Design of an in vitro biocatalytic cascade for the manufacture of islatravir
Huffman, Mark A, Fryszkowska, Anna, Alvizo, Oscar, Borra-Garske, Margie, Campos, Kevin R, Canada, Keith A, Devine, Paul N, Duan, Da, Forstater, Jacob H, Grosser, Shane T, Halsey, Holst M, Hughes, Gregory J, Jo, Junyong, Joyce, Leo A, Kolev, Joshua N, Liang, Jack, Maloney, Kevin M, Mann, Benjamin F, Marshall, Nicholas M, McLaughlin, Mark, Moore, Jeffrey C, Murphy, Grant S, Nawrat, Christopher C, Nazor, Jovana, Novick, Scott, Patel, Niki R, Rodriguez-Granillo, Agustina, Robaire, Sandra A, Sherer, Edward C, Truppo, Matthew D, Whittaker, Aaron M, Verma, Deeptak, Xiao, Li, Xu, Yingju, Yang, Hao
Published in Science (American Association for the Advancement of Science) (06.12.2019)
Published in Science (American Association for the Advancement of Science) (06.12.2019)
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Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture
Savile, Christopher K., Janey, Jacob M., Mundorff, Emily C., Moore, Jeffrey C., Tam, Sarena, Jarvis, William R., Colbeck, Jeffrey C., Krebber, Anke, Fleitz, Fred J., Brands, Jos, Devine, Paul N., Huisman, Gjalt W., Hughes, Gregory J.
Published in Science (American Association for the Advancement of Science) (16.07.2010)
Published in Science (American Association for the Advancement of Science) (16.07.2010)
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Advances in the Enzymatic Reduction of Ketones
Moore, Jeffrey C, Pollard, David J, Kosjek, Birgit, Devine, Paul N
Published in Accounts of chemical research (01.12.2007)
Published in Accounts of chemical research (01.12.2007)
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Hemoprotein‐Catalyzed Cyclopropanation En Route to the Chiral Cyclopropanol Fragment of Grazoprevir
Kim, Taejin, Kassim, Amude M., Botejue, Ajit, Zhang, Chen, Forte, Jared, Rozzell, David, Huffman, Mark A., Devine, Paul N., McIntosh, John A.
Published in Chembiochem : a European journal of chemical biology (02.05.2019)
Published in Chembiochem : a European journal of chemical biology (02.05.2019)
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Diastereoselective Reductive Amination of Aryl Trifluoromethyl Ketones and α-Amino Esters
Hughes, Greg, Devine, Paul N., Naber, John R., O'Shea, Paul D., Foster, Bruce S., McKay, Daniel J., Volante, R. P.
Published in Angewandte Chemie International Edition (01.01.2007)
Published in Angewandte Chemie International Edition (01.01.2007)
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Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-b][1,2,4]triazine: Synthesis of an α2/ 3-Selective GABA Agonist
Gauthier, Donald R, Limanto, John, Devine, Paul N, Desmond, Richard A, Szumigala, Ronald H, Foster, Bruce S, Volante, R. P
Published in Journal of organic chemistry (22.07.2005)
Published in Journal of organic chemistry (22.07.2005)
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Efficient Synthesis of NK1 Receptor Antagonist Aprepitant Using a Crystallization-Induced Diastereoselective Transformation
Brands, Karel M. J, Payack, Joseph F, Rosen, Jonathan D, Nelson, Todd D, Candelario, Alexander, Huffman, Mark A, Zhao, Matthew M, Li, Jing, Craig, Bridgette, Song, Zhiguo J, Tschaen, David M, Hansen, Karl, Devine, Paul N, Pye, Philip J, Rossen, Kai, Dormer, Peter G, Reamer, Robert A, Welch, Christopher J, Mathre, David J, Tsou, Nancy N, McNamara, James M, Reider, Paul J
Published in Journal of the American Chemical Society (26.02.2003)
Published in Journal of the American Chemical Society (26.02.2003)
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Journal Article
A kinase-cGAS cascade to synthesize a therapeutic STING activator
McIntosh, John A., Liu, Zhijian, Andresen, Brian M., Marzijarani, Nastaran Salehi, Moore, Jeffrey C., Marshall, Nicholas M., Borra-Garske, Margie, Obligacion, Jennifer V., Fier, Patrick S., Peng, Feng, Forstater, Jacob H., Winston, Matthew S., An, Chihui, Chang, Wonsuk, Lim, Jongwon, Huffman, Mark A., Miller, Steven P., Tsay, Fuh-Rong, Altman, Michael D., Lesburg, Charles A., Steinhuebel, Dietrich, Trotter, B. Wesley, Cumming, Jared N., Northrup, Alan, Bu, Xiaodong, Mann, Benjamin F., Biba, Mirlinda, Hiraga, Kaori, Murphy, Grant S., Kolev, Joshua N., Makarewicz, Amanda, Pan, Weilan, Farasat, Iman, Bade, Rachel S., Stone, Kevin, Duan, Da, Alvizo, Oscar, Adpressa, Donovan, Guetschow, Erik, Hoyt, Erik, Regalado, Erik L., Castro, Steve, Rivera, Nelo, Smith, Joseph P., Wang, Fengqiang, Crespo, Alejandro, Verma, Deeptak, Axnanda, Stephanus, Dance, Zachary E. X., Devine, Paul N., Tschaen, David, Canada, Keith A., Bulger, Paul G., Sherry, Benjamin D., Truppo, Matthew D., Ruck, Rebecca T., Campeau, Louis-Charles, Bennett, David Jonathan, Humphrey, Guy R., Campos, Kevin R., Maddess, Matthew L.
Published in Nature (London) (17.03.2022)
Published in Nature (London) (17.03.2022)
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A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins
Fryszkowska, Anna, An, Chihui, Alvizo, Oscar, Banerjee, Goutami, Canada, Keith A., Cao, Yang, DeMong, Duane, Devine, Paul N., Duan, Da, Elgart, David M., Farasat, Iman, Gauthier, Donald R., Guidry, Erin N., Jia, Xiujuan, Kong, Jongrock, Kruse, Nikki, Lexa, Katrina W., Makarov, Alexey A., Mann, Benjamin F., Milczek, Erika M., Mitchell, Vesna, Nazor, Jovana, Neri, Claudia, Orr, Robert K., Orth, Peter, Phillips, Eric M., Riggins, James N., Schafer, Wes A., Silverman, Steven M., Strulson, Christopher A., Subramanian, Nandhitha, Voladri, Rama, Yang, Hao, Yang, Jie, Yi, Xiang, Zhang, Xiyun, Zhong, Wendy
Published in Science (American Association for the Advancement of Science) (17.06.2022)
Published in Science (American Association for the Advancement of Science) (17.06.2022)
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Convergent Kilogram-Scale Synthesis of Dual Orexin Receptor Antagonist
Girardin, Mélina, Ouellet, Stéphane G, Gauvreau, Danny, Moore, Jeffrey C, Hughes, Greg, Devine, Paul N, O’Shea, Paul D, Campeau, Louis-Charles
Published in Organic process research & development (18.01.2013)
Published in Organic process research & development (18.01.2013)
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Asymmetric Synthesis of cis-2,5-Disubstituted Pyrrolidine, the Core Scaffold of β3‑AR Agonists
Xu, Feng, Chung, John Y. L, Moore, Jeffery C, Liu, Zhuqing, Yoshikawa, Naoki, Hoerrner, R. Scott, Lee, Jaemoon, Royzen, Maksim, Cleator, Ed, Gibson, Andrew G, Dunn, Robert, Maloney, Kevin M, Alam, Mahbub, Goodyear, Adrian, Lynch, Joseph, Yasuda, Nobuyashi, Devine, Paul N
Published in Organic letters (15.03.2013)
Published in Organic letters (15.03.2013)
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Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle
Song, Zhiguo J, Tellers, David M, Journet, Michel, Kuethe, Jeffrey T, Lieberman, David, Humphrey, Guy, Zhang, Fei, Peng, Zhihui, Waters, Marjorie S, Zewge, Daniel, Nolting, Andrew, Zhao, Dalian, Reamer, Robert A, Dormer, Peter G, Belyk, Kevin M, Davies, Ian W, Devine, Paul N, Tschaen, David M
Published in Journal of organic chemistry (07.10.2011)
Published in Journal of organic chemistry (07.10.2011)
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Journal Article
Chemo- and Enantioselective Routes to Chiral Fluorinated Hydroxyketones Using Ketoreductases
Grau, Brendan T, Devine, Paul N, DiMichele, Lisa N, Kosjek, Birgit
Published in Organic letters (22.11.2007)
Published in Organic letters (22.11.2007)
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Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation
Song, Zhiguo J, Tellers, David M, Dormer, Peter G, Zewge, Daniel, Janey, Jacob M, Nolting, Andrew, Steinhuebel, Dietrich, Oliver, Steven, Devine, Paul N, Tschaen, David M
Published in Organic process research & development (21.03.2014)
Published in Organic process research & development (21.03.2014)
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Journal Article
Production of ( S ) - γ -fluoroleucine ethyl ester by enzyme mediated dynamic kinetic resolution: Comparison of batch and fed batch stirred tank processes to a packed bed column reactor
Truppo, Matthew D., Pollard, David J., Moore, Jeffrey C., Devine, Paul N.
Published in Chemical engineering science (2008)
Published in Chemical engineering science (2008)
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