A gene editing approach for chronic hepatitis B: elimination of hepatitis B virus in vivo by targeting cccDNA and integrated viral genomes with a sequence-specific ARCUS nuclease
Gorsuch, Cassandra, Nemec, Paige, Yu, Mei, Xu, Simin, Han, Dong, Smith, Jeff, Lape, Janel, Van Buuren, Nicholas, Ramirez, Ricardo, Muench, Robert, Holdorf, Meghan, Feierbach, Becket, Falls, Greg, Holt, Jason, Shoop, Wendy, Sevigny, Emma, Karriker, Forrest, Brown, Robert, Joshi, Amod, Goodwin, Tyler, Tam, Ying, Lin, Paulo, Semple, Sean, Leatherbury, Neil, Delaney, William E., Jantz, Derek, Harrison, Emily, Smith, Amy Rhoden
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases
Ménoret, Séverine, Fontanière, Sandra, Jantz, Derek, Tesson, Laurent, Thinard, Reynald, Rémy, Séverine, Usal, Claire, Ouisse, Laure-Hélène, Fraichard, Alexandre, Anegon, Ignacio
Published in The FASEB journal (01.02.2013)
Published in The FASEB journal (01.02.2013)
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Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo
Gorsuch, Cassandra L., Nemec, Paige, Yu, Mei, Xu, Simin, Han, Dong, Smith, Jeff, Lape, Janel, van Buuren, Nicholas, Ramirez, Ricardo, Muench, Robert C., Holdorf, Meghan M., Feierbach, Becket, Falls, Greg, Holt, Jason, Shoop, Wendy, Sevigny, Emma, Karriker, Forrest, Brown, Robert V., Joshi, Amod, Goodwin, Tyler, Tam, Ying K., Lin, Paulo J.C., Semple, Sean C., Leatherbury, Neil, Delaney IV, William E., Jantz, Derek, Rhoden Smith, Amy
Published in Molecular therapy (07.09.2022)
Published in Molecular therapy (07.09.2022)
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Heritable targeted mutagenesis in maize using a designed endonuclease
Gao, Huirong, Smith, Jeff, Yang, Meizhu, Jones, Spencer, Djukanovic, Vesna, Nicholson, Michael G., West, Ande, Bidney, Dennis, Falco, S. Carl, Jantz, Derek, Lyznik, L. Alexander
Published in The Plant journal : for cell and molecular biology (01.01.2010)
Published in The Plant journal : for cell and molecular biology (01.01.2010)
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ENGINEERED NUCLEASES USEFUL FOR TREATMENT OF HEMOPHILIA A
SMITH JAMES JEFFERSON, VICTOR BARTSEVICH, CLAYTON BEARD, MICHAEL G NICHOLSON, DEREK JANTZ
Year of Publication 05.03.2024
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Year of Publication 05.03.2024
Patent
Treating Transthyretin Amyloidosis via Adeno-Associated Virus Vector Delivery of Meganucleases
Greig, Jenny A, Breton, Camilo, Ashley, Scott N, Martins, Kelly M, Gorsuch, Cassandra, Chorazeczewski, Joanna K, Furmanak, Thomas, Smith, Melanie K, Zhu, Yanqing, Bell, Peter, Shoop, Wendy, Li, Hui, Smith, Jeff, Tomberlin, Ginger, Clark, Peter, Mitchell, Thomas W, Buza, Elizabeth L, Yan, Hanying, Jantz, Derek, Wilson, James M
Published in Human gene therapy (01.11.2022)
Published in Human gene therapy (01.11.2022)
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TREATMENT OF RETINITIS PIGMENTOSA USING ENGINEERED MEGANUCLEASE
VICTOR BARTSEVICH, MICHAEL G NICHOLSON, JAMES JEFFERSON SMITH, DEREK JANTZ
Year of Publication 08.04.2021
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Year of Publication 08.04.2021
Patent
Efficient elimination of MELAS-associated m.3243G mutant mitochondrial DNA by an engineered mitoARCUS nuclease
Shoop, Wendy K., Lape, Janel, Trum, Megan, Powell, Alea, Sevigny, Emma, Mischler, Adam, Bacman, Sandra R., Fontanesi, Flavia, Smith, Jeff, Jantz, Derek, Gorsuch, Cassandra L., Moraes, Carlos T.
Published in Nature metabolism (01.12.2023)
Published in Nature metabolism (01.12.2023)
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Transient Expression of Virally Delivered Meganuclease In Planta Generates Inherited Genomic Deletions
Honig, Arik, Marton, Ira, Rosenthal, Michal, Smith, J. Jeff, Nicholson, Michael G., Jantz, Derek, Zuker, Amir, Vainstein, Alexander
Published in Molecular plant (03.08.2015)
Published in Molecular plant (03.08.2015)
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ENGINEERED MEGANUCLEASE WITH RECOGNITION SEQUENCE FOUND IN HUMAN β-2 MICROGLOBULIN GENE
SMITH JAMES JEFFERSON, VICTOR BARTSEVICH, CHRISTINA PHAM, MICHAEL G NICHOLSON, DEREK JANTZ, AARON MARTIN
Year of Publication 15.07.2021
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Year of Publication 15.07.2021
Patent
138. Potential Therapeutic Treatment of Friedrich's Ataxia Using Highly Specific Engineered Meganucleases
Davey, Roshni, Hekele, Armin, Hux, Jo Ann, Turner, Caitlin, Sharer, Wendy, Bartsevich, Victor, Tomberlin, Ginger, Liau, Gene, Nicholson, Michael G., Beard, Clayton W., Smith, Jeff, Jantz, Derek
Published in Molecular therapy (01.05.2016)
Published in Molecular therapy (01.05.2016)
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