Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
Ross, Leila S., Dhingra, Satish K., Mok, Sachel, Yeo, Tomas, Wicht, Kathryn J., Kümpornsin, Krittikorn, Takala-Harrison, Shannon, Witkowski, Benoit, Fairhurst, Rick M., Ariey, Frederic, Menard, Didier, Fidock, David A.
Published in Nature communications (17.08.2018)
Published in Nature communications (17.08.2018)
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Journal Article
Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
Veiga, M. Isabel, Dhingra, Satish K., Henrich, Philipp P., Straimer, Judith, Gnädig, Nina, Uhlemann, Anne-Catrin, Martin, Rowena E., Lehane, Adele M., Fidock, David A.
Published in Nature communications (18.05.2016)
Published in Nature communications (18.05.2016)
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Journal Article
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness
Stokes, Barbara H, Dhingra, Satish K, Rubiano, Kelly, Mok, Sachel, Straimer, Judith, Gnädig, Nina F, Deni, Ioanna, Schindler, Kyra A, Bath, Jade R, Ward, Kurt E, Striepen, Josefine, Yeo, Tomas, Ross, Leila S, Legrand, Eric, Ariey, Frédéric, Cunningham, Clark H, Souleymane, Issa M, Gansané, Adama, Nzoumbou-Boko, Romaric, Ndayikunda, Claudette, Kabanywanyi, Abdunoor M, Uwimana, Aline, Smith, Samuel J, Kolley, Olimatou, Ndounga, Mathieu, Warsame, Marian, Leang, Rithea, Nosten, François, Anderson, Timothy Jc, Rosenthal, Philip J, Ménard, Didier, Fidock, David A
Published in eLife (19.07.2021)
Published in eLife (19.07.2021)
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Journal Article
Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt
Pelleau, Stéphane, Moss, Eli L., Dhingra, Satish K., Volney, Béatrice, Casteras, Jessica, Gabryszewski, Stanislaw J., Volkman, Sarah K., Wirth, Dyann F., Legrand, Eric, Fidock, David A., Neafsey, Daniel E., Musset, Lise
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2015)
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Journal Article
Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance
Small-Saunders, Jennifer L, Hagenah, Laura M, Wicht, Kathryn J, Dhingra, Satish K, Deni, Ioanna, Kim, Jonathan, Vendome, Jeremie, Gil-Iturbe, Eva, Roepe, Paul D, Mehta, Monica, Mancia, Filippo, Quick, Matthias, Eppstein, Margaret J, Fidock, David A
Published in PLoS pathogens (07.02.2022)
Published in PLoS pathogens (07.02.2022)
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Journal Article
Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness
Dhingra, Satish K, Gabryszewski, Stanislaw J, Small-Saunders, Jennifer L, Yeo, Tomas, Henrich, Philipp P, Mok, Sachel, Fidock, David A
Published in mBio (30.04.2019)
Published in mBio (30.04.2019)
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Journal Article
Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology
Gabryszewski, Stanislaw J, Dhingra, Satish K, Combrinck, Jill M, Lewis, Ian A, Callaghan, Paul S, Hassett, Matthew R, Siriwardana, Amila, Henrich, Philipp P, Lee, Andrew H, Gnädig, Nina F, Musset, Lise, Llinás, Manuel, Egan, Timothy J, Roepe, Paul D, Fidock, David A
Published in PLoS pathogens (10.11.2016)
Published in PLoS pathogens (10.11.2016)
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Journal Article
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology
Hagenah, Laura M, Dhingra, Satish K, Small-Saunders, Jennifer L, Qahash, Tarrick, Willems, Andreas, Schindler, Kyra A, Rangel, Gabriel W, Gil-Iturbe, Eva, Kim, Jonathan, Akhundova, Emiliya, Yeo, Tomas, Okombo, John, Mancia, Filippo, Quick, Matthias, Roepe, Paul D, Llinás, Manuel, Fidock, David A
Published in mBio (16.01.2024)
Published in mBio (16.01.2024)
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Journal Article
Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter
Petersen, Ines, Gabryszewski, Stanislaw J., Johnston, Geoffrey L., Dhingra, Satish K., Ecker, Andrea, Lewis, Rebecca E., Almeida, Mariana Justino, Straimer, Judith, Henrich, Philipp P., Palatulan, Eugene, Johnson, David J., Coburn‐Flynn, Olivia, Sanchez, Cecilia, Lehane, Adele M., Lanzer, Michael, Fidock, David A.
Published in Molecular microbiology (01.07.2015)
Published in Molecular microbiology (01.07.2015)
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Journal Article
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT
Kim, Jonathan, Tan, Yong Zi, Wicht, Kathryn J., Erramilli, Satchal K., Dhingra, Satish K., Okombo, John, Vendome, Jeremie, Hagenah, Laura M., Giacometti, Sabrina I., Warren, Audrey L., Nosol, Kamil, Roepe, Paul D., Potter, Clinton S., Carragher, Bridget, Kossiakoff, Anthony A., Quick, Matthias, Fidock, David A., Mancia, Filippo
Published in Nature (London) (12.12.2019)
Published in Nature (London) (12.12.2019)
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Journal Article
Plasmodium falciparum resistance to piperaquine driven by PfCRT
Dhingra, Satish K, Small-Saunders, Jennifer L, Ménard, Didier, Fidock, David A
Published in The Lancet infectious diseases (01.11.2019)
Published in The Lancet infectious diseases (01.11.2019)
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Journal Article
Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study
McCarthy, James S, Yalkinoglu, Özkan, Odedra, Anand, Webster, Rebecca, Oeuvray, Claude, Tappert, Aliona, Bezuidenhout, Deon, Giddins, Marla J, Dhingra, Satish K, Fidock, David A, Marquart, Louise, Webb, Lachlan, Yin, Xiaoyan, Khandelwal, Akash, Bagchus, Wilhelmina M
Published in The Lancet infectious diseases (01.12.2021)
Published in The Lancet infectious diseases (01.12.2021)
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Journal Article
Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor
Rottmann, Matthias, Jonat, Brian, Gumpp, Christin, Dhingra, Satish K, Giddins, Marla J, Yin, Xiaoyan, Badolo, Lassina, Greco, Beatrice, Fidock, David A, Oeuvray, Claude, Spangenberg, Thomas
Published in Antimicrobial agents and chemotherapy (24.03.2020)
Published in Antimicrobial agents and chemotherapy (24.03.2020)
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Journal Article
A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine
Dhingra, Satish K, Redhi, Devasha, Combrinck, Jill M, Yeo, Tomas, Okombo, John, Henrich, Philipp P, Cowell, Annie N, Gupta, Purva, Stegman, Matthew L, Hoke, Jonathan M, Cooper, Roland A, Winzeler, Elizabeth, Mok, Sachel, Egan, Timothy J, Fidock, David A
Published in mBio (09.05.2017)
Published in mBio (09.05.2017)
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Journal Article
Integrative Genetic Manipulation of Plasmodium cynomolgi Reveals Multidrug Resistance-1 Y976F Associated With Increased In Vitro Susceptibility to Mefloquine
Ward, Kurt E, Christensen, Peter, Racklyeft, Annie, Dhingra, Satish K, Chua, Adeline C Y, Remmert, Caroline, Suwanarusk, Rossarin, Matheson, Jessica, Blackman, Michael J, Kaneko, Osamu, Kyle, Dennis E, Lee, Marcus C S, Moon, Robert W, Snounou, Georges, Rénia, Laurent, Fidock, David A, Russell, Bruce, Bifani, Pablo
Published in The Journal of infectious diseases (12.05.2023)
Published in The Journal of infectious diseases (12.05.2023)
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Journal Article
Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlands
van der Plas, Johan L, Kuiper, Vincent P, Bagchus, Wilhelmina M, Bödding, Matthias, Yalkinoglu, Özkan, Tappert, Aliona, Seitzinger, Andrea, Spangenberg, Thomas, Bezuidenhout, Deon, Wilkins, Justin, Oeuvray, Claude, Dhingra, Satish K, Thathy, Vandana, Fidock, David A, Smidt, Lisanne C A, Roozen, Geert V T, Koopman, Jan Pieter R, Lamers, Olivia A C, Sijtsma, Jeroen, van Schuijlenburg, Roos, Wessels, Els, Meij, Pauline, Kamerling, Ingrid M C, Roestenberg, Meta, Khandelwal, Akash
Published in The Lancet infectious diseases (01.10.2023)
Published in The Lancet infectious diseases (01.10.2023)
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Journal Article
Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter
Lee, Andrew H., Dhingra, Satish K., Lewis, Ian A., Singh, Maneesh K., Siriwardana, Amila, Dalal, Seema, Rubiano, Kelly, Klein, Matthias S., Baska, Katelynn S., Krishna, Sanjeev, Klemba, Michael, Roepe, Paul D., Llinás, Manuel, Garcia, Celia R. S., Fidock, David A.
Published in Scientific reports (11.09.2018)
Published in Scientific reports (11.09.2018)
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Journal Article
Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265
White, John, Dhingra, Satish K, Deng, Xiaoyi, El Mazouni, Farah, Lee, Marcus C. S, Afanador, Gustavo A, Lawong, Aloysus, Tomchick, Diana R, Ng, Caroline L, Bath, Jade, Rathod, Pradipsinh K, Fidock, David A, Phillips, Margaret A
Published in ACS infectious diseases (11.01.2019)
Published in ACS infectious diseases (11.01.2019)
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Journal Article
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness
Mok, Sachel, Yeo, Tomas, Hong, Davin, Shears, Melanie J, Ross, Leila S, Ward, Kurt E, Dhingra, Satish K, Kanai, Mariko, Bridgford, Jessica L, Tripathi, Abhai K, Mlambo, Godfree, Burkhard, Anna Y, Ansbro, Megan R, Fairhurst, Kate J, Gil-Iturbe, Eva, Park, Heekuk, Rozenberg, Felix D, Kim, Jonathan, Mancia, Filippo, Fairhurst, Rick M, Quick, Matthias, Uhlemann, Anne-Catrin, Sinnis, Photini, Fidock, David A
Published in Science advances (10.11.2023)
Published in Science advances (10.11.2023)
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Journal Article
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness
Mok, Sachel, Yeo, Tomas, Hong, Davin, Shears, Melanie J, Ross, Leila S, Ward, Kurt E, Dhingra, Satish K, Kanai, Mariko, Bridgford, Jessica L, Tripathi, Abhai K, Mlambo, Godfree, Burkhard, Anna Y, Fairhurst, Kate J, Gil-Iturbe, Eva, Park, Heekuk, Rozenberg, Felix D, Kim, Jonathan, Mancia, Filippo, Quick, Matthias, Uhlemann, Anne-Catrin, Sinnis, Photini, Fidock, David A
Published in bioRxiv (03.06.2023)
Published in bioRxiv (03.06.2023)
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Journal Article