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Casazza, A, Di Conza, G, Wenes, M, Finisguerra, V, Deschoemaeker, S, Mazzone, M
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Published in Oncogene (03.04.2014)
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Nodular goiter and laryngeal anatomic variant in two portraits of the hellenistic dramatist Menander
Toni, R., Barbaro, F., Di Conza, G., Trimarchi, F.
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Published in Journal of endocrinological investigation (01.11.2022)
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Characterization and translational development of IOA-289, a novel autotaxin inhibitor for the treatment of solid tumors
Deken, M.A., Niewola-Staszkowska, K., Peyruchaud, O., Mikulčić, N., Antolić, M., Shah, P., Cheasty, A., Tagliavini, A., Nizzardo, A., Pergher, M., Ziviani, L., Milleri, S., Pickering, C., Lahn, M., van der Veen, L., Di Conza, G., Johnson, Z.
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Published in Immuno-oncology technology (01.06.2023)
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Puzzling over MDM4–p53 network
Mancini, F., Di Conza, G., Monti, O., Macchiarulo, A., Pellicciari, R., Pontecorvi, A., Moretti, F.
Published in The international journal of biochemistry & cell biology (01.07.2010)
Published in The international journal of biochemistry & cell biology (01.07.2010)
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Regulation of MDM4 (MDMX) function by p76 : a new facet in the control of p53 activity
Giglio, S, Mancini, F, Pellegrino, M, Di Conza, G, Puxeddu, E, Sacchi, A, Pontecorvi, A, Moretti, F
Published in Oncogene (04.11.2010)
Published in Oncogene (04.11.2010)
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Regulation of MDM4 (MDMX) function by p76MDM2: a new facet in the control of p53 activity
Giglio, S, Mancini, F, Pellegrino, M, Di Conza, G, Puxeddu, E, Sacchi, A, Pontecorvi, A, Moretti, F
Published in Oncogene (04.11.2010)
Published in Oncogene (04.11.2010)
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33 (PB021): Loss-of-function and gain-of-function genetic screens identify potential biomarkers and combination partners for the highly selective allosteric PI3Kδ inhibitor roginolisib (IOA-244)
Tarantelli, C., Sartori, G., Spriano, F., Civanelli, E., Cascione, L., Rinaldi, A., Niewola-Staszkowska, K., Lahn, M., Napoli, S., Di Conza, G., Bertoni, F.
Published in European journal of cancer (1990) (01.10.2024)
Published in European journal of cancer (1990) (01.10.2024)
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626P Roginolisib (IOA-244), a first oral allosteric modulator of phosphoinositide 3-kinase inhibitor delta (PI3Kδ) in patients with metastatic uveal melanoma
Di Giacomo, A.M., Simonelli, M., Santangelo, F., Amato, G., Simonetti, E., Graham, J., Lahn, M., Di Conza, G., Hammett, T., Zorrilla, R., Kaur, P., Ziyang, T., Lakshmikanth, T., Brodin, P., Occhipinti, M., Carlo-Stella, C., Santoro, A., Spiliopoulou, P., Evans, T.R.J., Maio, M.
Published in Annals of oncology (01.09.2024)
Published in Annals of oncology (01.09.2024)
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Non-ATP competitive inhibition of PI3Kδ with IOA-244 shows anti-lymphoma activity
Tarantelli, C., Spriano, F., Cascione, L., Civanelli, E., Cannas, E., Mensah, A.A., Arribas, A.J., Rinaldi, A., Stathis, A., Di Conza, G., Niewola-Staszkowska, K., Lahn, M., Bertoni, F.
Published in European journal of cancer (1990) (01.10.2022)
Published in European journal of cancer (1990) (01.10.2022)
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Roginolisib, an oral, highly selective and allosteric modulator of phosphoinositide 3-kinase inhibitor delta (PI3Kδ) in patients with uveal melanoma and advanced cancers
Di Giacomo, Anna Maria, Simonelli, Matteo, Santangelo, Federica, Amato, Giovanni, Simonetti, Elena, Graham, Jill, Lahn, Michael M. F., Di Conza, Giusy, Hammett, Tracey, Zorrilla, Rebeca, Durini, Marco, Tan, Ziyang, Tadepally, Lakshmikanth, Brodin, Petter, Occhipinti, Mariaelena, Carlo-Stella, Carmelo, Santoro, Armando, Spiliopoulou, Pavlina, Evans, T.R. Jeffry, Maio, Michele
Published in JOURNAL OF CLINICAL ONCOLOGY (01.06.2024)
Published in JOURNAL OF CLINICAL ONCOLOGY (01.06.2024)
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Conference Proceeding
First-in-human (FIH) phase I dose escalation study (part A) of the first oral allosteric modulator of phosphoinositide 3-kinase inhibitor delta (PI3Kδ) roginolisib in patients with advanced cancer and dose confirmation in uveal melanoma (part B)
Di Giacomo, Anna Maria, Santangelo, Federica, Amato, Giovanni, Simonetti, Elena, Graham, Jill, Lahn, Michael M. F., Di Conza, Giusy, Hammett, Tracey, Zorrilla, Rebeca, Durini, Marco, Tan, Ziyang, Tadepally, Lakshmikanth, Brodin, Petter, Occhipinti, Mariaelena, Simonelli, Matteo, Carlo-Stella, Carmelo, Santoro, Armando, Spiliopoulou, Pavlina, Evans, T.R. Jeffry, Maio, Michele
Published in JOURNAL OF CLINICAL ONCOLOGY (01.06.2023)
Published in JOURNAL OF CLINICAL ONCOLOGY (01.06.2023)
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Conference Proceeding
53P Characterization of the non-ATP competitive PI3Kdelta inhibitor IOA-244 in lymphoma models: From single agent to combination screen and clinical investigation
Bertoni, F., Tarantelli, C., Spriano, F., Cascione, L., Civanelli, E., Cannas, E., Mensah, A.A., Arribas, A.J., Napoli, S., Rinaldi, A., Stathis, A., Niewola, K., Di Conza, G., Lahn, M., Santoro, A., Carlo-Stella, C.
Published in ESMO open (01.03.2023)
Published in ESMO open (01.03.2023)
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131P Safety and clinical efficacy of roginolisib (IOA-244): The first oral allosteric modulator of phosphoinositide 3-kinase inhibitor delta (PI3Kδ)
Di Giacomo, A.M., Simonelli, M., Santangelo, F., Amato, G., Simonetti, E., Graham, J., Lahn, M., Di Conza, G., Hammett, T., Zorrilla, R., Kaur, P., Ziyang, T., Lakshmikanth, T., Brodin, P., Occhipinti, M., Carlo-Stella, C., Santoro, A., Spiliopoulou, P., Evans, T.R.J., Maio, M.
Published in Immuno-oncology technology (01.12.2023)
Published in Immuno-oncology technology (01.12.2023)
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Regulation of MDM4 function by [p76.sup.MDM2]: a new facet in the control of p53 activity
Giglio, S, Mancini, F, Pellegrino, M, Di Conza, G, Puxeddu, E, Sacchi, A, Pontecorvi, A, Moretti, F
Published in Oncogene (04.11.2010)
Published in Oncogene (04.11.2010)
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Regulation of MDM4 (MDMX) function by p76 super(MDM2): a new facet in the control of p53 activity
Giglio, S, Mancini, F, Pellegrino, M, Di Conza, G, Puxeddu, E, Sacchi, A, Pontecorvi, A, Moretti, F
Published in Oncogene (04.11.2010)
Published in Oncogene (04.11.2010)
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