CCR5 Small-Molecule Antagonists and Monoclonal Antibodies Exert Potent Synergistic Antiviral Effects by Cobinding to the Receptor
Ji, Changhua, Zhang, Jun, Dioszegi, Marianna, Chiu, Sophie, Rao, Eileen, Derosier, Andre, Cammack, Nick, Brandt, Michael, Sankuratri, Surya
Published in Molecular pharmacology (01.07.2007)
Published in Molecular pharmacology (01.07.2007)
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The Second Extracellular Loop of CCR5 Contains the Dominant Epitopes for Highly Potent Anti-Human Immunodeficiency Virus Monoclonal Antibodies
JUN ZHANG, RAO, Eileen, CHANGHUA JI, DIOSZEGI, Marianna, KONDRU, Rama, DEROSIER, Andre, CHAN, Eva, SCHWOERER, Stephan, CAMMACK, Nick, BRANDT, Michael, SANKURATRI, Surya
Published in Antimicrobial Agents and Chemotherapy (01.04.2007)
Published in Antimicrobial Agents and Chemotherapy (01.04.2007)
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Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats
Collibee, Scott E., Romero, Antonio, Muci, Alexander R., Hwee, Darren T., Chuang, Chihyuan, Hartman, James J., Motani, Alykhan S., Ashcraft, Luke, DeRosier, Andre, Grillo, Mark, Lu, Qing, Malik, Fady I., Morgan, Bradley P.
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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Preclinical characterization of CK-4021586, a new class of cardiac myosin inhibitors for the treatment of hypertrophic cardiomyopathy
Sankar Sarkar, Saswata, Hartman, James J., Hwee, Darren T., Chuang, Chihyuan, Cremin, Peadar, deRosier, Andre, Edell, Samantha, Madhvani, Roshni, Wu, Yangsong, Yco, Lisette, Zamora, Jeanelle, Murphy, Anne, Morgan, Bradley P., Malik, Fady I.
Published in Biophysical journal (10.02.2023)
Published in Biophysical journal (10.02.2023)
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Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc
Lemoine, Rémy C., Petersen, Ann C., Setti, Lina, Baldinger, Thomas, Wanner, Jutta, Jekle, Andreas, Heilek, Gabrielle, deRosier, André, Ji, Changhua, Rotstein, David M.
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem-disubstituted azacycles
Lemoine, Rémy C., Petersen, Ann C., Setti, Lina, Wanner, Jutta, Jekle, Andreas, Heilek, Gabrielle, deRosier, André, Ji, Changhua, Berry, Pamela, Rotstein, David
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Discovery of a potent, selective and orally bioavailable 3,9-diazaspiro[5.5]undeca-2-one CCR5 antagonist
Yang, Hanbiao, Lin, Xiao-Fa, Padilla, Fernando, Gabriel, Stephen D., Heilek, Gabrielle, Ji, Changhua, Sankuratri, Surya, deRosier, André, Berry, Pamela, Rotstein, David M.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists
Lemoine, Rémy C., Petersen, Ann C., Setti, Lina, Chen, Lijing, Wanner, Jutta, Jekle, Andreas, Heilek, Gabrielle, deRosier, André, Ji, Changhua, Rotstein, David M.
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
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Exploration of a new series of CCR5 antagonists: Multi-dimensional optimization of a sub-series containing N-substituted pyrazoles
Lemoine, Rémy C., Petersen, Ann C., Setti, Lina, Jekle, Andreas, Heilek, Gabrielle, deRosier, André, Ji, Changhua, Berry, Pamela, Rotstein, David M.
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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Evaluation of amide replacements in CCR5 antagonists as a means to increase intrinsic permeability. Part 2: SAR optimization and pharmacokinetic profile of a homologous azacyle series
Wanner, Jutta, Chen, Lijing, Lemoine, Rémy C., Kondru, Rama, Jekle, Andreas, Heilek, Gabrielle, deRosier, André, Ji, Changhua, Berry, Pamela W., Rotstein, David M.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Two‐metal ion mechanism of RNA cleavage by HIV RNase H and mechanism‐based design of selective HIV RNase H inhibitors
Klumpp, Klaus, Hang, Julie Qi, Rajendran, Surendran, Yang, Yanli, Derosier, Andre, Wong Kai In, Philippe, Overton, Hilary, Parkes, Kevin E. B., Cammack, Nick, Martin, Joseph A.
Published in Nucleic acids research (01.12.2003)
Published in Nucleic acids research (01.12.2003)
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Spiropiperidine CCR5 antagonists
Rotstein, David M., Gabriel, Stephen D., Makra, Ferenc, Filonova, Lubov, Gleason, Shelley, Brotherton-Pleiss, Christine, Setti, Lina Q., Trejo-Martin, Alejandra, Lee, Eun Kyung, Sankuratri, Surya, Ji, Changhua, deRosier, Andre, Dioszegi, Marianna, Heilek, Gabrielle, Jekle, Andreas, Berry, Pamela, Weller, Paul, Mau, Cheng-I.
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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Synthesis, SAR and evaluation of [1,4′]-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists
Rotstein, David M., Gabriel, Stephen D., Manser, Nicole, Filonova, Lubov, Padilla, Fernando, Sankuratri, Surya, Ji, Changhua, deRosier, Andre, Dioszegi, Marianna, Heilek, Gabrielle, Jekle, Andreas, Weller, Paul, Berry, Pamela
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
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Journal Article
Novel hexahydropyrrolo[3,4- c]pyrrole CCR5 antagonists
Rotstein, David M., Melville, Chris R., Padilla, Fernando, Cournoyer, Dick, Lee, Eun K., Lemoine, Remy, Petersen, Ann C., Setti, Lina Q., Wanner, Jutta, Chen, Lijing, Filonova, Lubov, Loughhead, David G., Manka, Jason, Lin, Xiao-Fa, Gleason, Shelley, Sankuratri, Surya, Ji, Changhua, deRosier, Andre, Dioszegi, Marianna, Heilek, Gabrielle, Jekle, Andreas, Berry, Pamela, Mau, Cheng-I, Weller, Paul
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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