Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate
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Published in Journal of medicinal chemistry (14.12.2017)
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In Vivo Inhibition of RIPK2 Kinase Alleviates Inflammatory Disease
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Published in The Journal of biological chemistry (24.10.2014)
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Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles
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Published in ACS central science (26.10.2016)
Published in ACS central science (26.10.2016)
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Synthesis of 1-Boc-3-fluoroazetidine-3-carboxylic Acid
Van Hende, Eva, Verniest, Guido, Deroose, Frederik, Thuring, Jan-Willem, Macdonald, Gregor, De Kimpe, Norbert
Published in Journal of organic chemistry (06.03.2009)
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A General and Highly Efficient Solid Phase Synthesis of Oligosaccharides. Total Synthesis of a Heptasaccharide Phytoalexin Elicitor (HPE)
Nicolaou, K. C, Winssinger, Nicolas, Pastor, Joaquín, DeRoose, Frederik
Published in Journal of the American Chemical Society (15.01.1997)
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Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors
Andrés, J.Ignacio, Alonso, José M, Dı́az, Adolfo, Fernández, Javier, Iturrino, Laura, Martı́nez, Pedro, Matesanz, Encarna, Freyne, Eddy J, Deroose, Frederik, Boeckx, Gustaaf, Petit, Davy, Diels, Gaston, Megens, Anton, Somers, Marijke, Wauwe, Jean Van, Stoppie, Paul, Cools, Marina, Clerck, Fred De, Peeters, Danielle, de Chaffoy, Didier
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
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Synthesis of 3-Amino-4-fluoropyrazoles
Surmont, Riccardo, Verniest, Guido, De Schrijver, Mathias, Thuring, Jan Willem, ten Holte, Peter, Deroose, Frederik, De Kimpe, Norbert
Published in Journal of organic chemistry (20.05.2011)
Published in Journal of organic chemistry (20.05.2011)
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Synthesis of 4-Substituted 3,3-Difluoropiperidines
Surmont, Riccardo, Verniest, Guido, Thuring, Jan Willem, Macdonald, Gregor, Deroose, Frederik, De Kimpe, Norbert
Published in Journal of organic chemistry (05.02.2010)
Published in Journal of organic chemistry (05.02.2010)
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New Synthesis of 3-Fluoropyrroles
Surmont, Riccardo, Verniest, Guido, Colpaert, Filip, Macdonald, Gregor, Thuring, Jan Willem, Deroose, Frederik, De Kimpe, Norbert
Published in Journal of organic chemistry (06.02.2009)
Published in Journal of organic chemistry (06.02.2009)
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Synthesis of gem-difluorinated 1,6-naphthyridine-5,7-diones
Piron, Karel, Kenis, Sara, Verniest, Guido, Surmont, Riccardo, Thuring, Jan Willem, ten Holte, Peter, Deroose, Frederik, De Kimpe, Norbert
Published in Tetrahedron (26.08.2012)
Published in Tetrahedron (26.08.2012)
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Synthesis of 5-amino- and 5-hydroxy-3,3-difluoropiperidines
Surmont, Riccardo, Verniest, Guido, Thuring, Jan Willem, ten Holte, Peter, Deroose, Frederik, De Kimpe, Norbert
Published in Organic & biomolecular chemistry (21.10.2010)
Published in Organic & biomolecular chemistry (21.10.2010)
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New Entries toward 3,3-Difluoropiperidines
Verniest, Guido, Surmont, Riccardo, Hende, Eva Van, Deweweire, Arvid, Deroose, Frederik, Thuring, Jan Willem, De Kimpe, Norbert
Published in Journal of organic chemistry (18.07.2008)
Published in Journal of organic chemistry (18.07.2008)
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Synthesis of 2-aryl-3-hydroxymethyl-5,5-difluoropiperidines
Moens, Matthias, Verniest, Guido, De Schrijver, Matthias, ten Holte, Peter, Thuring, Jan-Willem, Deroose, Frederik, De Kimpe, Norbert
Published in Tetrahedron (11.11.2012)
Published in Tetrahedron (11.11.2012)
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Synthesis of 5-amino- and 5-hydroxy-3,3-difluoropiperidinesElectronic supplementary information (ESI) available: Experimental procedures and spectroscopic data for compounds 5a, 6b-d, 8-11 and 13-16 are available. See DOI: 10.1039/c0ob00231c
Surmont, Riccardo, Verniest, Guido, Thuring, Jan Willem, ten Holte, Peter, Deroose, Frederik, De Kimpe, Norbert
Year of Publication 29.09.2010
Year of Publication 29.09.2010
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Synthesis of 3-Aminomethyl-3-fluoropiperidines
Van Hende, Eva, Verniest, Guido, Thuring, Jan-Willem, Macdonald, Gregor, Deroose, Frederik, De Kimpe, Norbert
Published in Synlett (01.07.2009)
Published in Synlett (01.07.2009)
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Efficient Synthesis of 3-Alkoxy-4,4-difluoropiperidines
Surmont, Riccardo, Verniest, Guido, De Weweire, Arvid, Thuring, Jan Willem, Macdonald, Gregor, Deroose, Frederik, De Kimpe, Norbert
Published in Synlett (22.07.2009)
Published in Synlett (22.07.2009)
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Synthesis of aminomethylated 4-fluoropiperidines and 3-fluoropyrrolidinesElectronic supplementary information (ESI) available: Experimental procedures and spectroscopic data for compounds 6-8, 10, and 17-20 is available. See DOI: 10.1039/c003380d
Verniest, Guido, Piron, Karel, Van Hende, Eva, Thuring, Jan Willem, Macdonald, Gregor, Deroose, Frederik, De Kimpe, Norbert
Year of Publication 19.05.2010
Year of Publication 19.05.2010
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