Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5-and hypoxia-dependent upregulation of AXL
Dumas, Pierre-Yves, Naudin, Cécile, Martin-Lannerée, Séverine, Izac, Brigitte, Casetti, Luana, Mansier, Olivier, Rousseau, Benoît, Artus, Alexandre, Dufossée, Mélody, Giese, Alban, Dubus, Pierre, Pigneux, Arnaud, Praloran, Vincent, Bidet, Audrey, Villacreces, Arnaud, Guitart, Amélie, Milpied, Noël, Kosmider, Olivier, Vigon, Isabelle, Desplat, Vanessa, Dusanter-Fourt, Isabelle, Pasquet, Jean-Max
Published in Haematologica (Roma) (01.10.2019)
Published in Haematologica (Roma) (01.10.2019)
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Dual Inhibition of FLT3 and AXL by Gilteritinib Overcomes Hematopoietic Niche-Driven Resistance Mechanisms in FLT3 -ITD Acute Myeloid Leukemia
Dumas, Pierre-Yves, Villacreces, Arnaud, Guitart, Amélie V, El-Habhab, Ali, Massara, Layal, Mansier, Olivier, Bidet, Audrey, Martineau, Delphine, Fernandez, Solene, Leguay, Thibaut, Pigneux, Arnaud, Vigon, Isabelle, Pasquet, Jean-Max, Desplat, Vanessa
Published in Clinical cancer research (01.11.2021)
Published in Clinical cancer research (01.11.2021)
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Targeting Tyrosine Kinases in Acute Myeloid Leukemia: Why, Who and How?
Fernandez, Solène, Desplat, Vanessa, Villacreces, Arnaud, Guitart, Amélie V, Milpied, Noël, Pigneux, Arnaud, Vigon, Isabelle, Pasquet, Jean-Max, Dumas, Pierre-Yves
Published in International journal of molecular sciences (12.07.2019)
Published in International journal of molecular sciences (12.07.2019)
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A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection
Saleh, Rosine, Wedeh, Ghaith, Herrmann, Harald, Bibi, Siham, Cerny-Reiterer, Sabine, Sadovnik, Irina, Blatt, Katharina, Hadzijusufovic, Emir, Jeanningros, Sylvie, Blanc, Catherine, Legarff-Tavernier, Magali, Chapiro, Elise, Nguyen-Khac, Florence, Subra, Frédéric, Bonnemye, Patrick, Dubreuil, Patrice, Desplat, Vanessa, Merle-Béral, Hélène, Willmann, Michael, Rülicke, Thomas, Valent, Peter, Arock, Michel
Published in Blood (03.07.2014)
Published in Blood (03.07.2014)
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Design, Synthesis and Biological Evaluation of New Substituted Diquinolinyl-Pyridine Ligands as Anticancer Agents by Targeting G-Quadruplex
Das, Rabindra Nath, Chevret, Edith, Desplat, Vanessa, Rubio, Sandra, Mergny, Jean-Louis, Guillon, Jean
Published in Molecules (Basel, Switzerland) (30.12.2017)
Published in Molecules (Basel, Switzerland) (30.12.2017)
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New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: Synthesis, and in vitro antimalarial activity – Part II
Guillon, Jean, Mouray, Elisabeth, Moreau, Stéphane, Mullié, Catherine, Forfar, Isabelle, Desplat, Vanessa, Belisle-Fabre, Solene, Pinaud, Noël, Ravanello, François, Le-Naour, Augustin, Léger, Jean-Michel, Gosmann, Grace, Jarry, Christian, Déléris, Gérard, Sonnet, Pascal, Grellier, Philippe
Published in European journal of medicinal chemistry (01.06.2011)
Published in European journal of medicinal chemistry (01.06.2011)
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Synthesis, Crystal Structure and Anti-Leukemic Activity of 1,3-Dihydro-1-{1-[4-(4-phenylpyrrolo[1,2-a]quinoxalin-3-yl)benzyl]piperidin-4-yl}-2H-benzimidazol-2-one
Guillon, Jean, Savrimoutou, Solène, Albenque-Rubio, Sandra, Pinaud, Noël, Moreau, Stéphane, Desplat, Vanessa
Published in MolBank (01.03.2022)
Published in MolBank (01.03.2022)
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New 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazoline and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinoline Derivatives: Synthesis and Biological Evaluation as Novel Anticancer Agents by Targeting G-Quadruplex
Guillon, Jean, Le Borgne, Marc, Milano, Vittoria, Guédin-Beaurepaire, Aurore, Moreau, Stéphane, Pinaud, Noël, Ronga, Luisa, Savrimoutou, Solène, Albenque-Rubio, Sandra, Marchivie, Mathieu, Kalout, Haouraa, Walker, Charley, Chevallier, Louise, Buré, Corinne, Largy, Eric, Gabelica, Valérie, Mergny, Jean-Louis, Baylot, Virginie, Ferrer, Jacky, Idrissi, Yamina, Chevret, Edith, Cappellen, David, Desplat, Vanessa, Schelz, Zsuzsanna, Zupkó, István
Published in Pharmaceuticals (Basel, Switzerland) (01.01.2024)
Published in Pharmaceuticals (Basel, Switzerland) (01.01.2024)
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Synthesis, Crystal Structure and Anti-Leukemic Activity of (E)-Pyrrolo[1,2-a]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
Guillon, Jean, Savrimoutou, Solène, Albenque-Rubio, Sandra, Pinaud, Noël, Fillová, Nina, Moreau, Stéphane, Baylot, Virginie, Desplat, Vanessa
Published in MolBank (01.09.2023)
Published in MolBank (01.09.2023)
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1-Methyl-3-{4-[(4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole
Guillon, Jean, Savrimoutou, Solène, Rubio, Sandra, Desplat, Vanessa
Published in MolBank (01.12.2018)
Published in MolBank (01.12.2018)
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Journal Article
1-Phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity
Guillon, Jean, Savrimoutou, Solène, Rubio, Sandra, Moreau, Stéphane, Pinaud, Noël, Marchivie, Mathieu, Desplat, Vanessa
Published in MolBank (01.03.2020)
Published in MolBank (01.03.2020)
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Journal Article
Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II
Desplat, Vanessa, Moreau, Stephane, Gay, Aurore, Fabre, Solene Belisle, Thiolat, Denis, Massip, Stephane, Macky, Gregory, Godde, Frederic, Mossalayi, Djavad, Jarry, Christian, Guillon, Jean
Published in Journal of enzyme inhibition and medicinal chemistry (01.04.2010)
Published in Journal of enzyme inhibition and medicinal chemistry (01.04.2010)
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CD23 Mediates Antimycobacterial Activity of Human Macrophages
Mossalayi, M. Djavad, Vouldoukis, Ioannis, Mamani-Matsuda, Maria, Kauss, Tina, Guillon, Jean, Maugein, Jeanne, Moynet, Daniel, Rambert, Jérôme, Desplat, Vanessa, Mazier, Dominique, Vincendeau, Philippe, Malvy, Denis
Published in Infection and Immunity (01.12.2009)
Published in Infection and Immunity (01.12.2009)
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Journal Article
Prothrombotic and Hemorrhagic Effects of Aspirin
Aguejouf, Omar, Eizayaga, Francisco, Desplat, Vanessa, Belon, Philippe, Doutremepuich, Christian
Published in Clinical and applied thrombosis/hemostasis (01.10.2009)
Published in Clinical and applied thrombosis/hemostasis (01.10.2009)
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Molecular blocking of CD23 supports its role in the pathogenesis of arthritis
Rambert, Jérôme, Mamani-Matsuda, Maria, Moynet, Daniel, Dubus, Pierre, Desplat, Vanessa, Kauss, Tina, Dehais, Joël, Schaeverbeke, Thierry, Ezzedine, Khaled, Malvy, Denis, Vincendeau, Philippe, Mossalayi, M Djavad
Published in PloS one (12.03.2009)
Published in PloS one (12.03.2009)
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Journal Article
Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension
Eizayaga, Francisco X, Aguejouf, Omar, Desplat, Vanessa, Belon, Philippe, Doutremepuich, Christian
Published in World journal of gastroenterology : WJG (14.10.2007)
Published in World journal of gastroenterology : WJG (14.10.2007)
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Synthesis of new 4-(E)-alkenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents by Suzuki-Miyaura cross-coupling reactions
Guillon, Jean, Forfar, Isabelle, Desplat, Vanessa, Fabre, Solene Belisle, Thiolat, Denis, Massip, Stephane, Carrie, Helene, Mossalayi, Djavad, Jarry, Christian
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2007)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2007)
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Journal Article
Hypoxia Modifies Proliferation and Differentiation of CD34+ CML Cells
Desplat, Vanessa, Faucher, Jean‐Luc, Mahon, François Xavier, Sbarba, Persio Dello, Praloran, Vincent, Ivanovic, Zoran
Published in Stem cells (Dayton, Ohio) (01.01.2002)
Published in Stem cells (Dayton, Ohio) (01.01.2002)
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Thrombotic Events Associated to Aspirin Therapy
Duprat, Dominique, Aguejouf, Omar, Desplat, Vanessa, Eizayaga, Francisco X., Doutremepuich, Christian
Published in Thrombosis (2012)
Published in Thrombosis (2012)
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Journal Article
Paradoxical Effect of Aspirin
Doutremepuich, Christian, Aguejouf, Omar, Desplat, Vanessa, Eizayaga, Francisco X.
Published in Thrombosis (01.01.2012)
Published in Thrombosis (01.01.2012)
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