Joseph R, Rajendra, Eeson, Piscitello, Desiree, Johnson, Timothy I, Likhatcheva, Maria, Elinati, Elias, Majithiya, Jayesh, Neves, Joana, Grinkevich, Vera, Ranzani, Marco, Luzarraga, Marina Roy, Boursier, Marie, Armstrong, Lucy, Geo, Lerin, Lillo, Giorgia, Tse, Wai Yiu, Lazar, Alexander J, Kopetz, Scott E, Geck Do, Mary K, Lively, Sarah, Johnson, Michael G, Robinson, Helen M R, Smith, Graeme C M, Carroll, Christopher L, Di Francesco, M Emilia, Jones, Philip, Heffernan, Timothy P, Yap, Timothy A
Published in Clinical cancer research (15.05.2024)
Published in Clinical cancer research (15.05.2024)
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Abstract 1875: Oxidative metabolism as a novel therapeutic target to eradicate T-ALL with mitochondrial complex I inhibitor IACS-010759
Baran, Natalia, Lodi, Alessia, Sweeney, Shannon, Kuruvilla, Vinitha Mary, Cavazos, Antonio, Skwarska, Anna, Velandy, Sriram Shanmuga, Harutyunyan, Karine, Feng, Ningping, Gay, Jason, Kaminski, Marcin, Jabbour, Elias J., Ferrando, Adolfo, Francesco, M. Emilia Di, Marszalek, Joseph R., Tiziani, Stefano, Konopleva, Marina
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Mitochondrial Complex I Inhibition with Iacs-010759 in T-ALL Preclinical Models
Baran, Natalia, Molina, Jennifer, Cavazos, Antonio, Harutyunyan, Karine, Feng, Ningping, Gay, Jason, Piya, Sujan, Shanmuga Velandy, Sriram, Jabbour, Elias J., Andreeff, Michael, Tiziani, Stefano, Ferrando, Adolfo A., Zweidler-McKay, Patrick, Di Francesco, M. Emilia, Marszalek, Joseph R., Konopleva, Marina
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Abstract PR01: IACS-010759 a novel inhibitor of oxidative phosphorylation advancing into first-in-human studies to exploit metabolic vulnerabilities
Jones, Philip, Francesco, M Emilia Di, Molina, Jennifer M., Protopopova, Marina, Bandi, Madhavi, Bardenhagen, Jennifer, Bristow, Christopher A., Carroll, Christopher L., Feng, Ningping, Gay, Jason P., Do, Mary K. Geck, Greer, Jennifer M., Konopleva, Marina, Kang, Zhijun, Liu, Gang, McAfoos, Timothy, Morlacchi, Pietro, Smith, Melinda G., Fnu, Sonal, Theroff, Jay P., Draetta, Giulio, Toniatti, Carlo, Marszalek, Joseph R.
Published in Clinical cancer research (01.01.2017)
Published in Clinical cancer research (01.01.2017)
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Abstract 4971: IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors
Molina, Jennifer, Bandi, Madhavi, Bardenhagen, Jennifer, Bristow, Christopher, Carroll, Christopher, Chang, Edward, Cross, Jason, Daver, Naval, Feng, Ningping, Gay, Jason, Do, Mary Geck, Greer, Jennifer, Han, Jing, Hirst, Judy, Huang, Sha, Jiang, Yongying, Kang, Zhijun, Konopleva, Marina, Liu, Gang, Ma, Helen, Matre, Polina, McAfoos, Timothy, Meric-Bernstam, Funda, Morlacchi, Pietro, Muller, Florian, Protopopova, Marina, Smith, Melinda, Sonal, Sonal, Sun, Yuting, Theroff, Jay, Viale, Andrea, Xu, Quanyun, Toniatti, Carlo, Draetta, Giulio, Jones, Philip, Francesco, M. Emilia Di, Marszalek, Joseph R.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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