Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site
Matthew, Susan, Chen, Qi-Yin, Ratnayake, Ranjala, Fermaintt, Charles S., Lucena-Agell, Daniel, Bonato, Francesca, Prota, Andrea E., Lim, Seok Ting, Wang, Xiaomeng, Díaz, J. Fernando, Risinger, April L., Paul, Valerie J., Oliva, Maria Ángela, Luesch, Hendrik
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2021)
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Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention
Bohnacker, Thomas, Prota, Andrea E., Beaufils, Florent, Burke, John E., Melone, Anna, Inglis, Alison J., Rageot, Denise, Sele, Alexander M., Cmiljanovic, Vladimir, Cmiljanovic, Natasa, Bargsten, Katja, Aher, Amol, Akhmanova, Anna, Díaz, J. Fernando, Fabbro, Doriano, Zvelebil, Marketa, Williams, Roger L., Steinmetz, Michel O., Wymann, Matthias P.
Published in Nature communications (09.03.2017)
Published in Nature communications (09.03.2017)
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Taxanes convert regions of perturbed microtubule growth into rescue sites
Rai, Ankit, Liu, Tianyang, Glauser, Simon, Katrukha, Eugene A., Estévez-Gallego, Juan, Rodríguez-García, Ruddi, Fang, Wei-Shuo, Díaz, J. Fernando, Steinmetz, Michel O., Altmann, Karl-Heinz, Kapitein, Lukas C., Moores, Carolyn A., Akhmanova, Anna
Published in Nature materials (01.03.2020)
Published in Nature materials (01.03.2020)
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High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design
Bueno, Oskía, Estévez Gallego, Juan, Martins, Solange, Prota, Andrea E., Gago, Federico, Gómez-SanJuan, Asier, Camarasa, María-José, Barasoain, Isabel, Steinmetz, Michel O., Díaz, J. Fernando, Pérez-Pérez, María-Jesús, Liekens, Sandra, Priego, Eva-María
Published in Scientific reports (09.03.2018)
Published in Scientific reports (09.03.2018)
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A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin
Menchon, Grégory, Prota, Andrea E., Lucena-Agell, Daniel, Bucher, Pascal, Jansen, Rolf, Irschik, Herbert, Müller, Rolf, Paterson, Ian, Díaz, J. Fernando, Altmann, Karl-Heinz, Steinmetz, Michel O.
Published in Nature communications (29.05.2018)
Published in Nature communications (29.05.2018)
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Neuronal Subtype Specification within a Lineage by Opposing Temporal Feed-Forward Loops
Baumgardt, Magnus, Karlsson, Daniel, Terriente, Javier, Díaz-Benjumea, Fernando J., Thor, Stefan
Published in Cell (25.11.2009)
Published in Cell (25.11.2009)
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Synthesis, Characterization, and Application in HeLa Cells of an NIR Light Responsive Doxorubicin Delivery System Based on NaYF4:Yb,Tm@SiO2‑PEG Nanoparticles
Alonso-Cristobal, Paulino, Oton-Fernandez, Olalla, Mendez-Gonzalez, Diego, Díaz, J. Fernando, Lopez-Cabarcos, Enrique, Barasoain, Isabel, Rubio-Retama, Jorge
Published in ACS applied materials & interfaces (15.07.2015)
Published in ACS applied materials & interfaces (15.07.2015)
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Structural model for differential cap maturation at growing microtubule ends
Estévez-Gallego, Juan, Josa-Prado, Fernando, Ku, Siou, Buey, Ruben M, Balaguer, Francisco A, Prota, Andrea E, Lucena-Agell, Daniel, Kamma-Lorger, Christina, Yagi, Toshiki, Iwamoto, Hiroyuki, Duchesne, Laurence, Barasoain, Isabel, Steinmetz, Michel O, Chrétien, Denis, Kamimura, Shinji, Díaz, J Fernando, Oliva, Maria A
Published in eLife (10.03.2020)
Published in eLife (10.03.2020)
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PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin
Lucena-Agell, Daniel, Guillén, María José, Matesanz, Ruth, Álvarez-Bernad, Beatriz, Hortigüela, Rafael, Avilés, Pablo, Martínez-Díez, Marta, Santamaría-Núñez, Gema, Contreras, Julia, Plaza-Menacho, Iván, Giménez-Abián, Juan F., Oliva, María A., Cuevas, Carmen, Díaz, J. Fernando
Published in Journal of medicinal chemistry (22.02.2024)
Published in Journal of medicinal chemistry (22.02.2024)
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Lateral wedge insoles and their use in ankle instability
Palomo‐Fernández, Inés, Martín‐Casado, Laura, Marcos‐Tejedor, Félix, Aldana‐Caballero, Alberto, Rubio‐Arias, Jacobo. Á., Jiménez‐Díaz, J. Fernando
Published in Scandinavian journal of medicine & science in sports (01.09.2023)
Published in Scandinavian journal of medicine & science in sports (01.09.2023)
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Targeting the tubulin C-terminal tail by charged small molecules
Li, Shuo, Mori, Mattia, Yang, Mingyan, Elfazazi, Soumia, Hortigüela, Rafael, Chan, Peter, Feng, Xinyue, Risinger, April, Yang, Zhiyou, Oliva, María Ángela, Fernando Díaz, J, Fang, Wei-Shuo
Published in Organic & biomolecular chemistry (21.12.2022)
Published in Organic & biomolecular chemistry (21.12.2022)
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Structural insight into the stabilization of microtubules by taxanes
Prota, Andrea E, Lucena-Agell, Daniel, Ma, Yuntao, Estevez-Gallego, Juan, Li, Shuo, Bargsten, Katja, Josa-Prado, Fernando, Altmann, Karl-Heinz, Gaillard, Natacha, Kamimura, Shinji, Mühlethaler, Tobias, Gago, Federico, Oliva, Maria A, Steinmetz, Michel O, Fang, Wei-Shuo, Díaz, J Fernando
Published in eLife (06.03.2023)
Published in eLife (06.03.2023)
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Development of Potent Microtubule Targeting Agent by Structural Simplification of Natural Diazonamide
Kalnins, Toms, Vitkovska, Viktorija, Kazak, Mihail, Zelencova-Gopejenko, Diana, Ozola, Melita, Narvaiss, Nauris, Makrecka-Kuka, Marina, Domračeva, Ilona, Kinens, Artis, Gukalova, Baiba, Konrad, Nele, Aav, Riina, Bonato, Francesca, Lucena-Agell, Daniel, Díaz, J. Fernando, Liepinsh, Edgars, Suna, Edgars
Published in Journal of medicinal chemistry (13.06.2024)
Published in Journal of medicinal chemistry (13.06.2024)
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Self-Organization of FtsZ Polymers in Solution Reveals Spacer Role of the Disordered C-Terminal Tail
Huecas, Sonia, Ramírez-Aportela, Erney, Vergoñós, Albert, Núñez-Ramírez, Rafael, Llorca, Oscar, Díaz, J. Fernando, Juan-Rodríguez, David, Oliva, María A., Castellen, Patricia, Andreu, José M.
Published in Biophysical journal (17.10.2017)
Published in Biophysical journal (17.10.2017)
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Synthesis and Antimitotic and Tubulin Interaction Profiles of Novel Pinacol Derivatives of Podophyllotoxins
Abad, Andrés, López-Pérez, José L, del Olmo, Esther, García-Fernández, Luis F, Francesch, Andrés, Trigili, Chiara, Barasoain, Isabel, Andreu, José M, Díaz, J. Fernando, San Feliciano, Arturo
Published in Journal of medicinal chemistry (09.08.2012)
Published in Journal of medicinal chemistry (09.08.2012)
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Identification of the guanine nucleotide exchange factor for SAR1 in the filamentous fungal model Aspergillus nidulans
Bravo-Plaza, Ignacio, Hernández-González, Miguel, Pinar, Mario, Díaz, J. Fernando, Peñalva, Miguel A.
Published in Biochimica et biophysica acta. Molecular cell research (01.12.2019)
Published in Biochimica et biophysica acta. Molecular cell research (01.12.2019)
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Design and Synthesis of Pironetin Analogue/Colchicine Hybrids and Study of Their Cytotoxic Activity and Mechanisms of Interaction with Tubulin
Vilanova, Concepción, Díaz-Oltra, Santiago, Murga, Juan, Falomir, Eva, Carda, Miguel, Redondo-Horcajo, Mariano, Díaz, J. Fernando, Barasoain, Isabel, Marco, J. Alberto
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
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Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics
Boiarska, Zlata, Pérez‐Peña, Helena, Abel, Anne‐Catherine, Marzullo, Paola, Álvarez‐Bernad, Beatriz, Bonato, Francesca, Santini, Benedetta, Horvath, Dragos, Lucena‐Agell, Daniel, Vasile, Francesca, Sironi, Maurizio, Díaz, J. Fernando, Prota, Andrea E., Pieraccini, Stefano, Passarella, Daniele
Published in Chemistry : a European journal (24.01.2023)
Published in Chemistry : a European journal (24.01.2023)
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Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy
Campiani, Giuseppe, Khan, Tuhina, Ulivieri, Cristina, Staiano, Leopoldo, Papulino, Chiara, Magnano, Stefania, Nathwani, Seema, Ramunno, Anna, Lucena-Agell, Daniel, Relitti, Nicola, Federico, Stefano, Pozzetti, Luca, Carullo, Gabriele, Casagni, Alice, Brogi, Simone, Vanni, Francesca, Galatello, Paola, Ghanim, Magda, McCabe, Niamh, Lamponi, Stefania, Valoti, Massimo, Ibrahim, Ola, O'Sullivan, Jeffrey, Turkington, Richard, Kelly, Vincent P., VanWemmel, Ruben, Díaz, J. Fernando, Gemma, Sandra, Zisterer, Daniela, Altucci, Lucia, De Matteis, Maria Antonietta, Butini, Stefania, Benedetti, Rosaria
Published in European journal of medicinal chemistry (05.05.2022)
Published in European journal of medicinal chemistry (05.05.2022)
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Journal Article
Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics
Boiarska, Zlata, Pérez‐Peña, Helena, Abel, Anne‐Catherine, Marzullo, Paola, Álvarez‐Bernad, Beatriz, Bonato, Francesca, Santini, Benedetta, Horvath, Dragos, Lucena‐Agell, Daniel, Vasile, Francesca, Sironi, Maurizio, Díaz, J. Fernando, Prota, Andrea E., Pieraccini, Stefano, Passarella, Daniele
Published in Chemistry : a European journal (24.01.2023)
Published in Chemistry : a European journal (24.01.2023)
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