Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo
Zekonyte, Ugne, Bacman, Sandra R., Smith, Jeff, Shoop, Wendy, Pereira, Claudia V., Tomberlin, Ginger, Stewart, James, Jantz, Derek, Moraes, Carlos T.
Published in Nature communications (28.05.2021)
Published in Nature communications (28.05.2021)
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Journal Article
Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol
Wang, Lili, Smith, Jeff, Breton, Camilo, Clark, Peter, Zhang, Jia, Ying, Lei, Che, Yan, Lape, Janel, Bell, Peter, Calcedo, Roberto, Buza, Elizabeth L, Saveliev, Alexei, Bartsevich, Victor V, He, Zhenning, White, John, Li, Mingyao, Jantz, Derek, Wilson, James M
Published in Nature biotechnology (01.09.2018)
Published in Nature biotechnology (01.09.2018)
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Journal Article
Male‐sterile maize plants produced by targeted mutagenesis of the cytochrome P450‐like gene (MS26) using a re‐designed I–CreI homing endonuclease
Djukanovic, Vesna, Smith, Jeff, Lowe, Keith, Yang, Meizhu, Gao, Huirong, Jones, Spencer, Nicholson, Michael G, West, Ande, Lape, Janel, Bidney, Dennis, Carl Falco, Saverio, Jantz, Derek, Alexander Lyznik, Leszek
Published in The Plant journal : for cell and molecular biology (01.12.2013)
Published in The Plant journal : for cell and molecular biology (01.12.2013)
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Journal Article
Targeted molecular trait stacking in cotton through targeted double‐strand break induction
D'Halluin, Kathleen, Vanderstraeten, Chantal, Hulle, Jolien, Rosolowska, Joanna, Den Brande, Ilse, Pennewaert, Anouk, D'Hont, Kristel, Bossut, Martine, Jantz, Derek, Ruiter, Rene, Broadhvest, Jean
Published in Plant biotechnology journal (01.10.2013)
Published in Plant biotechnology journal (01.10.2013)
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Journal Article
Cytoplasmic male sterility and abortive seed traits generated through mitochondrial genome editing coupled with allotopic expression of atp1 in tobacco
Dewey, Ralph E., Selote, Devarshi, Griffin, H. Carol, Dickey, Allison N., Jantz, Derek, Smith, J. Jeff, Matthiadis, Anna, Strable, Josh, Kestell, Caitlin, Smith, William A.
Published in Frontiers in plant science (15.09.2023)
Published in Frontiers in plant science (15.09.2023)
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Journal Article
Targeted DNA excision in Arabidopsis by a re-engineered homing endonuclease
Antunes, Mauricio S, Smith, J Jeff, Jantz, Derek, Medford, June I
Published in BMC biotechnology (13.11.2012)
Published in BMC biotechnology (13.11.2012)
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Journal Article
The Design of Functional DNA-Binding Proteins Based on Zinc Finger Domains
Jantz, Derek, Amann, Barbara T, Gatto, Gregory J, Berg, Jeremy M
Published in Chemical reviews (01.02.2004)
Published in Chemical reviews (01.02.2004)
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Journal Article
Long-term stable reduction of low-density lipoprotein in nonhuman primates following in vivo genome editing of PCSK9
Wang, Lili, Breton, Camilo, Warzecha, Claude C., Bell, Peter, Yan, Hanying, He, Zhenning, White, John, Zhu, Yanqing, Li, Mingyao, Buza, Elizabeth L., Jantz, Derek, Wilson, James M.
Published in Molecular therapy (02.06.2021)
Published in Molecular therapy (02.06.2021)
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Journal Article
Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells
MacLeod, Daniel T., Antony, Jeyaraj, Martin, Aaron J., Moser, Rachel J., Hekele, Armin, Wetzel, Keith J., Brown, Audrey E., Triggiano, Melissa A., Hux, Jo Ann, Pham, Christina D., Bartsevich, Victor V., Turner, Caitlin A., Lape, Janel, Kirkland, Samantha, Beard, Clayton W., Smith, Jeff, Hirsch, Matthew L., Nicholson, Michael G., Jantz, Derek, McCreedy, Bruce
Published in Molecular therapy (05.04.2017)
Published in Molecular therapy (05.04.2017)
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Journal Article
TREATMENT OF RETINITIS PIGMENTOSA USING ENGINEERED MEGANUCLEASES
VICTOR BARTSEVICH, MICHAEL G NICHOLSON, JAMES JEFFERSON SMITH, DEREK JANTZ
Year of Publication 21.02.2024
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Year of Publication 21.02.2024
Patent
A gene editing approach for chronic hepatitis B: elimination of hepatitis B virus in vivo by targeting cccDNA and integrated viral genomes with a sequence-specific ARCUS nuclease
Gorsuch, Cassandra, Nemec, Paige, Yu, Mei, Xu, Simin, Han, Dong, Smith, Jeff, Lape, Janel, Van Buuren, Nicholas, Ramirez, Ricardo, Muench, Robert, Holdorf, Meghan, Feierbach, Becket, Falls, Greg, Holt, Jason, Shoop, Wendy, Sevigny, Emma, Karriker, Forrest, Brown, Robert, Joshi, Amod, Goodwin, Tyler, Tam, Ying, Lin, Paulo, Semple, Sean, Leatherbury, Neil, Delaney, William E., Jantz, Derek, Harrison, Emily, Smith, Amy Rhoden
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article