A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
Shapira, Tirosh, Monreal, I. Abrrey, Dion, Sébastien P., Buchholz, David W., Imbiakha, Brian, Olmstead, Andrea D., Jager, Mason, Désilets, Antoine, Gao, Guang, Martins, Mathias, Vandal, Thierry, Thompson, Connor A. H., Chin, Aaleigha, Rees, William D., Steiner, Theodore, Nabi, Ivan Robert, Marsault, Eric, Sahler, Julie, Diel, Diego G., Van de Walle, Gerlinde R., August, Avery, Whittaker, Gary R., Boudreault, Pierre-Luc, Leduc, Richard, Aguilar, Hector C., Jean, François
Published in Nature (London) (12.05.2022)
Published in Nature (London) (12.05.2022)
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Journal Article
Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology?
Derosa, Lisa, Routy, Bertrand, Desilets, Antoine, Daillère, Romain, Terrisse, Safae, Kroemer, Guido, Zitvogel, Laurence
Published in Cancer discovery (01.10.2021)
Published in Cancer discovery (01.10.2021)
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Journal Article
Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes
Béliveau, François, Tarkar, Aarti, Dion, Sébastien P, Désilets, Antoine, Ghinet, Mariana Gabriela, Boudreault, Pierre-Luc, St-Georges, Catherine, Marsault, Éric, Paone, Daniel, Collins, Jon, Macphee, Colin H, Campobasso, Nino, Groy, Arthur, Cottom, Josh, Ouellette, Michael, Pope, Andrew J, Leduc, Richard
Published in Cell chemical biology (21.11.2019)
Published in Cell chemical biology (21.11.2019)
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Journal Article
Matriptase Proteolytically Activates Influenza Virus and Promotes Multicycle Replication in the Human Airway Epithelium
Beaulieu, Alexandre, Gravel, Émilie, Cloutier, Alexandre, Marois, Isabelle, Colombo, Éloïc, Désilets, Antoine, Verreault, Catherine, Leduc, Richard, Marsault, Éric, Richter, Martin V
Published in Journal of Virology (01.04.2013)
Published in Journal of Virology (01.04.2013)
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Journal Article
Inhibitors of type II transmembrane serine proteases in the treatment of diseases of the respiratory tract - A review of patent literature
Murza, Alexandre, Dion, Sébastien P, Boudreault, Pierre-Luc, Désilets, Antoine, Leduc, Richard, Marsault, Éric
Published in Expert opinion on therapeutic patents (01.11.2020)
Published in Expert opinion on therapeutic patents (01.11.2020)
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Journal Article
The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction
Ronaghan, Natalie J, Shang, Judie, Iablokov, Vadim, Zaheer, Raza, Colarusso, Pina, Dion, Sébastien, Désilets, Antoine, Leduc, Richard, Turner, Jerrold R, MacNaughton, Wallace K
Published in American journal of physiology: Gastrointestinal and liver physiology (01.09.2016)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.09.2016)
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Journal Article
Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals
Pérez-Vargas, Jimena, Lemieux, Gabriel, Thompson, Connor A.H., Désilets, Antoine, Ennis, Siobhan, Gao, Guang, Gordon, Danielle G., Schulz, Annika Lea, Niikura, Masahiro, Nabi, Ivan Robert, Krajden, Mel, Boudreault, Pierre-Luc, Leduc, Richard, Jean, François
Published in Antiviral research (01.05.2024)
Published in Antiviral research (01.05.2024)
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Journal Article
Optimization of Ketobenzothiazole‐Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication
Colombo, Éloïc, Désilets, Antoine, Hassanzadeh, Malihe, Lemieux, Gabriel, Marois, Isabelle, Cliche, Dominic, Delbrouck, Julien A., Murza, Alexandre, Jean, François, Marsault, Eric, Richter, Martin V., Leduc, Richard, Boudreault, Pierre‐Luc
Published in ChemMedChem (15.01.2024)
Published in ChemMedChem (15.01.2024)
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Journal Article
Matriptase Induction of Metalloproteinase‐Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms
Wilkinson, David J., Habgood, Angela, Lamb, Heather K., Thompson, Paul, Hawkins, Alastair R., Désilets, Antoine, Leduc, Richard, Steinmetzer, Torsten, Hammami, Maya, Lee, Melody S., Craik, Charles S., Watson, Sharon, Lin, Hua, Milner, Jennifer M., Rowan, Andrew D.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.08.2017)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.08.2017)
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Journal Article
Physiologic colonic uptake of 18F-FDG on PET/CT is associated with clinical response and gut microbiome composition in patients with advanced non-small cell lung cancer treated with immune checkpoint inhibitors
Cvetkovic, Lena, Régis, Claudine, Richard, Corentin, Derosa, Lisa, Leblond, Antoine, Malo, Julie, Messaoudene, Meriem, Desilets, Antoine, Belkaid, Wiam, Elkrief, Arielle, Routy, Bertrand, Juneau, Daniel
Published in European journal of nuclear medicine and molecular imaging (01.05.2021)
Published in European journal of nuclear medicine and molecular imaging (01.05.2021)
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Journal Article
Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids
St-Georges, Catherine, Désilets, Antoine, Béliveau, François, Ghinet, Mariana, Dion, Sébastien P., Colombo, Éloic, Boudreault, Pierre-Luc, Najmanovich, Rafael J., Leduc, Richard, Marsault, Éric
Published in European journal of medicinal chemistry (31.03.2017)
Published in European journal of medicinal chemistry (31.03.2017)
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Journal Article
Upfront DPYD Genotyping and Toxicity Associated with Fluoropyrimidine-Based Concurrent Chemoradiotherapy for Oropharyngeal Carcinomas: A Work in Progress
Desilets, Antoine, McCarvill, William, Aubin, Francine, Bahig, Houda, Ballivy, Olivier, Charpentier, Danielle, Filion, Édith, Jamal, Rahima, Lambert, Louise, Nguyen-Tan, Phuc Felix, Vadnais, Charles, Weng, Xiaoduan, Soulières, Denis
Published in Current oncology (Toronto) (26.01.2022)
Published in Current oncology (Toronto) (26.01.2022)
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Journal Article
Antibiotics are associated with worse outcomes in lung cancer patients treated with chemotherapy and immunotherapy
Elkrief, Arielle, Méndez-Salazar, Eder Orlando, Maillou, Jade, Vanderbilt, Chad M., Gogia, Pooja, Desilets, Antoine, Messaoudene, Meriem, Kelly, Daniel, Ladanyi, Marc, Hellmann, Matthew D., Zitvogel, Laurence, Rudin, Charles M., Routy, Bertrand, Derosa, Lisa, Schoenfeld, Adam J.
Published in NPJ precision oncology (16.07.2024)
Published in NPJ precision oncology (16.07.2024)
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Journal Article
679 High fiber diet modifies gut microbiome, propionate production, intratumor immune response and is associated with outcome in patients with lung cancer treated with immune checkpoint inhibitors
Richard, Corentin, Benlaifaoui, Myriam, Ouarzadi, Omar El, Diop, Khoudia, Desilets, Antoine, Malo, Julie, Belkaid, Wiam, Leblanc, Andréanne, Lamontagne, Julien, Messaoudene, Meriem, Elkrief, Arielle, Routy, Bertrand
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Mutation G827R in Matriptase Causing Autosomal Recessive Ichthyosis with Hypotrichosis Yields an Inactive Protease
Désilets, Antoine, Béliveau, François, Vandal, Guillaume, McDuff, François-Olivier, Lavigne, Pierre, Leduc, Richard
Published in The Journal of biological chemistry (18.04.2008)
Published in The Journal of biological chemistry (18.04.2008)
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