A Selective and Slowly Reversible Inhibitor of l‑Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells
Huttunen, Kristiina M, Gynther, Mikko, Huttunen, Johanna, Puris, Elena, Spicer, Julie A, Denny, William A
Published in Journal of medicinal chemistry (23.06.2016)
Published in Journal of medicinal chemistry (23.06.2016)
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Effect of wet milling process on the solid state of indomethacin and simvastatin
Sharma, Puneet, Denny, William A., Garg, Sanjay
Published in International journal of pharmaceutics (01.10.2009)
Published in International journal of pharmaceutics (01.10.2009)
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Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality
Chan, Denise A, Sutphin, Patrick D, Nguyen, Phuong, Turcotte, Sandra, Lai, Edwin W, Banh, Alice, Reynolds, Gloria E, Chi, Jen-Tsan, Wu, Jason, Solow-Cordero, David E, Bonnet, Muriel, Flanagan, Jack U, Bouley, Donna M, Graves, Edward E, Denny, William A, Hay, Michael P, Giaccia, Amato J
Published in Science translational medicine (03.08.2011)
Published in Science translational medicine (03.08.2011)
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Genotoxicity of non-covalent interactions: DNA intercalators
Ferguson, Lynnette R, Denny, William A
Published in Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis (01.10.2007)
Published in Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis (01.10.2007)
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Inhibition of strigolactone receptors by N-phenylanthranilic acid derivatives: Structural and functional insights
Hamiaux, Cyril, Drummond, Revel S.M., Luo, Zhiwei, Lee, Hui Wen, Sharma, Prachi, Janssen, Bart J., Perry, Nigel B., Denny, William A., Snowden, Kimberley C.
Published in The Journal of biological chemistry (27.04.2018)
Published in The Journal of biological chemistry (27.04.2018)
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A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types
Jamieson, Stephen, Flanagan, Jack U, Kolekar, Sharada, Buchanan, Christina, Kendall, Jackie D, Lee, Woo-Jeong, Rewcastle, Gordon W, Denny, William A, Singh, Ripudaman, Dickson, James, Baguley, Bruce C, Shepherd, Peter R
Published in Biochemical journal (15.08.2011)
Published in Biochemical journal (15.08.2011)
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Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs
Gynther, Mikko, Pickering, Darryl S, Spicer, Julie A, Denny, William A, Huttunen, Kristiina M
Published in Molecular pharmaceutics (05.07.2016)
Published in Molecular pharmaceutics (05.07.2016)
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Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria
Zhuang, Zhijun, Wan, Dawei, Ding, Jun, He, Shijie, Zhang, Qian, Wang, Xiaomei, Yuan, Ying, Lu, Yu, Ding, Charles Z, Lynch, Anthony Simon, Upton, Anna M, Cooper, Christopher B, Denny, William A, Ma, Zhenkun
Published in Molecules (Basel, Switzerland) (22.05.2020)
Published in Molecules (Basel, Switzerland) (22.05.2020)
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Structure-Activity Relationships for the Anaesthetic and Analgaesic Properties of Aromatic Ring-Substituted Ketamine Esters
Dimitrov, Ivaylo V, Harvey, Martyn G, Voss, Logan J, Sleigh, James W, Bickerdike, Michael J, Denny, William A
Published in Molecules (Basel, Switzerland) (26.06.2020)
Published in Molecules (Basel, Switzerland) (26.06.2020)
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Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogue of Bedaquiline
Choi, Peter J, Conole, Daniel, Sutherland, Hamish S, Blaser, Adrian, Tong, Amy S T, Cooper, Christopher B, Upton, Anna M, Palmer, Brian D, Denny, William A
Published in Molecules (Basel, Switzerland) (20.03.2020)
Published in Molecules (Basel, Switzerland) (20.03.2020)
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Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors
HICKS, Kevin O, SIIM, Bronwyn G, DENNY, William A, HAY, Michael P, WILSON, William R, JAISWAL, Jagdish K, PRUIJN, Frederik B, FRASER, Annie M, PATEL, Rita, HOGG, Alison, SARATH LIYANAGE, H. D, JO DORIE, Mary, BROWN, J. Martin
Published in Clinical cancer research (15.10.2010)
Published in Clinical cancer research (15.10.2010)
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Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling
Chaussade, Claire, Rewcastle, Gordon W, Kendall, Jackie D, Denny, William A, Cho, Kitty, Grønning, Line M, Chong, Mei Ling, Anagnostou, Sasha H, Jackson, Shaun P, Daniele, Nathalie, Shepherd, Peter R
Published in Biochemical journal (15.06.2007)
Published in Biochemical journal (15.06.2007)
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Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104
PATTERSON, Adam V, FERRY, Dianne M, SHANGJIN YANG, DENNY, William A, WILSON, William R, EDMUNDS, Shelley J, YONGCHUAN GU, SINGLETON, Rachelle S, PATEL, Kashyap, PULLEN, Susan M, HICKS, Kevin O, SYDDALL, Sophie P, ATWELL, Graham J
Published in Clinical cancer research (01.07.2007)
Published in Clinical cancer research (01.07.2007)
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Involvement of the tumour necrosis factor receptor system in glioblastoma cell death induced by palbociclib-heptamethine cyanine dye conjugate
Cooper, Elizabeth, Oyagawa, Caitlin R M, Johnson, Rebecca, Choi, Peter J, Foliaki, Jena Macapagal, Correia, Jason, Schweder, Patrick, Heppner, Peter, Mee, Edward, Turner, Clinton, Faull, Richard, Denny, William A, Dragunow, Mike, Jose, Jiney, Park, Thomas I-H
Published in Cell communication and signaling (11.01.2024)
Published in Cell communication and signaling (11.01.2024)
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Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain
Jacobson, Gregory M, Voss, Logan J, Klockars, Anica, Bird, Steve, Dimitrov, Ivo, Denny, William A, Olszewski, Pawel K, Sleigh, James W, Harvey, Martyn G
Published in BMC genomics (11.04.2019)
Published in BMC genomics (11.04.2019)
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