Loss of Spastin Function Results in Disease‐Specific Axonal Defects in Human Pluripotent Stem Cell‐Based Models of Hereditary Spastic Paraplegia
Denton, Kyle R., Lei, Ling, Grenier, Jeremy, Rodionov, Vladimir, Blackstone, Craig, Li, Xue‐Jun
Published in Stem cells (Dayton, Ohio) (01.02.2014)
Published in Stem cells (Dayton, Ohio) (01.02.2014)
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Journal Article
Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor
Wang, Sijie, Denton, Kyle E, Hobbs, Kathryn F, Weaver, Tyler, McFarlane, James M. B, Connelly, Katelyn E, Gignac, Michael C, Milosevich, Natalia, Hof, Fraser, Paci, Irina, Musselman, Catherine A, Dykhuizen, Emily C, Krusemark, Casey J
Published in ACS chemical biology (17.01.2020)
Published in ACS chemical biology (17.01.2020)
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Journal Article
Reduced C9orf72 expression exacerbates polyGR toxicity in patient iPSC-derived motor neurons and a Type I protein arginine methyltransferase inhibitor reduces that toxicity
Dane, Therese L, Gill, Anna L, Vieira, Fernando G, Denton, Kyle R
Published in Frontiers in cellular neuroscience (17.04.2023)
Published in Frontiers in cellular neuroscience (17.04.2023)
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Journal Article
Application of a Substrate-Mediated Selection with c-Src Tyrosine Kinase to a DNA-Encoded Chemical Library
Kim, Dongwook, Sun, Yixing, Xie, Dan, Denton, Kyle E, Chen, Hao, Lin, Hang, Wendt, Michael K, Post, Carol Beth, Krusemark, Casey J
Published in Molecules (Basel, Switzerland) (30.07.2019)
Published in Molecules (Basel, Switzerland) (30.07.2019)
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Journal Article
Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia
Mou, Yongchao, Dong, Yi, Chen, Zhenyu, Denton, Kyle R, Duff, Michael O, Blackstone, Craig, Zhang, Su-Chun, Li, Xue-Jun
Published in Acta neuropathologica communications (07.12.2020)
Published in Acta neuropathologica communications (07.12.2020)
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Journal Article
Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke
Yuan, Hui, Denton, Kyle, Liu, Lin, Li, Xue-Jun, Benashski, Sharon, McCullough, Louise, Li, Jun
Published in Neurobiology of disease (01.07.2016)
Published in Neurobiology of disease (01.07.2016)
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Journal Article
Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl‑1 from a DNA-Encoded Chemical Library Screen
Lucas, Simon C. C., Blackwell, J. Henry, Börjesson, Ulf, Hargreaves, David, Milbradt, Alexander G., Ahmed, Samiyah, Bostock, Mark J., Guerot, Carine, Gohlke, Andrea, Kinzel, Olaf, Lamb, Michelle L., Selmi, Nidhal, Stubbs, Christopher J., Su, Nancy, Su, Qibin, Luo, Haiou, Xiong, Ting, Zuo, Xiaoqian, Bazzaz, Sana, Bienstock, Corey, Centrella, Paolo A., Denton, Kyle E., Gikunju, Diana, Guié, Marie-Aude, Guilinger, John P., Hupp, Christopher, Keefe, Anthony D., Satoh, Takashi, Zhang, Ying, Rivers, Emma L.
Published in ACS medicinal chemistry letters (13.06.2024)
Published in ACS medicinal chemistry letters (13.06.2024)
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Journal Article
Modeling Axonal Phenotypes with Human Pluripotent Stem Cells
Denton, Kyle R, Xu, Chong-Chong, Li, Xue-Jun
Published in Methods in molecular biology (Clifton, N.J.) (2016)
Published in Methods in molecular biology (Clifton, N.J.) (2016)
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Journal Article
Modeling axonal defects in hereditary spastic paraplegia with human pluripotent stem cells
Denton, Kyle R., Xu, Chongchong, Shah, Harsh, Li, Xue-Jun
Published in Frontiers in biology (01.10.2016)
Published in Frontiers in biology (01.10.2016)
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Journal Article
Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias
Denton, Kyle, Mou, Yongchao, Xu, Chong-Chong, Shah, Dhruvi, Chang, Jaerak, Blackstone, Craig, Li, Xue-Jun
Published in Human molecular genetics (15.07.2018)
Published in Human molecular genetics (15.07.2018)
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Journal Article
Kinetic Heterogeneity of Cancer Cell Fractional Killing
Inde, Zintis, Forcina, Giovanni C., Denton, Kyle, Dixon, Scott J.
Published in Cell reports (Cambridge) (07.07.2020)
Published in Cell reports (Cambridge) (07.07.2020)
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Journal Article
Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded librariesThe authors declare no competing interests.Electronic supplementary information (ESI) available: Data for Kd determination of ligands on-DNA (Fig. S1-S4, Tables S1-S3), figures for CBX8 (Fig. S5) and PKA crosslinking (Fig. S6), oligonucleotide sequences and structural modifications, experimental procedures for synthesis and characterization of DNA conjugates and small molecules. See DOI: 10.1039/c6md00
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Calcium/calmodulin-dependent protein kinase kinase β is neuroprotective in stroke in aged mice
Liu, Lin, Yuan, Hui, Denton, Kyle, Li, Xue-jun, McCullough, Louise, Li, Jun
Published in The European journal of neuroscience (01.08.2016)
Published in The European journal of neuroscience (01.08.2016)
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Journal Article
Abstract C049: Identification of novel K-Ras G12C inhibitors using a DNA encoded library platform
Arora, Shilpi, Hupp, Chris, Talcott, Sarah, Narayanan, Usha, Gikunju, Diana, Rechenberg, Mortiz Von, Monteiro, Michael I, Giulinger, John P, Denton, Kyle, Clark, Matt, Ferguson, Andrew, McRiner, Andrew J, Cuozzo, John, Huguet, Christelle, Keefe, Anthony D
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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신경변성 질환의 치료를 위한 CuPTSM
GILL ALAN, LUKASHEV MATVEY, PERRIN STEVEN, VIEIRA FERNANDO G, DENTON KYLE, HATZIPETROS THEO
Year of Publication 17.08.2022
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Year of Publication 17.08.2022
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