Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability
Brouwer, Philip J M, Caniels, Tom G, van der Straten, Karlijn, Snitselaar, Jonne L, Aldon, Yoann, Bangaru, Sandhya, Torres, Jonathan L, Okba, Nisreen M A, Claireaux, Mathieu, Kerster, Gius, Bentlage, Arthur E H, van Haaren, Marlies M, Guerra, Denise, Burger, Judith A, Schermer, Edith E, Verheul, Kirsten D, van der Velde, Niels, van der Kooi, Alex, van Schooten, Jelle, van Breemen, Mariëlle J, Bijl, Tom P L, Sliepen, Kwinten, Aartse, Aafke, Derking, Ronald, Bontjer, Ilja, Kootstra, Neeltje A, Wiersinga, W Joost, Vidarsson, Gestur, Haagmans, Bart L, Ward, Andrew B, de Bree, Godelieve J, Sanders, Rogier W, van Gils, Marit J
Published in Science (07.08.2020)
Published in Science (07.08.2020)
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HIV-1 neutralizing antibodies induced by native-like envelope trimers
Sanders, Rogier W., van Gils, Marit J., Derking, Ronald, Sok, Devin, Ketas, Thomas J., Burger, Judith A., Ozorowski, Gabriel, Cupo, Albert, Simonich, Cassandra, Goo, Leslie, Arendt, Heather, Kim, Helen J., Lee, Jeong Hyun, Pugach, Pavel, Williams, Melissa, Debnath, Gargi, Moldt, Brian, van Breemen, Mariëlle J., Isik, Gözde, Medina-Ramírez, Max, Back, Jaap Willem, Koff, Wayne C., Julien, Jean-Philippe, Rakasz, Eva G., Seaman, Michael S., Guttman, Miklos, Lee, Kelly K., Klasse, Per Johan, LaBranche, Celia, Schief, William R., Wilson, Ian A., Overbaugh, Julie, Burton, Dennis R., Ward, Andrew B., Montefiori, David C., Dean, Hansi, Moore, John P.
Published in Science (American Association for the Advancement of Science) (10.07.2015)
Published in Science (American Association for the Advancement of Science) (10.07.2015)
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A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies
Sanders, Rogier W, Derking, Ronald, Cupo, Albert, Julien, Jean-Philippe, Yasmeen, Anila, de Val, Natalia, Kim, Helen J, Blattner, Claudia, de la Peña, Alba Torrents, Korzun, Jacob, Golabek, Michael, de Los Reyes, Kevin, Ketas, Thomas J, van Gils, Marit J, King, C Richter, Wilson, Ian A, Ward, Andrew B, Klasse, P J, Moore, John P
Published in PLoS pathogens (01.09.2013)
Published in PLoS pathogens (01.09.2013)
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Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers
Falkowska, Emilia, Le, Khoa M., Ramos, Alejandra, Doores, Katie J., Lee, Jeong Hyun, Blattner, Claudia, Ramirez, Alejandro, Derking, Ronald, van Gils, Marit J., Liang, Chi-Hui, Mcbride, Ryan, von Bredow, Benjamin, Shivatare, Sachin S., Wu, Chung-Yi, Chan-Hui, Po-Ying, Liu, Yan, Feizi, Ten, Zwick, Michael B., Koff, Wayne C., Seaman, Michael S., Swiderek, Kristine, Moore, John P., Evans, David, Paulson, James C., Wong, Chi-Huey, Ward, Andrew B., Wilson, Ian A., Sanders, Rogier W., Poignard, Pascal, Burton, Dennis R.
Published in Immunity (Cambridge, Mass.) (15.05.2014)
Published in Immunity (Cambridge, Mass.) (15.05.2014)
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Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers
Blattner, Claudia, Lee, Jeong Hyun, Sliepen, Kwinten, Derking, Ronald, Falkowska, Emilia, de la Peña, Alba Torrents, Cupo, Albert, Julien, Jean-Philippe, van Gils, Marit, Lee, Peter S., Peng, Wenjie, Paulson, James C., Poignard, Pascal, Burton, Dennis R., Moore, John P., Sanders, Rogier W., Wilson, Ian A., Ward, Andrew B.
Published in Immunity (Cambridge, Mass.) (15.05.2014)
Published in Immunity (Cambridge, Mass.) (15.05.2014)
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Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9
Julien, Jean-Philippe, Lee, Jeong Hyun, Cupo, Albert, Murin, Charles D., Derking, Ronald, Hoffenberg, Simon, Caulfield, Michael J., King, C. Richter, Marozsan, Andre J., Klasse, Per Johan, Sanders, Rogier W., Moore, John P., Wilson, Ian A., Ward, Andrew B.
Published in Proceedings of the National Academy of Sciences - PNAS (12.03.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (12.03.2013)
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Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation
Ringe, Rajesh P., Sanders, Rogier W., Yasmeen, Anila, Kim, Helen J., Lee, Jeong Hyun, Cupo, Albert, Korzun, Jacob, Derking, Ronald, van Montfort, Thijs, Julien, Jean-Philippe, Wilson, Ian A., Klasse, Per Johan, Ward, Andrew B., Moore, John P.
Published in Proceedings of the National Academy of Sciences - PNAS (05.11.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (05.11.2013)
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Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer
Derking, Ronald, Ozorowski, Gabriel, Sliepen, Kwinten, Yasmeen, Anila, Cupo, Albert, Torres, Jonathan L, Julien, Jean-Philippe, Lee, Jeong Hyun, van Montfort, Thijs, de Taeye, Steven W, Connors, Mark, Burton, Dennis R, Wilson, Ian A, Klasse, Per-Johan, Ward, Andrew B, Moore, John P, Sanders, Rogier W
Published in PLoS pathogens (01.03.2015)
Published in PLoS pathogens (01.03.2015)
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Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike
Derking, Ronald, Allen, Joel D., Cottrell, Christopher A., Sliepen, Kwinten, Seabright, Gemma E., Lee, Wen-Hsin, Aldon, Yoann, Rantalainen, Kimmo, Antanasijevic, Aleksandar, Copps, Jeffrey, Yasmeen, Anila, Cupo, Albert, Cruz Portillo, Victor M., Poniman, Meliawati, Bol, Niki, van der Woude, Patricia, de Taeye, Steven W., van den Kerkhof, Tom L.G.M., Klasse, P.J., Ozorowski, Gabriel, van Gils, Marit J., Moore, John P., Ward, Andrew B., Crispin, Max, Sanders, Rogier W.
Published in Cell reports (Cambridge) (06.04.2021)
Published in Cell reports (Cambridge) (06.04.2021)
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Gp120/CD4 blocking antibodies are frequently elicited in ART-naïve chronically HIV-1 infected individuals
Carrillo, Jorge, Molinos-Albert, Luis Manuel, Rodríguez de la Concepción, Maria Luisa, Marfil, Silvia, García, Elisabet, Derking, Ronald, Sanders, Rogier W, Clotet, Bonaventura, Blanco, Julià
Published in PloS one (24.03.2015)
Published in PloS one (24.03.2015)
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Structure‐guided envelope trimer design in HIV‐1 vaccine development: a narrative review
Derking, Ronald, Sanders, Rogier W.
Published in Journal of the International AIDS Society (01.11.2021)
Published in Journal of the International AIDS Society (01.11.2021)
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A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene
Pugach, Pavel, Ozorowski, Gabriel, Cupo, Albert, Ringe, Rajesh, Yasmeen, Anila, de Val, Natalia, Derking, Ronald, Kim, Helen J, Korzun, Jacob, Golabek, Michael, de Los Reyes, Kevin, Ketas, Thomas J, Julien, Jean-Philippe, Burton, Dennis R, Wilson, Ian A, Sanders, Rogier W, Klasse, P J, Ward, Andrew B, Moore, John P
Published in Journal of virology (01.03.2015)
Published in Journal of virology (01.03.2015)
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Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface
Huang, Jinghe, Kang, Byong H., Pancera, Marie, Lee, Jeong Hyun, Tong, Tommy, Feng, Yu, Imamichi, Hiromi, Georgiev, Ivelin S., Chuang, Gwo-Yu, Druz, Aliaksandr, Doria-Rose, Nicole A., Laub, Leo, Sliepen, Kwinten, van Gils, Marit J., de la Peña, Alba Torrents, Derking, Ronald, Klasse, Per-Johan, Migueles, Stephen A., Bailer, Robert T., Alam, Munir, Pugach, Pavel, Haynes, Barton F., Wyatt, Richard T., Sanders, Rogier W., Binley, James M., Ward, Andrew B., Mascola, John R., Kwong, Peter D., Connors, Mark
Published in Nature (London) (06.11.2014)
Published in Nature (London) (06.11.2014)
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Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
Yasmeen, Anila, Ringe, Rajesh, Derking, Ronald, Cupo, Albert, Julien, Jean-Philippe, Burton, Dennis R, Ward, Andrew B, Wilson, Ian A, Sanders, Rogier W, Moore, John P, Klasse, Per Johan
Published in Retrovirology (29.05.2014)
Published in Retrovirology (29.05.2014)
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Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike
Lee, Jeong Hyun, Leaman, Daniel P., Kim, Arthur S., Torrents de la Peña, Alba, Sliepen, Kwinten, Yasmeen, Anila, Derking, Ronald, Ramos, Alejandra, de Taeye, Steven W., Ozorowski, Gabriel, Klein, Florian, Burton, Dennis R., Nussenzweig, Michel C., Poignard, Pascal, Moore, John P., Klasse, Per Johan, Sanders, Rogier W., Zwick, Michael B., Wilson, Ian A., Ward, Andrew B.
Published in Nature communications (25.09.2015)
Published in Nature communications (25.09.2015)
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Conjugation of a Toll‐Like Receptor Agonist to Glycans of an HIV Native‐Like Envelope Trimer Preserves Neutralization Epitopes
Li, Zeshi, Derking, Ronald, Lee, Wen‐Hsin, Bosman, Gerlof P., Ward, Andrew B., Sanders, Rogier W., Boons, Geert‐Jan
Published in Chembiochem : a European journal of chemical biology (17.08.2022)
Published in Chembiochem : a European journal of chemical biology (17.08.2022)
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Mosaic and mixed HIV-1 glycoprotein nanoparticles elicit antibody responses to broadly neutralizing epitopes
Brinkkemper, Mitch, Kerster, Gius, Brouwer, Philip J M, Tran, Andy S, Torres, Jonathan L, Ettema, Roos A, Nijhuis, Haye, Allen, Joel D, Zhu, Wenwen, Gao, Hongmei, Lee, Wen-Hsin, Bijl, Tom P L, Snitselaar, Jonne L, Burger, Judith A, Bontjer, Ilja, Olijhoek, Wouter, Ravichandran, Rashmi, van Breemen, Marielle J, Del Moral-Sánchez, Iván, Derking, Ronald, Sliepen, Kwinten, Ozorowski, Gabriel, Crispin, Max, Montefiori, David C, Claireaux, Mathieu, Ward, Andrew B, van Gils, Marit J, King, Neil P, Sanders, Rogier W
Published in PLoS pathogens (03.10.2024)
Published in PLoS pathogens (03.10.2024)
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B cells expressing IgM B cell receptors of HIV-1 neutralizing antibodies discriminate antigen affinities by sensing binding association rates
Hossain, Md Alamgir, Anasti, Kara, Watts, Brian, Cronin, Kenneth, Derking, Ronald, Groschel, Bettina, Kane, Advaiti Pai, Edwards, R J, Easterhoff, David, Zhang, Jinsong, Rountree, Wes, Ortiz, Yaneth, Saunders, Kevin, Schief, William R, Sanders, Rogier W, Verkoczy, Laurent, Reth, Michael, Alam, S Munir
Published in Cell reports (Cambridge) (28.06.2022)
Published in Cell reports (Cambridge) (28.06.2022)
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Interplay between viral Tat protein and c-Jun transcription factor in controlling LTR promoter activity in different human immunodeficiency virus type I subtypes
van der Sluis, Renée M, Derking, Ronald, Breidel, Seyguerney, Speijer, Dave, Berkhout, Ben, Jeeninga, Rienk E
Published in Journal of general virology (01.04.2014)
Published in Journal of general virology (01.04.2014)
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Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions
Caniels, Tom G., Medina-Ramírez, Max, Zhang, Jinsong, Sarkar, Anita, Kumar, Sonu, LaBranche, Alex, Derking, Ronald, Allen, Joel D., Snitselaar, Jonne L., Capella-Pujol, Joan, Sánchez, Iván del Moral, Yasmeen, Anila, Diaz, Marilyn, Aldon, Yoann, Bijl, Tom P.L., Venkatayogi, Sravani, Martin Beem, Joshua S., Newman, Amanda, Jiang, Chuancang, Lee, Wen-Hsin, Pater, Maarten, Burger, Judith A., van Breemen, Mariëlle J., de Taeye, Steven W., Rantalainen, Kimmo, LaBranche, Celia, Saunders, Kevin O., Montefiori, David, Ozorowski, Gabriel, Ward, Andrew B., Crispin, Max, Moore, John P., Klasse, Per Johan, Haynes, Barton F., Wilson, Ian A., Wiehe, Kevin, Verkoczy, Laurent, Sanders, Rogier W.
Published in Cell reports. Medicine (18.04.2023)
Published in Cell reports. Medicine (18.04.2023)
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