Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference
Heinzer, Daniel, Avar, Merve, Pease, Daniel Patrick, Dhingra, Ashutosh, Yin, Jiang-An, Schaper, Elke, Doğançay, Berre, Emmenegger, Marc, Spinelli, Anna, Maggi, Kevin, Chincisan, Andra, Mead, Simon, Hornemann, Simone, Heutink, Peter, Aguzzi, Adriano
Published in PLoS pathogens (01.10.2021)
Published in PLoS pathogens (01.10.2021)
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Journal Article
C9orf72 is differentially expressed in the central nervous system and myeloid cells and consistently reduced in C9orf72, MAPT and GRN mutation carriers
Rizzu, Patrizia, Blauwendraat, Cornelis, Heetveld, Sasja, Lynes, Emily M, Castillo-Lizardo, Melissa, Dhingra, Ashutosh, Pyz, Elwira, Hobert, Markus, Synofzik, Matthis, Simón-Sánchez, Javier, Francescatto, Margherita, Heutink, Peter
Published in Acta neuropathologica communications (14.04.2016)
Published in Acta neuropathologica communications (14.04.2016)
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Journal Article
A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes
Menden, Kevin, Francescatto, Margherita, Nyima, Tenzin, Blauwendraat, Cornelis, Dhingra, Ashutosh, Castillo-Lizardo, Melissa, Fernandes, Noémia, Kaurani, Lalit, Kronenberg-Versteeg, Deborah, Atasu, Burcu, Sadikoglou, Eldem, Borroni, Barbara, Rodriguez-Nieto, Salvador, Simon-Sanchez, Javier, Fischer, Andre, Craig, David Wesley, Neumann, Manuela, Bonn, Stefan, Rizzu, Patrizia, Heutink, Peter
Published in Scientific data (01.12.2023)
Published in Scientific data (01.12.2023)
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Journal Article
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2
Ging, Kathi, Frick, Lukas, Schlachetzki, Johannes, Armani, Andrea, Zhu, Yanping, Gilormini, Pierre-André, Dhingra, Ashutosh, Böck, Desirée, Marques, Ana, Deen, Matthew, Chen, Xi, Serdiuk, Tetiana, Trevisan, Chiara, Sellitto, Stefano, Pisano, Claudio, Glass, Christopher K., Heutink, Peter, Yin, Jiang-An, Vocadlo, David J., Aguzzi, Adriano
Published in NPJ Parkinson's Disease (22.10.2024)
Published in NPJ Parkinson's Disease (22.10.2024)
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Journal Article
iPS Cell-Based Model for MAPT Haplotype as a Risk Factor for Human Tauopathies Identifies No Major Differences in TAU Expression
Strauß, Tabea, Marvian-Tayaranian, Amir, Sadikoglou, Eldem, Dhingra, Ashutosh, Wegner, Florian, Trümbach, Dietrich, Wurst, Wolfgang, Heutink, Peter, Schwarz, Sigrid C, Höglinger, Günter U
Published in Frontiers in cell and developmental biology (31.08.2021)
Published in Frontiers in cell and developmental biology (31.08.2021)
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Journal Article
Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression
Reinhardt, Peter, Schmid, Benjamin, Burbulla, Lena F., Schöndorf, David C., Wagner, Lydia, Glatza, Michael, Höing, Susanne, Hargus, Gunnar, Heck, Susanna A., Dhingra, Ashutosh, Wu, Guangming, Müller, Stephan, Brockmann, Kathrin, Kluba, Torsten, Maisel, Martina, Krüger, Rejko, Berg, Daniela, Tsytsyura, Yaroslav, Thiel, Cora S., Psathaki, Olympia-Ekaterini, Klingauf, Jürgen, Kuhlmann, Tanja, Klewin, Marlene, Müller, Heiko, Gasser, Thomas, Schöler, Hans R., Sterneckert, Jared
Published in Cell stem cell (07.03.2013)
Published in Cell stem cell (07.03.2013)
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A Pentanucleotide ATTTC Repeat Insertion in the Non-coding Region of DAB1, Mapping to SCA37, Causes Spinocerebellar Ataxia
Seixas, Ana I., Loureiro, Joana R., Costa, Cristina, Ordóñez-Ugalde, Andrés, Marcelino, Hugo, Oliveira, Cláudia L., Loureiro, José L., Dhingra, Ashutosh, Brandão, Eva, Cruz, Vitor T., Timóteo, Angela, Quintáns, Beatriz, Rouleau, Guy A., Rizzu, Patrizia, Carracedo, Ángel, Bessa, José, Heutink, Peter, Sequeiros, Jorge, Sobrido, Maria J., Coutinho, Paula, Silveira, Isabel
Published in American journal of human genetics (06.07.2017)
Published in American journal of human genetics (06.07.2017)
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Journal Article
Novel regulators of PrP.sup.C biosynthesis revealed by genome-wide RNA interference
Heinzer, Daniel, Avar, Merve, Pease, Daniel Patrick, Dhingra, Ashutosh, Yin, Jiang-An, Schaper, Elke, Dogançay, Berre, Emmenegger, Marc, Spinelli, Anna, Maggi, Kevin, Chincisan, Andra, Mead, Simon, Hornemann, Simone, Heutink, Peter, Aguzzi, Adriano
Published in PLoS pathogens (27.10.2021)
Published in PLoS pathogens (27.10.2021)
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Journal Article
Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference
Daniel Heinzer, Merve Avar, Daniel Patrick Pease, Ashutosh Dhingra, Jiang-An Yin, Elke Schaper, Berre Doğançay, Marc Emmenegger, Anna Spinelli, Kevin Maggi, Andra Chincisan, Simon Mead, Simone Hornemann, Peter Heutink, Adriano Aguzzi
Published in PLoS pathogens (01.10.2021)
Published in PLoS pathogens (01.10.2021)
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Journal Article
Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G 4 C 2 ) n expression in C9orf72 ALS/FTD
Czuppa, Mareike, Dhingra, Ashutosh, Zhou, Qihui, Schludi, Carina, König, Laura, Scharf, Elisabeth, Farny, Daniel, Dalmia, Anupriya, Täger, Joachim, Castillo-Lizardo, Melissa, Katona, Eszter, Mori, Kohji, Aumer, Tina, Schelter, Florian, Müller, Markus, Carell, Thomas, Kalliokoski, Tuomo, Messinger, Josef, Rizzu, Patrizia, Heutink, Peter, Edbauer, Dieter
Published in Cell reports (Cambridge) (07.06.2022)
Published in Cell reports (Cambridge) (07.06.2022)
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Automated Production of Human Induced Pluripotent Stem Cell-Derived Cortical and Dopaminergic Neurons with Integrated Live-Cell Monitoring
Dhingra, Ashutosh, Täger, Joachim, Bressan, Elisangela, Rodriguez-Nieto, Salvador, Bedi, Manmeet-Sakshi, Bröer, Stefanie, Sadikoglou, Eldem, Fernandes, Noémia, Castillo-Lizardo, Melissa, Rizzu, Patrizia, Heutink, Peter
Published in Journal of visualized experiments (06.08.2020)
Published in Journal of visualized experiments (06.08.2020)
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Journal Article
Automated Production of Human Induced Pluripotent Stem Cell-Derived Cortical and Dopaminergic Neurons with Integrated Live-Cell Monitoring
Dhingra, Ashutosh, Täger, Joachim, Bressan, Elisangela, Rodriguez-Nieto, Salvador, Bedi, Manmeet-Sakshi, Bröer, Stefanie, Sadikoglou, Eldem, Fernandes, Noémia, Castillo-Lizardo, Melissa, Rizzu, Patrizia, Heutink, Peter
Published in Journal of visualized experiments (06.08.2020)
Published in Journal of visualized experiments (06.08.2020)
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Journal Article
In Vitro Differentiated Human Stem Cell-Derived Neurons Reproduce Synaptic Synchronicity Arising during Neurodevelopment
Rosa, Filip, Dhingra, Ashutosh, Uysal, Betül, Mendis, G. Dulini C., Loeffler, Heidi, Elsen, Gina, Mueller, Stephan, Schwarz, Niklas, Castillo-Lizardo, Melissa, Cuddy, Claire, Becker, Felicitas, Heutink, Peter, Reid, Christopher A., Petrou, Steven, Lerche, Holger, Maljevic, Snezana
Published in Stem cell reports (14.07.2020)
Published in Stem cell reports (14.07.2020)
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Journal Article
Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis
Pal, Arun, Kretner, Benedikt, Abo-Rady, Masin, Glaβ, Hannes, Dash, Banaja P, Naumann, Marcel, Japtok, Julia, Kreiter, Nicole, Dhingra, Ashutosh, Heutink, Peter, Böckers, Tobias M, Günther, René, Sterneckert, Jared, Hermann, Andreas
Published in Life science alliance (01.04.2021)
Published in Life science alliance (01.04.2021)
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Journal Article
Rescue of the increased susceptibility to Mild Chronic Oxidative Stress of iNeurons carrying the MAPT Chromosome 17q21.3 H1/H1 risk allele by FDA-approved compounds
Eldem Sadikoglou, Domingo-Fernandez, Daniel, Savytska, Natalia, Fernandes, Noemia, Rizzu, Patrizia, Illarionova, Anastasia, Strauss, Tabea, Schwarz, Sigrid, Kodamullil, Alpha, Hoeglinger, Guenter, Dhingra, Ashutosh, Heutink, Peter
Published in bioRxiv (07.11.2022)
Published in bioRxiv (07.11.2022)
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Paper
Robust and Versatile Arrayed Libraries for Human Genome-Wide CRISPR Activation, Deletion and Silencing
Jiang-An, Yin, Frick, Lukas, Scheidmann, Manuel C, Trevisan, Chiara, Dhingra, Ashutosh, Spinelli, Anna, Wu, Yancheng, Yao, Longping, Vena, Dalila Laura, De Cecco, Elena, Ging, Kathi, Liu, Tingting, Tager, Joachim, Rodriguez, Salvador, Guo, Jingjing, Berry, Scott, Losa, Marco, Hornemann, Simone, Kampmann, Martin, Lucas Pelkmans, Hoepfner, Dominic, Heutink, Peter, Aguzzi, Adriano
Published in bioRxiv (25.05.2022)
Published in bioRxiv (25.05.2022)
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Paper
The landscape of PrPC biosynthesis revealed by an arrayed genome-wide interference screen
Heinzer, Daniel, Avar, Merve, Pease, Daniel Patrick, Dhingra, Ashutosh, Jiang-An, Yin, Schaper, Elke, Berre Doğançay, Emmenegger, Marc, Spinelli, Anna, Maggi, Kevin, Chincisan, Andra, Mead, Simon, Hornemann, Simone, Heutink, Peter, Aguzzi, Adriano
Published in bioRxiv (24.02.2021)
Published in bioRxiv (24.02.2021)
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Paper
Integrated multi-omics analysis reveals common and distinct dysregulated pathways for genetic subtypes of Frontotemporal Dementia
Menden, Kevin, Francescatto, Margherita, Nyima, Tenzin, Blauwendraat, Cornelis, Dhingra, Ashutosh, Castillo-Lizardo, Melissa, Fernandes, Noémia, Kaurani, Lalit, Kronenberg-Versteeg, Deborah, Atarsu, Burcu, Eldem Sadikoglou, Borroni, Barbara, Rodriguez-Nieto, Salvador, Simon-Sanchez, Javier, Fischer, Andre, Craig, David Wesley, Neumann, Manuela, Bonn, Stefan, Rizzu, Patrizia, Heutink, Peter
Published in bioRxiv (12.03.2021)
Published in bioRxiv (12.03.2021)
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