Functional interpretation of single cell similarity maps
DeTomaso, David, Jones, Matthew G, Subramaniam, Meena, Ashuach, Tal, Ye, Chun J, Yosef, Nir
Published in Nature communications (26.09.2019)
Published in Nature communications (26.09.2019)
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Journal Article
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity
Wagner, Allon, Wang, Chao, Fessler, Johannes, DeTomaso, David, Avila-Pacheco, Julian, Kaminski, James, Zaghouani, Sarah, Christian, Elena, Thakore, Pratiksha, Schellhaass, Brandon, Akama-Garren, Elliot, Pierce, Kerry, Singh, Vasundhara, Ron-Harel, Noga, Douglas, Vivian Paraskevi, Bod, Lloyd, Schnell, Alexandra, Puleston, Daniel, Sobel, Raymond A., Haigis, Marcia, Pearce, Erika L., Soleimani, Manoocher, Clish, Clary, Regev, Aviv, Kuchroo, Vijay K., Yosef, Nir
Published in Cell (05.08.2021)
Published in Cell (05.08.2021)
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Journal Article
Performance Assessment and Selection of Normalization Procedures for Single-Cell RNA-Seq
Cole, Michael B., Risso, Davide, Wagner, Allon, DeTomaso, David, Ngai, John, Purdom, Elizabeth, Dudoit, Sandrine, Yosef, Nir
Published in Cell systems (24.04.2019)
Published in Cell systems (24.04.2019)
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Journal Article
259 Discovery of synthetic signaling pathway receptors that increase the potency of CAR-T cells through optimized STAT activity
Gardner, Thomas J, Millare, Beatriz, Yao, Anzhi, Chen, Lan, Cass, Ashley, Mohanty, Suchismita, Chen, Jeremy, Gomez, Alma, DeTomaso, David, Ku, Manching, Berthoin, Lionel, Lim, Meng, Ong, Azalea, Thomas, Vince, Quant, Nicholas, Hsu, Brian, Casbon, Amy-Jo, Bezman, Natalie, Cooper, Aaron, Gray-Rupp, Levi, Boroughs, Angela, Nicholas Haining, W
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
213 AB-X integrated circuit T cells demonstrate improved potency, expansion, and specificity compared to MSLN CAR T cells
Santoro, Stephen, Cooper, Aaron, Bezman, Natalie, Feng, Jun, Chawla, Kanika, Williams, Jaspar, Gagnon, John, Hall, Jason, Polyak, Dina, Boroughs, Angela, Nguyen, Michelle, Mohanty, Suchismita, Litterman, Adam, Granja, Jeff, DeTomaso, David, Zheng, Grace, Smith, Jenessa, LeFace, Drake, Mikkelsen, Tarjei, Jun, Susie
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling
Pawlak, Mathias, DeTomaso, David, Schnell, Alexandra, Meyer Zu Horste, Gerd, Lee, Youjin, Nyman, Jackson, Dionne, Danielle, Regan, Brianna M L, Singh, Vasundhara, Delorey, Toni, Schramm, Markus A, Wang, Chao, Wallrapp, Antonia, Burkett, Patrick R, Riesenfeld, Samantha J, Anderson, Ana C, Regev, Aviv, Xavier, Ramnik J, Yosef, Nir, Kuchroo, Vijay K
Published in Immunity (Cambridge, Mass.) (13.09.2022)
Published in Immunity (Cambridge, Mass.) (13.09.2022)
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Journal Article
Cell-specific metabolic models reveal novel metabolic regulators of Th17 pathogenicity: from single-cell RNA-Seq to actionable metabolic targets
Wagner, Allon, Wang, Chao, DeTomaso, David, Koul, Arman, Regev, Aviv, Kuchroo, Vijay K., Yosef, Nir
Published in The Journal of immunology (1950) (01.05.2018)
Published in The Journal of immunology (1950) (01.05.2018)
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Journal Article
In Silico Modeling of Metabolic State in Single Th17 Cells Reveals Novel Regulators of Inflammation and Autoimmunity
Wagner, Allon, Wang, Chao, DeTomaso, David, Pacheco, Julian Avila, Zaghouani, Sarah, Fessler, Johannes, Akama-Garren, Elliot, Pierce, Kerry, Ron-Harel, Noga, Haigis, Marcia, Sobel, Raymond A, Clish, Clary, Regev, Aviv, Kuchroo, Vijay K, Yosef, Nir
Published in The Journal of immunology (1950) (01.05.2020)
Published in The Journal of immunology (1950) (01.05.2020)
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Journal Article
Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity
Kohnz, Rebecca A, Roberts, Lindsay S, DeTomaso, David, Bideyan, Lara, Yan, Peter, Bandyopadhyay, Sourav, Goga, Andrei, Yosef, Nir, Nomura, Daniel K
Published in ACS chemical biology (19.08.2016)
Published in ACS chemical biology (19.08.2016)
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Journal Article
Abstract 7034: Pooled CRISPR screening coupled with single-cell sequencing identifies modifiers of CAR T cell state in the context of chronic antigen stimulation
Joshi, Sahil, Wozniak, Glenn, Gagnon, John, Vucci, Kristina, Merrell, Allyson, Simon, Mandi, Oh, Catherine, Cardozo, Andrew, DeTomaso, David, Chow, Julie, Zheng, Grace, Boroughs, Angela, Joho, Keith, Thakore, Pratiksha, Oh, Soyoung, Freimer, Jake, Cass, Ashley, Sail, Vibhavari, Tocchini, Carla, Sandoval, Marian, Liu, Andrea, Cui, Eric, Drever, Matt, Galvin, Brendan, Milush, Jeff, Gray-Rupp, Levi, Wheeler, Emily, Chen, Bob, Levine, Jacob, Eidenschenk, Celine, Schartner, Jill, Geiger-Schuller, Katie, Huetter, Jan-Christian, Rutz, Sascha, Rozenblatt-Rosen, Orit, Mellman, Ira, Haining, W. Nicholas
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract 4073: Tunable STAT activation by synthetic pathway activators (SPAs) increases engineered T-cell potency and persistence
Gardner, Thomas J., Millare, Beatriz, Yao, Anzhi, Cass, Ashley, Mohanty, Suchismita, Chen, Jeremy, Gomez, Alma, DeTomaso, David, Ku, Manching, Berthoin, Lionel, Lim, Meng, Ong, Azalea, Thomas, Vince, Quant, Nicholas, Hsu, Brian, Casbon, Amy-Jo, Bezman, Natalie, Cooper, Aaron, Gray-Rupp, Levi, Boroughs, Angela C., Haining, W. Nicholas
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Abstract 2830: Multiplexed shRNAs targeting FAS and PTPN2 enhance CAR T persistence and anti-tumor efficacy
Gagnon, John, Litterman, Adam J., Hall, Jason A., Polyak, Dina, Zhou, Stanley, Joshi, Sahil, Takacsi-Nagy, Oliver, Pope, Hans, silva, luisa, Singh, brenal K., Granja, jeffrey M., DeTomaso, david, Aristil-Lepe, Edgar, Tan, Michelle, Galvin, Brendan, Zheng, Grace X., Santoro, Stephen, Cooper, Aaron, Bezman, Natalie, Haining, W Nicholas
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
The glycolytic reaction PGAM unexpectedly restrains Th17 pathogenicity and Th17-dependent autoimmunity
Wang, Chao, Wagner, Allon, Fessler, Johannes, DeTomaso, David, Zaghouani, Sarah, Zhou, Yulin, Pierce, Kerry, Sobel, Raymond A, Clish, Clary, Yosef, Nir, Kuchroo, Vijay K
Published in bioRxiv (19.08.2024)
Published in bioRxiv (19.08.2024)
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Journal Article
IMMUNE CELLS WITH COMBINATION GENE PERTURBATIONS
LITTERMAN, Adam, WILLIAMS, Samuel, GRAY-RUPP, Levi, SINGH, Brenal, DETOMASO, David, CASS, Ashley, GAGNON, John
Year of Publication 25.04.2024
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Year of Publication 25.04.2024
Patent
MODULATION OF A PATHOGENIC PHENOTYPE IN TH1 CELLS
KUCHROO, Vijay, YOSEF, Nir, XAVIER, Ramnik, PAWLAK, Mathias, DETOMASO, David
Year of Publication 28.07.2022
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Year of Publication 28.07.2022
Patent
MODULATION OF A PATHOGENIC PHENOTYPE IN TH1 CELLS
Pawlak, Mathias, Kuchroo, Vijay K, Yosef, Nir, Xavier, Ramnik, DeTomaso, David
Year of Publication 04.04.2024
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Year of Publication 04.04.2024
Patent